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combining GLP-1 receptor agonists and SGLT-2 inhibitors for cardiovascular disease prevention in type 2 diabetes:A systematic review with multiple network meta-regressions

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World Journal of diabetes 2024年第10期15卷 2135-2146页

作者： Jing-Jing Zhu john P H Wilding Xiao-Song Gu department of Endocrinology and Metabolic Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina department of cardiovascular and Metabolic Medicine University of LiverpoolLiverpool L697ZXUnited Kingdom clinical Sciences centre Liverpool University Hospitals NHS Foundation TrustLiverpool L97ALUnited Kingdom department of cardiovascular Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina

BAcKGROUNd Glucagon-like peptide-1 receptor agonists(GLP-1RA)and sodium-glucose co-transporter-2 inhibitors(SGLT-2I)are associated with significant cardiovascular benefit in type 2 diabetes(T2d).However,GLP-1RA or SGLT-2I alone may not improve some cardiovascular outcomes in patients with prior cardiovascular *** To explore whether combining GLP-1RA and SGLT-2I can achieve additional benefit in preventing cardiovascular diseases in *** The systematic review was conducted according to PRISMA *** protocol was registered on PROSPERO(Id:42022385007).A total of 107049 participants from eligible cardiovascular outcomes trials of GLP-1RA and SGLT-2I were included in network meta-regressions to estimate cardiovascular benefit of the combination *** modification of prior myocardial infarction(MI)and heart failure(HF)was also explored to provide clinical insight as to when the INTROdUcTION The macro-and micro-vascular benefits of glucagon-like peptide-1 receptor agonists(GLP-1RA)and sodium-glucose co-transporter-2 inhibitors(SGLT-2I)are independent of their glucose-lowering effects[1].In patients with type 2 diabetes(T2d),the major cardiovascular outcome trials(cVOT)showed that dipeptidyl peptidase-4 inhibitors(dPP-4I)did not improve cardiovascular outcomes[2],whereas cardiovascular benefit of GLP-1RA or SGLT-2I was significant[3,4].Further subgroup analyses indicated that the background cardiovascular risk should be considered when examining the cardiovascular outcomes of these newer glucose-lowering *** instance,prevention of major adverse cardiovascular events(MAcE)was only seen in those patients with baseline atherosclerotic cardiovascular disease[3,4].Moreover,a series of cVOT conducted in patients with heart failure(HF)have demonstrated that(compared with placebo)SGLT-2I significantly reduced risk of hospitalization for HF or cardiovascular death,irrespective of their history of T2d[5-8].However,similar car

关键词： Type 2 diabetes Glucagon-like peptide-1 receptor agonist Sodium-glucose co-transporter-2 inhibitor combination treatment cardiovascular outcome Systematic review Network meta-regression

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The risk of prostate cancer on incidental finding of an avid prostate uptake on 2-deoxy-2-[^(18)F]fluoro-d-glucose positron emission tomography/computed tomography for non-prostate cancer-related pathology:A single centre retrospective study

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Asian Journal of Urology 2024年第1期11卷 33-41页

作者： Anthony Franklin Troy Gianduzzo Boon Kua david Wong Louise McEwan James Walters Rachel Esler Matthew J.Roberts Geoff coughlina john W.Yaxley department of Urology The Wesley HospitalBrisbaneQLDAustralia Wesley Medical Research BrisbaneQLDAustralia School of Medicine The University of QueenslandBrisbaneQLDAustralia department of Radiology Wesley Medical ImagingBrisbaneQLDAustralia department of Urology Royal Brisbane and Women's HospitalBrisbaneQLDAustralia

Objective:To review the risk of prostate cancer(Pca)in men with incidentally reported increased intraprostatic uptake at 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography(18F-FdG PET/cT)ordered at department of Urology,The Wesley Hospital,Brisbane,QLd,Australia for non-Pca related ***:Retrospective analysis of consecutive men between August 2014 and August 2019 presenting to a single institution for 18F-FdG PET/cT for non-prostate related conditions was *** were classified as benign,indeterminate,or malignant depending of the results of prostate-specific antigen(PSA),PSA velocity,biopsy histopathology,and three-Tesla(3 T)multiparametric MRI(mpMRI)Prostate Imaging Reporting and data System score,or gallium-68-prostate-specific membrane antigen(68Ga-PSMA)PET/cT ***:Three percent(273/9122)of men demonstrated 18F-FdG avidity within the ***-five percent(231/273)were further investigated,including with PSA tests(227/231,98.3%),3 T mpMRI(68/231,29.4%),68Ga-PSMA PET/cT(33/231,14.3%),and prostate biopsy(57/231,24.7%).Results were considered benign in 130/231(56.3%),indeterminate in 31/231(13.4%),and malignant in 70/231(30.3%).Pca was identified in 51/57(89.5%)of the men who proceeded to biopsy,including 26/27(96.3%)men with Prostate Imaging Reporting and data System scores 4-5 mpMRI and six men with a positive 68Ga-PSMA PET/*** most common Gleason score on biopsy was greater than or equal to 4+5(14/51,27.5%).68Ga-PSMA PET/cT was concordant with the 18F-FdG findings in 26/33(78.8%).All 13 men with a positive concordant 18F-FdG,3 T mpMRI,and 68Ga-PSMA PET/cT had Pca on *** was no statistically significant difference in the 18F-FdG maximum standardized uptake value between the benign or malignant groups(5.7 vs.6.1;p=0.580).conclusion:In this study,after an incidental finding of an avid intraprostatic lesion on 18F-FdG PET/cT,70 of the 231 cases(30.3%;0.8%of the entire cohort)had results c

关键词： Prostatecancer Positionemission tomography Multiparametric magneticresonance imaging Prostatebiopsy

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(Super)paramagnetic nanoparticles as platform materials for environmental applications: From synthesis to demonstration

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Frontiers of Environmental Science & Engineering 2020年第5期14卷 15-23页

作者： Wenlu Li john d.Fortner department of chemical and Environmental Engineering Yale UniversityNew HavenCT 06520USA

Over the past few decades,engineered,(super)paramagnetic nanoparticles have drawn extensive research attention for a broad range of applications based on their tunable size and shape,surface chemistries,and magnetic *** review summaries our recent work on the synthesis,surface modification,and environmental application of(super)paramagnetic *** utilizing high-temperature thermo-decomposition methods,first,we have broadly demonstrated the synthesis of highly monodispersed,(super)paramagnetic nanoparticles,via the pyrolysis of metal carboxylate salts in an organic *** uniform magnetic nanoparticles with various size,composition,and shape can be precisely tuned by controlled reaction parameters,such as the initial precursors,heating rate,final reaction temperature,reaction time,and the *** materials can be further rendered water stable via functionalization with surface mono/bi-layer coating structure using a series of tunable ionic/non-ionic ***,we have demonstrated platform potential of these materials for heavy metal ions sensing,sorption,and separation from the aqueous phase.

关键词： Superparamagnetic nanoparticles Surface functionalization Environmental sensing Heavy metal ion sorption

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computational Modeling of dual-Phase ceramics with Finsler-Geometric Phase Field Mechanics

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computer Modeling in Engineering & Sciences 2019年第8期120卷 333-350页

作者： john d.clayton US ARL Impact Physics BranchAberdeen Proving GroundMD21005-5066USA

A theory invoking concepts from differential geometry of generalized Finsler space in conjunction with diffuse interface modeling is described and implemented in finite element(FE)simulations of dual-phase polycrystalline ceramic *** parameters accounting for fracture and other structural transformations,notably partial dislocation slip,twinning,or phase changes,are dimensionless entries of an internal state vector of generalized pseudo-Finsler *** investigated in computations are a boron carbide-titanium diboride(B4c-TiB2)composite and a diamond-silicon carbide(c-Sic)*** mechanisms-in addition to elasticity and cleavage fracture in grains of any phase-include restricted dislocation glide(TiB2 phase),deformation twinning(B4c and-Sic phases),and stress-induced amorphization(B4c phase).The metric tensor of generalized Finsler space is scaled conformally according to dilatation induced by cavitation or other fracture modes and densification induced by phase *** of pure shear consider various morphologies and lattice *** of microstructure on overall strength of each composite are *** B4c-TiB2,minor improvements in shear strength and ductility are observed with an increase in the second phase from 10 to 18%by volume,suggesting that residual stresses or larger-scale crack inhibition may be responsible for toughness gains reported *** diamond-Sic,a composite consisting of diamond crystals encapsulated in a nano-crystalline Sic matrix shows improved strength and ductility relative to a two-phase composite with isolated bulk Sic grains.

关键词： Micromechanics ceramic composites,Finsler space differential geometry phase field finite elements

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c1c2 Wiring and Posttraumatic Atlantoaxial dislocation: An Effective and cheap Surgical Procedure in a developing country

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Surgical Science 2024年第5期15卷 357-370页

作者： Ibrahim dao Massimiliano Visocchi Salah Sow john Jabang Ousmane Ouattara Astride Somda Abdoulaye Sanou Elie dibloni Nassoum Arsène Tossou Narcisse Ouedraogo Frédéric Bako Massadiami Soulama Malick diallo Patrick Wendpouiré Hamed dakouré department of Neurosurgery University Hospital Souro Sanou Nazi Boni University Bobo Dioulasso Burkina Faso High Institute of Health Sciences Nazi Boni University Bobo Dioulasso Burkina Faso Military Hospital colonel Major Tanguet Ouattara Bobo Dioulasso Burkina Faso Institute of Neurosurgery Craniovertebral Junction Surgery Unit School of Medicine Catholic University Rome Italy department of Radiology and Medical Imaging University Hospital Yalgado Ouedraogo Joseph Ki-Zerbo University Ouagadougou Burkina Faso department of Neurosurgery (Unit) Edward Francis Small Teaching Hospital Banjul Gambia department of Neurosurgery University Hospital Yalgado Ouedraogo Joseph Ki-Zerbo University Ouagadougou Burkina Faso department of Neurosurgery Military Hospital Capitaine Halassane Coulibaly Ouagadougou Burkina Faso department of Orthopedic Surgery University Hospital Souro Sanou Nazi Boni University Bobo Dioulasso Burkina Faso

Objectives: Atlantoaxial dislocation remains a rare and serious condition with a high preoperative and postoperative morbidity and mortality. Its successful surgical management is still challenging and gratifying for neurosurgeons. Several technics have been described such as wiring, trans articular screwing, c1c2 screwing with plate and screw introduced by Goel et al., and modified by insertion of polyaxially screw and rod many years later by Harms. Unavailability and expensiveness of upper cervical spine instrumentation device led us to c1c2 Wiring resulting in a good outcome. Finally, a quadriplegic patient with a more comfortable financial condition had ordered devices from abroad and benefit for Goel and Harms screwing technique and improved dramatically from ASIA A to ASIA E. Material and methods: This is a retrospective study of patients managed in our department by a same neurosurgeon from January 2019 to April 2024. Results: We defined 6 men and 1 woman with an average age of 33 years. Unrestrained driver in a rollover motor vehicle accident was most common. Only one patient was neurologically intact on admission. Neurovegetative disorders were noticed in one patient. dislocation was associated to a fracture of the dens in two patients. Three patients have been successfully operated with remarkable outcome, mostly from ASIA A to E. conclusion: c1c2 dislocation is a serious condition and c1c2 Wiring represents an effective and cheaper technic. Therefore, this technic should deserve consideration above all in low incomes countries when screwing devices are not available. Seatbelt should be demanded for motor vehicle drivers and passengers.

关键词： Superior cervical Spine dislocation Fracture Wiring Screwing Neurovegetative disorders

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高、低核酸含量原核生物应对资源可利用性降低和原生动物选择性摄食的适应性策略

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中国科学：地球科学 2024年第6期54卷 1901-1913页

作者：胡晨余柳倩陈晓炜刘纪化张瑶 john BATT 肖喜林石蔷张锐骆庭伟焦念志徐大鹏厦门大学环境与生态学院厦门361102 近海海洋环境科学国家重点实验室厦门大学海洋与地球学院福建省海洋碳汇重点实验室厦门361102 Joint Lab for Ocean Research and Education(LORE)of dalhousie University Canadaand Shandong University and Xiamen UniversityXiamen 361102China 香港科技大学(广州)地球与海洋大气科学学域广州510000 山东大学海洋研究院青岛266237 department of Oceanography Dalhousie UniversityHalifaxNova Scotia B3H 4R2Canada 深圳大学高等研究院深圳518060 厦门大学碳中和创新研究中心厦门361102

原核生物在全球海洋生物地球化学循环中发挥重要作用,然而对它们不同生态亚群(即:高核酸(HNA)和低核酸(LNA)含量亚群)的丰度和代谢活性,以及它们的调控因素如何随着海洋环境条件的变化而变化,仍知之甚少.我们在117,000升的大体积培养体... 详细信息

原核生物在全球海洋生物地球化学循环中发挥重要作用,然而对它们不同生态亚群(即:高核酸(HNA)和低核酸(LNA)含量亚群)的丰度和代谢活性,以及它们的调控因素如何随着海洋环境条件的变化而变化,仍知之甚少.我们在117,000升的大体积培养体系中进行了73天的培养实验,深入研究HNA和LNA亚群对资源可利用性降低和原生动物选择性摄食随时间变化的动态响应.研究结果显示,当培养环境资源充足时, HNA亚群的代谢活性高于LNA亚群,但随着资源日益稀缺, HNA亚群代谢下降速度比LNA亚群快,从而使LNA亚群对原核生物活性的贡献稳步增加.与此同时,随着培养体系资源可利用性逐步降低,原生动物的摄食偏好从HNA亚群转向LNA亚群,使得LNA亚群对培养体系的碳流贡献增加.这些结果突显了LNA亚群在资源有限环境中的韧性,阐明了原生动物选择性摄食在资源条件变化时平衡不同亚群中的关键作用,并展示了在不同环境背景下原生动物和原核生物之间复杂的相互适应性.

关键词：微生物环大体积培养实验原核生物自上而下和自下而上调控作用碳流

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Optimized cUdA Implementation to Improve the Performance of Bundle Adjustment Algorithm on GPUs

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Journal of Software Engineering and Applications 2024年第4期17卷 172-201页

作者： Pranay R. Kommera Suresh S. Muknahallipatna john E. McInroy department of Electrical Engineering and computer Science University of Wyoming Laramie Wyoming USA

The 3d reconstruction pipeline uses the Bundle Adjustment algorithm to refine the camera and point parameters. The Bundle Adjustment algorithm is a compute-intensive algorithm, and many researchers have improved its performance by implementing the algorithm on GPUs. In the previous research work, “Improving Accuracy and computational Burden of Bundle Adjustment Algorithm using GPUs,” the authors demonstrated first the Bundle Adjustment algorithmic performance improvement by reducing the mean square error using an additional radial distorting parameter and explicitly computed analytical derivatives and reducing the computational burden of the Bundle Adjustment algorithm using GPUs. The naïve implementation of the cUdA code, a speedup of 10× for the largest dataset of 13,678 cameras, 4,455,747 points, and 28,975,571 projections was achieved. In this paper, we present the optimization of the Bundle Adjustment algorithm cUdA code on GPUs to achieve higher speedup. We propose a new data memory layout for the parameters in the Bundle Adjustment algorithm, resulting in contiguous memory access. We demonstrate that it improves the memory throughput on the GPUs, thereby improving the overall performance. We also demonstrate an increase in the computational throughput of the algorithm by optimizing the cUdA kernels to utilize the GPU resources effectively. A comparative performance study of explicitly computing an algorithm parameter versus using the Jacobians instead is presented. In the previous work, the Bundle Adjustment algorithm failed to converge for certain datasets due to several block matrices of the cameras in the augmented normal equation, resulting in rank-deficient matrices. In this work, we identify the cameras that cause rank-deficient matrices and preprocess the datasets to ensure the convergence of the BA algorithm. Our optimized cUdA implementation achieves convergence of the Bundle Adjustment algorithm in around 22 seconds for the largest dataset compared

关键词： Scene Reconstruction Bundle Adjustment Levenberg-Marquardt Non-Linear Least Squares Memory Throughput computational Throughput contiguous Memory Access cUdA Optimization

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chronic liver disease in Aboriginal North Americans

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World Journal of Gastroenterology 2008年第29期14卷 4607-4615页

作者： john d Scott Naomi Garland department of Medicine Division of Allergy and Infectious Diseases University of WashingtonSeattle WA 98144 United States department of Laboratory Medicine University of WashingtonSeattle WA 98144 United States

A structured literature review was performed to detail the frequency and etiology of chronic liver disease (cLd) in Aboriginal North Americans. cLd affects Aboriginal North Americans disproportionately and is now one of the most common causes of death. Alcoholic liver disease is the leading etiology of cLd, but viral hepatitis, particularly hepatitis c, is an important and growing cause of cLd. High rates of autoimmune hepatitis and primary biliary cirrhosis (PBc) are reported in regions of coastal British columbia and southeastern Alaska. Non-alcoholic liver disease is a common, but understudied, cause of cLd. Future research should monitor the incidence and etiology of cLd and should be geographically inclusive. In addition, more research is needed on the treatment of hepatitis c virus (HcV) infection and non-alcoholic fatty liver disease (NAFLd) in this population.

关键词： Hepatitis c virus Hepatitis B virus American Indian Alaska Native chronic liver disease

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Biomarkers for diet and cancer prevention research:potentials and challenges

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Acta Pharmacologica Sinica 2007年第9期28卷 1262-1273页

作者： cindy d dAVIS john A MILNER Nutritional Science Research GroupNational cancer InstituteRockvilleMd 20892USA

As cancer incidence is projected to increase for decades there is a need for effec-tive preventive ***,evidence continues to mount that alteringdietary habits is an effective and cost-efficient approach for reducing cancer riskand for modifying the biological behavior of ***,validated andsensitive biomarkers,including those that reliably evaluate"intake"or exposureto a specific food or bioactive component,that assess one or more specific bio-logical"effects"that are linked to cancer,and that effectively predict individual"susceptibility"as a function of nutrient-nutrient interactions and genetics,arefundamental to evaluating who will benefit most from dietary *** must be readily accessible,easily and reliably assayed,and predictiveof a key process(es) involved in *** response to a food is determined notonly by the effective concentration of the bioactive food component(s) reachingthe target tissue,but also by the amount of the target requiring ***,this threshold response to foods and their components will vary from indi-vidual to *** key to understanding a personalized response is a greaterknowledge of nutrigenomics,proteomics and metabolomics.

关键词： exposure biomarker effect biomarker susceptibility biomarker nutrigenomics

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Outcomes of combined mitochondria and mesenchymal stem cellsderived exosome therapy in rat acute respiratory distress syndrome and sepsis

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World Journal of Stem cells 2024年第6期16卷 690-707页

作者： Kun-chen Lin Wen-Feng Fang Jui-Ning Yeh john Y chiang Hsin-Ju chiang Pei-Lin Shao Pei-Hsun Sung Hon-Kan Yip department of Anesthesiology Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina division of Pulmonary and critical care Medicine Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung 83301TaiwanChina department of cardiology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina department of computer Science and Engineering National Sun Yat-sen UniversityKaohsiung 804201TaiwanChina department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 40201TaiwanChina department of Nursing Asia UniversityTaichung 41354TaiwanChina division of cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301TaiwanChina Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina School of Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

BAcKGROUNd The treatment of acute respiratory distress syndrome(ARdS)complicated by sepsis syndrome(SS)remains *** To investigate whether combined adipose-derived mesenchymal-stem-cells(AdMScs)-derived exosome(EXAd)and exogenous mitochondria(mitoEx)protect the lung from ARdS complicated by *** In vitro study,including L2 cells treated with lipopolysaccharide(LPS)and in vivo study including male-adult-Sd rats categorized into groups 1(sham-operated-control),2(ARdS-SS),3(ARdS-SS+EXAd),4(ARdS-SS+mitoEx),and 5(ARdS-SS+EXAd+mitoEx),were included in the present *** In vitro study showed an abundance of mitoEx found in recipient-L2 cells,resulting in significantly higher mitochondrial-cytochrome-c,adenosine triphosphate and relative mitochondrial dNA levels(Pcrosis factor(TNF)-α/nuclear factor-κB/toll-like receptor(TLR)-4/matrix-metalloproteinase(MMP)-9/oxidative-stress(NOX-1/NOX-2)/apoptosis(cleaved-caspase3/cleaved-poly(AdP-ribose)polymerase)]were significantly attenuated in lipopolysaccharide(LPS)-treated L2 cells with EXAd treatment than without EXAd treatment,whereas the protein expressions of cellular junctions[occluding/β-catenin/zonula occludens(ZO)-1/E-cadherin]exhibited an opposite pattern of inflam-mation(all Pd by 72 h post-48 h-ARdS induction,and lung tissues were *** 72 h,flow cytometric analysis of bronchoalveolar lavage fluid demonstrated that the levels of inflam-matory cells(Ly6G+/cd14+/cd68+/cd11b/c+/myeloperoxidase+)and albumin were lowest in group 1,highest in group 2,and significantly higher in groups 3 and 4 than in group 5(all Pdisplayed an opposite pattern of albumin among the *** findings of lung injury/fibrosis area and inflammatory/dNA-damaged markers(cd68+/γ-H2AX)displayed an identical pattern of SaO2%among the groups(all P<0.0001).The pro

关键词： Acute respiratory distress syndrome Sepsis syndrome Exosomes Mitochondria Adipose tissue-derived mesenchymal stem cells Inflammation

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