检索结果-南通市图书馆

Physics prospects of the Jinping neutrino experiment

在线全文

学校读者我要写书评

暂无评论

chinese Physics c 2017年第2期41卷 9-32页

作者： john *** 陈少敏程建平 Sayed N.doustimotlagh 高原宁龚光华宫辉郭磊韩然何红建黄性涛李荐民李金李默涵李学潜廖玮林贵林刘佐伟 William Mc donough Ondˇrej rmek 唐健万林焱王元清王喆王综轶魏瀚宇习宇飞徐晔许勋杰杨振伟姚春发 Minfang Yeh 岳骞张黎明张洋赵志宏郑阳恒周详朱相雷 Kai Zuber dept. of Physics Dept. of Astronomy and CCAPP The Ohio State University department of Engineering Physics Tsinghua University Science and Technology on Reliability and Environmental Engineering Laboratory Beijing Institute of Spacecraft Environment Engineering School of Physics Shandong University School of Physics Nankai University Institute of Modern Physics East China University of Science and Technology Institute of Physics National Chiao-Tung University University of Maryland College Park department of Geophysics Faculty of Mathematics and Physics Charles University in Prague School of Physics Sun Yat-Sen University department of civil Engineering Tsinghua University Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological Sciences Fujian University of Technology department of Structural Steels China Iron & Steel Research Institute Group Brookhaven National Laboratory School of Physical Sciences University of Chinese Academy of Sciences School of Physics and Technology Wuhan University Institut für Kern- und Teilchenphysik Technische Universitt Dresden

The china Jinping Underground Laboratory（cJPL）, which has the lowest cosmic-ray muon flux and the lowest reactor neutrino flux of any laboratory, is ideal to carry out low-energy neutrino experiments. With two detectors and a total fiducial mass of 2000 tons for solar neutrino physics（equivalently, 3000 tons for geo-neutrino and supernova neutrino physics）, the Jinping neutrino experiment will have the potential to identify the neutrinos from the cNO fusion cycles of the Sun, to cover the transition phase for the solar neutrino oscillation from vacuum to matter mixing, and to measure the geo-neutrino flux, including the Th/U ratio. These goals can be fulfilled with mature existing techniques. Efforts on increasing the target mass with multi-modular neutrino detectors and on developing the slow liquid scintillator will increase the Jinping discovery potential in the study of solar neutrinos,geo-neutrinos, supernova neutrinos, and dark matter.

关键词： cJPL Jinping neutrino experiment solar neutrino geo-neutrino supernova neutrino

Researching the Research: Applying Machine Learning Techniques to dissertation classification

在线全文

学校读者我要写书评

暂无评论

Journal of computer Science Research 2020年第4期2卷 7-15页

作者： Suzanna Schmeelk Tonya L.Fields Lisa R.Ellrodt Ion c.Freeman Ashley J.Haigler St.john's University United States Pace University United States

This research examines industry-based dissertation research in a doctoralcomputing program through the lens of machine learning algorithms todetermine if natural language processing-based categorization on abstractsalone is adequate for classification. This research categorizes dissertationby both their abstracts and by their full-text using the GraphLabcreate library from Apple’s Turi to identify if abstract analysis is anadequate measure of content categorization, which we found was not. Wealso compare the dissertation categorizations using IBM’s Watson discoverydeep machine learning tool. Our research provides perspectiveson the practicality of the manual classification of technical documents;and, it provides insights into the: (1) categories of academic work createdby experienced fulltime working professionals in a computing doctoralprogram, (2) viability and performance of automated categorization of theabstract analysis against the fulltext dissertation analysis, and (3) natuallanguage processing versus human manual text classification abstraction.

关键词： Machine learning Natural language processing(NLP) Abstract vs fulltext dissertation analysis Industry-based dissertation research classification GraphLab create library IBM Watson discovery

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

医海拾贝

英国医学杂志中文版 2007年第6期10卷 387-387页

作者： K darlow c calderwood 付希娟（译） department of obstetrics and gynaecology St John＇s Hospital Livingston West Lothian EH54 6PP 不详

自认为对乳汁不耐受的女孩比其他女孩每天少吸收212毫克钙。一项对13岁儿童的调查发现，经氢呼吸试验检测，自认为乳汁不耐受者中有近半数的人并非不耐受（Pediatrics 2007；120：e669—77）。作者认为，由于自认为乳汁不耐受而早在10... 详细信息

自认为对乳汁不耐受的女孩比其他女孩每天少吸收212毫克钙。一项对13岁儿童的调查发现，经氢呼吸试验检测，自认为乳汁不耐受者中有近半数的人并非不耐受（Pediatrics 2007；120：e669—77）。作者认为，由于自认为乳汁不耐受而早在10岁时就对乳品自我设限，与脊柱矿物质浓度较低和以后发生骨质疏松症的风险相关联。

关键词：氢呼吸试验骨质疏松症不耐受乳汁矿物质女孩

与斑贴试验反应强度有关的副-苯二胺过敏患者的分析

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（皮肤病学分册） 2005年第11期1卷 35-35页

作者： Ho S.G.Y. Basketter d.A. Jefferies d. J.P. Mcfadden 刘艳 dr. contact dermatitis clinic St. John's Institute of Dermatology St. Thomas'Hospital Lambeth Palace Rd London SE1 7EH United Kingdom

Background: despite having a positive patch test reaction to para-phenylenediamine (PPd), some patients continue to dye their hair, while others are forced to give up or abandon this practice. This difference in patient behaviour could be due to the degree of sensitization. Objectives: To establish whether the ability to continue dyeing hair in PPd allergic patients is related to the strength of patch test reaction. To note differences in other clinical features in relation to the strength of patch test reaction. Methods We analysed retrospectively the patch test records of 400 sequential PPd-positive patients for the strength of patch test reaction (+, ++, +++) and different clinical features. data were analysed using cochran-Mantel-Haenszel χ2 tests. Results: There was a strong linear relationship between the strength of patch test reaction and continuation with hair dyeing. Patients were more likely to report a history of hair dye reaction with increasing strength of patch test reaction. There was no difference in strength of patch test reaction in relation to age, site of rash, occupation (hairdressing) or history of atopic eczema. Overall concomitant reactivity with related aromatic amine allergens (benzocaine,N-isopropyl-Nphenyl-para-phenylenediamine, para-aminobenzoic acid) was infrequent. conclusions: Patients with stronger patch test reactions (++, +++) are more likely to have a clear history of reacting to hair dye and are less likely to still be dyeing their hair.

关键词：斑贴试验过敏患者苯二胺反应强度特应性皮炎发疹苯佐卡因 cochran 线性关系数据分析

在线全文

学校读者我要写书评

暂无评论

有机负荷对连续生物制氢反应器中氢气的影响

中国甜菜糖业 2019年第1期 29-33,35页

作者：郝鑫敖梓鼎卡不贝尔季丹丹张伊帆李永峰东北林业大学林业学院哈尔滨150040

本实验以红糖水为发酵基质,污泥为反应起始物,采用连续搅拌釜式反应器(cSTR)。在pH7.0±0.1、氧化还原电位(ORP)为-420mV、温度(35±1)℃、水力停留时间(HRT)为6h的条件下,产氢量达到稳定水平。(氢气是乙醇型发酵的主要成分)。通过保持... 详细信息

本实验以红糖水为发酵基质,污泥为反应起始物,采用连续搅拌釜式反应器(cSTR)。在pH7.0±0.1、氧化还原电位(ORP)为-420mV、温度(35±1)℃、水力停留时间(HRT)为6h的条件下,产氢量达到稳定水平。(氢气是乙醇型发酵的主要成分)。通过保持所有其他参数的一致性,我们能够关注改变有机负荷对氢生产的影响。同时,通过调节pH值,使微生物保持较高的活性。结果表明,当有机负荷从12kg/m-d增加到32kg/m-d时,沼气和产氢速率持续增加。当有机负荷为32kg/m_-d时,最大产气速率为18.6L/d,产氢速率为6.4L/d,与原始的12kg/m_-d相比,产气量分别提高了89%和87%。在系统运行过程中,降低进水pH值至5.85,抑制了厌氧发酵的微生物活性,导致产氢速率下降,ORP增加到-328mV。在此条件下,通过在反应器中加入一定量的NaOH来调节pH值,可使反应器保持较高的乙醇型发酵产氢速率。

关键词： cSTR pH值产氢量有机负荷乙醇型发酵

disrupted ca^(2+) h homeostasis and immunodeficiency in patients with functional IP_(3) receptor subtype 3 defects

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

cellular & Molecular Immunology 2023年第1期20卷 11-25页

作者： Julika Neumann Erika Van Nieuwenhove Lara E.Terry Frederik Staels Taylor R.Knebel Kirsten Welkenhuyzen Kourosh Ahmadzadeh Mariah R.Baker Margaux Gerbaux Mathijs Willemsen john S.Barber Irina I.Serysheva Liesbeth de Waele François Vermeulen Susan Schlenner Isabelle Meyts david IYule Geert Bultynck Rik Schrijvers Stephanie Humblet-Baron Adrian Liston VIB center for Brain and disease Research LeuvenBelgium department of Microbiology and Immunology KU LeuvenLeuvenBelgium UZ Leuven LeuvenBelgium department of Pharmacology and Physiology University of RochesterRochesterNY14526USA Laboratory of Molecular and cellular Signaling Department of Cellular and Molecular MedicineLeuven KankerinstituutKU LeuvenLeuvenBelgium Laboratory of Immunobiology Department Microbiology and ImmunologyRega InstituteKU LeuvenLeuvenBelgium department of Biochemistry and Molecular Biology Structural Biology Imaging CenterMcGovern Medical School at The University of Texas Health Science Center at HoustonHoustonTX77030USA Pediatric department Academic Children Hospital Queen FabiolaUniversitéLibre de BruxellesBrusselsBelgium department of Pediatric Neurology University Hospitals LeuvenLeuvenBelgium department of Pulmonology University Hospitals LeuvenLeuvenBelgium Laboratory for Inborn Errors of Immunity Department of Immunology and MicrobiologyKU LeuvenLeuvenBelgium Laboratory for Allergy and clinical Immunology and Immunogenetics Research Group Department of MicrobiologyImmunology and TransplantationKU LeuvenLeuvenBelgium Immunology Programme The Babraham InstituteBabraham Research CampusCambridgeCB223ATUK

calcium signaling is essential for lymphocyte activation, with genetic disruptions of store-operated calcium (ca^(2+)) entry resulting in severe immunodeficiency. The inositol 1,4,5-trisphosphate receptor (IP_(3)R), a homo- or heterotetramer of the IP_(3)R1-3 isoforms, amplifies lymphocyte signaling by releasing ca^(2+) from endoplasmic reticulum stores following antigen stimulation. Although knockout of all IP_(3)R isoforms in mice causes immunodeficiency, the seeming redundancy of the isoforms is thought to explain the absence of variants in human immunodeficiency. In this study, we identified compound heterozygous variants of ITPR3 (a gene encoding IP_(3)R subtype 3) in two unrelated caucasian patients presenting with immunodeficiency. To determine whether ITPR3 variants act in a nonredundant manner and disrupt human immune responses, we characterized the ca^(2+) signaling capacity, the lymphocyte response, and the clinical phenotype of these patients. We observed disrupted ca^(2+) signaling in patient-derived fibroblasts and immune cells, with abnormal proliferation and activation responses following T-cell receptor stimulation. Reconstitution of IP_(3)R3 in IP_(3)R knockout cell lines led to the identification of variants as functional hypomorphs that showed reduced ability to discriminate between homeostatic and induced states, validating a genotype–phenotype link. These results demonstrate a functional link between defective endoplasmic reticulum ca^(2+) channels and immunodeficiency and identify IP_(3)Rs as diagnostic targets for patients with specific inborn errors of immunity. These results also extend the known cause of ca^(2+)-associated immunodeficiency from store-operated entry to impaired ca^(2+) mobilization from the endoplasmic reticulum, revealing a broad sensitivity of lymphocytes to genetic defects in ca^(2+) signaling.

关键词： Primary immunodeficiency calcium signalling Whole exome sequencing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nature:揭示干细胞惊人异质性

岭南现代临床外科 2014年第6期14卷 722-722页

作者： Roshan M.Kumar Patrick cahan Alex K.Shalek Rahul Satija A.Jay daley Keyser Hu Li Jin Zhang Keith Pardee david Gennert john J.Trombetta Thomas c.Ferrante Aviv Regev George Q.daley James J. collins

论文作者George daley教授说：＂这是一项非常基础的研究,但它阐明了多能性状态广泛性。我们捕获了干细胞不同状态的详细分子谱。＂研究人员通过采用多种变量如不同的化学物质、培养环境和遗传敲除来扰乱多能干细胞,研究人员探究了它们... 详细信息

论文作者George daley教授说：＂这是一项非常基础的研究,但它阐明了多能性状态广泛性。我们捕获了干细胞不同状态的详细分子谱。＂研究人员通过采用多种变量如不同的化学物质、培养环境和遗传敲除来扰乱多能干细胞,研究人员探究了它们的发育景观。随后,他们分析了每个细胞的遗传组成,观察了每个细胞多能状态的微小波动。他们发现内部、化学和环境信号影响干细胞方式的许多细微差异,揭示出了复杂的发育调控因子＂决策＂回路。

关键词：环境信号 Nature 多能性异质性发育调控化学物质细胞类型 pluripotent 博士后研究人员 heterogeneity

新辅助化疗病人对侧正常乳腺密度降低的MRI评价

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2010年第3期 278-278页

作者：张丽娜 S. Bahri c.c. Hsu F.T. Hsu H.N. Shih john Tu and Thomas Yuen center for Functional OncoImaging University of California Irvine

摘要目的探讨通过定量MR成像技术观察新辅助化疗病人对侧正常乳腺密度的改变。材料与方法本研究符合科学与伦理委

关键词：乳腺密度 MRI 新辅助化疗对侧病人

五羟色胺2c受体结构揭示GPcR多重药理学特性的结构基础

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

科学新闻 2019年第2期 48-48页

作者：彭瑶 john d.Mccorvy Kasper Harps?e Katherine Lansu Shuguang Yuan Petr Popov Lu Qu Mengchen Pu Tao che Louise F.Nikolajsen Xi-Ping Huang Yiran Wu Ling Shen Walden E.Bj?rn-Yoshimoto Kang ding daniel Wacker Gye Won Han Jianjun cheng Vsevolod Katritch Anders A.Jensen Michael A.Hanson Suwen Zhao david E.Gloriam Bryan L.Roth Raymond c.Stevens 刘志杰上海科技大学iHuman研究所中国科学院生物物理研究所上海科技大学

文章简介有些药物往往需要作用于多个靶点,即多重药理学作用发挥其疗效。目前,针对多种血清素受体的药物,包括5-HT2c受体,对治疗肥胖、药物滥用和精神分裂症意义重大。开发具有针对5-HT2c受体选择性的配体或设计具有明确的多重药理学特... 详细信息

文章简介有些药物往往需要作用于多个靶点,即多重药理学作用发挥其疗效。目前,针对多种血清素受体的药物,包括5-HT2c受体,对治疗肥胖、药物滥用和精神分裂症意义重大。开发具有针对5-HT2c受体选择性的配体或设计具有明确的多重药理学特征的药物仍然是极其困

关键词：五羟色胺