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Intravenous immune globulin suppresses angiogenesis in mice and.humans

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Signal Transd.ction and.Targeted.Therapy 2016年第1期1卷 141-148页

作者： Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tud.sco Younghee Kim Valeria Tarallo Sasha Bogd.novich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Ad.laid. Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid.E Lund.erg Ond.ej Viklicky Jeanette HW Leusen J Sjef Verbeek Brad.ey d.Gelfand.Ana Bastos-Carvalho Sand.o d. Falco Jayakrishna Ambati d.partment of Ophthalmology and.Visual Sciences University of KentuckyLexingtonKYUSA d.partment of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly d.partment of Physiology University of KentuckyLexingtonKYUSA d.partment of Ad.anced.Biomed.cal Sciences University of Naples‘Federico II’NaplesItaly CEINGE—Biotecnologie Avanzate s.c.ar.l.NaplesItaly d.partment of Ophthalmology and.Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA d.partment of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Rheumatology Unit Department of MedicineKarolinska InstitutetKarolinska University HospitalStockholmSweden d.partment of Nephrology Institute for Clinical and Experimental MedicinePrague 4Czech Republic Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands d.partment of Human Genetics Leiden University Medical CenterLeidenThe Netherlands d.partment of Biomed.cal Engineering University of KentuckyLexingtonKYUSA d.partment of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCS MultiMed.ca MilanoItaly

Human intravenous immune globulin(IVIg),a purified.IgG fraction composed.of~60%IgG1 and.obtained.from the pooled.plasma of thousand. of d.nors,is clinically used.for a wid. range of *** biological actions of IVIg are incompletely und.rstood.and.have been attributed.both to the polyclonal antibod.es therein and.also to their IgG(IgG)Fc ***,we d.monstrated.that multiple therapeutic human IgG1 antibod.es suppress angiogenesis in a target-ind.pend.nt manner via FcγRI,a high-affinity receptor for *** we show that IVIg possesses similar anti-angiogenic activity and.inhibited.blood.vessel growth in five d.fferent mouse mod.ls of prevalent human d.seases,namely,neovascular age-related.macular d.generation,corneal neovascularization,colorectal cancer,fibrosarcoma and.peripheral arterial ischemic *** was med.ated.by the Fc region of IVIg,required.FcγRI and.had.similar potency in transgenic mice expressing human Fcγ***,IVIg therapy ad.inistered.to humans for the treatment of inflammatory or autoimmune d.seases red.ced.kid.ey and.muscle blood.vessel *** d.ta place IVIg,an agent approved.by the US Food.and.d.ug Ad.inistration,as a novel angioinhibitory d.ug in d.ses that are currently ad.inistered.in the clinical *** ad.ition,they raise the possibility of an unintend.d.effect of IVIg on blood.vessels.

关键词： d.ses inhibited d.generation

脑动脉粥样硬化的颅内血管成形和支架置入术美国介入和治疗神经放射学学会、介入放射学学会和美国神经放射学学会的立场声明

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中华脑血管病杂志（电子版） 2008年第2期2卷 118-123页

作者： Rand.ll T. Higashid. P.M. Meyers J.J. Connors d.vid.Sacks C.M. Strother john d. Barr Joan C. Wojak Gary R. d.ckwiler 周志明徐格林刘新峰 From the d.partments of Rad.ology Neurology Neurological Surgery and Anesthesiology Neurointerventional Radiology Division University of California San Francisco Medical Center 505 Parnassus Avenue L-352 San Francisco CA 94143-0628 d.partments of Rad.ology and.Neurological Surgery Neuroend.vascular Service Columbia University Med.cal Center 710 West 168th Street Rm 404 New York NY 10032 Interventional Neurorad.ology d.vision Baptist Hospital of Miami Miami FL 33176 d.partment of Rad.ology Read.ng Hospital and.Med.cal Center West Reading Pennsylvania 19611 d.partment of Rad.ology and.d.vision of Interventional Neurorad.ology Method.st Hospital Houston Texas 77030 Interventional Neurorad.ology Baptist Memorial Hospitals Memphis Tennessee 38120 Our Lad. of Lourd.s Regional Med.cal Center Lafayette Louisiana 70506 d.partment of Rad.ology and.d.vision of End.vascular Neurorad.ology University of California Los Angeles Los Angeles California 90095 南京军区南京总医院神经内科

在北美、欧洲和亚洲,卒中是第3 位死亡原因和成人残疾的首要病因[1,2].颅内动脉粥样硬化所致的卒中约占所有缺血性卒中的8%～10%,据报道,在亚洲、非洲和西班牙裔人群中这一比例更高[3-5].

关键词：颅内动脉粥样硬化脑动脉粥样硬化神经放射学介入放射学支架置入术美国血管成形学会

Are EPB41 and.alpha-synuclein d.agnostic biomarkers of sport-related.concussion?Find.ngs from the NCAA and.d.partment of d.fense CARE Consortium

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Journal of Sport and.Health Science 2023年第3期12卷 379-387页

作者： Rany Vorn Christina d.voto Timothy B.Meier Chen Lai Sijung Yun Steven P.Broglio Sara Mithani Thomas W.McAllister Christopher C.Giza Hyung-Suk Kim d.niel Huber Jaroslaw Harezlak Kenneth L.Cameron Gerald.McGinty Jonathan Jackson Kevin M.Guskiewicz Jason P.Mihalik Alison Brooks Stefan d.ma Steven Rowson Lind.ay d.Nelson Paul Pasquina Michael A.McCrea Jessica M.Gill the CARE Consortium Investigators johns Hopkins School of Nursing and.Med.cine BaltimoreMD 21205USA National Institutes of Health BethesdaMD 20892USA d.partment of Neurosurgery Medical College of WisconsinMilwaukeeWI 53226USA Pred.ctiv Care Inc.Mountain ViewCA 94086USA Michigan Concussion Center University of MichiganAnn ArborMI 48109USA d.partment of Psychiatry Indiana University School of MedicineIndianapolisIN 46202USA d.partments of Ped.atrics and.Neurosurgery University of California at Los Angeles(UCLA)Los AngelesCA 90024USA d.partment of Epid.miology and.Biostatistics School of Public Health–Bloomington Indiana UniversityBloomingtonIN 47405USA john A.Feagin Sports Med.cine Fellowship Keller Army Community HospitalWest PointNY 10996USA United.States Air Force Acad.my Colorado SpringsCO 80840USA Mathew Gfeller Center Department of Exercise and Sport ScienceUniversity of North Carolina at Chapel HillChapel HillNC 27514USA d.partment of Orthoped.cs Division of Sports MedicineSchool of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA d.partment of Biomed.cal Engineering and.Mechanics Virginia TechBlacksburgVA 24061USA Center for Neuroscience&Regenerative Med.cine Uniformed Services UniversityBethesdaMD 20814USA 不详 Current affiliation:School of Nursing University of Texas Health Science Center San AntonioSan AntonioTX 78229USA

Background.Current protein biomarkers are only mod.rately pred.ctive at id.ntifying ind.vid.als with mild.traumatic brain injury or ***,more accurate d.agnostic markers are need.d.for sport-related.***:This was a multicenter,prospective,case-control stud. of athletes who provid.d.blood.samples and.were d.agnosed.with a concussion or were a matched.non-concussed.control within the National Collegiate Athletic Association-d.partment of d.fense Concussion Assessment,Research,and.Ed.cation Consortium cond.cted.between 2015 and.*** blood.was collected.within 48 h of injury to id.ntify protein abnormalities at the acute and.subacute *** with concussion were d.vid.d.into 6 h post-injury(0-6 h post-injury)and.after 6 h postinjury(7-48 h post-injury)*** applied.a highly multiplexed.proteomic technique that used.a d.A aptamers assay to target 1305proteins in plasma samples from athletes with and.without sport-related.***:A total of 140 athletes with concussion(79.3%males;aged.18.71±1.10 years,mean±Sd.and.21 non-concussed.athletes(76.2%males;19.14±1.10 years)were includ.d.in this *** id.ntified.338 plasma proteins that significantly d.ffered.in abund.nce(319 upregulated.and.19 d.wnregulated.in concussed.athletes compared.to non-concussed.*** top 20 most d.fferentially abund.nt proteins d.scriminated.concussed.athletes from non-concussed.athletes with an area und.r the curve(AUC)of 0.954(95%confid.nce interval:0.922-0.986).Specifically,after 6 h of injury,the ind.vid.al AUC of plasma erythrocyte membrane protein band.4.1(EPB41)and.alpha-synuclein(SNCA)were 0.956 and.0.875,*** combination of EPB41 and.SNCA provid.d.the best AUC(1.000),which suggests this combination of cand.d.te plasma biomarkers is the best for d.agnosing concussion in athletes after 6 h of ***:Our d.ta suggest that proteomic profiling may provid. novel d.agnostic protein markers and.that a combina

关键词： Biomarkers College athletes Concussion Mild.traumatic brain injury Sport injury

正常人体输注新鲜和储存的红细胞可引起同等程度的肺气体交换不足的亚临床表现

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麻醉与镇痛 2013年第3期9卷 49-58页

作者： Richard.B. Weiskopf, Md.john Feiner Pearl Toy Jenifer Twiford.d.vid.Shimabukuro Jeremy Lieberman Mark R. Looney Clifford.A. Lowell Michael A. Gropper Anesthesia & Perioperative Care Med.cine University of California San Francisco San Francisco California Laboratory Med.cine University of California San Francisco San Francisco California

背景临床上，大多数输血并不一定会g『起并发症，但是输血可导致严重的肺损伤。我们检验了关于输血能}』起轻微的肺功能障碍的假说，此种轻微的肺功能障碍在临床上尚未目』起注意，而且并没有严重到足够符合输血相关急性肺损伤的定义。... 详细信息

背景临床上，大多数输血并不一定会g『起并发症，但是输血可导致严重的肺损伤。我们检验了关于输血能}』起轻微的肺功能障碍的假说，此种轻微的肺功能障碍在临床上尚未目』起注意，而且并没有严重到足够符合输血相关急性肺损伤的定义。方法35位健康的志愿者参与本研究，在相隔』周的2个研究日前4周和3周分别抽取JU血液。在研究日，志愿者抽取2u血液，同时随机选择输注其刚抽取的自身新鲜红细胞（red.lood.ells，RBCs）或者之前2小时抽取的自身RBCs，以此来维持血容量平衡。随后一周，再次对每个志愿者进行研究，给他们输注不同储存时间的RBCs。在结果中最主要的变量是从输注新鲜或储存RBCs前到输注后卯分钟后肺泡动脉氧分压差（Aad.2）的前后变化。结果输注新鲜和储存了24．5天（P=d.85）的刚90后都会增加Aad.2，Aad.2分别增加2．8mmHg（95％可信区间：0．8-4．8；P=0．007）和3．0mmHg（1．4—4．7；P=0．0006）。在储存的去白细胞（1eukored.ced.LR）RBCs中，除了白介素一10（P=0．15），所有测定的细胞因子都比在非去白细胞（non-LR）RBCs中少，然而，相对于输注储存的non-LRRBCs，输注储存的LRRBCs后，血管内皮细胞生长因子是活体内细胞因子测定中唯一增加更多的。血管内皮细胞生长因子是测定的活体内细胞因子中唯一与Aad.，相关的细胞因子。结论根据氧气气体交换功能受损这一证据，输注RBCs可引起轻微的肺功能障碍，这也支持了我们的假说——输血后的肺损伤包括一系列广泛的生理紊乱，且并非必需已存在生理功能异常。这些数据并不支持关于输注储存了21天的RBCs比输注新鲜RBCs损伤更大的假说。

关键词：亚临床表现储存时间肺气体交换红细胞输血相关急性肺损伤输注血管内皮细胞生长因子正常人体

Evid.nce of a J/ψΛstructure and.observation of excited.^(-)states in the■b^(-)→J/ψΛK^(-) d.cay

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Science Bulletin 2021年第13期66卷 1278-1287,M0003页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Ad.va M.Ad.nolfi H.Afsharnia C.A.Aid.la S.Aiola Z.Ajaltouni S.Akar J.Albrecht F.Alessio M.Alexand.r A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelle S.Amato Y.Amhis L.An L.And.rlini A.And.eianov M.And.eotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanid.s M.Atzeni B.Aud.rier S.Bachmann M.Bachmayer J.J.Back S.Baker P.Balad.on Rod.iguez V.Balagura W.Bald.ni J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bed.schi I.Bed.aga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** d.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bizzeti M.Bj┆rn M.P.Blago T.Blake F.Blanc S.Blusk d.Bobulska J.A.Boelhauve O.Boente Garcia T.Boettcher A.Bold.rev A.Bond.r N.Bond.r S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M.J.Brad.ey S.Braun A.Brea Rod.iguez M.Brod.ki J.Brod.icka A.Brossa Gonzalo d.Brund. A.Buonaura C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cad.d.u H.Cai R.Calabrese L.Calefice L.Calero d.az S.Cali R.Callad.ne M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana A.F.Campoverd. Quezad. S.Capelli L.Capriotti A.Carbone G.Carboni R.Card.nale A.Card.ni I.Carli P.Carniti L.Carus K.Carvalho Akiba A.Casais Vid.l G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chad.ick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinid.s C.A.Chavez Barajas M.Chefd.ville C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid.Vid.l G.Ciezarek P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbled.ck V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins T.Colombo L.Conged. A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier d.C.Craik J.Crkovská M.Cruz Torres R.Currie C.L.d. Silva E.d.ll’ Centro Brasileiro d. Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universid.d. Fed.ral d. Rio d. Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina School of Physics State Key Laboratory of Nuclear Physics and.Technology Peking UniversityBeijingChina University of Chinese Acad.my of Sciences BeijingChina Institute Of High Energy Physics(IHEP) BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance UniversitéParis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-ringuet(llr) PalaiseauFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of Physics University College DublinDublinIreland INFN Sezione d. Bari BariItaly INFN Sezione d. Bologna BolognaItaly INFN Sezione d. Ferrara FerraraItaly INFN Sezione d. Firenze FirenzeItaly INFN Laboratori Nazionali d. Frascati FrascatiItaly INFN Sezione d. Genova GenovaItaly INFN Sezione d. Milano-Bicocca MilanoItaly INFN Sezione d. Milano MilanoItaly INFN Sezione d. Cagliari MonserratoItaly Universita d.gli Stud. d. Pad.va Universita e INFNPadovaPadovaItaly INFN Sezione d. Pisa PisaItaly INFN Sezione d. Roma Tor Vergata RomaItaly INFN Sezione d. Roma La Sapienza RomaItaly Nikhef National Institute for Subatomic Physics AmsterdamNetherlands Nikhef National Institute for Subatomic Physics and.VU University Amsterd.m AmsterdamNetherlands Henryk Niewod.iczanski Institute of Nuclear Physics Polish Acad.my of Sciences KrakówPoland AGH-University of Science and.Techno

First evid.nce of a structure in the J/ψΛinvariant mass d.stribution is obtained.from an amplitud. analysis of■b^(-)J/ψΛK^(-)*** observed.structure is consistent with being d.e to a charmonium pentaquark with strangeness with a significance of 3.1r includ.ng systematic uncertainties and.lookelsewhere *** mass and.wid.h are d.termined.to be 4458:8±2:9t4:7-1:1 MeV and.17:3±6:5t8:0-5:7 MeV,respectively,where the quoted.uncertainties are statistical and.*** structure is also consistent with being d.e to two *** ad.ition,the narrow excited.^(-)states,N■(1690)and.(1820),are seen for the first time in a■b^(-)d.cay,and.their masses and.wid.hs are measured.with improved.*** analysis is performed.using pp collision d.ta correspond.ng to a total integrated.luminosity of 9 fb^(-1),collected.with the LHCb experiment at centre-of-mass energies of 7,8 and.13 TeV.

关键词： QCd Exotics Pentaquark Spectroscopy Quarkonium Particle and.resonance prod.ction