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国外医学（妇幼保健分册） 2005年第5期16卷 319-322页

作者： Sven O.Skouby Farook Al-Azzawi David Barlow Joaquin calaf-Alsina Erdogan Ert ungealp Anne Gompel Alessandra Graziottin Decebal Hudita Amos ines Serge Rozenberg Gran Samsioe john c.stevenson 陈瑛

目前从大量的随机对照临床试验(RcT)中已得出结论性的证据:对于经历令人痛苦的更年期症状的围绝经期和绝经后妇女,任何形式的全身HRT均可以缓解症状,没有其它治疗手段能产生相似效果。尽管这种证据与日俱增,但如何提供最好的临床医疗以... 详细信息

目前从大量的随机对照临床试验(RcT)中已得出结论性的证据:对于经历令人痛苦的更年期症状的围绝经期和绝经后妇女,任何形式的全身HRT均可以缓解症状,没有其它治疗手段能产生相似效果。尽管这种证据与日俱增,但如何提供最好的临床医疗以减轻绝经症状和预防较远期的绝经后退化性疾病,仍在争论之中。当提供更年期医药时,HRT的剂量和方案的个体化是基于与症状的严重程度和绝经时间相关的最低有效剂量的原则。然而,在有症状的妇女中,尚没有多少关于长期应用不同HRT方案的资料,同时赖以说明心血管疾病、乳腺癌和骨质疏松症的基线风险的影响。在大多数病例中,个体化的处方联同生活方式的调整就可能对更年期症状、生活质量、性问题和骨质疏松症产生最终有益的作用,罕见严重副反应。基于最近的流行病学研究,不少是来自WHI中单用雌激素组的结果,欧洲男女更年期协会(EMAS)支持在有症状的妇女中进行新的HRT方案的研究,以提高临床中受益和风险之间的平衡,包括生活质量方面特有的信息;并解释美国和欧洲之间在治疗模式上的传统差异,以及在BMI、生活方式和饮食习惯方面的不同所产生的影响。对于早绝经(<45岁)的妇女,现有的资料支持HRT所特有的总体益处。目前,具有骨质疏松性骨折高危险性的妇女可考虑应用较长期的全身HRT,尤其是当其它治疗措施既不恰当又疗效不佳时,因为此时收益大于风险。而对于泌尿生殖道症状,已认为长期的局部雌激素治疗可能安全和有效。

关键词：男女更年期协会立场声明更年期医药围绝经期绝经后激素补充治疗更年期症状绝经后妇女围绝经期激素补充治疗欧洲协会随机对照临床试验 HRT方案最低有效剂量

Wrapping up the role of pericytes in Parkinson's disease

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Neural Regeneration Research 2023年第11期18卷 2395-2396页

作者： Taylor john stevenson Birger Victor Dieriks Department of Pharmacology University of AucklandAucklandNew Zealand centre for Brain Research University of AucklandAucklandNew Zealand Department of Anatomy and Medical Imaging University of AucklandAucklandNew Zealand

Pericytes are classically defined as contra ctile cells within the central nervous system that regulate blood flow and permeability of the blood-brain barrier(BBB).This one-sided view is gradually changing,and pericytes are now considered versatile cells that can switch their function in response to different stimuli(Uemura et al.,2020).In addition to their role as gatekeepers of the BBB and maintaining homeostasis of the brain’s microenvironment through adj usting the vascular intraluminal dia meter,pericytes are both sensors and initiators of inflammation.

关键词： homeostasis pericyte

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin Huang john Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase cγ-ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

cascade degradation and electrocatalytic upcycling of waste poly(ethylene terephthalate)to valued products

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Nano Research 2025年第1期18卷 76-93页

作者： Xin Li Zirui Jiang Zongkui Kou john Wang Shiyou Zheng School of Materials and chemistry University of Shanghai for Science and TechnologyShanghai 200093China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China Department of Materials Science and Engineering National University of SingaporeSingapore 117574Singapore

The global annual production of poly(ethylene terephthalate)(PET)has reached 82 million tons,yet only a small fraction(less than 20%)is *** ultra-slow degradation rate of PET results in the accumulation of PET waste in the environment,causing serious plastic pollution and posing severe challenges to *** response,great efforts have been directed toward developing a cascade degradation and electrocatalytic upcycling strategy,which serves as a“waste-towealth”*** strategy involves electro-reforming PEThydrolyzed intermediates or using PET pyrolyzed products as electrocatalysts to generate high-value *** review provides an overview of the state-of-the-art strategies for the“degradation-electrocatalytic upcycling(De-eUp)”of PET ***,an introduction to the strategy is provided,categorizing it into two main frameworks:“pyrolysis-electrocatalytic upcycling”and“hydrolysis-electrocatalytic upcycling”.The section on“pyrolysis-electrocatalytic upcycling”delves into the degradation methods for designing derived carbon nanomaterials and their utilization as high-performance ***“hydrolysis-electrocatalytic upcycling”section discusses recent advancements in electro-reforming of PET hydrolyzed intermediates for the production of c_(1) and c_(2) *** review concludes by examining the challenges and future prospects in developing an efficient and economical PET upcycling *** is anticipated that this review will stimulate further progress in plastic waste valorization.

关键词： poly(ethylene terephthalate)waste electrocatalytic upcycling pyrolysis hydrolysis ethylene glycol oxidation reaction

cold plasma redistribution throughout geospace

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Science china(Technological Sciences) 2016年第9期59卷 1340-1345页

作者： Foster john c. Massachusetts Institute of Technology Haystack Observatory

The redistribution of the electrically charged cold plasma of ionospheric origin involves the equatorial,low,mid,auroral,and polar-latitude regions in a multi-step,system-wide process linking the regions of *** with ground and space-based instruments characterize the geospace plume-regularly occurring channels of enhanced plasma density flowing at both ionospheric and magnetospheric *** in the SAPS channel transports the eroded material to the noontime cusp in the ionosphere and to the dayside magnetopause at high *** the fluxes of cold plume plasma traverse the cusp and enter the polar cap,they form the polar tongue of *** the cusp the plume plasma provides a rich source of heavy ions for the magnetospheric injection and acceleration via the mechanisms operative on those field lines.

关键词： plasmasphere ionosphere geospace GPS TEc ionospheric electric field plume

Isoscalar monopole strength in ^(100)Mo: an indicator for static triaxial 100 deformation in the ground state

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chinese Physics c 2023年第3期47卷 180-186页

作者：石跃 P.D.stevenson Department of Physics Harbin Institute of TechnologyHarbin 150001China Department of Physics University of SurreyGuildfordGU27XHUnited Kindom

We perform deformation constraint symmetry-unrestricted three-dimensional time-dependent density functional theory(TDDFT)calculations for the isoscalar monopole(ISM)mode in ^(100)*** moments are obtained as a function of time using time propagating states based on different deformations.A Fourier transform is then performed on the obtained response *** resulting ISM strength functions are compared with experimental *** the static potential-energy-surface(PES)calculations,the results using the SkM*and UNEDF1 energy-density functionals(EDFs)show spherical ground states and considerable softness in the triaxial *** PES obtained with the SLy4 EDF shows static triaxial *** TDDFT results based on different deformations show that a quadrupole deformation(characterized byβ_(2))value of 0.25-0.30 gives a two-peak structure of the strength *** triaxial deformation(characterized by)from 0°to 30°results in the occurrence of an additional peak between the two,making the general shape of the strength functions closer to that of the *** microscopic TDDFT analyses suggest that ^(100)Mo is triaxially deformed in the ground *** calculated isoscalar Q_(20) and Q_(22) strength functions show peaks at lower *** coupling of these two modes with the ISM mode is the reason for the three-peak/plateau structure in the strengths of ^(100)Mo.

关键词： nuclear structure nuclear vibration time-dependent density functional theory

Modern quantum theories and experimental achievements motivate new exploration of acupuncture in traditional chinese medicine

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Journal of Acupuncture and Tuina Science 2018年第4期16卷 282-288页

作者： stevenson Xutian john Junion canadian Institute of complementary and Alternative Medicine Research EdmontonAlberta T6AOX9Canada AdvanceMed corporation Ohio 43123USA

Traditional chinese medicine （TcM）, a theoretical medical system founded about three thousand years ago, originated from the richness of chinese culture with the support and development of ancient astronomy and philosophy. It has illuminated many mysteries of nature and the human body. This has not always been easy for the layperson to understand. In modern times, some of these processes have been gradually discovered or confirmed by frontier science. The experiments of quantum physics have shaken the fundamental concepts of conventional science, refuting criticism of chinese culture and TcM theories. The new discoveries have triggered a new understanding of TcM theories. For example, the theory of quantum mechanics interfering with certain human functions helps explain a series of phenomena that were previously difficult to understand. The veil of many wonderful phenomena of chinese culture and TcM acupuncture has not yet been fully pierced. For example, the body＇s energy system, the invisible qi, and the phenomenon of consciousness and subconscious function remain mysterious. However, quantum theory and numerous scientific experiments can lead to the explanations of difficult problems which were not understood in the past. For example, the nature of the changes in yin and yang, and associated principles; the five-element principles; consciousness and sub-consciousness which might affect scientific experiments and treatment outcomes; the objective existence of qi and qi field; and the essence of the meridian system in the human body and the principles of acupuncture. This article explores the scientific principles of TcM and acupuncture. The unique characteristics of TcM and acupuncture position themselves as Eastern cultural treasures. The authors endeavor to strengthen readers＇ confidence in theoretical TcM and believe that it is a major step in integrating TcM acupuncture into modern science and medicine.

关键词： Traditional chinese Medicine Western Medicine Qi Qi Field Spirit consciousness View of Life and View of Body Quantum Theory

Metagenomics: Facts and Artifacts, and computational challenges

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Journal of computer Science & Technology 2010年第1期25卷 71-81页

作者： john c. Wooley 叶玉珍 center for Research on BioSystems Calit2 University of California San Diego School of Informatics and computing Indiana University

Metagenomics is the study of microbial communities sampled directly from their natural environment, without prior culturing. By enabling an analysis of populations including many （so-far） unculturable and often unknown microbes, metagenomics is revolutionizing the field of microbiology, and has excited researchers in many disciplines that could benefit from the study of environmental microbes, including those in ecology, environmental sciences, and biomedicine. Specific computational and statistical tools have been developed for metagenomic data analysis and comparison. New studies, however, have revealed various kinds of artifacts present in metagenomics data caused by limitations in the experimental protocols and/or inadequate data analysis procedures, which often lead to incorrect conclusions about a microbial community. Here, we review some of the artifacts, such as overestimation of species diversity and incorrect estimation of gene family frequencies, and discuss emerging computational approaches to address them. We also review potential challenges that metagenomics may encounter with the extensive application of next-generation sequencing （NGS） techniques.

关键词： metagenomics next-generation sequencing (NGS) taxonomic/functional profiling statistical approaches comparative metagenomics

Human thrombin for the treatment of gastric and ectopic varices

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World Journal of Gastroenterology 2012年第41期18卷 5912-5917页

作者： Norma c McAvoy john N Plevris Peter c Hayes Department of Hepatology University of EdinburghRoyal Infirmary of EdinburghEdinburgh EH16 4SAUnited Kingdom

AIM:To evaluate the efficacy of human thrombin in the treatment of bleeding gastric and ectopic ***:Retrospective observational study in a Tertiary Referral *** January 1999-October 2005,we identified 37 patients who were endoscopically treated with human thrombin injection therapy for bleeding gastric and ectopic *** details including age,gender and aetiology of liver disease/segmental portal hypertension were *** thrombin was obtained from the Scottish National Blood Transfusion Service and prepared to give a solution of 250 IU/mL which was injected via a standard injection *** patient case notes were reviewed and the total dose of thrombin given along with the number of endoscopy sessions was *** haemostasis rates,rebleeding rates and mortality were catalogued along with the incidence of any immediate complications which could be attributable to the thrombin *** duration of follow up was also *** study was conducted according to the United Kingdom research ethics ***:Thirty-seven patients were included.33 patients(89%) had thrombin(250 U/mL) for gastric varices,2(5.4%) for duodenal varices,1 for rectal varices and 1 for gastric and rectal varices.(1) Gastric varices,an average of 15.2 mL of thrombin was used per ***-bleeding occurred in 4 patients(10.8%),managed in 2 by a transjugular intrahepatic portosystemic shunt(TIPSS)(one unsuccessfully who died) and in other 2 by a distal splenorenal shunt;(2) Duodenal varices(or type 2 isolated gastric varices),an average of 12.5 mL was used per patient over 2-3 endoscopy ***-bleeding occurred in one patient,which was treated by TIPSS;and(3) Rectal varices,an average of 18.3 mL was used per patient over 3 endoscopy *** re-bleeding occurred in this ***:Human thrombin is a safe,easy to use and effective therapeutic option to control haemorrhage from gastric and ectopic varices.

关键词： Variceal haemorrhage Ectopic Varices Gastric varices, Portal hypertension Thrombin