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Asymmetric reinforcement in Lucania killifish:assessing reproductive isolation when both sexes choose

current Zoology 2021年第2期67卷 215-224页

作者： Michelle E.ST.john Rebecca c.FULLER School of Integrative Biology University of liois Urbana-ChampaignChampaignIL 61820USA

Reinforcement can occur when maladaptive hybridization in sympatry favors the evolution of con-specific preferences and target traits that promote behav ioral isolation(BI).In many systems,enhanced BI is due to increased female preference for *** others,BI is driven by male preference,and in other systems both sexes exert *** of these patterns can be atributed to classic sex-specific costs and benefits of ***,sex differences in conspecific preference can emerge due to asymmetric postzygotic isolation(e.g.,hybrid offspring from female A × male B have lower fitness than hybrid offspring from female B × male A),which can lead to asymmetric BI(e.g.,female A and male B are less likely to mate than female B and male A).Understanding reinforcement requires understanding how conspecific preferences evolve in ***,estimating conspecific preferences can be difficult when both sexes are *** this study,we use Lucania killifish to test the hypothesis that patterns of reinforcement are driven by asymmetric postzygotic isolation between *** true,we predicted that sympatric female Lucania goodei and sympatric male *** should have lower levels of BI compared with their sympatric counterparts,as they produce hybrid offspring with the highest *** address the problem of measuring BI when both sexes are choosy,we inferred the contribution to BI of each partner using assays where one sex in the mating pair comes from an allopatric population with potentially low preference,whereas the other comes from a sympatric population with high *** one hybrid cross direction,we found that both female *** and male *** have high contributions to BI in *** the other hybrid cross direction,we found that only female *** contribute to *** male *** readily engaged in hybrid spawnings with allo-patric *** *** results indicate that both asymmetric postzygotic isolation

关键词： reinforcement behavioral isolatin female mate choice male mate choice asymmetric costs to hybridization

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Teachers' perceived importance of sportspersonship and social responsibility in the development of a moral-based olympic physical education programme

Teachers' perceived importance of sportspersonship and socia...

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2008奥林匹克科学大会

作者： ha,Amy S.c. Lee,john c.K. The chinese University of Hong Kong

Introduction Recently,schools in Hong Kong have been encouraged to include moral and civic education as one of the major learning experiences(cDc,2001) for holistic development with five priority values,namely, perseverance,respect for others,responsibility,national identity,and commitment,by integrating each of these concepts with the school mission and the aims of moral and value education.

关键词： Teachers perceived importance of sportspersonship and social responsibility in the development of a moral-based olympic physical education programme

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Positional goods and the challenge of chinese regional inequality

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Economic and Political Studies 2018年第1期6卷 4-10页

作者： john V.c.Nye Department of Economics George Mason UniversityFairfaxVAUSA NRU-Higher Schoolof Economics MoscowRussia

Scholars have focussed on income inequality as a major source of social *** the focus on crude income inequality has masked the deeper developmental problem facing many fast-growing *** is an extreme case of this issue inasmuch as its coastal regions can be viewed as comparable to middle income states,while the greater part of its rural and west-erm areas would be comparable to the poorer nations of the *** means that the new middle class pays attention to issues such as pollution and status or positional goods than simple material *** costs of houses are in particular less than *** status goods are similar because they are not amenable to simple productivity *** will make policies more difficult as conflict increases between those areas who are still eager for basic economic development and those richer areas whose wants and needs start to more closely resemble the preferences of richer developed countries.

关键词： Positional goods regional inequality statusgoods

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高、低核酸含量原核生物应对资源可利用性降低和原生动物选择性摄食的适应性策略

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中国科学：地球科学 2024年第6期54卷 1901-1913页

作者：胡晨余柳倩陈晓炜刘纪化张瑶 john BATT 肖喜林石蔷张锐骆庭伟焦念志徐大鹏厦门大学环境与生态学院厦门361102 近海海洋环境科学国家重点实验室厦门大学海洋与地球学院福建省海洋碳汇重点实验室厦门361102 Joint Lab for Ocean Research and Education(LORE)of Dalhousie University Canadaand Shandong University and Xiamen UniversityXiamen 361102China 香港科技大学(广州)地球与海洋大气科学学域广州510000 山东大学海洋研究院青岛266237 Department of Oceanography Dalhousie UniversityHalifaxNova Scotia B3H 4R2Canada 深圳大学高等研究院深圳518060 厦门大学碳中和创新研究中心厦门361102

原核生物在全球海洋生物地球化学循环中发挥重要作用,然而对它们不同生态亚群(即:高核酸(HNA)和低核酸(LNA)含量亚群)的丰度和代谢活性,以及它们的调控因素如何随着海洋环境条件的变化而变化,仍知之甚少.我们在117,000升的大体积培养体... 详细信息

原核生物在全球海洋生物地球化学循环中发挥重要作用,然而对它们不同生态亚群(即:高核酸(HNA)和低核酸(LNA)含量亚群)的丰度和代谢活性,以及它们的调控因素如何随着海洋环境条件的变化而变化,仍知之甚少.我们在117,000升的大体积培养体系中进行了73天的培养实验,深入研究HNA和LNA亚群对资源可利用性降低和原生动物选择性摄食随时间变化的动态响应.研究结果显示,当培养环境资源充足时, HNA亚群的代谢活性高于LNA亚群,但随着资源日益稀缺, HNA亚群代谢下降速度比LNA亚群快,从而使LNA亚群对原核生物活性的贡献稳步增加.与此同时,随着培养体系资源可利用性逐步降低,原生动物的摄食偏好从HNA亚群转向LNA亚群,使得LNA亚群对培养体系的碳流贡献增加.这些结果突显了LNA亚群在资源有限环境中的韧性,阐明了原生动物选择性摄食在资源条件变化时平衡不同亚群中的关键作用,并展示了在不同环境背景下原生动物和原核生物之间复杂的相互适应性.

关键词：微生物环大体积培养实验原核生物自上而下和自下而上调控作用碳流

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SPEcIAL ISSUE EDITORIAL ON ADVANcES IN cOLLABORATIVE SYSTEMS ENGINEERING FOR PRODUcT DESIGN, PRODUcTION AND SERVIcE NETWORK

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Journal of Systems Science and Systems Engineering 2016年第2期25卷 139-141页

作者： Amy J.c. Trappey Weiming Shen john Jianzhong cha Department of Industrial Engineering and Engineering Management National Tsing Hua University Taiwan China Integrated Manufacturing Technologies Institute National Research Council Canada Canada Department of Mechanical Engineering Beijing Jiaotong University China

From the perspectives of engineering （cE）, computer concurrent supported cooperative work （cScW）, product lifecycle management （PLM）, to collaborative supply chain and service network, collaborative systems engineering （cSE） has been extended and enriched in many research efforts. cSE is not just a technique or method but also a fundamental business philosophy and strategy.

关键词： perspectives concurrent engineering

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Envita’s Precision cancer care: 35-Fold Improvement in Response Rates

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Journal of cancer Therapy 2024年第4期15卷 99-120页

作者： Sheba Goklany john c. Oertle III Ronald Matthias Jr. Daniel Warren David Medina Rory Sears Robert Zieve Kendra Quart christopher Aussems Jon Moma Shannon Miller Zach Poteet conner coffin courtney Middleton Erika Ware Phylicia Zarnosky Julie Nowak Winlove Suasin Daniel conway chad Burk Ruth Tan-Lim Dino Prato Envita Medical centers Scottsdale AZ USA

New clinical approaches are imperative beyond the widely adopted National comprehensive cancer Network (NccN) guidelines, utilized by prominent cancer institutions. cancer is the leading cause of death among individuals younger than 85 years within the United States. Despite significant technological advances, including the expenditure of hundreds of billions, treatment outcomes and overall survival have not notably improved for most types of advanced cancer over the last several decades. Over the past 24 years, Envita Medical centers has pioneered a unique form of personalized treatment approach for late-stage and refractory cancer patients, introducing groundbreaking innovations in the field. Our integrated algorithm utilizes advanced genomics, transcriptomics, and highly tailored immunotherapy, resulting in remarkable outcome improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outcomes of 199 late-stage cancer patients treated at Envita Medical centers over a two-year period. compared to standard of care and palliative chemotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with Stage 3 or 4 cancer, experienced a 43-fold improvement in quality of life with minimal side effects, as compared to standard of care chemotherapy and palliative care. This revolutionary success is attributed to Envita’s personalized therapeutic algorithms, which incorporate customized immunotherapy. Envita’s precision care approach has also achieved a 100% better response rate compared to over 65 global chemotherapy clinical trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approach can significantly benefit patients with late-stage and refractory cancer.

关键词： Envita Medical centers Late-stage cancer Overall Response Rate Quality of Life circulating Tumor cells (cTcs) Mutant Allele Frequency (MAF) Precision care

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can an 8^(th) grade student learn point of care ultrasound?

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World Journal of Emergency Medicine 2019年第2期10卷 109-113页

作者： Alexander S.Kwon Shadi Lahham john c.Fox Sage Hill School Department of Emergency Medicine UC Irvine Medical Center UC Irvine School of Medicine

BAcKGROUND: Point-of-care ultrasound has gained widespread use in developing countries due to decreased cost and improved telemedicine capabilities. Ultrasound training, specifi cally image acquisition skills, is occurring with more frequency in non-medical personnel with varying educational levels in these underdeveloped areas. This study evaluates if students without a high school education can be trained to acquire useful FAST images, and to determine if an 8^(th) grade student can teach peers these ***: The 8^(th) grade students at a small middle school were divided into two groups. One group received training by a certified medical sonographer, while the other group received training by a peer 8^(th) grade student trainer who had previously received training by the sonographer. After training, each student was independently tested by scanning the four FAST locations. A blinded ultrasound expert evaluated these images and deemed each image adequate or inadequate for clinical ***: Eighty video image clips were obtained. The overall image adequacy rate was 74%. The splenorenal window had the highest rate at 95%, followed by retrovesical at 90%, hepatorenal at 75%, and subxiphoid cardiac at 35%. The adequacy rate of the sonographer-trained group was 78%, while the adequacy rate of the student-trained group was 70%. The difference in image adequacy rate between the two groups was not signifi cant(P-value 0.459).cONcLUSION: The majority of 8^(th) graders obtained clinically adequate FAST images after minimal training. Additionally, the student-trained group performed as well as the sonographer-trained group.

关键词： Point of care ultrasound FAST Image acquisition Training

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Update of endoscopy in liver disease:More than just treating varices

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World Journal of Gastroenterology 2012年第5期18卷 401-411页

作者： christoforos Krystallis Gail S Masterton Peter c hayes john N Plevris centre for Liver and Digestive Disorders The Royal InfirmaryUniversity of EdinburghEdinburgh EH16 4SAUnited Kingdom

The management of complications in liver disease is often complex and *** has undergone a period of rapid expansion with numerous novel and specialized endoscopic modalities that are of increasing value in the investigation and management of the patient with liver *** this review,relevant literature search and expert opinions have been used to provide a brief overview and update of the current endoscopic management of patients with liver disease and portal *** main areas covered are safety of endoscopy in patients with liver disease,the use of standard endoscopy for the treatment of varices and the role of new endoscopic modalities such as endoscopic ultrasound,esophageal capsule,argon plasma coagulation,spyglass and endomicroscopy in the investigation and treatment of liver-related gastrointestinal and biliary *** is clear that the role of the endoscopy in liver disease is well beyond that of just treating *** the technology in endoscopy expands,so does the role of the endoscopist in liver disease.

关键词： cirrhosis Portal hypertension Varices En-doscopic ultrasound Esophageal capsule Endoscopicretrograde cholangiopancreatography Endomicros-copy Spyglass

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Myosin XI Is Required for Actin-Associated Movement of Plastid Stromules

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Molecular Plant 2009年第6期2卷 1262-1272页

作者： Senthil Kumar A. Natesan James A. Sullivan john c. Gray Department of Plant Sciences University of Cambridge Downing Street Cambridge CB2 3EA UK Present address: Sir William Dunn School of Pathology University of Oxford South Parks Road Oxford OX1 3RE UK Present address: School of Biological and chemical Sciences Queen Mary University of London Mile End Road London E1 4NS UK

Stromules are highly dynamic stroma-filled tubules extending from the surface of plastids and occasionally interconnecting individual plastids, allowing the movement of complex biological molecules between the interconnected plastids. Experiments with inhibitors of cytoskeleton assembly have indicated the involvement of an actin-based system in stromule movement. However, the motor protein associated with the system had not been identified. Here, we present direct evidence that myosin XI is involved in the formation and movement of stromules in tobacco leaves. Application of 2,3-butanedione 2-monoxime, an inhibitor of myosin ATPase activity, resulted in the loss of stromules from tobacco leaf epidermal cells. Transient RNA interference of myosin XI in leaves of Nicotiana benthamiana also resulted in the loss of stromules from epidermal cells, without any effect on transcripts for actin or myosin VIII. Transient expression of a GFP- tagged myosin XI tail domain in tobacco leaf epidermal cells showed that the fusion protein localized to the chloroplast envelope, as well as to mitochondria and other organelles. Our findings identify myosin XI as a key protein involved in the formation and movement of stromules.

关键词： chloroplast biology cytoskeleton organelle biogenesis/function tobacco.

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Life cycle assessment of low impact development technologies combined with conventional centralized water systems for the city of Atlanta, Georgia

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Frontiers of Environmental Science & Engineering 2016年第6期10卷 3-15页

作者： Hyunju Jeong Osvaldo A. Broesicke Bob Drew Duo Li john c. crittenden Department of civil and Environmental Engineering South Dakota School of Mines and Technology Rapid City SD 57701 USA Brook Byers Institute for Sustainable Systems School of Civil and Environmental Engineering Georgia Institute of Technology 828 West Peachtree Street Suite 320 Atlanta GA 30332-0595 USA EcOVIE Rainwater Collection Systems 4287 Club Drive N.E. Atlanta GA 30319 USA crittenden and Associates C-305 Building E Wangjing High-tech Park LizezhongEr Road Chaoyang District Beijing 100102 China

Low-impact development （LID） technologies, such as bioretention areas, rooftop rainwater harvesting, a_nd xeris_caping can co_ntrol stormwater runoff, supply non-potable water, and landscape open *** study examines a hybrid system （HS） that combines LID technologies with a centralized water system to lessen the burden on a conventional system （cS）. cS is defined as the stormwater collection and water supply infrastructure, and the conventional landscaping choices in the city of Atlanta. The study scope is limited to five single-family residential zones （SFZs）, classified R-1 through R-5, and four multi-family residential zones （MFZs）, classified RG-2 through RG-5. Population density increases from 0.4 （R-1） to 62.2 （RG-5） persons per 1,000 m2. We performed a life cycle assessment （LcA） comparison of cS and HS using TRAcI 2.1 to simulate impacts on the ecosystem, human health, and natural resources. We quantified the impact of freshwater consumption using the freshwater ecosystem impact （FEI） indicator. Test results indicate that HS has a higher LcA single score than cS in zones with a low population density; however, the difference becomes negligible as population density increases. Incorporating LID in SFZs and MFZs can reduce potable water use by an average of 50%. and 25%,respectively.; however, water savings are negligible in zones with high population density （i.e., RG-5） due to the diminished surface area per capitaavailable for LID technoogies. The results demonstrate that LID technologies effectively reduce outdoor water demand and therefore would be a good choice to decrease the water consumption impact in the city of Atlanta.

关键词： Life cycle assessment (LcA) Low impact development (LID) Bioretention area Rainwater harvesting Xeriscaping

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