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Storylines of family medic.ne Ⅻ:family medic.ne and the healthc.re system

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Family Medic.ne and c.mmunity Health 2024年第S3期12卷 109-118页

作者： William B Ventres Leslie A Stone Jeannette E South-Paul Kendall M c.mpbell Aerial R Petty Hima Ekanadham Kurt c.Stange Rebec.a S Etz William L Miller Robert L Ferrer Marianna Kong Thomas Bodenheimer Roger Strasser Sharon c.M Reec. Joshua Freeman john M Westfall Family and Preventive Medic.ne University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Meharry Medic.l c.llege NashvilleTennesseeUSA Family Medic.ne University of Texas Medical Branch at Galveston School of MedicineGalvestonTexasUSA Family Medic.ne Residenc. Program New York-Presbyterian Columbia University Medical CenterNew YorkNew YorkUSA c.nter for Family and c.mmunity Medic.ne Columbia University Vagelos College of Physicians and SurgeonsNew YorkNew YorkUSA c.nter for c.mmunity Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA Family Medic.ne and Population Health Virginia Commonwealth University School of MedicineRichmondVirginiaUSA Family Medic.ne Lehigh Valley Health NetworkAllentownPennsylvaniaUSA University of South Florida Morsani c.llege of Medic.ne TampaFloridaUSA Family and c.mmunity Medic.ne UT Health San Antonio Long School of MedicineSan AntonioTexasUSA Family and c.mmunity Medic.ne University of California San Francisco School of MedicineSan FranciscoCaliforniaUSA Northern Ontario Sc.ool of Medic.ne University SudburyOntarioCanada Family Medic.ne Baylor Scott and White HealthTempleTexasUSA Family Medic.ne University of Kansas School of MedicineKansas CityKansasUSA DARTNet Insitute AuroraColoradoUSA

Storylines of Family Medic.ne is a 12-part series of thematic.lly linked mini-essays with ac.ompanying illustrations that explore the many dimensions of family medic.ne,as interpreted by individual family physic.ans and medic.l educ.tors in the USA and elsewhere around the ***‘Ⅻ:Family medic.ne and the future of the healthc.re system’,authors address the following themes:‘Leadership in family medic.ne’,‘Bec.ming an ac.demic.family physic.an’,‘Advoc.re—our c.ll to ac.’,‘The paradox of primary c.re and three simple rules’,‘The quadruple aim—melding the patient and the health system’,‘Fit-for-purpose medic.l workforc.’,‘Universal healthc.re—c.verage for all’,‘The futures of family medic.ne’and‘The 100th essay.’May readers of these essays feel empowered to be part of family medic.ne’s exc.ting future.

关键词： system illustration family

Imaging approac. for jaw and maxillofac.al bone tumors with updates from the 2022 World Health Organization c.assific.tion

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World Journal of Radiology 2024年第8期16卷 294-316页

作者： Woongsoon john c.oi Peggy Lee Penelope c.Thomas Tanya J Rath Monique A Mogensen Roberta W Dalley Pattana Wangaryattawanic. Division of Neuroradiology Department of RadiologyUniversity of Washington School of MedicineSeattleWA 98195United States Department of Radiology M&S Radiology AssociatesSan AntonioTX 78217United States Division of Oral Radiology University of Washington School of DentistrySeattleWA 98195United States Division of Neuroradiology Department of RadiologyMayo ClinicPhoenixAZ 85054United States

Jaw and maxillofac.al bone lesions enc.mpass a wide variety of both neoplastic.and non-neoplastic.*** lesions c.n arise from various tissues,inc.uding bone,c.rtilage,and soft tissue,eac. presenting distinc. c.allenges in diagnosis and *** some pathologies exhibit c.arac.eristic.imaging features that aid in diagnosis,many others are *** overlap often nec.ssitates a multimodal imaging approac.,c.mbining tec.niques suc. as radiographs,c.mputed tomography,and magnetic.resonanc. imaging to ac.ieve a diagnosis or narrow the diagnostic.*** artic.e provides a c.mprehensive review of the imaging approac. to jaw and maxillofac.al bone tumors,inc.uding updates on the 2022 World Health Organization c.assific.tion of these *** relevant anatomy of the jaw and dental struc.ures that is important for ac.urate imaging interpretation is disc.ssed.

关键词： Mandible Maxilla Maxillofac.al Jaw Tumor Neoplasm

Superior antibody and membrane protein‑spec.fic.T‑c.ll responses to c.ronaVac.by intradermal versus intramusc.lar routes in adolesc.nts

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World Journal of Pediatric. 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.c.eng c.rolyn A.c.hen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet c.ung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo c.H.Tsang Sara c.aothai Tsz c.un Kwan john K.c.Li Karl c.K.c.an Leo L.H.Luk Jenson c.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.Lam Sau Man c.an Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatric. and Adolesc.nt Medic.ne The University of Hong KongHong KongChina Sc.ool of Public.Health The University of Hong KongHong KongChina HKU‑Pasteur Researc. Pole School of Public HealthThe University of Hong KongHong KongChina Researc. Institute for Bioresourc.s and Biotec.nology Ishikawa Prefectural UniversityNonoichiJapan Department of Mic.obiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia c.nter for Immunology and Infec.ion c.i Hong KongChina

Bac.ground Optimising the immunogenic.ty of c.VID-19 vac.ines to improve their protec.ion against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic.as intramusc.lar(IM)administration for several vac.ines,but the immunogenic.ty of ID inac.ivated whole severe ac.te respiratory syndrome c.ronavirus 2(SARS-c.V-2)at the full dose is *** study(Nc.04800133)investigated the superiority of antibody and T-c.ll responses of full-dose c.ronaVac.by ID over IM administration in *** Partic.pants aged 11–17 years rec.ived two doses of IM or ID vac.ine,followed by the 3rd dose 13–42 days *** and c.llular immunogenic.ty outc.mes were measured post-dose 2(IM-c. versus ID-c.)and post-dose 3(IMc.c.versus ID-c.c..Doses 2 and 3 were administered to 173 and 104 adolesc.nts,*** Spike protein(S)immunoglobulin G(IgG),S-rec.ptor-binding domain(RBD)IgG,S IgG Fc.rec.ptor IIIa(Fc.RIIIa)-binding,SNM[sum of individual(S),nuc.eoc.psid protein(N),and membrane protein(M)peptide pool]-spec.fic.interleukin-2(IL-2)+c.4^(+),SNM-spec.fic.IL-2^(+)c.8^(+),S-spec.fic.IL-2^(+)c.8^(+),N-spec.fic.IL-2^(+)c.4^(+),N-spec.fic.IL-2^(+)c.8^(+)and M-spec.fic.IL-2^(+)c.4^(+)responses fulfilled the superior and non-inferior c.iteria for ID-c. c.mpared to IM-c.,whereas IgG avidity was *** ID-c.c.S-RBD IgG,surrogate virus neutralisation test,90%plaque reduc.ion neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG Fc.RIIIa-binding,M-spec.fic.IL-2^(+)c.4^(+),interferon-γ+c.8^(+)and IL-2^(+)c.8^(+)responses were superior and non-inferior to *** estimated vac.ine effic.c.es were 49%,52%,66%and 79%for IM-c.,ID-c.,IM-c.c.and ID-c.c.*** ID groups reported more loc.l,mild adverse *** This is the first study to demonstrate superior antibody and M-spec.fic.T-c.ll responses by ID inac.ivated SARSc.V-2 vac.ination and serves as the basis for future researc. to improve the

关键词： c.ronaVac c.ronavirus disease 2019 Immunity Intradermal Vac.ine

An elec.roc.emic.l proc.ss that uses an Fe^0/TiO2 c.thode to degrade typic.l dyes and antibiotic. and a bio-anode that produc.s elec.ric.ty

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Frontiers of Environmental Sc.enc. & Engineering 2016年第4期10卷 25-32页

作者： c.aojie Jiang Lifen Liu john c. c.ittenden Key Laboratory of Industrial Ec.logy and Environmental Engineering (Ministry of Educ.tion) School of Environmental Science and Technology Dalian University of Technology Dalian 116024 China Sc.ool of c.vil and Environmental Engineering Georgia Institute of Technology Atlanta GA 30332 USA

In this study a new water treatment system that c.uples （photo-） elec.roc.emic.l c.talysis （PEc.or Ec. in a mic.obial fuel c.ll （MFc. was c.nfigured using a stainless-steel （SS） c.thode c.ated w th Fe / TiO2. We examined the destruc.ion of methylene blue （MB） and tetrac.c.ine. Fe^0/TiO2 was prepared using a c.emic.l reduc.ion-deposition method and c.ated onto an SS wire mesh （500 mesh） using a sol tec.nique. The anode generates elec.ric.ty using mic.obes （bio-anode）. c.nnec.ed via wire and ohmic.resistanc., the system requires a short reac.ion time and operates at a low c.st by effec.ively remowng 94% MB （initial c.nc.ntration 20 mg·L^-1） and 83% TOc.TOc. under visible light illumination （50 W; 1.99 mW·c.^-2 for 120 rain, MFc.PEc.. The removal was similar even without light irradiation （MFc.Ec.. The EEo of the MFc.PEc.system was approximately 0.675 kWh·m^-3. order-l whereas that of the MFc.Ec.system was zero. The system was able to remove 70% c.D in tetrac.c.ine solution （initial tetrac.c.ine c.nc.ntration 100 mg·L^-1） after 120 min of visible light illumination; without light, the removal was 15% lower. The destruc.ion of MB and tetrac.c.ine in both traditional photoc.talysis and photoelec.roc.talysis systems was notably low. The elec.ron spinresonanc. spec.rosc.py （ESR） study demonstrated that. OH was formed under visible light, and. 02 was formed without light. The bio-elec.ric.ty-ac.ivated O2 and ROS （reac.ive oxidizing spec.es） generation by Fe^0/TiO2 effec.ively degraded the pollutants. This c.thodic.degradation improved the elec.ric.ty generation by ac.epting and c.nsuming more elec.rons from the bio-anode.

关键词： Bio-anodePhotoc.talytic.c.thode Fe^0/TiO2 ESRDye and antibiotic.Advanc.d oxidation

Geothermo-mec.anic.l alterations due to heat energy extrac.ion in enhanc.d geothermal systems: Overview and prospec.ive direc.ions

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Deep Underground Sc.enc. and Engineering 2024年第3期3卷 256-268页

作者： Mary c.Ngoma Oladoyin Kolawole Olufemi Olorode john A.Reif Jr.Department of Civil and Environmental EngineeringNew Jersey Institute of TechnologyNewarkUSA Department of Petroleum Engineering Louisiana State UniversityBaton RougeUSA

Geothermal energy from deep underground (or geologic.l) formations,with or without its c.mbination with c.rbon c.pture and storage (c.S),c.n be a key tec.nology to mitigate anthropogenic.greenhouse gas emissions and meet the 2050 net‐zero c.rbon emission *** resourc.s in low‐permeability and medium‐and high‐temperature reservoirs in sedimentary sequenc. require hydraulic.stimulation for enhanc.d geothermal systems (EGS).However,fluid migration for geothermal energy in EGS or with potential c._(2) storage in a c._(2)‐EGS are both dependent on the in situ flow pathway network c.eated by induc.d fluid *** thermo‐mec.anic.l interac.ions c.n be c.mplex and induc. varying alterations in the mec.anic.l response when the working fluid is water (in EGS) or superc.itic.l c._(2)(in c._(2)‐EGS),whic. c.uld impac. the geothermal energy rec.very from geologic.l ***,there is a need for a deeper understanding of the heat extrac.ion proc.ss in EGS and c._(2)‐*** study presents a systematic.review of the effec.s of c.anges in mec.anic.l properties and behavior of deep underground roc.s on the induc.d flow pathway and heat rec.very in EGS reservoirs with or without c._(2) storage in c._(2) ‐***,we proposed waterless‐stimulated EGS as an alternative approac. to improve heat energy extrac.ion in ***,based on the results of our literature review and proposed ideas,we rec.mmend promising areas of investigation that may provide more insights into understanding geothermo‐mec.anic. to further stimulate new researc. studies and ac.elerate the development of geothermal energy as a viable c.ean energy tec.nology.

关键词： c._(2)-EGS enhanc.d geothermal systems geomec.anic. geothermal energy underground thermal energy

New markers of fibrosis in hepatitis c.A step towards the Holy Grail?

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World Journal of Hepatology 2024年第2期16卷 112-114页

作者： Konstantinos john Dabos Department of Hepatology St Hohn's HospitalLivingston EH546PPWest LothianUnited Kingdom

In the present issue of the World Journal of Hepatology,Ferrassi et al examine the problem of liver fibrosis staging in c.ronic.hepatitis *** identify novel biomarkers in an effort to predic. ac.urate fibrosis staging with the aid of the metabolome of Hepatitis c.*** I think Ferrassi et al took a different approac. in identifying fibrosis biomarkers,by looking at the patients’*** biomarkers c.early separate patients from *** c.n also separate out,patients with minimal fibrosis(F0-F1 stage)and patients with c.rrhosis(F4 stage).Obviously,if these biomarkers were to be widely used,tests for all the important metabolites would need to be readily available for use in hospitals or outpatient setting and that may prove diffic.lt and above all,***,this step c.uld eventually lead to a metabolomic.approac. for novel biomarkers of ***,it would need to be validated,but c.uld represent a step towards the Holy Grail of Hepatology.

关键词： Hepatitis c.metabolomic. Fibrosis Non invasive markers Metavir

Key findings of the 2016 symposium on the frontiers of c.emic.l sc.enc. and engineering： Environment and sustainable development

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Frontiers of c.emic.l Sc.enc. and Engineering 2017年第3期11卷 305-307页

作者： Zhongming Lu Duo Li john c. c.ittenden Sc.ool of Environment Beijing Normal University Beijing 100875 China c.ittenden and Assoc.ates Beijing 100102 China Brook Byers Institute for Sustainable Systems School of Civil and Environmental Engineering Georgia Institute of Technology Atlanta GA 30332-0355 USA

There were 30 speakers and the proc.edings c.ntained 28 abstrac.s that disc.ssed the start-of-the art applic.tions of sustainable c.emic.l engineering [1]. We summarized topic. that were disc.ssed in the 28 abstrac.s using the non-negative matrix fac.orization （NMF） algorithm. The ＂topic.＂ were synthesized without reading the abstrac.s. Here we will not disc.ss the algorithm of NMF in detail bec.use of the spac. limitation and please refer to referenc.s for the desc.iption of NMF [2,3]. Topic.modeling will be more valuable as the number of the abstrac.s inc.eases.

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New dating indic.tes intermittent human oc.upation of the Nwya Devu Paleolithic.site on the high-altitude c.ntral Tibetan Plateau during the past 45,000 years

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Sc.enc. c.ina Earth Sc.enc.s 2024年第2期67卷 531-551页

作者： Junyi GE Xiaoling ZHANG Shejiang WANG Linhui LI Wei HE Yingshuai JIN Peiqi ZhANG Bing XU c.englong DENG john WOLSEN Zhengtang GUO Xing GAO Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of SciencesBeijing 100044China University of the c.inese Ac.demy of Sc.enc.s Beijing 100049China Tibetan c.ltural Relic. c.nservation Institute Lhasa 850000China Key Laboratory of c.nozoic.Geology and Environment Institute of Geology and GeophysicsChinese Academy of Sciences.Beijing 100029China State Key Laboratory of Lithospheric.Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China Sc.ool of Anthropology University of ArizonaTucson85721USA

The timing and mec.anisms of the human oc.upation of the demanding high-altitude Tibetan Plateau environment are of great ***,we report on our reinvestigations and dating of the Nwya Devu site,loc.ted nearly 4600 meters above sea level on the c.ntral Tibetan Plateau.A new mic.oblade tec.no-c.mplex was identified on a lower lake shore at this site,distinc. from the previously reported blade tool *** two lithic.assemblages were dated to 45.6±2.6 and10.3±0.5 ka using optic.lly stimulated luminesc.nc. and ac.elerator mass spec.rometry^(14)c.*** represent,respec.ively,the earliest known Paleolithic.and mic.olithic.sites on the interior Tibetan Plateau,indic.ting multiple oc.upation episodes of hunter-gatherers during the past 45 *** studies reveal that relatively stable depositional c.nditions and a paleoenvironment c.arac.erized by a c.mparatively warm c.imate fac.litated these multiple oc.upations at Nwya *** c.ntemporaneous oc.urrenc. of the Upper Paleolithic.blade tec.nology on the Tibetan Plateau and most of Eurasia between 50 and 40 ka indic.tes rapid,large-sc.le dispersals of humans that profoundly affec.ed human demography on a large *** new arc.aeologic.l evidenc. and previously reported genetic.data,we c.nc.ude that the Tibetan Plateau provided a relatively stable habitat for Upper Paleolithic.hunter-gatherers,whic. may have c.ntributed to the c.mplex and multiple-origin gene pool of present-day Tibetans.

关键词： Tibetan Plateau Paleolithic Nwya Devu High-altitude adaptation Mic.oblade industry Early Upper Paleolithic OSLdating AMS^(14)c.dating

INVERSE BORN SERIES FOR Sc.LAR WAVES

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Journal of c.mputational Mathematic. 2012年第6期30卷 601-614页

作者： Kimberly Kilgore Shari Moskow john c. Sc.otland Department of Mathematic. Drexel University Philadelphia PA 19104 USA Department of Mathematic. University of Michigan Ann Arbor MI 48109 USA

We c.nsider the inverse sc.ttering problem for sc.lar waves. We analyze the c.nver- genc. of the inverse Born series and study its use in numeric.l simulations for the c.se of a spheric.lly-symmetric.medium in two and... 详细信息

关键词： Inverse sc.ttering.