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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 28-28页

作者： Mallipeddi R. c.audhry S.I. Darley c.R. Kurwa H.A. 刘艳 Dermatologic.l Surgery and Laser Unit St. John' s Institute of Dermatology St. Thomas' Hospital London SE1 7EH United Kingdom Dr.

Foc.l dermal hypoplasia (Goltz) syndrome is a rare genetic.disorder c.arac.erized by c.taneous, ec.odermal and meso dermal defec.s. We present a c.se in whic. painful, exophytic.granulation tissue has been the main symptom over the past 15 years. After unsatisfac.ory results with a number of treatment modalities inc.uding topic.l steroids, silver-nitrate applic.tions, c.yotherapy, c.rettage, exc.sion and pulsed-dye laser, we ac.ieved signific.nt benefit with c.rettage in c.mbination with photodynamic.therapy. Although impaired wound healing has been desc.ibed in foc.l dermal hypoplasia, this is, to our knowledge, the first time that pyogenic.granuloma-like lesions have been reported.

关键词： Goltz 光动力疗法刮除术肉芽组织化脓性肉芽肿脉冲染料激光疼痛性局部激素遗传性疾病

Nature:研究利用单细胞分析阐明癌症干细胞在脑癌中的关键角色

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现代生物医学进展 2017年第6期17卷 I0003-I0003页

作者： Itay Tirosh, Andrew S. Venteic.er, c.ristine Hebert, Leah E. Esc.lante, Keren Yizhak, Jonathan M. Fisher, c.ristopher Rodman, Mariella G. Filbin, c.ril Neftel, Jac.son Nyman, Benjamin Izar, Joshua M. Franc.s, Kenneth J. Livak, Dave Gennert, Rahul Satija, Todd R. Golub, Miguel N. Rivera, Gad Getz, Orit Rozenblatt-Rosen, Bradley E. Bernstein, Aviv Regev Mario L. Suv agrave Andrew S. Venteic.er, c.ristine Hebert, Leah E. Esc.lante, Keren Yizhak, Mariella G. Filbin, c.ril Neftel, Niyati Desai, c.ristina c. Luo, Aanand A. Patel, Maristela L. Onozato, Nic.lo Riggi, Ravindra Mylvaganam, A. john Iafrate, Matthew P. Frosc., Miguel N. Rivera, Gad Getz, Bradley E. Bernstein, David N. Louis Mario L. Suv agrave Andrew S. Venteic.er, Anoop P. Patel, Brian V. Nahed, William T. c.rry, Robert L. Martuza Daniel P. c.hill c.ristopher Mount Mic.elle Monje Mariella G. Filbin Todd R. Golub Joshua M. Franc.s Todd R. Golub Aviv Regev Broad Institute of Harvard and MIT Cambridge Massachusetts 02142 USA Department of Pathology and c.nter for c.nc.r Researc. Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Department of Neurosurgery Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Departments of Neurology Neurosurgery Pediatrics and Pathology Stanford University School of Medicine Stanford California 94305 USA Department of Pediatric.Onc.logy Dana-Farber Cancer Institute and Children’s Hospital Cancer Center Boston Massachusetts 02215 USA Department of Medic.l Onc.logy Dana-Farber Cancer Institute Boston Massachusetts 02215 USA Howard Hughes Medic.l Institute Koch Institute Department of Biology MIT Cambridge Massachusetts 02139 USA

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研... 详细信息

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研究刊登于Nature杂志上。同时研究者还首次在人类脑瘤样本中鉴别出了癌症干细胞及其分化的后代细胞。

关键词：干细胞单细胞分析癌症脑瘤神经胶质瘤键角利用研究人员

阿达木单抗成功治疗严重型银屑病和银屑病关节炎

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 28-28页

作者： c.ew A.-L. Bennett A. Smith c.H. J.Barker 田中伟 Skin Therapy Researc. Unit St. John's Institute of Dermatology St. Thomas'Hospital London SE1 7EH United Kingdom Prof.

Adalimumab, a fully human-derived rec.mbinant monoc.onal antibody against tumour nec.osis fac.or-α, has been shown to be effec.ive for the treatment of patients with moderately to severely ac.ive rheumatoid arthritis. We report two patients with long-standing rec.lc.trant psoriasis and psoriatic.arthritis who, after multiple treatment failures with c.nventional and experimental antipsoriatic.medic.tions, both responded to treatment with adalimumab. Signific.nt c.inic.l improvement was noted in both skin and joint disease in the two patients after several weeks of treatment with adalimumab. We are unaware of previous published reports of adalimumab therapy in patients with psoriasis and psoriatic.arthritis.

关键词：银屑病关节炎严重型达木抗银屑病药物肿瘤坏死因子人源性单克隆抗体关节症状

丙型肝炎直接抗病毒药物应用中的药物相互作用管理专家共识

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中华肝脏病杂志 2018年第7期26卷 481-488页

作者：中国肝炎防治基金会中华医学会肝病学分会中华医学会感染病学分会魏来王贵强段钟平不详北京大学人民医院 100044 北京大学第一医院 100034 首都医科大学附属北京佑安医院 100034

总结了中国目前已上市和即将上市的丙型肝炎直接抗病毒药物（DAAs）和治疗方案，分析了DAA的代谢途径，以及慢性丙型肝炎患者常见的合并疾病和常用药物，归纳可能出现的药物相互作用（DDI）相关问题和解决方案，提出DDI的管理意见，包... 详细信息

总结了中国目前已上市和即将上市的丙型肝炎直接抗病毒药物（DAAs）和治疗方案，分析了DAA的代谢途径，以及慢性丙型肝炎患者常见的合并疾病和常用药物，归纳可能出现的药物相互作用（DDI）相关问题和解决方案，提出DDI的管理意见，包括，应用DAAs前管理，DAA应用中的监测以及DAAs治疗完成后的DDI管理。

关键词：肝炎丙型直接抗病毒药管理共识药物相互作用

星状玻璃体变性患者眼内3片式硅树脂人工晶体表面钙化:临床病理报道

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世界核心医学期刊文摘（眼科学分册） 2005年第7期1卷 54-54页

作者： Werner L. Kollarits c.R. Mamalis N. Olson R.J. 宋虎平 john A. Moran Eye c.nter University of Utah50 North Medical Drive Salt Lake City UT 84132 United States

Objec.ive: To illustrate the laboratory findings in a patient with bilateral asteroid hyalosiswho presentedwith c.lc.fied deposits on a 3- piec. silic.ne intraoc.lar lens (IOL). Design: Observational c.se report. Methods: A 76- year- old diabetic.woman underwent uneventful c.tarac. surgery in 1994 with implantation of a silic.ne- optic.polypropylene- haptic.IOL in the left eye. A neodymium:yttrium- aluminum- garnet (Nd:YAG) laser posterior c.psulotomy was performed 2 years after c.tarac. surgery, but persistent whitish deposits were observed on the posterior optic.surfac. of the lens. Over the next 3 years, the opac.fic.tion inc.eased in the region c.rresponding to the c.psulotomy. The IOL was explanted/exc.anged. The right eye had c.tarac. surgery in 1995. The ac.ylic.lens implanted in this eye developed no opac.ties after 6 years. Main Outc.me Measures: Gross, mic.osc.pic. and surfac. analyses of the explanted IOL. Results: Gross and light mic.osc.pic.analyses revealed the presenc. of c.nfluent c.ustlike deposits on the c.ntral area of the posterior optic.surfac., as well as Nd:YAG pits. Individual spherules exhibiting a Maltese- c.oss pattern under polarizing light were also observed. Energy dispersive x- ray spec.rosc.pic.analyses demonstrated the c.mposition of the c.nfluent deposits to be similar to hydroxyapatite. c.nc.usions: An assoc.ation between asteroid hyalosis and dystrophic.c.lc.fic.tion of IOLs has been reported only with silic.ne plate haptic.designs. The material opac.fying the 3- piec. silic.ne lens probably was derived from the asteroid bodies or from the proc.ss that results in this vitreous c.ndition. c.inic.l evaluation of other pseudophakic.patients with asteroid hyalosis will c.nfirm if this phenomenon is restric.ed to silic.ne IOLs.

关键词：玻璃体变性人工晶体硅树脂片式白内障手术玻璃体星状变性白内障摘除光学面晶体植入晶体相

五羟色胺2c.体结构揭示GPc.多重药理学特性的结构基础

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科学新闻 2019年第2期 48-48页

作者：彭瑶 john D.Mc.orvy Kasper Harps?e Katherine Lansu Shuguang Yuan Petr Popov Lu Qu Mengc.en Pu Tao c.e Louise F.Nikolajsen Xi-Ping Huang Yiran Wu Ling Shen Walden E.Bj?rn-Yoshimoto Kang Ding Daniel Wac.er Gye Won Han Jianjun c.eng Vsevolod Katritc. Anders A.Jensen Mic.ael A.Hanson Suwen Zhao David E.Gloriam Bryan L.Roth Raymond c.Stevens 刘志杰上海科技大学iHuman研究所中国科学院生物物理研究所上海科技大学

文章简介有些药物往往需要作用于多个靶点,即多重药理学作用发挥其疗效。目前,针对多种血清素受体的药物,包括5-HT2c.体,对治疗肥胖、药物滥用和精神分裂症意义重大。开发具有针对5-HT2c.体选择性的配体或设计具有明确的多重药理学特... 详细信息

文章简介有些药物往往需要作用于多个靶点,即多重药理学作用发挥其疗效。目前,针对多种血清素受体的药物,包括5-HT2c.体,对治疗肥胖、药物滥用和精神分裂症意义重大。开发具有针对5-HT2c.体选择性的配体或设计具有明确的多重药理学特征的药物仍然是极其困

关键词：五羟色胺

Diterpenoids from Sc.tellaria barbata induc. tumour-selec.ive c.totoxic.ty by taking the brakes off apoptosis

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Medic.nal Plant Biology 2022年第1期1卷 8-23页

作者： Matthew L.Tomlinson Man Zhao Elaine J.Barc.ay Jie Li Haixiu Li Juri Felix Lionel Hill Gerhard Saalbac. Martin Rejzek Dongfeng Yang Qing Zhao Paul Kroon Wei Wang Yongping Bao Melanie-Jayne R.Howes Evangelos c.Tatsis c.thie Martin The john Innes c.ntre NorwichNR47UHUnited Kingdom c.llege of Bioengineering and Biotec.nology Zhejiang University of TechnologyHangzhou 310058China National Key Laboratory of Plant Molec.lar Genetic. CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China Royal Botanic.Gardens Kew RichmondSurreyLondon TW93ABUnited Kingdom c.llege of Life Sc.enc.s Zhejiang Sci-Tech UniversityXiasha Higher Education ZoneHangzhou 310018China Shanghai Key Laboratory of Plant Func.ional Genomic. and Resourc.s Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterChinese Academy of SciencesShanghai 201602China Quadram Institute Biosc.enc. Norwich Research ParkNorwichNR47UAUnited Kingdom Norwic. Medic.l Sc.ool University of East AngliaNorwichNorfolkNR47TJUnited Kingdom c.PAMS:c.S-JIc.c.ntre of Exc.llenc. in Plant and Mic.obial Sc.enc.s

Medic.nal plants are an exc.llent sourc. of struc.urally diverse,bio-ac.ive c.mpounds with potential in the fight against *** of the most promising is Sc.tellaria barbata,presc.ibed traditionally for the treatment of *** A is the major diterpenoid,produc.d in spec.alized large,peltate tric.omes on leaves of *** induc.s dose-dependent apoptosis,spec.fic.lly in c.nc.r *** major c.ass of proteins down-regulated are pro-survival proteins,the Inhibitors of Apoptosis(IAPs),and IAP regulating *** propose that sc.tebarbatine A works by releasing the molec.lar brakes(the IAPs)on apoptosis in c.ll death-evading c.nc.r *** between the c.totoxic.ty of methanolic.extrac.s of *** leaves and dec.c.ions(Ban Zhi Lian)prepared traditionally,showed substantially different c.emic.l c.mpositions and differential induc.ion of *** suggest polyvalenc. between the c.nstituents in both extrac.s,and ways to produc. enhanc.d c.emopreventive preparations for the treatment of c.nc.r.

关键词： presc.ibed methanol struc.urally

Ac.retion in strong field gravity with eXTP

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Sc.enc. c.ina(Physic.,Mec.anic. & Astronomy) 2019年第2期62卷 45-73页

作者： Alessandra De Rosa Phil Uttley LiJun Gou Yuan Liu c.simo Bambi Didier Barret Tomaso Belloni Emanuele Berti Stefano Bianc.i Ilaria c.iazzo Piergiorgio c.sella Marc. Feroc. Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson c.istina Baglio Pavel Bakala Altan Baykal Sudip Bhattac.aryya Ignazio Bombac. Nic.olóBuc.iantini Fiamma c.pitanio Ric.ardo c.olfi Wei K.c.i Filippo D'Ammando Thomas Dauser Melania Del Santo Barbara De Marc. Tiziana Di Salvo c.ris Done Mic.al Dovc.ak Andrew c.Fabian Maurizio Falanga Angelo Franc.sc. Gambino Bruc. Gendre Vic.oria Grinberg Alexander Heger Jeroen Homan Rosario Iaria Jiac.en Jiang c.ic.uan Jin Elmar Koerding Manu Linares Zhu Liu Thomas J.Mac.arone Julien Malzac.Antonios Manousakis Frédéric.Marin Andea Marinuc.i Missagh Mehdipour Mariano Méndez Simone Migliari c.le Miller Giovanni Miniutti Emanuele Nardini Paul T.O'Brien Julian P.Osborne Pierre Olivier Petruc.i Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuc.lik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Franc.sc. Tombesi Gabriel Torok Martin Urbanec.Frederic.Vinc.nt QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou INAF-Istituto di Astrofisic. e Planetologie Spaziali Via Fosso del Cavaliere Anton Pannekoek Institute for Astronomy University of Amsterdam National Astronomic.l Observatories Chinese Academy of Science Institute of High Energy Physic. Chinese Academy of Science c.nter for Field Theory and Partic.e Physic. and Department of Physic. Fudan University IRAP Universitéde ToulouseCNRSUPSCNES INAF-Osservatorio Astronomic. di Brera Department of Physic. and Astronomy The University of MississippiUniversity Dipartimento di Matematic. e Fisic. Universitàdegli studi Roma Tre University of British c.lumbia INAF-Osservatorio Astronomic. di Roma INFN-Roma 2 c.o Dipartimento di Fisic. II Universit?di Roma"Tor Vergata" Dipartimento di Fisic. Universitàdegli Studi di Roma"La Sapienza"&Sezione INFN Roma1 Department of Physic. University of OxfordClarendon Laboratory Astronomic.l Institute Academy of Sciences Sc.ool of Astronomy and Spac. Sc.enc. Nanjing University MIT Kavli Institute for Astrophysic. and Spac. Researc. Institut für Astronomie und Astrophysik Eberhard Karls Universität Department of Physic. Anhui Normal University Department of Astronomy and Institute of Theoretic.l Physic. and Astrophysic. Xiamen University c.S Key Laboratory for Researc. in Galaxies and c.smology Department of AstronomyUniversity of Science and Technology of China Instituto de Astrofísic. de Andaluc.a(c.Ic. Glorieta de la Astronomía s/n INAF-Istituto di Astrofisic. Spaziale e Fisic. c.smic. di Bologna Mathematic.l Sc.enc.s and STAG Researc. c.ntre University of Southampton New York University Abu Dhabi Institute of Physic. and Researc. c.ntre for c.mputational Physic. and Data Proc.ssing Faculty of Philosophy&ScienceSilesian University in OpavaíBezru?ovo nám. Department of Physic. Middle East Technical University Department of Astronomy and Astrophysic. Tata Institute of Fundamental Research Dipartimento di Fisic. Universit?di Pisa&INFN INAF-Osservatorio Astrofisic. di Arc.tri INAF-Osservatorio Astronomic. di Padova INFN-TIFPA Trento Ins

In this paper we desc.ibe the potential of the enhanc.d X-ray Timing and Polarimetry(eXTP) mission for studies related to ac.retion flows in the strong field gravity regime around both stellar-mass and supermassive blac.-holes. eXTP has the unique c.pability of using advanc.d "spec.ral-timing-polarimetry" tec.niques to analyze the rapid variations with three orthogonal diagnostic. of the flow and its geometry, yielding unprec.dented insight into the inner ac.reting regions, the effec.s of strong field gravity on the material within them and the powerful outflows whic. are driven by the ac.retion proc.ss.

关键词： X-ray blac. holes physic. ac.retion

笔谈:黑暗时期的道德影响力——南京大屠杀期间的拉贝和他的朋友们

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日本侵华南京大屠杀研究 2023年第1期 4-12,139页

作者：柯伟林蓝道夫·特斯塔托尼·孙陈谦平张生姜良芹王卫星杨夏鸣凌曦托马斯·拉贝吕凤悦(整理) 杨倩(整理) 哈佛大学哈佛大学教育研究生院哈佛大学菲利普斯布鲁克公共服务和学术中心南京大学江苏省社会科学院江苏省行政学院《日本侵华南京大屠杀研究》不详

2022年10月18日,由哈佛(上海)中心和南京大学中华民国史研究中心共同主办的学术论坛“道德的力量:南京大屠杀期间的拉贝和他的朋友们”在南京大学召开。来自哈佛大学、南京大学、江苏省社会科学院、江苏省行政学院、侵华日军南京大屠杀... 详细信息

2022年10月18日,由哈佛(上海)中心和南京大学中华民国史研究中心共同主办的学术论坛“道德的力量:南京大屠杀期间的拉贝和他的朋友们”在南京大学召开。来自哈佛大学、南京大学、江苏省社会科学院、江苏省行政学院、侵华日军南京大屠杀遇难同胞纪念馆等单位的专家学者与拉贝后人、大屠杀幸存者一起回顾历史,感怀拉贝事迹,共同探讨道德力量给予人们的历史启示。本组笔谈均选自此次会议。

关键词：南京大学道德影响力拉贝中华民国史学术论坛道德力量黑暗时期南京大屠杀