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Evaluation of method performance for osteometric sorting of commingled human remains

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Forensic Sciences Research 2018年第4期3卷 343-349页

作者： john E.byrd Carrie B.LeGarde Laboratory Defense POW/MIA Accounting AgencyJoint Base Pearl Harbor-HickamHIUSA

Evaluation of method performance involves the consideration of numerous factors that can contribute to error.A variety of measures of performance can be borrowed from the signal detection literature and others are drawn from statistical *** article demonstrates the principles of performance evaluation by applying multiple measures to osteometric sorting models for paired elements run against data from known *** indicate that false positive rates are close,on average,to expected *** assemblage size grows,the false positive rate becomes unimportant and the false negative rate becomes *** disparity among the commingled individuals plays a significant role in method performance,showing that case-specific circumstances(*** size and size disparity)will determine method power.

关键词： Forensic sciences forensic anthropology statistics test method method performance error signal detection osteometric sorting

Low-cost,simple,and scalable self-assembly of DNA origami nanostructures

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Nano Research 2019年第5期12卷 1207-1215页

作者： Patrick D.Halley Randy A.Patton Amjad Chowdhury john C.byrd Carlos E.Castro Department of Chemical and Biomolecular Engineering The Ohio State UniversityColumbusOH 43210USA Department of Mechanical and Aerospace Engineering The Ohio State UniversityColumbusOH 43210USA Division of Hematology Department of Internal Medicineand OSU Comprehensive Cancer CenterThe Ohio State UniversityColumbusOH 43210USA Biophysics Graduate Program The Ohio State UniversityColumbusOH 43210USA

Despite demonstrating exciting potential for applications such as drug delivery and biosensing,the development of nanodevices for practical applications and broader use in research and education are still hindered by the time,effort,and cost associated with DNA origami *** and robust methods to perform and scale the DNA origami self-assembly process are critical to facilitate broader use and translation to industrial or clinical *** report a simple approach to fold DNA origami nanostructures that is fast,robust,and *** demonstrate fabrication at scales approximately 100-1,500-fold higher than typical *** further demonstrate an approach we termed low-cost efficient annealing (LEAN) self-assembly involving initial heating at 65 ℃ for 10 min,then annealing at 51 ℃ for 2 h,followed by brief quenching at 4 ℃ that leads to effective assembly of a range of DNA origami structures *** contrast to other methods for scaling DNA origami assembly,this approach can be carried out using cheap and widely available equipment (e.g.,hot plates,water baths,and laboratory burners) and uses standard recipes and materials so is readily applied to any existing or new DNA origami *** envision these methods can facilitate device development for commercial applications and facilitate broader use of DNA origami in research and education.

关键词： DNA origami DNA nanotechnology self assembly scalable nanofabrication low cost fabrication nanotechnology education

Extracting cavity and pulse phases from limited data for coherent pulse stacking

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Chinese Optics Letters 2018年第4期16卷 51-55页

作者： Yilun Xu Russell Wilcox john byrd Lawrence Doolittle Qiang Du Gang Huang Yawei Yang Tong Zhou Lixin Yah Wenhui Huang Chuanxiang Tang Accelerator Technology and Appfied Physics Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Department of Engineering Physics Tsinghua University Beijing 100084 China Key Laboratory of Particle and Radiation Imaging Ministry of Education Tsinghua University Beijing 100084 China

Coherent pulse stacking（CPS） is a new time-domain coherent addition technique that stacks several optical pulses into a single output pulse, enabling high pulse energy and high average power. A Z-domain model targeting the pulsed laser is assembled to describe the optical interference process. An algorithm, extracting the cavity phase and pulse phases from limited data, where only the pulse intensity is available, is developed to diagnose optical cavity resonators. We also implement the algorithm on the cascaded system of multiple optical cavities,achieving phase errors less than 1.0°（root mean square）, which could ensure the stability of CPS.

关键词： Extracting cavity and pulse phases from limited data for coherent pulse stacking

美国制造技术协会(AMT)会长john *** Ⅲ先生的贺信

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世界制造技术与装备市场 2007年第2期 129-129页

作者： john B.byrd Ⅲ 美国制造技术协会

第十届国际机床展览会将在北京开幕,这是一睹世界上最先进的制造技术设备的绝好机会。这次展览会上展示的制造方法制都是创新的前沿技术。全球制造业专家齐集一堂表明,CIMT2007是最重要的国际展览会之一。

关键词：国际展览会 AMT john B.byrd 制造技术美国美利坚合众国北美洲

Improving risk stratification for 2022 European LeukemiaNet favorablerisk patients with acute myeloid leukemia

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The Innovation 2024年第6期5卷 89-99页

作者： Kellie J.Archer Han Fu Krzysztof Mrózek Deedra Nicolet Alice S.Mims Geoffrey L.Uy Wendy Stock john C.byrd Wolfgang Hiddemann Klaus H.Metzeler Christian Rausch Utz Krug Cristina Sauerland Dennis Görlich Wolfgang E.Berdel Bernhard J.Woermann Jan Braess Karsten Spiekermann Tobias Herold Ann-Kathrin Eisfeld Division of Biostatistics College of Public HealthThe Ohio State UniversityColumbusOHUSA Google Inc.Mountain ViewCAUSA Clara D.Bloomfield Center for Leukemia Outcomes Research The Ohio State University Comprehensive Cancer CenterColumbusOHUSA Alliance Statistics and Data Management Center The Ohio State University Comprehensive Cancer CenterColumbusOHUSA Department of Medicine Division of OncologyWashington University School of MedicineSt.LouisMOUSA Department of Medicine Section of Hematology/OncologyUniversity of ChicagoChicagoILUSA Department of Internal Medicine University of CincinnatiCincinnatiOHUSA Department of Medicine III University HospitalLMU MunichMunichGermany Department of Oncology and Hematology Hospital Barmherzige Br€uderRegensburgGermany Department of Medicine 3 Klinikum LeverkusenLeverkusenGermany Institute of Biostatistics and Clinical Research University of M€unsterM€unsterGermany Department of Medicine A University Hospital M€unsterM€unsterGermany German Society of Hematology and Oncology BerlinGermany

Assignment of patients diagnosed with acute myeloid leukemia(AML)to the 2022 European LeukemiaNet(ELN)favorable genetic risk group has important clinical implications,as allogeneic stem cell transplantation in first complete remission(CR)is not advised due to a relatively good outcome of patients receiving chemotherapy alone and transplant-associated ***,not all favorable genetic risk patients experience long-term relapse-free survival(RFS),making recognition of patients who would most likely be cured of high importance.

关键词： patients myeloid Leukemia

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin Huang john Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria

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Neural Regeneration Research 2025年第4期20卷 1081-1082页

作者： john Mitrofanis Jonathan Stone Michael R.Hamblin Pierre Magistretti Alim-Louis Benabid Glen Jeffery Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah University of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neurons are notoriously vulnerable cell *** the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper *** most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell *** challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological *** interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical *** this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective *** are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

关键词： protective dosage distress

Prof. john Chabot: working hard and asking important questions, but also keeping focused

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 269-270页

作者： john Chabot 不详

Expert's introduction *** Chabot(Figure 1)received his medical degree from Dartmouth College School of Medicine and completed a residency in General Surgery at Columbia Presbyterian Medical Center and a fellowship in Surgery at Dartmouth-Hitchcock Medical *** joined New York-Presbyterian/Columbia in 1983 and has since become Professor of Surgery and Executive Director of the Pancreas Center and Chief of Gastrointestinal/Endocrine ***’s clinical interest is focused on the prevention,treatment,and cure of cancers involving the gastrointestinal tract(especially pancreatic cancer)and other areas of surgical oncology such as the surgical treatment of thyroid cancer and mesothelioma of the *** has published extensively in leading medical journals including Pancreas,Journal of Clinical Oncology,Journal of Gastrointestinal Surgery,and other notable *** also actively leads Columbia Doctors in responding to the challenges associated with rapid innovation,advancing technology,and the highly informed *** has received numerous awards during his career,including the Jerry Gliklich Practitioner of the Year Award,Teaching Award in Surgery for Excellence in Teaching and Mentoring,and has been named multiple times as one of New York Magazine’s Top Doctors.

关键词： Surgery prevention Figure

Effects of resistance and Tai Ji training on mobility and symptoms in knee osteoarthritis patients

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Journal of Sport and Health Science 2013年第4期2卷 209-214页

作者： Michael Wortley Songning Zhang Maxime Paquette Erin byrd Lucas Baumgartner Gary Klipple john Krusenklaus Larry Brown Pellessippi State Community College Department of Kinesiology Recreation and Sport StudiesThe University of Tennessee Department of Health & Sport Sciences University of Memphis Department of Rheumatology The University of Tennessee Medical Center Tennessee Sports Medicine Group

Background:No studies have compared effectiveness of resistance training and Tai Ji exercise on relieving symptoms of knee osteoarthritis(OA).The purpose of the study was to evaluate effects of a 10-week Tai Ji and resistance training intervention on improving OA symptoms and mobility in seniors with knee ***:Thirty-one seniors(60-85 years)were randomly assigned to a Tai Ji program(n=12),a resistance training program(n=13),and a control group(n=6).All participants completed the Western Ontario and McMaster(WOMAC)Osteoarthritis Index and performed three physical performance tests(6-min walk,timed-up-and-go,and timed stair climb and descent)before and after the 10-week ***:The participants in the resistance training group significantly improved on the timed-up-and-go test(p<0.001),the WOMAC pain subscore(p=0.006),WOMAC stiffness sub-score(p<0.001),and WOMAC physical function sub-score(p=0.011).The Tai Ji group significantly improved on the timed-up-and-go test(p<0.001),but not on the WOMAC ***:Resistance training was effective for improving mobility and improving the symptoms of knee *** Ji was also effective for improving mobility,but did not improve knee OA symptoms.

关键词： Knee Osteoarthritis Resistance training Tai Chi Tai Ji