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Transdermal delivery of 4-aminopyridine accelerates motor functional recovery and improves nerve morphology following sciatic nerve crush injury in mice

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Neural Regeneration Research 2020年第1期15卷 136-144页

作者： Andrew RClark Chia George Hsu M A Hassan Talukder mark Noble john CElfar Center for Orthopaedic Research and Translational Science Penn State Hershey College of MedicineMilton S.Hershey Medical CenterHersheyPAUSA Department of Orthopaedics The University of Rochester Medical CenterRochesterNYUSA Department of Medicine Aab Cardiovascular Research InstituteUniversity of Rochester School of Medicine and DentistryRochesterNYUSA Department of Biomedical Genetics The University of Rochester Medical CenterRochesterNYUSA

Oral 4-aminopyridine(4-AP)is clinically used for symptomatic relief in multiple sclerosis and we recently demonstrated that systemic 4-AP had previously unknown clinically-relevant effects after traumatic peripheral nerve injury including the promotion of re-myelination,improvement of nerve conductivity,and acceleration of functional *** hypothesized that,instead of oral or injection administration,transdermal 4-AP(TD-4-AP)could also improve functional recovery after traumatic peripheral nerve *** with surgical traumatic peripheral nerve injury received TD-4AP or vehicle alone and were examined for skin permeability,pharmacokinetics,functional,electrophysiological,and nerve morphological properties.4-AP showed linear pharmacokinetics and the maximum plasma 4-AP concentrations were proportional to TD-4-AP *** a single dose of TD-4-AP administration demonstrated rapid transient improvement in motor function,chronic TD-4-AP treatment significantly improved motor function and nerve conduction and these effects were associated with fewer degenerating axons and thicker myelin sheaths than those from vehicle *** findings provide direct evidence for the potential transdermal applicability of 4-AP and demonstrate that 4-AP delivered through the skin can enhance in-vivo functional recovery and nerve conduction while decreasing axonal *** animal experiments were approved by the University Committee on Animal Research(UCAR)at the University of Rochester(UCAR-2009-019)on March 31,2017.

关键词： 4-aminopyridine electron microscopy functional recovery nerve conduction velocity peripheral nerve injury pharmacokinetics transdermal administration

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Coal rib response during bench mining: A case study

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International Journal of Mining Science and Technology 2018年第1期28卷 107-113页

作者： Morgan M.Sears john Rusnak mark Van Dyke Gamal Rashed Khaled Mohamed Michael Sloan Ground Control Branch NIOSH Pittsburgh Mining Research Division

In 2016, room-and-pillar mining provided nearly 40% of underground coal production in the United *** the past decade, rib falls have resulted in 12 fatalities, representing 28% of the ground fall fatalities in *** coal *** of these 12 fatalities(75%) have occurred in room-andpillar *** objective of this research is to study the geomechanics of bench room-and-pillar mining and the associated response of high pillar ribs at overburden depths greater than 300 *** paper provides a definition of the bench technique, the pillar response due to loading, observational data for a case history, a calibrated numerical model of the observed rib response, and application of this calibrated model to a second site.

关键词： Deep cover Bench mining Thick seam Retreat mining Rib response Rib support

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Unexplained iron deficiency anemia:does Helicobacter pylori have a role to play?

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Gastroenterology Report 2018年第3期6卷 215-220,I0003页

作者： Savio john Juan Diego Baltodano Nilesh Mehta Katherine mark Uma Murthy Division of Gastroenterology and Hepatology State University of New York(SUNY)Upstate Medical UniversitySyracuseNew YorkNYUSA Department of Medicine SUNY Upstate Medical UniversitySyracuseNYUSA Department of Gastroenterology Syracuse VA Medical CenterSyracuseNYUSA

Background and aim:Testing for Helicobacter pylori(Hp)infection is recommended for work-up of unexplained iron deficiency anemia(IDA),although the evidence supporting this recommendation is *** aim of this study was to investigate the association between Hp infection and unexplained iron deficiency(ID)or IDA in the older adult population without significant upper gastrointestinal source of blood ***:Retrospective single-center cohort study;523 out of 1253 consecutive patients who underwent esophagogastroduodenoscopy with no significant upper and/or lower gastrointestinal source for blood loss or risk factors for *** were made between the Hp-positive and Hp-negative groups using Fisher exact test,chi-square test and Student’s *** and multiple logistic regression analyses were used to identify significant risk factors associated with ID and ***:One hundred and three subjects(19.7%)had Hp infection and 420(80.3%)were negative for ***-eight(22.1%)out of 307 subjects with available serum iron profile had unexplained ID and 28(5.4%)out of 510 subjects with available hemoglobin profile had unexplained *** association was found between ID/IDA and Hp infection in univariate and multiple logistic regression ***:We found no association between unexplained ID or IDA and Hp infection in older adult population without peptic ulcer disease or significant upper gastrointestinal source of blood loss.

关键词： Helicobacter pylori anemia iron deficiency

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Scientific challenges and instrumentation for the International Meridian Circle Program

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Science China Earth Sciences 2021年第12期64卷 2090-2097页

作者： William LIU Michel BLANC Chi WANG Eric DONAVAN john FOSTER mark LERTER Hermann OPGENOOTYH Liwen REN National Space Science Centre Chinese Academy of SciencesBeijing100190China University of Toulouse Toulouse31400France University of Calgary CalgaryT2N 1N4Canada MIT Haystack Observatory CambridgeMA01886USA University of Leicester LeicesterLE17RHUK University of Umeå UmeåSE-90187Sweden

Earth’s ecosystems and human activities are threatened by a broad spectrum of hazards of major importance for the safety of ground infrastructures,space systems and space flight:solar activity,earthquakes,atmospheric and climatic disturbances,changes in the geomagnetic field,fluctuations of the global electric *** and understanding these major hazards to better predict and mitigate their effects is one of the greatest scientific and operational challenges of the 21st *** diverse,these hazards share one feature in common:they all leave their characteristic imprints on a critical layer of the Earth’s environment:its ionosphere,middle and upper atmosphere(IMUA).The objective of the International Meridian Circle Program(IMCP),a major international program led by the Chines Academy of Sciences(CAS),is to deploy,integrate and operate a global network of research and monitoring instruments to use the IMUA as a screen on which to detect these *** this article,we first show that the geometry required for the IMCP global observation system leads to a deployment of instruments in priority along the 120°E-60°W great meridian circle,which will cover in an optimal way both the dominant geographic and geomagnetic latitude variations,possibly complemented by a second Great Circle along the 30°E-150°W meridians to capture longitude ***,starting from the Chinese Meridian Project(CMP)network and using it as a template,we give a preliminary and promising description of the instruments to be integrated and deployed along the 120°E-60°W great circle running across China,Australia and the Americas.

关键词： International Meridian Circle Program Ionosphere Middle-upper atmosphere Space weather Chinese Meridian Project

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空间弹性变形构件的李群和李代数分析方法

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机械工程学报 2005年第1期41卷 16-23页

作者：丁希仑 Selig john mark 北京航空航天大学机器人研究所北京100083 London South Bank University London UK

重点研究了具有三维空间弹性变形的杆件,即杆件同时受弯曲、拉伸和扭转等力作用而发生空间变形的李群和李代数理论描述问题。将杆件任意一点处的弹性变形与力的关系进行分析得到系统的空间变形柔度矩阵,并通过对弹性势能的分析,进一步... 详细信息

重点研究了具有三维空间弹性变形的杆件,即杆件同时受弯曲、拉伸和扭转等力作用而发生空间变形的李群和李代数理论描述问题。将杆件任意一点处的弹性变形与力的关系进行分析得到系统的空间变形柔度矩阵,并通过对弹性势能的分析,进一步得到了弹性杆件系统的空间变形的柔性密度。结合Rayleigh-Ritz法计算了系统的特征频率。阐明了所用理论方法解决空间弹性变形杆件问题的方便和有效性,并以空间变形简化处理为简单变形的传统方法进行了仿真结果的分析对比。

关键词：李群李代数弹性杆件柔度特征频率

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What diameter?What height?Influence of measures of average tree size on area-based allometric volume relationships

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Forest Ecosystems 2024年第1期11卷 100-109页

作者： Yilin Wang john A.Kershaw mark J.Ducey Yuan Sun James B.McCarter Integrated Forest Mensuration and Systems Analysis Laboratory Faculty of Forestry and Environmental ManagementUniversity of New BrunswickFrederictonNBCanada Department of Natural Resources and the Environment University of New HampshireDurhamNHUSA College of Forestry Nanjing Forestry UniversityNanjing210037China Scientific Programmer RayonierYuleeFLUSA

Volume is an important attribute used in many forest management *** from 83 fixed-area plots located in central New Brunswick,Canada,are used to examine how different measures of stand-level diameter and height influence volume prediction using a stand-level variant of Honer's(1967)volume *** density was included in the models(Volume=f(Diameter,Height,Density))choice of diameter measure was more important than choice of height *** density was not included(Volume=f(Diameter,Height)),the opposite was *** models with density included,moment-based estimators of stand diameter and height performed better than all other *** models without density,largest tree estimators of stand diameter and height performed better than other *** overall best equation used quadratic mean diameter,Lorey's height,and density(root mean square error=5.26 m^3·ha^(-1);1.9%relative error).The best equation without density used mean diameter of the largest trees needed to calculate a stand density index of 400 and the mean height of the tallest 400 trees per ha(root mean square error=32.08 m^(3)·ha^(-1);11.8%relative error).The results of this study have some important implications for height subsampling and LiDAR-derived forest inventory analyses.

关键词： Allometric relationships Stand structure Volume estimation Stand-level attributes

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Review of research methodologies for tigers:Telemetry

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Integrative Zoology 2010年第4期5卷 378-389页

作者： Clayton S.MILLER mark HEBBLEWHITE john M.GOODRICH Dale G.MIQUELLE Wildlife Conservation Society BronxNYUSA Wildlife Biology Program College of Forestry and ConservationUniversity of MontanaMissoulaMontanaUSA

Over the past half century,wildlife research has relied on technological advances to gain additional insight into the secretive lives of *** revolution started in the 1960s with the development of radio telemetry and continues today with the use of Global Positioning System(GPS)-based research *** the present paper we review the history of radio telemetry from its origins with grizzly bears in Yellowstone to its early applications in tiger research and conservation in *** address the different types of data that are available using radio telemetry as opposed to using other research techniques,such as behavioral observations,camera trapping,DNA analysis and scat *** the late 1990s,the rapid development of GPS collar technology revolutionized wildlife *** new technology has enabled researchers to dramatically improve their ability to gather data on animal movements and *** the ecological and conservation benefits of radio telemetry,there have been few telemetry studies of tigers in the wild,and most have been on the Bengal or Amur *** close with an assessment of the current tiger conservation efforts using GPS technology and discuss how this new information can help to preserve tigers for future generations.

关键词： Global Positioning System technology Panthera tigris radio telemetry research methodologies tiger

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Stepping up to meet the challenge of freezing of gait in Parkinson’s disease

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Translational Neurodegeneration 2022年第1期11卷 589-600页

作者： Simon Lewis Stewart Factor Nir giladi Alice Nieuwboer john Nutt mark Hallett ForeFront Parkinson’s Disease Research Clinic Brain and Mind CentreSchool of Medical SciencesUniversity of SydneySydneyNSWAustralia Jean and Paul Amos Parkinson’s Disease and Movement Disorders Program Emory University School of MedicineAtlantaGAUSA Movement Disorders Unit Department of NeurologyTel-Aviv Sourasky Medical CenterSackler School of Medicine and Sagol School of NeuroscienceTel Aviv UniversityTel AvivIsrael Department of Rehabilitation Sciences KU LeuvenLeuvenBelgium Movement Disorder Section Department of NeurologyOregon Health&Science UniversityPortlandORUSA Human Motor Control Section National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaMDUSA.

There has been a growing appreciation for freezing of gait as a disabling symptom that causes a significant burden in Parkinson’s disease. Previous research has highlighted some of the key components that underlie the phenomenon, but these reductionist approaches have yet to lead to a paradigm shift resulting in the development of novel treatment strategies. Addressing this issue will require greater integration of multi-modal data with complex computational modeling, but there are a number of critical aspects that need to be considered before embarking on such an approach. This paper highlights where the field needs to address current gaps and shortcomings including the standardization of definitions and measurement, phenomenology and pathophysiology, as well as considering what available data exist and how future studies should be constructed to achieve the greatest potential to better understand and treat this devastating symptom.

关键词： Freezing of gait Computational modeling Standardized definitions and assessments Novel paradigms Phenomenology Pathophysiology Treatment

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Hepatic artery stenosis angioplasty and implantation of Wingspan neurovascular stent: A case report and discussion of stenting in tortuous vessels

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World Journal of Gastroenterology 2020年第4期26卷 448-455页

作者： mark Barahman Lourdes Alanis Joseph DiNorcia john M Moriarty Justin P McWilliams Department of Pathology Albert Einstein College of Medicine and Montefiore Medical CenterBronxNY 10461United States Department of Radiology Division of Interventional RadiologyRonald Reagan Medical Center at UCLADavid Geffen School of Medicine at UCLALos AngelesCA 90095United States Division of Interventional Radiology Ronald Reagan Medical Center at UCLADavid Geffen School of Medicine at UCLALos AngelesCA 90095United States Department of Surgery Ronald Reagan Medical Center at UCLADavid Geffen School of Medicine at UCLALos AngelesCA 90095United States

BACKGROUND Hepatic artery stenosis is a complication of orthotopic liver transplant occurring in 3.1%-7.4%of patients that can result in graft failure and need for *** therapy with angioplasty and stenting has been used with a high degree of technical success and good clinical outcomes,but tortuous hepatic arteries present a unique challenge for *** stents for this application should be maneuverable and conformable while also exerting adequate radial force to maintain a patent *** SUMMARY Herein we report our experience with a neurovascular Wingspan stent system in a challenging case of recurrent hepatic artery stenosis and discuss the literature of stenting in tortuous transplant hepatic *** Wingspan neurovascular stent is self-expanding,has good conformability,and adequate radial resistance and as such it could be added to the armamentarium of interventionalists in the setting of a tortuous and stenotic transplant hepatic artery.

关键词： Hepatic artery stenosis Case report Endovascular Angioplasty Stent Wingspan neurointerventional stent

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Case of early right ventricular pacing lead perforation and review of the literature

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World Journal of Clinical Cases 2014年第6期2卷 206-208页

作者： Gary Nash john mark Williams Rajasekhar Nekkanti Assad Movahed Department of Cardiovascular Sciences East Carolina University Brody School of Medicine East Carolina Heart Institute

We report a case of a 77-year-old patient with complete atrioventricular block. She underwent permanent pacemaker implantation complicated by right ventricular lead perforation. This was suspected on transthoracic echocardiogram and confirmed by chest computed tomography. The lead was repositioned in the cardiac electrophysiology lab followed by an uneventful course thereafter.

关键词： Pacemaker Lead Perforation

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