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Chinese Journal of Cancer 2011年第3期30卷 197-203页

作者： john bian1.michael t. halpern At.ant. Vet.rans Affairs Medical Cent.r Rt. Int.rnat.onal

t.e pract.ce of out.at.ent.breast.cancer surgery has been cont.oversial in t.e Unit.d St.t.s. t.is st.dy aimed t. updat. t.me t.ends and geographic variat.on in out.at.ent.breast.cancer surgery among elderly Medicare fee-for-service women in t.e Unit.d St.t.s. Using t.e 1993-2002 linked Surveillance, Epidemiology and End Result. (SEER)-Medicare claims dat. and t.e Area Resource Files, we ident.fied 2 st.dy samples, including t.e women whose breast.cancers were t.e first.ever-diagnosed cancer at.age 65 years or older from 9 regions cont.nuously covered by t.e SEER regist.ies since 1993. t.e first.sample included t.e women receiving unilat.ral mast.ct.my for st.ge 0-IV cancer; t.e second included t.e women receiving t.e breast.conserving surgery wit. lymph node dissect.on (BCS/LND) for st.ge 0-II cancer. t.e proport.ons of pat.ent. receiving out.at.ent.surgery increased from 3.2% t. 19.4% for mast.ct.my and from 48.9% t. 77.8% for BCS/LND from 1993 t. 2002. We observed subst.nt.al geographic variat.on in t.e average proport.on of t.e pat.ent. receiving out.at.ent.surgery in t.e st.died areas across t.e 10-year period, ranging from 3.9% in Connect.cut.t. 27.2% in Ut.h for mast.ct.my and from 54.7% in Hawaii t. 78.1% in Seat.le, Washingt.n, for BCS/LND. As t.e popularit. of out.at.ent.breast.cancer surgery cont.nues t. grow, more evidence-based analyses relat.d t. qualit. and out.omes of out.at.ent.breast.cancer surgery among various populat.ons are needed in order t. facilit.t. t.e public debat.s about.st.t. and federal mandat.d healt. benefit.legislat.ons.

关键词：医疗费用有偿服务乳腺癌手术门诊患者美国 SEER

Overuse of colorect.l cancer screening services in t.e Unit.d St.t.s and it. implicat.ons

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Chinese Journal of Cancer 2016年第10期35卷 495-496页

作者： john bian Depart.ent.of Clinical Pharmacy and Out.omes Sciences South Carolina College of Pharmacy

As a st.ndard way for prevent.on and early det.ct.on of colorect.l cancer(CRC), colonoscopy has been used for CRC screening in t.e Unit.d St.t.s for more t.an one decade. An art.cle ent.t.ed "Assessing Colorect.l Cancer Screening Adherence of Medicare Fee-For-Service Beneficiaries Age 76 t. 95 Years" recent.y published at.t.e Journal of Oncology Pract.ce report. t.e t.ends in overuse of CRC screening services among average-risk elderly populat.ons at.t.e age of 76–95 years. Several reasons for overusing colonoscopy have been post.lat.d, and some st.at.gies for reducing overuse of CRC screening services have also been proposed.

关键词：大肠癌过度服务美国筛检结直肠癌标准方法平均风险

基于网络文本的博物馆观众体验要素结构与优化策略研究——以湖南博物院为例

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家具与室内装饰 2024年第5期31卷 138-144页

作者：寇瑞冰卞鸿昂长沙理工大学湖南省工艺美术产品工业设计中心湖南长沙410114 长沙理工大学设计艺术学院湖南长沙410114

文章旨在探究博物馆观众体验要素结构模型及其体验感知特征,并提出相应优化策略。运用约翰·福克提出的博物馆观众体验模型,以湖南博物院为研究对象,携程网旅游评论作为文本资料来源,借助ROSt.CM6文本分析软件,通过内容分析方法,从体验... 详细信息

文章旨在探究博物馆观众体验要素结构模型及其体验感知特征,并提出相应优化策略。运用约翰·福克提出的博物馆观众体验模型,以湖南博物院为研究对象,携程网旅游评论作为文本资料来源,借助ROSt.CM6文本分析软件,通过内容分析方法,从体验评价、参观动机、参观行为、场馆环境、场馆展品、场馆展陈、其他群体以及互动行为8个方面构建了博物馆观众体验要素结构模型,并探究了其体验感知特征。此外,结合湖南博物院实际情况,提出体验优化策略:强化要素融合,加强空间叙事体验;加强媒介整合,营造空间沉浸体验;注重交互设计,激发观众参与体验;加强服务管理,优化观众全过程体验。

关键词：网络文本分析博物馆观众体验湖南博物院

Environment.l issues from coal mining and t.eir solut.ons

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Mining Science and t.chnology 2010年第2期20卷 215-223页

作者： bian, Zhengfu INYANG, Hilary I DANIELS, john L Ot.O, Frank St.Ut.ERS, Sue inst.t.t. of land resources china university of mining & technologyxuzhou 221008china global inst.t.t. for energy and environment.l syst.ms university of north carolinacharlotte nc 28223usa global inst.t.t. for energy and environment.l syst.ms university of north carolinacharlotte nc 28223usa nat.ral science foundat.on of t.e usa arlington va 22230usa depart.ent.of geoengineering and mining university of applied sciencebochum 44801germany skapa mining services orkney kw172sxuk

t.e environment.l challenges from coal mining include coal mine accident.,land subsidence,damage t. t.e wat.r environment.mining wast. disposal and air *** are eit.er environment.l pollut.on or landscape change.A concept.al framework for solving mine environment.l issues is *** processes,or remediat.on measures,are designed t. address environment.l *** measures are proposed t. handle landscape *** t.t.l met.ane drainage from 56 Chinese high met.ane concent.at.on coal mines is about.101.94 million cubic *** t.is met.ane,19.32 million,35.58 million and 6.97 million cubic met.rs are ut.lized for elect.icit. generat.on,civil fuel supplies and ot.er indust.ial purposes,*** 39% of t.e met.ane is emit.ed int. t.e *** product.on of coal mining wast.s can be decreased 10% by reuse of mining wast.s as underground fills,or by using t.e wast. as fuel for power plant. or for raw mat.rial t. make bricks or ot.er infrast.uct.re *** proper use of mined land must.be decided in t.rms of local physical and socio-economical *** European count.ies more t.an 50% of previously mined lands are reclaimed as forest.or grass ***,in China more t.an 70% of t.e mined lands are reclaimed for agricult.ral purposes because t.e large populat.on and a short.ge of farmlands make t.is *** of rural communit.es or nat.ve resident.al improvement.is one environment.l problem arising from *** suggest.t.o ways t. reconst.uct.a farmer's house in China.

关键词： mine environment management.of mining wast.s reuse of mine gas mined land reclamat.on clean coal mining

MDMX phosphorylat.on-dependent.p53 downregulat.on cont.ibut.s t. an immunosuppressive t.mor microenvironment

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Journal of Molecular Cell Biology 2020年第9期12卷 713-722页

作者： Bing Wang Chuan-bian Lim Jiawei Yan Lizhen Li Jufang Wang john B.Lit.le Zhi-Min Yuan Key Laborat.ry of Space Radiobiology of Gansu Province&Key Laborat.ry of Heavy Ion Radiat.on Biology and Medicine of Chinese Academy of Sciences Institute of Modern PhysicsChinese Academy of SciencesLanzhouChina Universit. of Chinese Academy of Sciences BeijingChina john B.Lit.le Cent.r for Radiat.on Sciences Harvard T.H.Chan School of Public HealthBostonMAUSA Present.address:School of Life Sciences and t.chnology ShanghaiTech UniversityShanghaiChina

A role of t.mor-suppressive act.vit. of p53 in t.e t.mor microenvironment.t.E)has been implicat.d but.remains fairly *** address t.is knowledge gap,we leveraged our MdmxS314A mice as recipient. t. invest.gat. how implant.d t.mor cells incapacit.t. host.p53 creat.ng a conducive t.E for t.mor *** found t.at.t.mor cell-associat.d st.ess induced p53 downregulat.on in perit.mor cells via an MDMX-Ser314 phosphorylat.on-dependent.*** a result.an immunosuppressive t.E was developed,as reflect.d by diminished immune cell infilt.at.on int. t.mors and compromised macrophage M1 ***,ablat.on of MDMX-Ser314 phosphorylat.on at.enuat.d p53 decline in perit.mor cells,which was associat.d wit. mit.gat.on of immunosuppression and significant.t.mor growt. *** dat. collect.vely uncover a novel role of p53 in regulat.ng t.e t.mor immune microenvironment.suggest.ng t.at.p53 rest.rat.on in t.e t.E can be exploit.d as a pot.nt.al st.at.gy of ant.cancer t.erapy.

关键词： p53 MDMX t.mor microenvironment immune cell infilt.at.on macrophage polarizat.on

Digit.l Eart. 2020:t.wards t.e vision for t.e next.decade

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Int.rnat.onal Journal of Digit.l Eart. 2012年第1期5卷 4-21页

作者： Max Craglia Kees de Bie Davina Jackson Mart.no Pesaresi Gabor Remet.y-Fulopp Changlin Wang Alessandro Annoni Ling bian Fred Campbell Manfred Ehlers john van Genderen michael Goodchild Huadong Guo Ant.ony Lewis Richard Simpson Andrew Skidmore Pet.r Woodgat. European Commission Joint.Research Cent.e IspraItaly It. University of TwenteEnschedeThe Netherlands D_Cit.net.ork SydneyAustralia Hungarian Associat.on for Geo-Informat.on(HUNAGI) BudapestHungary Cent.r for Eart. Observat.on and Digit.l Eart. Chinese Academy of SciencesBeijingChina Depart.ent.of Geography University at BuffaloState University of New YorkBuffaloNYUSA Canada Cent.e for Remot. Sensing OttawaONCanada Inst.t.t. for Geoinformat.cs and Remot. Sensing University of OsnabruckOsnabruckGermany Depart.ent.of Geography Center for Spatial StudiesUniversity of CaliforniaSanta BarbaraCAUSA Depart.ent.of Geography and Ant.ropology Louisiana State UniversityBaton RougeLAUSA Next.pace AucklandNew Zealand Cooperat.ve Research Cent.r for Spat.al Informat.on Australia and New Zealand Land Information CouncilCanberraAustralia

t.is posit.on paper is t.e out.ome of a brainst.rming workshop organised by t.e Int.rnat.onal Societ. for Digit.l Eart.(ISDE)in Beijing in March *** argues t.at.t.e vision of Digit.l Eart.(DE)put.forward by Vice-President.Al Gore 13 years ago needs t. be re-evaluat.d in t.e light.of t.e many development. in t.e fields of informat.on t.chnology,dat. infrast.uct.res and eart. observat.on t.at.have t.ken place *** paper ident.fies t.e main policy,scient.fic and societ.l drivers for t.e development.of DE and illust.at.s t.e mult.-facet.d nat.re of a new vision of DE grounding it.wit. a few examples of pot.nt.al *** no single organisat.on can on it. own develop all t.e aspect. of DE,it.is essent.al t. develop a series of collaborat.ons at.t.e global level t. t.rn t.e vision out.ined in t.is paper int. realit..

关键词： Digit.l Eart. spat.al dat. infrast.uct.res eart. observat.on GEOSS geobrowsers volunt.ry geographic informat.on

Global regulat.ry cont.xt.and government.l research progress on bisphenol a t.xicology

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Global regulatory context and governmental research progress...

Improved spat.al resolut.on in soil moist.re ret.ieval at.arid mining area using apparent.t.ermal inert.a

中国毒理学会第九次全国毒理学大会

作者： john （Jun） Yang Sam（Huasong） bian Kai Zhao St.ve Hent.es Covest.o Polymers （China） Co. Lt. SABIC China Pet.oleum and Chemical Indust.y Federat.on American Chemist.y Council

Bisphenol A（BPA, CAS #80-05-7）, a high-product.on-volume indust.ial chemical is mainly used as a monomer for polycarbonat. plast.cs and epoxy resins, bot. of which are used ina broad range ofdownst.eam applicat.ons. t.ese mat.rials have beenaut.orized globallyfor use in sensit.ve consumer product.（e.g., food cont.ct.mat.rials）and have a long hist.ry of safe use. t.e pot.nt.al t.xicit. of low doses of BPA t. humanshas been ext.nsivelyevaluat.din t.e last.wo decadesby academic researchers and wit. government.l or indust.ial guideline st.dies. Alt.ough no credible risk from BPA exposure at.any life st.ge has been concluded by most.int.rnat.onal regulat.ry agencies,rest.ict.onshave been imposed by regulat.rs and legislat.rsbased on t.e "precaut.onary principle".As t.e final part.of a comprehensive series of st.dieson BPA conduct.d by US federal government.scient.st., t.e Consort.um Linking Academic and Regulat.ry Insight. on Bisphenol A t.xicit.（CLARIt.-BPA） project.was init.at.d t. resolve remaining uncert.int.es concerning BPA *** project.was comprised of a "core" guideline-compliant.chronic st.dy conduct.d by FDA scient.st. at.t.e Nat.onal Cent.r for t.xicological Research（NCt.） according t. FDA Good Laborat.ry Pract.ce（GLP） regulat.ons, and grant.e st.dies of various healt. endpoint., conduct.d by NIEHS-funded researchers at.academic inst.t.t.ons using animals born t. t.e same exposed pregnant.rat. as t.e core GLP st.dy. t.e overall aim was t. bridge guideline-compliant.research wit. hypot.esis-based research *** CLARIt.-BPA core st.dy report.was released in 2018 and is an import.nt.piece of support.for FDA’’s clear posit.on on t.e safet. of *** European Food Safet. Aut.orit. has assessed BPA as a subst.nce used in food cont.ct.mat.rialsseveral t.mes. In 2015 EFSA′s expert. commit.ed t. re-evaluat. t.e subst.nce′s t.xicit. when t.e result. of t.e CLARIt.-BPA project.become ***’s Panel on Food Cont.ct.Mat.rials,Enzymes and Proce

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t.ansact.ons of Nonferrous Met.ls Societ. of China 2014年第6期24卷 1866-1873页

作者：雷少刚卞正富 john L.DANIELS 刘东烈中国矿业大学深部岩土力学与地下工程国家重点实验室徐州221116 北卡罗纳莱纳大学土木学院中国矿业大学环境与测绘学院徐州221116

A surface soil moist.re model wit. improved spat.al resolut.on was developed using remot.ly sensed apparent.t.ermal inert.a（At.）.t.e model int.grat.s t.e surface t.mperat.re derived from t./Et.＋ image and t.e mean surface t.mperat.re from MODIS images t. improve t.e spat.al resolut.on of soil t.mperat.re difference based on t.e heat.conduct.on equat.on,which is necessary t. calculat. t.e ***,t.e spat.al resolut.on of At. and SMC can be enhanced from 1 km t. 120 m（t.） or 60m（Et.＋）.Moreover,t.e enhanced At. has a much st.onger correlat.on coefficient.R^2） wit. SMC（0.789） t.an t.e surface reflect.nce（0.108） or t.e At. derived only from MODIS images（0.264）.Based on t.e regression st.t.st.cs of t.e field SMC measurement.and enhanced At.,a linear regression model wit. an RMS error of 1.90%was found.

关键词： soil wat.r cont.nt soil t.mperat.re difference t.ermal inert.a remot. sensing spat.al resolut.on

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黑木耳多糖生物功能的研究进展

食品工业科技 2015年第16期36卷 390-394,400页

作者：卞春王振宇 john Shi 哈尔滨工业大学化工学院黑龙江哈尔滨150090 哈尔滨学院工学院黑龙江哈尔滨150086 加拿大农业及农业食品部圭尔夫食品研究中心

黑木耳是一种药食同源类食用菌,黑木耳多糖是其含量最高、最主要的功能性成分。黑木耳多糖集多种生物功能于一身,具有广阔的食用和药用开发利用前景。本文系统阐述了不同提取方法制备的黑木耳多糖、分级黑木耳多糖和修饰黑木耳多糖的抗... 详细信息

黑木耳是一种药食同源类食用菌,黑木耳多糖是其含量最高、最主要的功能性成分。黑木耳多糖集多种生物功能于一身,具有广阔的食用和药用开发利用前景。本文系统阐述了不同提取方法制备的黑木耳多糖、分级黑木耳多糖和修饰黑木耳多糖的抗氧化、抗癌(肿瘤)、提高免疫力、降血脂、抗凝血、降血糖和抗病毒等生物功能;并介绍了各种生物功能的相应实验方法及结果。为黑木耳多糖的进一步研究以及应用提供借鉴。

关键词：黑木耳多糖生物功能实验方法

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非肝素类天然抗凝血多糖的研究进展

食品工业科技 2019年第18期40卷 300-308页

作者：卞春王振宇 john Shi 季澜洋董世荣哈尔滨工业大学化工与化学学院黑龙江哈尔滨150001 哈尔滨学院食品工程学院黑龙江哈尔滨150086 加拿大农业及农业食品部圭尔夫食品研究中心加拿大安大略省圭尔夫N1G5C9 黑龙江省粮油卫生检验监测中心黑龙江哈尔滨150001

血液凝固和血小板凝集是局部缺血性疾病发病的最重要的原因,诱发心血管和脑血管甚至全身各处的相关疾病。肝素类物质已被广泛应用于相关疾病的治疗,作用效果显著但副作用较大。本文介绍了非肝素类具有抗凝血功能的天然多糖类物质,其单... 详细信息

血液凝固和血小板凝集是局部缺血性疾病发病的最重要的原因,诱发心血管和脑血管甚至全身各处的相关疾病。肝素类物质已被广泛应用于相关疾病的治疗,作用效果显著但副作用较大。本文介绍了非肝素类具有抗凝血功能的天然多糖类物质,其单糖组成主要是葡萄糖(醛酸)、半乳糖(醛酸)、阿拉伯糖、甘露糖、木糖、鼠李糖等,其中源于海洋的多糖均含有硫酸根,与多糖形成多糖硫酸酯类物质;而源于陆地的,一般不含硫酸根,含己糖醛酸或尿酸等酸性成分。不同来源的多糖其分子组成和结构差异较大,抗凝作用机理也不尽相同。本文着重阐述了海藻类、海洋无脊椎动物、植物及其果实、可食用菌等来源的抗凝血多糖结构特点、抗凝作用机理,希望能为高抗凝活性、低毒副作用的天然多糖类药物的进一步研究提供一定的参考。

关键词：非肝素类天然抗凝血多糖来源结构特点抗凝血机理