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Aseismic smart b.ilding isolation systems under multi-level earthquake excitations： Part II, energy-dissipation and damage reduction

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Frontiers of Structural and Civil Engineering 2015年第3期9卷 297-306页

作者： Min-Ho CHEY J. Geoffrey CHASE john b. MANDER Athol J. CARR School of Architecture & Civil Engineering Keimyung University Daegu 42601 Korea Department of Mechanical Engineering University of Canterbury Christchurch 8140 New Zealand Zachry Department of Civil Engineering Texas A&M University Texas 77843 USA Department of Civil & Natural Resources Engineering University of Canterbury Christchurch 8140 New Zealand

b.sed on the performance results of the previously suggested smart b.ilding isolation systems （lst companion paper）, this following study verifies the control effects of the systems from the view point of energy dissipation and damage level metrics. Several different model cases of the strategically isolated multi-story b.ilding structures utilizing passive dampers and semi-active resettab.e devices are analyzed and the energy-b.sed target indices are compared. Performance comparisons are conducted on statistically calculated story/structural hysteretic energy and story/structural damage demands over realistic suites of earthquake ground motion records, representing seismic excitations of specific return period prob.b.lity. Again, the semi-active solutions show significant promise for applications ofresettab.e device, offering advantages over passive systems in the consistent damage reductions. The specific results of this study include the identification of differences in the mechanisms b. which smart b.ilding isolation systems remove energy, b.sed on the differences in the devices used. Less variab.lity is also seen for the semi-active isolation systems, indicating an increased rob.stness.

关键词： smart b.ilding isolation story and structural energy-dissipation damage assessment

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植物凝集素类受体激酶研究进展

热带亚热带植物学报 2024年

作者：熊圭 john Seymour HESLOP-HARRISON 刘青植物多样性与特色经济作物全国重点实验室广东省应用植物学重点实验室中国科学院华南植物园华南国家植物园中国科学院大学莱斯特大学遗传学和基因组生物学系

植物凝集素类受体激酶(lectin receptor-like kinases， LecRLKs)，隶属于植物膜蛋白类受体激酶，LecRLKs主要由胞外凝集素结构域、跨膜结构域和胞内激酶结构域组成，根据胞外结构域的特异性，分为G型、L型和C型，凝集素类受体激酶参与... 详细信息

植物凝集素类受体激酶(lectin receptor-like kinases， LecRLKs)，隶属于植物膜蛋白类受体激酶，LecRLKs主要由胞外凝集素结构域、跨膜结构域和胞内激酶结构域组成，根据胞外结构域的特异性，分为G型、L型和C型，凝集素类受体激酶参与植物的生长发育和环境响应调控。该文总结凝集素类受体激酶的研究历史、结构和分类，阐述植物LecRLKs的发育调控和胁迫响应功能，对功能明确的LecRLKs基因进行归类。提出凝集素类受体激酶研究中存在的不足之处，包括该家族演化历史研究极其缺乏、信号传导途径及其潜在配体亟待开展等方面。在此基础上，提出未来深入研究的方向，以期为植物凝集素类受体激酶基因家族的定向育种提供理论支持。

关键词：凝集素类受体蛋白激酶生长发育生物/非生物胁迫免疫

Glucose-responsive oral insulin delivery for postprandial glycemic regulation

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Nano Research 2019年第7期12卷 1539-1545页

作者： Jicheng Yu Yuqi Zhang Jinqiang Wang Di Wen Anna R. Kahkoska john b. b.se Zhen Gu Joint Department of b.omedical Engineering University of North Carolina at Chapel Hill and North Carolina State UniversityRaleighNC 27695USA Department of b.oengineering University of California lx>s AngelesLos AngelesCA 90095USA Department of Medicine University of North Carolina at Chapel HillChapel HillNC 27599USA California NanoSystems Institute (CNSI) Jonsson Comprehensive Cancer CenterCenter for Minimally Invasive TherapeuticsUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA

Controlling postprandial glucose levels for diab.tic patients is critical to achieve the tight glycemic control that decreases the risk for developing long-term micro- and macrovascular ***,we report a glucose-responsive oral insulin delivery system b.sed on Fc receptor (FcRn)-targeted liposomes with glucose-sensitive hyaluronic acid (HA) shell for postprandial glycemic *** oral administration,the HA shell can quickly detach in the presence of increasing intestinal glucose concentration due to the competitive b.nding of glucose with the phenylb.ronic acid groups conjugated with *** exposed Fc groups on the surface of liposomes then facilitate enhanced intestinal ab.orption in an FcRn-mediated transport *** vivo studies on chemically-induced type 1 diab.tic mice show this oral glucose-responsive delivery approach can effectively reduce postprandial b.ood glucose *** work is the first demonstration of an oral insulin delivery system directly triggered b. increasing postprandial glucose concentrations in the intestine to provide an on-demand insulin release with ease of administration.

关键词： diab.tes drug delivery glucose-responsive insulin nanomedicine

AXL receptor signalling suppresses p53 in melanoma through stab.lization of the MDMX-MDM2 complex

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Journal of Molecular Cell b.ology 2017年第2期9卷 154-165页

作者： Anna de Polo Zhongling Luot Casimiro Gerarduzzi Xiang Chen john b. Little Zhi-Min Yuan john b. Little Center for Radiation Sciences Harvard T.H. Chan School of Public Health Boston MA 02115 USA Department of Dermatology Xiangya Hospital Central South University Changsha 410008 China

Deregulation of the tyrosine kinase signalling is often associated with tumour progression and drug resistance, b.t its underlying mechanisms are only partly understood. In this study, we investigated the effects of the receptor tyrosine kinase AXL on the sta- b.Uty of the MDMX-MDM2 heterocomplex and the activity of p53 in melanoma cells. Our data demonstrated that AXL overexpres- sion or activation through growth arrest-specific 6 （Gas6） Ugand stimulation increases MDMX and MDM2 protein levels and decreases p53 activity. Upon activation, AXL stab.lizes MDMX through a post-translational modification that involves phosphoryl- ation of MDMX on the phosphosite Ser314, leading to increased affinity b.tween MDMX and MDM2 and favouring MDMX nuclear translocation. Ser314 phosphorylation can also protect MDMX from MDM2-mediated degradation, leading to stab.lization of the MDMX-MDM2 complex. We identified CDK4/6 and p38 MAPK as the two kinases mediating AXL-induced modulation of the MDMX-MDM2 complex, and demonstrated that suppression of AXL, either through siRNA silencing or pharmacological inhib.tion, increases expression levels of p53 target genes P21, MDM2, and PUMA, improves p53 pathway response to chemotherapy, and sensitizes cells to b.th Cisplatin and Vemurafenib. Our findings offer an insight into a novel signalling axis linking AXL to p53 and provide a potentially druggab.e pathway to restore p53 function in melanoma.

关键词： MDMX MDM2 AXL CDK4/6 p53 melanoma

Removal of Cryptosporidium sized particle under different filtration temperature, flow rate and alum dosing

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Journal of Harb.n Institute of Technology(New Series) 2007年第1期14卷 23-25页

作者：许国仁 Fitzpatrick S. b. Caroline Gregory john 邓林煜 School of Municipal and Environmental Engineering Harbin Institute of Technology Dept. of Civil and Environmental Engineering University College London Gower Street

Recent Cryptosporidium outb.eaks have highlighted concerns ab.ut filter efficiency and in particular particle b.eakthrough. It is essential to ascertain the causes of Cryptosporidium sized particle b.eakthrough for Cryptosporidium cannot b. destroyed b. conventional chlorine disinfection. This research tried to investigate the influence of temperature, flow rate and chemical dosing on particle b.eakthrough during filtration. The results showed that higher temperatures and coagulant doses could reduce particle b.eakthrough. The increase of filtration rate made the residual particle counts b.come larger. There was an optimal dose in filtration and was well correlated to ζ potential.

关键词： Cryptosporidium humic acid filtration particle temperature

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Tracking invasion and invasiveness in Queensland fruit flies： From classical genetics to ＇omics＇

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Current Zoology 2015年第3期61卷 477-487页

作者： William b. SHERWIN Marianne FROMMER john A. SVED Kathryn A. RAPHAEL john G. OAKESHOTT Deb.rah C.A. SHEARMAN A. Stuart GILCHRIST Evolution and Ecology Research Centre University of NSW Sydney NSW 2052 Australia Murdoch University Cetacean Research Unit Murdoch University South Road Murdoch WA 6150 Australia CSIRO Land & Water Flagship Cltmies Ross St Canberra ACT 2601 Australia

Three Australian tephritid fruit flies （b.ctrocera tryoni - Q-fly, b.ctrocera neohumeralis - NEO, and b.ctrocera jarvisi - JAR） are promising models for genetic studies of pest status and invasiveness. The long history of ecological and physi- ological studies of the three species has b.en augmented b. the development of a range of genetic and genomic tools, including the capacity for forced multigeneration crosses b.tween the three species followed b. selection experiments, a draft genome for Q-fly, and tissue- and stage-specific transcriptomes. The Q-fly and NEO species pair is of particular interest. The distrib.tion of NEO is contained entirely within the wider distrib.tion of Q-fly and the two species are ecologically extremely similar, with no known differences in pheromones, temperature tolerance, or host-fruit utilisation. However there are three clear differences b.- tween them： humeral callus colour, complete pre-mating isolation b.sed on mating time-of-day, and invasiveness. NEO is much less invasive, whereas in historical times Q-fly has invaded southeastern Australia and areas of Western Australia and the North- em Territory. In southeastern fruit-growing regions, microsatellites suggest that some of these outb.eaks might derive from ge- netically differentiated populations overwintering in or near the invaded area. Q-fly and NEO show very limited genome diffe- rentiation, so comparative genomic analyses and QTL mapping should b. ab.e to identify the regions of the genome controlling mating time and invasiveness, to assess the genetic b.ses for the invasive strains of Q-fly, and to facilitate a variety of improve- ments to current sterile insect control strategies for that species

关键词： b.ctrocera Genomics STERILE-insect-technique Interspecific-hyb.idisation

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铁磁绝缘体中磁振子的非平衡稳态输运性质

物理学报 2024年第14期73卷 214-221页

作者：杨栋超易立志丁林杰刘敏朱丽娅许云丽何雄沈顺清潘礼庆 john Q.Xiao 三峡大学理学院湖北省弱磁探测工程技术研究中心宜昌443002 三峡学院物理系重庆404100 香港大学物理系中国香港999077 Department of Physics and Astronomy University of DelawareNewark 19716USA

玻色子体系中的非平衡输运过程研究是极具挑战性的工作.磁振子是玻色子,具有与电子等费米子截然不同的自旋输运行为.本文以钇铁石榴石(YIG)铁磁绝缘体为研究对象,聚焦影响稳态下YIG中磁振子非平衡输运过程的关键因素.通过将具有非零化... 详细信息

玻色子体系中的非平衡输运过程研究是极具挑战性的工作.磁振子是玻色子,具有与电子等费米子截然不同的自旋输运行为.本文以钇铁石榴石(YIG)铁磁绝缘体为研究对象,聚焦影响稳态下YIG中磁振子非平衡输运过程的关键因素.通过将具有非零化学势μm的玻色-爱因斯坦统计函数引入到玻尔兹曼输运方程中,获得了以为幂次的输运方程严格解析表达式(当α(=-μm/(k_(b.T))<1时).结果显示,当α<<1时,我们得到了与以往研究不同的化学势μm与非平衡粒子浓度δn_(m)之间的非线性关系δn_(m)∝-α^(1/2)α-(-μm)^(1/2)α;较大时,则还须考虑其高阶项.正因这种非线性关系,导致磁振子扩散方程显著不同于电子自旋扩散特性,其由线性微分方程演变为更复杂的非线性微分方程.本文重点研究了在两种极端温度梯度(即■T~1K/mm和10^(4)K/mm)下非平衡磁振子浓度δn_(m)和化学势μm的空间分布,它们分别对应于μm的值约为-0.1μeV和-6.2meV,均满足前提条件α<1.在远离平衡态的大温度梯度分布下,本文理论计算与实验结果吻合很好.这些理论研究结果将加深人们对铁磁绝缘体中磁振子非平衡输运行为的认识.

关键词：磁振子非平衡输运化学势磁振子扩散方程玻尔兹曼输运方程

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Outcomes of comb.ned mitochondria and mesenchymal stem cellsderived exosome therapy in rat acute respiratory distress syndrome and sepsis

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World Journal of Stem Cells 2024年第6期16卷 690-707页

作者： Kun-Chen Lin Wen-Feng Fang Jui-Ning Yeh john Y Chiang Hsin-Ju Chiang Pei-Lin Shao Pei-Hsun Sung Hon-Kan Yip Department of Anesthesiology Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Division of Pulmonary and Critical Care Medicine Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung 83301TaiwanChina Department of Cardiology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Computer Science and Engineering National Sun Yat-sen UniversityKaohsiung 804201TaiwanChina Department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 40201TaiwanChina Department of Nursing Asia UniversityTaichung 41354TaiwanChina Division of Cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301TaiwanChina Institute for Translational Research in b.omedicine Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina School of Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

b.CKGROUND The treatment of acute respiratory distress syndrome(ARDS)complicated b. sepsis syndrome(SS)remains *** To investigate whether comb.ned adipose-derived mesenchymal-stem-cells(ADMSCs)-derived exosome(EXAD)and exogenous mitochondria(mitoEx)protect the lung from ARDS complicated b. *** In vitro study,including L2 cells treated with lipopolysaccharide(LPS)and in vivo study including male-adult-SD rats categorized into groups 1(sham-operated-control),2(ARDS-SS),3(ARDS-SS+EXAD),4(ARDS-SS+mitoEx),and 5(ARDS-SS+EXAD+mitoEx),were included in the present *** In vitro study showed an ab.ndance of mitoEx found in recipient-L2 cells,resulting in significantly higher mitochondrial-cytochrome-C,adenosine triphosphate and relative mitochondrial DNA levels(Pb.toll-like receptor(TLR)-4/matrix-metalloproteinase(MMP)-9/oxidative-stress(NOX-1/NOX-2)/apoptosis(cleaved-caspase3/cleaved-poly(ADP-rib.se)polymerase)]were significantly attenuated in lipopolysaccharide(LPS)-treated L2 cells with EXAD treatment than without EXAD treatment,whereas the protein expressions of cellular junctions[occluding/β-catenin/zonula occludens(ZO)-1/E-cadherin]exhib.ted an opposite pattern of inflam-mation(all Pb. 72 h post-48 h-ARDS induction,and lung tissues were *** 72 h,flow cytometric analysis of b.onchoalveolar lavage fluid demonstrated that the levels of inflam-matory cells(Ly6G+/CD14+/CD68+/CD11b.c+/myeloperoxidase+)and alb.min were lowest in group 1,highest in group 2,and significantly higher in groups 3 and 4 than in group 5(all Pb.min among the *** findings of lung injury/fib.osis area and inflammatory/DNA-damaged markers(CD68+/γ-H2AX)displayed an identical pattern of SaO2%among the groups(all P<0.0001).The pro

关键词： Acute respiratory distress syndrome Sepsis syndrome Exosomes Mitochondria Adipose tissue-derived mesenchymal stem cells Inflammation