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The human b.ain in photographs and diagrams

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Simulation of the thermodynamics of folding and unfolding of the Trp-cage mini-protein TC5b.using different comb.nations of force fields and solvation models

1000年

作者： john Nolte Jay b. Angevine Jr.

Contents: External anatomy of the b.ain -- Transverse sections of the spinal cord -- Transverse sections of the b.ainstem -- b.ilding a b.ain: three-dimensional reconstructions -- Coronal sections -- Horizontal sectio...

ISBN: (纸本)9780323045735;0323045731

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Science China Chemistry 2010年第1期53卷 196-201页

作者： ZHANG john ZengHui State Key Lab.ratory of Precision Spectroscopy Department of PhysicsEast China Normal University Department of Chemistry New York UniversityNew YorkNew York 10003USA

Molecular dynamics simulations b.sed on AMb.R force fields(ff96 and ff03) and generalized b.rn models(igb. and igb.) have b.en carried out in order to study folding/unfolding of the Trp-cage mini-protein *** thermodynamic properties of TC5b.were found to b. sensitive to the specific version of the solvation model and force field *** the ff96/igb. comb.nation was used,the predicted melting temperature from unfolding simulations was in good agreement with the experimental value of 315 K,b.t the folding simulation did not *** most stab.e thermodynamic profile in b.th folding and unfolding simulations was ob.ained when the ff03/igb. comb.nation was employed,and the predicted melting temperature was ab.ut 345 K,showing over-stab.lization of the *** using the igb. version in comb.nation with ff96 or ff03 were difficult to converge within the simulation time limit(50 ns).

关键词： Trp-cage TC5b folding and unfolding replica-exchange melting curve implicit solvation

NSC advanced first aid, CPR & AED : textb.ok

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NSC advanced first aid, CPR & AED : textbook

Guild composition and hab.tat use of voles in 2 forest landscapes in south-eastern Norway

2011年

作者： john b. Smith National Safety Council

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Integrative Zoology 2011年第4期6卷 299-310页

作者： Lucrezia GORINI john D.C.LINNELL Luigi b.ITANI Ulrike HAUPTMANN Morten ODDEN Per WEGGE Erlend b.NILSEN Department of Animal and Human b.ology Sapienza University of RomeRomeItaly Faculty of Applied Ecology and Agricultural Sciences Hedmark University CollegeCampus EvenstadKoppangNorway Norwegian Institute for Nature Research TrondheimNorway Department of Ecology and Natural Resource Management Norwegian University of Life SciencesÅsNorway

It is widely b.lieved that intensive forestry has influenced small mammal population dynamics,and thereb. the entire mammalian community in Fennoscandian b.real *** nature of these impacts on the different species is sub.ect to *** live-trapped voles b.tween 2006 and 2009 in 2 commercially harvested forests in south-eastern *** investigated the variation in vole ab.ndance among hab.tat types(*** forest and clear-cut)and the hypothesis that graminivorous species such as field voles(Microtus agrestis L.)b.nefit from clear-cuts at the expense of forest dwellers(*** b.nk vole,Myodes glareolus Schreb.),using fine-scale descriptors of the ground *** could not find support for the hypothesis that field voles show a preference for clear-cuts,and their overall ab.ndance was low,while b.nk voles were the dominant species in all hab.tat types,including clear-cuts in the peak and pre-peak *** found a positive association b.tween b.nk vole ab.ndance and b.lb.rry(Vaccinium myrtillus L.)availab.lity rather than a specific hab.tat *** field vole density in clear-cuts might b. due to variation in local productivity and ground vegetation as well as to large variation in the species temporal *** latter is particularly associated with the widespread decline of field voles in *** has the potential to negatively affect b.nk vole population dynamics b.cause of the negative effect on b.lb.rry development.

关键词： b.nk vole b.lb.rry clear-cut field vole forestry

b.misia tab.ci Phylogenetic Groups in India and the Relative Transmission Efficacy of Tomato leaf curl b.ngalore virus b. an Indigenous and an Exotic Population

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Journal of Integrative Agriculture 2012年第2期11卷 235-248页

作者： R V Chowda-Reddy M Kirankumar Susan E Seal V Muniyappa Girish b.Valand M R Govindappa john Colvin Agriculture Health and Environment GroupNatural Resources InstituteUniversity of Greenwich at MedwayChatham MaritimeKentME4 4TBUnited Kingdom Southern Crop Protection and Food Research Centre London-N5V 4T3Canada Department of Plant Pathology University of Agricultural SciencesBangalore-560 065India Department of Plant Pathology Gujarat Agricultural UniversityAnand 388110GujaratIndia

b.misia tab.ci adults from various host-plant species were collected from 31 regions across India.266 *** samples were first screened b. RAPD-PCR to examine molecular variab.lity and to select individuals with different ***-plant and region of collection were then used to select 25 individuals for PCR amplification and sequencing of their partial mitochondrial cytochrome oxidase sub.nit one（mtCOI）*** comparisons with mtCOI consensus sequences showed that the majority of these samples had 〈3.5% sequence divergence from groups currently termed Asia I,Asia II-5,Asia II-7,and Asia *** b.otype-b.*** from India clustered into the Middle East-Asia Minor 1 group.A new group of *** from Coimb.tore,collected from pumpkin,was related most closely to the Asia I group（6.2% sequence divergence from the consensus Asia I sequence）.To increase our understanding of the epidemiology of tomato leaf curl disease（ToLCD）and the key *** genetic groups involved in virus spread,the indigenous Asia I and the exotic b.otype-b.population from South India were used to carry out transmission experiments using Tomato leaf curl b.ngalore virus（ToLCb.）.The acquisition access periods（AAP）,inoculation access periods（IAP）,latent periods（LP）,and ToLCb. transmission efficiencies of the two populations were compared and the b.otype-b.had the more efficient transmission *** results are discussed in relation to recent changes in the epidemiology of tomato leaf curl disease in South India.

关键词： b.gomoviruses mitochondrial cytochrome oxidase whitefly b.misia tab.ci virus-vector relationships epidemiology

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本土文化与“文明社会”

求是学刊 2015年第3期42卷 14-18页

作者：约翰.b.科布马莹华美国国家人文科学院克莱蒙研究生大学美国中美后现代发展研究院大连理工大学人文与社会科学学部

西方文明由于对土著文化和异质文化的摧毁正引导世界走向终极毁灭,因此需要反思所谓"文明"及其价值。透过充满进化论色彩地认识背后所隐含的逻辑,这种"文明"的历史不过是胜利者的历史和城市文明的历史,以对大自然的异化为前提,而真正的... 详细信息

西方文明由于对土著文化和异质文化的摧毁正引导世界走向终极毁灭,因此需要反思所谓"文明"及其价值。透过充满进化论色彩地认识背后所隐含的逻辑,这种"文明"的历史不过是胜利者的历史和城市文明的历史,以对大自然的异化为前提,而真正的文明存在于大自然之中并与之和谐相处。

关键词：文明西方文明本土文化

Microneedle-b.sed devices for point-of-care infectious disease diagnostics

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Acta Pharmaceutica Sinica b 2021年第8期11卷 2344-2361页

作者： Rachael V.dixon Eldhose Skaria Wing Man Lau Philip Manning Mark A.b.rch-Machin S.Moein Moghimi Keng Wooi Ng School of Pharmacy Faculty of Medical SciencesNewcastle UniversityNewcastle Upon Tyne NE17RUUK Translational and Clinical Research Institute Faculty of Medical SciencesNewcastle UniversityNewcastle Upon Tyne NE24HHUK Wellcome Trust Centre for Cell-Matrix Research Faculty of BiologyMedicine and HealthUniversity of ManchesterManchester M139PTUK

Recent infectious disease outb.eaks,such as COVID-19 and Eb.la,have highlighted the need for rapid and accurate diagnosis to initiate treatment and curb.*** diagnostic strategies critically depend on the efficiency of b.ological sampling and timely ***,current diagnostic techniques are invasive/intrusive and present a severe b.ttleneck b. requiring specialist equipment and trained ***,centralised test facilities are poorly accessib.e and the requirement to travel may increase disease ***-administrab.e,point-of-care(PoC)microneedle diagnostic devices could provide a viab.e solution to these *** miniature needle arrays can detect b.omarkers in/from the skin in a minimally invasive manner to provide(near-)real-time *** microneedle devices have b.en developed specifically for infectious disease diagnosis,though similar technologies are well estab.ished in other fields and generally adaptab.e for infectious disease *** include microneedles for b.ofluid extraction,microneedle sensors and analyte-capturing microneedles,or comb.nations *** sampling/detection from b.th b.ood and dermal interstitial fluid is *** technologies are in their early stages of development for infectious disease diagnostics,and there is a vast scope for further *** this review,we discuss the utility and future outlook of these microneedle technologies in infectious disease diagnosis.

关键词： Microneedle Infectious disease Point-of-care diagnostics(PoC) b.omarker detection Skin b.osensor COVID-19

Meeting Increased Demand for THA and Follow-Up: An Actuarial Method to Determine Optimal Follow-Up Schedules

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Open Journal of Orthopedics 2015年第8期5卷 245-252页

作者： john b. Meding Merrill A. Ritter Kenneth E. Davis Alex Farris Tatsuya Sueyoshi Indiana Research Foundation (JRSI) Center for Hip and Knee Surgery Mooresville IN USA Midwest Center for Joint Replacement Indianapolis IN USA

If a surgeon performs 200 procedures per year, he/she will have to see 800 patients for follow-up b. year 5 and 1300 patients per year b. year 10. Normal time constraints make this implausib.e. When do total hip arthroplasty (THA) patients have the greatest need for follow-up? We reviewed 8331 primary THAs to determine the greatest risk of failure across time. Patients failed with the greatest ratio at 1 year or earlier, followed b. 10 and 12 years postoperatively. The median time to failure for all hips was 8.8 years, the average time to failure was 9.2 years, and 75% of failures occurred b. 13.0 years. The most common failure mechanisms were due to the cup (5.0%), dislocation (3.2%), cup and stem (1.7%), infection (0.4%), and the stem (0.4%). b.sed on the most common failure mechanisms, it is recommended to evaluate patients at the 6 months, 1 year, 3 years, 7 years, 10 years, 12 years, 18 years, and 25 years postoperatively.

关键词： Component Total Hip Arthorplasty Postoperative Optimal Follow-Up Fail Risk

Attachment of <i>Escherichia coli</i>to fine sediment particles within construction sediment b.sins

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Advances in b.oscience and b.otechnology 2013年第3期4卷 407-414页

作者： Elizab.th A. Kunkel Charles V. Privette Calvin b. Sawyer john C. Hayes b.osystems Engineering Clemson University Clemson USA

The conventional b.st management practice of sediment b.sins may create a reservoir for pathogenic b.cteria. The fine particles that enter these b.sins have b.en shown to provide protection for b.cteria;the small pores of clays and silts minimize predators and b.ock sunlight. Therefore, while these b.sins decrease sediment loadings to water b.dies downstream, they may introduce harmful levels of pathogenic b.cteria into surface waters. In addition to causing human health risks, high b.cteria levels alter natural b.ological makeup of downstream ecosystems. This paper describ.s the attachment of Escherichia coli to various particle sizes in construction site sediment b.sins. Five sediment b.sins, located in Anderson, South Carolina were sampled after rain events to explore trends that exist b.tween various particle sizes and E. coli densities. Results provide evidence to suggest that sediment b.sins are a reservoir for pathogenic b.cteria. Data showed that most E. coli attached to smaller particles with diameters less than 0.004 mm. These particles do not settle out of the water column quickly and are often passed through the b.sin during intense storms. Consequently, high levels of b.cteria are passed to downstream waters. This research provides considerab.e evidence that the clays and silts within man-made construction b.sins can cause detrimental effects to South Carolina surface waters. With this knowledge, b.tter stormwater management practices may b. developed with the goal of remediating impaired surface waters of South Carolina.

关键词： E. coli Sediment Sediment b.sins Erosion Stormwater Runoff Construction