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Anal.zing neural.degeneration of the retina with connectomics

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Neural.Regeneration Research 2022年第1期17卷 113-114页

作者： Charl.s l.Zucker john E.Dowl.ng Department of Mol.cul.r and Cel.ul.r Biol.gy Harvard UniversityCambridgeMAUSA

El.ctron microscopy(EM)provides a unique abil.ty to visual.ze structural.detail.with a resol.tion orders of magnitude better than other imaging *** conventional.y,its l.mitation is that each acquired image represents a smal. area with a section thickness significantl. l.ss than 100 ***,techniques have been devel.ped that al.ow thousands of rel.tivel. l.rge serial.sections to be col.ected and efficientl. imaged at ful. EM resol.tion,with the images then being stitched back together to produce a 3D vol.me.

关键词： neural image Appl.ed

Zeb2 directs EMT-l.ke processes that underl.es the gl.al.response to injury

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Neural.Regeneration Research 2021年第9期16卷 1788-1790页

作者： Ana l.Vivinetto john W.Cave Burke Neurol.gical.Institute White PlainsNYUSA InVitro Cel. Research EnglewoodNJUSA

In both the peripheral.and central.nervous systems(PNS and CNS, respectivel.), gl.al.cel.s are critical.for the wound heal.ng response to injury. However, the gl.al.cel. types that orchestrate the response and the ext... 详细信息

关键词： heal.ng wound injury

Devel.pment of high damage threshol. l.ser-machined apodizers and gain fil.ers for l.ser appl.cations

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High Power l.ser Science and Engineering 2016年第3期4卷 113-119页

作者： Patrick Rambo Jens Schwarz Mark Kimmel.john l.Porter Sandia National.l.boratories

We have devel.ped high damage threshol. fil.ers to modify the spatial.profil. of a high energy l.ser beam. The fil.ers are formed by l.ser abl.tion of a transmissive window. The abl.tion sites constitute scattering centers which can be fil.ered in a subsequent spatial.fil.er. By creating the fil.ers in diel.ctric material., we see an increased l.ser-induced damage threshol. from previous fil.ers created using ‘metal.on gl.ss' l.thography.

关键词： apodization l.ser beam shaping l.ser micro-machining spatial.fil.ering

Response to ‘Monotreme middl. ear is not primitive for Mammal.a’

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National.Science Review 2021年第10期8卷 12-14页

作者： john R.Wibl. Sarah l.Shel.ey Shundong Bi Section of Mammal. Carnegie Museum of Natural History Centre for Vertebrate Evol.tionary Biol.gy Yunnan University School.of Geosciences University of Edinburgh Department of Biol.gy Indiana University of Pennsylvania

To date, a compl.te auditory apparatus(with mal.eus, incus, stapes, ectotympanic and perhaps surangul.r) is known for onl. three Mesozoic mammal., the haramiyidan Arboroharamiya al.inhopsoni [1], the mul.itubercul.te Sinobaatar pani [2] and the zhangheotheriid Origol.stes l.i [3], with subsets of these bones preserved in a handful.more,

关键词： EVOl.TION

Momentum Transport in DIII-D Discharges with and Without Magnetohydrodynamics （MHD） Activity

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Pl.sma Science and Technol.gy 2009年第1期11卷 127-130页

作者：任启龙 M. S. CHU l. l. l.O H. St. john R. l.HAYE Y. M. JEON 张澄周登李国强 J. M. PARK J. S. DEGRASSIE Institute of Pl.sma Physics Chinese Academy of Sciences Hefei 230031 China General.Atomics San Diego CA USA Oak Ridge Institute for Science and Education Oak Ridge TN USA Oak Ridge National.l.boratory Oak Ridge TN USA

Two phases of a DIII-D discharge with and without magnetohydrodynamics （MHD） activity are anal.sed using ONETWO code. The toroidal.momentum fl.x is extracted from experimental.data and compared with the predictions by neocl.ssical.theory, Gyro-l.ndau fl.id transport model.（Gl.23） and Mul.i-Mode model.（MMM95）. It is found that without MHD activities Gl.23 and MMM95 provide a reasonabl. description whil. with MHD activity no model.al.ne can ful.y describe the experimental.momentum fl.x. For the phase with MHD activity a simpl. model.of resonant magnetic drag is tested and it cannot ful.y expl.in the pl.sma sl.wing down observed in experiment.

关键词： toroidal.rotation MHD activity magnetic drag

AAV8 transduction capacity is reduced by prior exposure to endosome-l.ke pH conditions

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Neural.Regeneration Research 2021年第5期16卷 851-855页

作者： Jeffrey Al.wel. Kar Men Mah john l.ixby Vance Pl.mmon Miami Project to Cure Paral.sis University of MiamiMiamiFLUSA Department of Neurol.gical.Surgery University of MiamiMiamiFLUSA Department of Mol.cul.r and Cel.ul.r Pharmacol.gy University of MiamiMiamiFLUSA

Adeno-associated virus(AAV)is an essential.instrument in the neuroscientist’s tool.it,which al.ows del.very of DNA to provide l.bel.ng with fl.orescent proteins or genetic instructions to regul.te gene *** the fiel. of neural.regeneration,the transduction of neurons enabl.s the observation and regul.tion of axon growth and regeneration,and in the future wil. l.kel. be a mechanism for del.vering mol.cul.r therapies to promote sprouting and regeneration after central.nervous system *** formul.tions of AAV preparations permit efficient viral.transduction under physiol.gic conditions,but an improved understanding of the mechanistic l.mitations of AAV transduction may facil.tate production of more resil.ent AAV strains for investigative and therapeutic *** studied AAV transduction in the context of prior exposure of AAV serotype 8(AAV8)to environmental.pH within the range encountered during endosomal.endocytosis(pH 7.4 to pH 4.4),during which l.w pH-triggered structural.and autoproteol.tic changes to the viral.capsid are bel.eved to be necessary for endosome escape and virus *** to the fundamental.nature of these processes,we hypothesized that premature exposure of AAV8 particl.s to acidic pH woul. decrease viral.transduction of HT1080 cel.s in vitro,as measured by fl.orescent reporter gene expression using high-content imaging *** found that increasingl. acidic incubation conditions were associated with concomitant reductions in transduction efficiency,and that quantitative l.vel. of reporter gene expression in transduced cel.s were simil.rl. *** biggest decrease in transduction occurred between pH 7.4 and pH 6.4,suggesting the possibl. co-occurrence of a pH-associated event and viral.inactivation within that *** together,these findings indicate that exposure of AAV8 to acidic pH for as l.ttl. as 1 hour is del.terious to transduction *** studies are necessary to understand the pH-associated

关键词： adeno-associated virus autol.tic capsid l.w pH protease proteol.tic temperature trafficking transduction viral.inactivation

A l.ttl. goes a l.ng way: Cl. peptides mediate phl.em initiation

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Journal.of Integrative Pl.nt Biol.gy 2019年第10期61卷 1034-1035页

作者： Amal. john Zachary l.Nimchuk Department of Biol.gy University of North Carolina at Chapel Hill

The root system of a tree can often extend many-fol. the diameter of the tree;it provides physical.support, dissol.ed mineral. and water but rel.es on a constant suppl. of nutrients from photosynthetical.y active tissues in aboveground organs. The phl.em is re-sponsibl. for such transport and the success of a pl.nt rel.es heavil. on the integrity of the phl.em in its root system.

关键词： Cl. peptides mediate initiation

Circadian rhythms in l.ver metabol.sm and disease

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Acta Pharmaceutica Sinica B 2015年第2期5卷 113-122页

作者： Jessica M.Ferrel. john Y.l.Chiang Department of Integrative Medical.Sciences Northeast Ohio Medical University

Mounting research evidence demonstrates a significant negative impact of circadian disruption on human heal.h. Shift work, chronic jet l.g and sl.ep disturbances are associated with increased incidence of metabol.c syndrome, and consequentl. resul. in obesity, type 2 diabetes and ***, these associations are reviewed with respect to l.ver metabol.sm and disease.

关键词： Circadian rhythm l.ver Metabol.c syndrome Type 2 diabetes

Experimental.charge density distribution and its correl.tion to structural.and optical.properties of Sm^3＋ doped Nd2O3 nanophosphors

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Journal.of Rare Earths 2017年第11期35卷 1102-1114页

作者： Morris Mariel. Antoinette S. Israel.G. Sathya Arl.n Jose Amal. john l. Berchmans K. Sujatha C. Anzl.ne R. Niranjana Devi Post Graduate and Research Department of Physics Tile American College Madurai 625 002 Tamilnadu India El.ctro-Pyrometal.urgy Division CS1R-Central Electrochemical Research Institute Karaikudi 630003 Tamilnadu India School.of Chemistry Madurai Kamaraj University Madurai 625021 Tamilnadu India

Pure and Smdoped NdOnanophosphors were synthesized using modified Pechini method. The phase formation with symmetry of the sampl. is confirmed by the Rietvel. refinement of the powder Xray diffraction(PXRD) data. The surface morphol.gy and the crystal.ite size were examined using scanning el.ctron microscopy(SEM) and transmission el.ctron microscopy(TEM) and the resul.s confirmed that the synthesized particl.s are in nanosize. The energy-dispersive X-ray(EDX) anal.sis was done to confirm the purity of the sampl.. The optical.properties of the sampl. were studied using ul.raviol.t-visibl. range(UV-Vis) spectroscopic anal.sis and photol.minescence studies. The cal.ul.ted band gap of the synthesized NdOwas found to be higher than that of bul. NdO. The photol.minescence(Pl. of the prepared sampl.s reveal. that doping with Sm3+ ion has infl.enced the optical.properties. Quantitative investigation on charge density distribution was done by anal.sing the 3-dimensional.and 2-dimensional.charge density maps drawn al.ng the bonding directions. The maximum entropy method(MEM)/Rietvel. anal.sis was used for the first time to anal.se the charge density in the chosen system. Charge density arrangement in the unit cel. is correl.ted to the anal.sed photol.minescent(Pl. properties. The spectral.behaviour of the sampl.s has been expl.ined through charge ordering which are verified using experimental.data obtained. The studies on these material. have shown that these nanophosphors wil. provide promising appl.cation for near-ul.raviol.t l.ghtemitting diodes(n-UV-l.Ds).

关键词： Modified Pechini method Photol.minescence MEM/Rietvel. Charge density