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Autonomic Disturbances in Acute Cerebrovascular Disease

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Neuroscience Bulletin 2019年第1期35卷 133-144页

作者： Jun Mo Lei huang Jianhua Peng Umut Ocak Jianmin zhang john h.zhang Department of Neurosurgery The Fourth Affiliated HospitalZhejiang University School of Medicine Department of Physiology and Pharmacology Loma Linda University Department of Neurosurgery Loma Linda University Department of Neurosurgery The Second Affiliated HospitalZhejiang University School of Medicine Brain Research Institute Zhejiang University Collaborative Innovation Center for Brain Science Zhejiang University Department of Anesthesiology Loma Linda University

Autonomic disturbances often occur in patients with acute cerebrovascular disease due to damage of the central autonomic network. We summarize the structures of the central autonomic network and the clinical tests used to evaluate the functions of the autonomic nervous *** review the clinical and experimental findings as well as management strategies of post-stroke autonomic disturbances including electrocardiographic changes, cardiac arrhythmias, myocardial damage, thermoregulatory dysfunction, gastrointestinal dysfunction, urinary incontinence, sexual disorders, and hyperglycemia. The occurrence of autonomic disturbances has been associated with poor outcomes in stroke patients. Autonomic nervous system modulation appears to be an emerging therapeutic strategy for stroke management in addition to treatments for sensorimotor dysfunction.

关键词： Autonomic disturbance Autonomic nervous system Cerebrovascular disease Stroke

Thermodynamic Insights of Base Flipping in TNA Duplex: Force Fields, Salt Concentrations, and Free-Energy Simulation Methods

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CCS Chemistry 2021年第2期3卷 1026-1039页

作者： Zhaoxi Sun john Z.h.zhang State Key Laboratory of Precision Spectroscopy School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062 NYU-ECNU Center for Computational Chemistry at NYU Shanghai Shanghai 200062 Department of Chemistry New York UniversityNYNY 10003

Threofuranosyl nucleic acid(TNA)is an analogue of DNA with a shift in the internucleotide linkages from the wild-type 5’-to-3’direction to 3’-to-2.’This alteration leads to higher chemical stability,less reactive groups,and lower conformational *** observations indicate that these characteristic changes are attributable to a minimal perturbation of the interaction network,but the thermodynamic stability of the duplex remains unaltered in the TNA *** applied the equilibrium and nonequilibrium free-energy simulations employing three popular assisted model building with energy refinement(AMBER)force fields for nucleotides to investigate this mutation-dependent behavior in the base flipping from T(DNA)residue to the T-to-TFT mutation(TNA)*** force fields were performed similarly,as described in the base-paired ***,after exploring the high-energy regions with free-energy simulations,we observed that these three force fields behaved *** reports conclude that the net-neutral and excess-salt simulations provided similar ***,our free-energy simulation indicated that the presence of excess salt affected the thermodynamic *** free-energy barrier along the base-flipping pathway was generally elevated upon the addition of excess salts,but the relative height of the free-energy barriers in DNA and TNA duplexes did not change *** phenomenon emphasizes the importance of adding sufficient salts in the simulation scheme to reproduce the experimental condition.

关键词： free-energy simulation base flipping,TNA AMBER force fields salt concentration

Three-dimensional quantum dynamics study of vibrational predissociation of heI_2 van der Waals molecule for low vibrational excitation using the time-dependent wave packet method

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Science China Chemistry 1997年第4期40卷 442-448页

作者：关大任赵显邓从豪 john Z.h.zhang Institute of Theoretical Chemistry Shandong UniversityJinan 250100China Department of Chemistry New York UniversityNew YorkNY 10003USA

Three-dimensional quantum mechanical calculations for vibrational predissociation of heI2(B) van der Waals molecules are presented using the time-dependent wave packet technique within the golden rule approxima *** total and partial decay widths,lifetimes,rates and their dependence on initial vibrational states were obtained for heI2 at low initial vibrational excited *** calculations show that the calculated tota decay widths,lifetimes and rates agree well with those extrapolated from experimental data available The predicted total decay widths as a function of initial vibrational states exhibit highly nonlinear *** very short propagation time (*** 1 ps) required in the golden rule wave packet calculation is determined by the duration time of the final state inter-action between the fragments on the vibrationally deexcited adiabatic potential *** final state interaction between the fragments is shown to play an important role in determining the final rotational distribution This interpreta tion clearly explains the dynamical effect that the final rotational distribution shifts to the lower rotational energy levels as the initial vibrational quantum number v increases.

关键词： time-dependent golden rule wave packet approach vibrational predissociation heI2 van der Waats molecule decay widths final rotational distribution

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氢——一种内源性抗氧化剂(英文)

第二军医大学学报 2008年第3期29卷 233-235页

作者：孙学军 john h zhang 第二军医大学海医系潜水医学教研室上海200433 Department of Physiology and Pharmacology Loma Linda University School of Medicine Loma Linda California USA

最近Ohsawa等报道,呼吸氢气能通过抗氧化作用,减少动物脑和肝缺血再灌注引起的细胞凋亡。实际上,人和动物消化道内许多正常细菌能产生氢气,这些氢气可被消化道吸收进入血液循环。考虑到小鼠部分器官内氢气水平已达到产生抗氧化作用的浓... 详细信息

最近Ohsawa等报道,呼吸氢气能通过抗氧化作用,减少动物脑和肝缺血再灌注引起的细胞凋亡。实际上,人和动物消化道内许多正常细菌能产生氢气,这些氢气可被消化道吸收进入血液循环。考虑到小鼠部分器官内氢气水平已达到产生抗氧化作用的浓度,我们认为,氢是一种内源性抗氧化物质。

关键词：氢抗氧化剂再灌注损伤

Peroxisome and pexophagy in neurological diseases

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Fundamental Research 2024年第6期4卷 1389-1397页

作者： Weilin Xu Jun Yan Anwen Shao Cameron Lenahan Liansheng Gao haijian Wu Jingwei Zheng Jianmin zhang john h.zhang Department of Neurosurgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases Hangzhou 310009China Department of Neurosurgery Affiliated Tumor Hospital of Guangxi Medical UniversityGuangxi 537406China Burrell College of Osteopathic Medicine New Mexico State UniversityLas CrucesNM 88001USA Department of Physiology&Pharmacology Loma Linda University Loma LindaCA 92350USA Department of Neurosurgery Loma Linda University Loma LindaCA 92350USA

Peroxisomes and pexophagy have gained increasing attention in their role within the central nervous system(CNS)in recent *** this review,we comprehensively discussed the physiological and pathological mech-anisms of peroxisomes and pexophagy in neurological *** communicate with mitochondria,endoplasmic reticulum,and lipid *** types,sizes,and shapes vary in different regions of the ***,peroxisomes play an important role in oxidative homeostasis,lipid synthesis,and degradation in the CNS,whereas its dysfunction causes various neurological ***,selective removal of dysfunctional or superfluous peroxisomes(pexophagy)provides neuroprotective effects,which indicate a promising therapeu-tic ***,pexophagy largely remains unexplored in neurological *** studies are needed to explore the pexophagy’s crosstalk mechanisms in neurological pathology.

关键词： Peroxisome Pexophagy Autophagy Neurological diseases Neuroprotection

A PTEN inhibitor,BPV（pic）,ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats

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A PTEN inhibitor,BPV（pic）,ameliorates early brain injury a...

Efferocytosis:A new therapeutic target for stroke

中国医师协会神经外科医师分会第六届全国代表大会

作者： john h zhang 第三军医大学西南医院神经外科全军神经系统疾病微创诊治专科中心

＜正＞The goal of this study was to investigate the role of phosphatase and tensin homolog deleted on chromosome ten（PTEN） in early brain injury after subarachnoid hemorrhage（SAh）.The standard intravascular perfor...

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Chinese Medical Journal 2024年第23期137卷 2843-2850页

作者： Li Gao Anatol Manaenko Feng Zeng Jingchen Li Lele Liu Ruichuan Xie Xiaohua zhang john hzhang Qiyong Mei Jiping Tang Qin hu Department of Neurosurgery Ren Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Neurology Ren Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Clinical Neuroanatomy Department of NeurologySchool of MedicineUlm UniversityUlm 89081Germany Department of Neurosurgery Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of Physiology and Pharmacology Loma Linda UniversityLoma LindaCA 92354USA Key Laboratory of Anesthesiology(Shanghai Jiao Tong University) Ministry of EducationShanghai 200127China

Efferocytosis refers to the process that phagocytes recognize and remove the apoptotic cells,which is essential for maintaining tissue homeostasis both in physiological and pathological *** studies have demonstrated that efferocytosis can prevent secondary necrosis and proinflammatory factor release,leading to the resolution of inflammation and tissue immunological tolerance in numerous diseases such as *** is a leading cause of death and morbidity for adults *** inflammation triggered by the dead cells or cell debris is a major contributor to post-stroke brain *** efferocytosis might be an efficient strategy to minimize inflammation and restore brain homeostasis for neuronal regeneration and function *** this review,we will discuss the phagocytes in the brain,the molecular mechanisms underlying efferocytosis,the role of efferocytosis in inflammation resolution,and the potential therapeutic applications targeting efferocytosis in stroke.

关键词： Stroke Efferocytosis Inflammation resolution Apoptotic cell clearance

Interaction Entropy and Quantitative Analysis of Protein-Protein Interaction

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Interaction Entropy and Quantitative Analysis of Protein-Pro...

Force Field Development and Fragment based Ab Initio Molecular Dynamic Simulation for MetalloProteins

第十三届全国量子化学会议

作者： john Z.h.zhang School of Chemistry and Molecular Engineering East China Normal University NYU-ECNU Center for Computational Chemistry at New York University Shanghai Department of Chemistry New York University

＜正＞The theoretical calculation of protein-protein binding free energy is a grand challenge in computational biology. Accurate prediction of critical residues along with their specific and quantitative contributions to protein-protein binding free energy is extremely helpful to reveal binding mechanisms and identify druglike molecules that alter protein-protein interactions. In this talk we develop an efficient Interaction

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Force Field Development and Fragment based Ab Initio Molecul...