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Autonomic Disturbances in Acute Cerebrovascular Disease

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Neuroscience Bulletin 2019年第1期35卷 133-144页

作者： Jun Mo Lei huang Jianhua Peng Umut Ocak Jianmin zhang john h.zhang Department of Neurosurgery The Fourth Affiliated HospitalZhejiang University School of Medicine Department of Physiology and Pharmacology Loma Linda University Department of Neurosurgery Loma Linda University Department of Neurosurgery The Second Affiliated HospitalZhejiang University School of Medicine Brain Research Institute Zhejiang University Collaborative Innovation Center for Brain Science Zhejiang University Department of Anesthesiology Loma Linda University

Autonomic disturbances often occur in patients with acute cerebrovascular disease due to damage of the central autonomic network. We summarize the structures of the central autonomic network and the clinical tests used to evaluate the functions of the autonomic nervous *** review the clinical and experimental findings as well as management strategies of post-stroke autonomic disturbances including electrocardiographic changes, cardiac arrhythmias, myocardial damage, thermoregulatory dysfunction, gastrointestinal dysfunction, urinary incontinence, sexual disorders, and hyperglycemia. The occurrence of autonomic disturbances has been associated with poor outcomes in stroke patients. Autonomic nervous system modulation appears to be an emerging therapeutic strategy for stroke management in addition to treatments for sensorimotor dysfunction.

关键词： Autonomic disturbance Autonomic nervous system Cerebrovascular disease Stroke

Three-dimensional quantum dynamics study of vibrational predissociation of heI_2 van der Waals molecule for low vibrational excitation using the time-dependent wave packet method

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Science China Chemistry 1997年第4期40卷 442-448页

作者：关大任赵显邓从豪 john Z.h.zhang Institute of Theoretical Chemistry Shandong UniversityJinan 250100China Department of Chemistry New York UniversityNew YorkNY 10003USA

Three-dimensional quantum mechanical calculations for vibrational predissociation of heI2(B) van der Waals molecules are presented using the time-dependent wave packet technique within the golden rule approxima *** total and partial decay widths,lifetimes,rates and their dependence on initial vibrational states were obtained for heI2 at low initial vibrational excited *** calculations show that the calculated tota decay widths,lifetimes and rates agree well with those extrapolated from experimental data available The predicted total decay widths as a function of initial vibrational states exhibit highly nonlinear *** very short propagation time (*** 1 ps) required in the golden rule wave packet calculation is determined by the duration time of the final state inter-action between the fragments on the vibrationally deexcited adiabatic potential *** final state interaction between the fragments is shown to play an important role in determining the final rotational distribution This interpreta tion clearly explains the dynamical effect that the final rotational distribution shifts to the lower rotational energy levels as the initial vibrational quantum number v increases.

关键词： time-dependent golden rule wave packet approach vibrational predissociation heI2 van der Waats molecule decay widths final rotational distribution

Thermodynamic Insights of Base Flipping in TNA Duplex: Force Fields, Salt Concentrations, and Free-Energy Simulation Methods

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CCS Chemistry 2021年第2期3卷 1026-1039页

作者： Zhaoxi Sun john Z.h.zhang State Key Laboratory of Precision Spectroscopy School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062 NYU-ECNU Center for Computational Chemistry at NYU Shanghai Shanghai 200062 Department of Chemistry New York UniversityNYNY 10003

Threofuranosyl nucleic acid(TNA)is an analogue of DNA with a shift in the internucleotide linkages from the wild-type 5’-to-3’direction to 3’-to-2.’This alteration leads to higher chemical stability,less reactive groups,and lower conformational *** observations indicate that these characteristic changes are attributable to a minimal perturbation of the interaction network,but the thermodynamic stability of the duplex remains unaltered in the TNA *** applied the equilibrium and nonequilibrium free-energy simulations employing three popular assisted model building with energy refinement(AMBER)force fields for nucleotides to investigate this mutation-dependent behavior in the base flipping from T(DNA)residue to the T-to-TFT mutation(TNA)*** force fields were performed similarly,as described in the base-paired ***,after exploring the high-energy regions with free-energy simulations,we observed that these three force fields behaved *** reports conclude that the net-neutral and excess-salt simulations provided similar ***,our free-energy simulation indicated that the presence of excess salt affected the thermodynamic *** free-energy barrier along the base-flipping pathway was generally elevated upon the addition of excess salts,but the relative height of the free-energy barriers in DNA and TNA duplexes did not change *** phenomenon emphasizes the importance of adding sufficient salts in the simulation scheme to reproduce the experimental condition.

关键词： free-energy simulation base flipping,TNA AMBER force fields salt concentration

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氢——一种内源性抗氧化剂(英文)

第二军医大学学报 2008年第3期29卷 233-235页

作者：孙学军 john h zhang 第二军医大学海医系潜水医学教研室上海200433 Department of Physiology and Pharmacology Loma Linda University School of Medicine Loma Linda California USA

最近Ohsawa等报道,呼吸氢气能通过抗氧化作用,减少动物脑和肝缺血再灌注引起的细胞凋亡。实际上,人和动物消化道内许多正常细菌能产生氢气,这些氢气可被消化道吸收进入血液循环。考虑到小鼠部分器官内氢气水平已达到产生抗氧化作用的浓... 详细信息

最近Ohsawa等报道,呼吸氢气能通过抗氧化作用,减少动物脑和肝缺血再灌注引起的细胞凋亡。实际上,人和动物消化道内许多正常细菌能产生氢气,这些氢气可被消化道吸收进入血液循环。考虑到小鼠部分器官内氢气水平已达到产生抗氧化作用的浓度,我们认为,氢是一种内源性抗氧化物质。

关键词：氢抗氧化剂再灌注损伤

A PTEN inhibitor,BPV（pic）,ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats

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A PTEN inhibitor,BPV（pic）,ameliorates early brain injury a...

Stable hydrogen isoscape in precipitation generated using data fusion for East China

中国医师协会神经外科医师分会第六届全国代表大会

作者： john h zhang 第三军医大学西南医院神经外科全军神经系统疾病微创诊治专科中心

＜正＞The goal of this study was to investigate the role of phosphatase and tensin homolog deleted on chromosome ten（PTEN） in early brain injury after subarachnoid hemorrhage（SAh）.The standard intravascular perfor...

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Science China Earth Sciences 2024年第9期67卷 2972-2988页

作者： Jiacheng ChEN Jie ChEN Xunchang john zhang Peiyi PENG State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan 430072China hubei Key Laboratory of Water System Science for Sponge City Construction Wuhan UniversityWuhan 430072China USDA-ARS Oklahoma and Central Plains Agricultural Research Center El Reno OK 73036USA Southwest Research Institute for hydraulic and Water Transport Engineering Chongqing Jiaotong UniversityChongqing 400016China

The stable hydrogen isotope in precipitation is an effective environmental tracer for climatic and hydrologic ***,accurate and high-precision precipitation hydrogen isoscapes are currently unavailable in *** this study,a data fusion method based on Convolutional Neural Networks(CNN)is used to fuse the hydrogen isotopic composition(δ^(2)h_(p))of observations and isotope-equipped general circulation model(iGCM)simulations.A precipitation hydrogen isoscape with a temporal resolution of monthly and a spatial resolution of 50-60 km is established for East China for the 1969-2017 *** to building the isoscape,the performance of three data fusion methods(DFMs)and two bias correction methods(BCMs)is *** results indicate that the CNN fusion method performs the best with a correlation coefficient larger than 0.90 and root mean square error smaller than 10.5‰ when using observation as a *** fusion methods based on back propagation and long short-term memory neural network perform similarly,while slightly outperforming the bias correction ***,the CNN method is used to generate the hydrogen isoscape,and the temporal and spatial distribution characteristics of the hydrogen isotope in precipitation are analyzed based on this *** generated isoscape shows similar spatial and temporal distribution characteristics to *** general,the distribution pattern of δ^(2)h_(p) is consistent with the temperature effect in northern China,and consistent with the precipitation amount effect in southern *** trend of the δ^(2)h_(p) time series is consistent with that of observed precipitation and ***,the generated isoscape effectively reproduces the observations,and has the characteristics of time continuity and relative spatial regularity,which can provide valuable data support for tracking atmospheric and hydrological processes.

关键词： Precipitation Precipitation isotope General circulation model Data fusion Dataset

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Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression

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Research 2024年第3期2023卷 35-50页

作者： June Li Danielle Karakas Feng Xue Yingyu Chen Guangheng Zhu Yeni h.Yucel Sonya A.MacParland haibo zhang john W.Semple john Freedman Qizhen Shi heyu Ni Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Toronto Platelet Immunobiology Group TorontoONCanada Keenan Research Centre for Biomedical Science of St.Michael's hospital TorontoONCanada Canadian Blood Services Centre for Innovation TorontoONCanada Departments of Pediatrics Medical College of WisconsinMilwaukeeWIUSA Blood Research Institute Versiti WisconsinMilwaukeeWIUSA Departments of Ophthalmology and Vision Sciences Medicine University of TorontoTorontoONCanada Faculty of Engineering and Architectural Science Ryerson UniversityTorontoONCanada Multi-Organ Transplant Program Toronto General Hospital Research InstituteTorontoONCanada Department of Immunology University of TorontoTorontoONCanada Critical Care Medicine Department ofAnesthesiology and PainUniversity of TorontoTorontoONCanada Department of Physiology University of TorontoTorontoONCanada Department of Pharmacology University of TorontoTorontoONCanada. Division of hematology and Transfusion Medicine Lund UniversityLundSweden clinical Immunology and Transfusion Medicine Ofice of Medical ServicesRegion SkaneLundSweden Department of Medicine University of TorontoTorontoONCanada Children's Research Institute Children's WisconsinWauwatosaWIUSA Midwest Athletes Against Childhood Cancer Fund Research Center MilwaukeeWIUSA.

Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. however, the anti-inflammatory/immunosuppressive potential of platelets has been poorly explored. here, we uncovered, unexpectedly, desialylated platelets (dPLTs) down-regulated immune responses against both platelet-associated and -independent antigen challenges. Utilizing multispectral photoacoustic tomography, we tracked dPLT trafficking to gut vasculature and an exclusive Kupffer cell-mediated dPLT clearance in the liver, a process that we identified to be synergistically dependent on platelet glycoprotein Ibα and hepatic Ashwell–Morell receptor. Mechanistically, Kupffer cell clearance of dPLT potentiated a systemic immunosuppressive state with increased anti-inflammatory cytokines and circulating CD4+ regulatory T cells, abolishable by Kupffer cell depletion. Last, in a clinically relevant model of hemophilia A, presensitization with dPLT attenuated anti-factor VIII antibody production after factor VIII ( infusion. As platelet desialylation commonly occurs in daily-aged and activated platelets, these findings open new avenues toward understanding immune homeostasis and potentiate the therapeutic potential of dPLT and engineered dPLT transfusions in controlling autoimmune and alloimmune diseases.

关键词： Platelet transfusion homeostasis

Interaction Entropy and Quantitative Analysis of Protein-Protein Interaction

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Interaction Entropy and Quantitative Analysis of Protein-Pro...

Force Field Development and Fragment based Ab Initio Molecular Dynamic Simulation for MetalloProteins

第十三届全国量子化学会议

作者： john Z.h.zhang School of Chemistry and Molecular Engineering East China Normal University NYU-ECNU Center for Computational Chemistry at New York University Shanghai Department of Chemistry New York University

＜正＞The theoretical calculation of protein-protein binding free energy is a grand challenge in computational biology. Accurate prediction of critical residues along with their specific and quantitative contributions to protein-protein binding free energy is extremely helpful to reveal binding mechanisms and identify druglike molecules that alter protein-protein interactions. In this talk we develop an efficient Interaction

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Force Field Development and Fragment based Ab Initio Molecul...