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Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging

Chinese Chemical Letters 2024年第6期35卷 433-438页

作者： Boran Cheng Lei Cao Chen Li Fang-Yi Huo Qian-Fang Meng Ganglin Tong Xuan Wu Lin-Lin Bu lang Rao Shubin Wang department of Oncology Shenzhen Key Laboratory of Gastrointestinal Cancer Translational ResearchCancer InstitutePeking University Shenzhen HospitalShenzhen-Peking University-Hong Kong University of Science and Technology Medical CenterShenzhen 518036China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 518132China The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School&Hospital of StomatologyWuhan UniversityWuhan 430079China

As a type of new carbon-based nanomaterials,carbon dots(Cds)possess exceptional optical properties,making them highly desirable for use in fluorescent ***,the Cds with deep-red(dR)or near-infrared(NIR)emission have rarely been *** this work,we prepared deep-red emissive fluorine-doped carbon quantum dots(F-Cds)by introducing a precursor simultaneously containing fluorine and *** synergistic effect of nitrogen doping and d-π-A pattern production contributed to the maximum emission of F-Cds at 636 nm with an absolute quantum yield of 36.00%±0.68%.Moreover,we designed an F-Cds-based fluorescence assay to determine the content of hypochlorite(ClO^(-)),with a limit of detection(LOd)as low as 15.4 nmol/L,indicating the high sensitivity of F-Cds to ClO^(-).In real samples,the F-Cds-based fluorescent sensor exhibited excellent sensitivity and selectivity in the detection of ClO^(-),with an error below 2%,suggesting their great potential in daily *** cancer cell imaging,the F-Cds not only demonstrated high sensitivity to ClO^(-)but also exhibited excellent mitochondria targeting,as evidenced by the high Pearson's correlation coefficient(PCC)of 0.93 in colocalization *** work presented here suggests the great potential of replacing commercial dyes with F-Cds for highly specific mitochondria labeling and cell imaging.

关键词： Carbon dots Near-infrared Cell imaging Mitochondria labeling Hypochlorite determination

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Hepatic angiotensin-converting enzyme 2 expression in metabolic dysfunction-associated steatotic liver disease and in patients with fatal COVId-19

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World Journal of Gastroenterology 2024年第31期30卷 3705-3716页

作者： Angus K Jacobs Steven d Morley Kay Samuel Katie Morgan Lyndsey Boswell Timothy J Kendall david A dorward Jonathan A Fallowfield Peter C Hayes john N Plevris Hepatology Laboratory University of EdinburghEdinburgh EH164SBUnited Kingdom Scottish National Blood Transfusion Service Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute for Regeneration and Repair University of EdinburghEdinburgh EH164UUUnited Kingdom Edinburgh Pathology University of EdinburghEdinburgh EH164SBUnited Kingdom

BACKGROUNd Metabolic dysfunction-associated steatotic liver disease(MASLd),characterised by hepatic lipid accumulation,causes inflammation and oxidative stress accompanied by cell damage and *** injury(LI)is also frequently reported in patients hospitalised with coronavirus disease 2019(COVId-19),while preexisting MASLd increases the risk of LI and the development of COVId-19-associated *** of injury at the cellular level remain unclear,but it may be significant that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)which causes COVId-19,uses angiotensin-converting expression enzyme 2(ACE2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attachment and host cell *** To determine if hepatic ACE2 levels are altered during progression of MASLd and in patients who died with severe *** ACE2 protein levels and localisation,and histological fibrosis and lipid droplet accumulation as markers of MASLd were determined in formalin-fixed liver tissue sections across the MASLd pathological spectrum(isolated hepatocellular steatosis,metabolic dysfunction-associated steatohepatitis(MASH)+/-fibrosis,end-stage cirrhosis)and in post-mortem tissues from patients who had died with severe COVId-19,using ACE2 immunohistochemistry and haematoxylin and eosin and picrosirius red staining of total collagen and lipid droplet areas,followed by quantification using machine learning-based image pixel *** ACE2 staining is primarily intracellular and concentrated in the cytoplasm of centrilobular hepatocytes and apical membranes of bile duct ***,ACE2 protein levels are elevated in non-fibrotic MASH compared to healthy controls but not in the progression to MASH with fibrosis and in ***2 protein levels and histological fibrosis are not associated,but ACE2 and liver lipid droplet content are significantly correlated across the MASLd *** A

关键词： Metabolic dysfunction-associated steatotic liver disease Angiotensin-converting enzyme 2 Immunohistochemistry COVId-19 COVId-19-associated cholangiopathy

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襕干裙的结构创想与三维虚拟复原

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纺织学报 2024年第9期45卷 154-163页

作者：黄紫薇杨浪湖北理工学院艺术学院湖北黄石435003

为适应数智博物馆的纺织服装文物展示,并为新中式服装品牌的结构设计注入灵感。以北京服装学院民族服饰博物馆馆藏的3款襕干裙为研究对象,首先通过图片分析、等比缩放及工艺推断获得其结构数据;然后利用AutoCAd软件绘制其结构图,并将A... 详细信息

为适应数智博物馆的纺织服装文物展示,并为新中式服装品牌的结构设计注入灵感。以北京服装学院民族服饰博物馆馆藏的3款襕干裙为研究对象,首先通过图片分析、等比缩放及工艺推断获得其结构数据;然后利用AutoCAd软件绘制其结构图,并将A型裙结构理论引入到襕干裙裙幅的结构创想中以优化其腰口与下摆;最后在CLO3d软件中进行包含上下搭配与内外层次的三维虚拟复原,得到襕干裙的静态着装效果与动态展示模型。结果表明:通过控制新中式襕干裙的扇形裙幅展开圆心角可以实现其裙摆截面形态的结构平衡与摆围大小的直观可控;通过压力对比与问卷调查的综合评价,3款襕干裙的复原效果良好,为纺织服装软文物的理论研究与新中式服装工业生产建立了有效联系。

关键词：马面裙襕干裙 A型裙三维虚拟复原 CLO3d 数智博物馆新中式

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Provenance and tectonic setting of sandstones of the Lomas Coloradas Formation, Cabullona Group, Sonora, México: Constraints on petrography and geochemistry

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Journal of Palaeogeography 2024年第4期13卷 839-861页

作者： J.Madhavaraju d.G.Noriega-Montoya E.Ramirez-Montoya C.M.Gonz alez-Le on john S.Armstrong-Altrin Estaci on Regional del Noroeste Instituto de GeologíaUniversidad Nacional Aut onoma de Mexico Ingeniería en Geociencias Universidad Estatal de Sonora Posgrado en Ciencias de la Tierra Estaci on Regional del NoroesteInstituto de GeologíaUniversidad Nacional Aut onoma de Mexico Universidad Nacional Aut onoma de Mexico Instituto de Ciencias del Mar y LimnologíaUnidad de Procesos Oce anicos y CosterosCiudad Universitaria

The sedimentary rocks of the Cabullona Group are well exposed in the Cabullona Basin of northeastern Sonora, Mexico, which represent syntectonic sedimentation associated with Laramide-style deformation during the Campanian-early Maastrichtian. The sandstones of the Lomas Coloradas Formation deposited at the upper part of the Cabullona Group. Petrography and geochemical(major, trace, and rare earth elements) studies were carried out on the sandstones to interpret the palaeoweathering, provenance,and tectonic setting of the Lomas Coloradas Formation sandstones. Most of the sandstone modal analysis data plotted in the QFL and Qm FLt ternary diagrams fall into the fields of dissected arcs and recycled orogens,respectively. Geochemically the sandstones are classified as litharenites while few samples plot into the arkosic field. The chondrite-normalized REE diagrams for sandstones have LREE-enriched, relatively flat HREE patterns with negative Eu anomalies. CIA values and the A-CN-K diagram indicate a low intensity of chemical weathering in the source area. The tectonic setting diagram suggests both arc and rift settings for the studied sandstones. The bivariate and ternary diagrams and elemental ratios suggest a felsic source for the Lomas Coloradas Formation. The average REE patterns of the studied sandstones are comparable with REE patterns of the granite from the Caborca block, the rhyolite and granite of the Tarahumara Formation, and the Mesozoic felsic volcanic rocks. The modeled mixture of 40% Proterozoic granite, 30% Triassic arc, 10% Jurassic arc, and 20% Laramide arc represents the probable source rocks for the Lomas Coloradas Formation.

关键词： Provenance Petrography Geochemistry Lomas Coloradas Formation Cabullona Group Mexico

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desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression

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Research 2024年第3期2023卷 35-50页

作者： June Li danielle Karakas Feng Xue Yingyu Chen Guangheng Zhu Yeni H.Yucel Sonya A.MacParland Haibo Zhang john W.Semple john Freedman Qizhen Shi Heyu Ni department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Toronto Platelet Immunobiology Group TorontoONCanada Keenan Research Centre for Biomedical Science of St.Michael's Hospital TorontoONCanada Canadian Blood Services Centre for Innovation TorontoONCanada departments of Pediatrics Medical College of WisconsinMilwaukeeWIUSA Blood Research Institute Versiti WisconsinMilwaukeeWIUSA departments of Ophthalmology and Vision Sciences Medicine University of TorontoTorontoONCanada Faculty of Engineering and Architectural Science Ryerson UniversityTorontoONCanada Multi-Organ Transplant Program Toronto General Hospital Research InstituteTorontoONCanada department of Immunology University of TorontoTorontoONCanada Critical Care Medicine Department ofAnesthesiology and PainUniversity of TorontoTorontoONCanada department of Physiology University of TorontoTorontoONCanada department of Pharmacology University of TorontoTorontoONCanada. division of Hematology and Transfusion Medicine Lund UniversityLundSweden clinical Immunology and Transfusion Medicine Ofice of Medical ServicesRegion SkaneLundSweden department of Medicine University of TorontoTorontoONCanada Children's Research Institute Children's WisconsinWauwatosaWIUSA Midwest Athletes Against Childhood Cancer Fund Research Center MilwaukeeWIUSA.

Platelets are small, versatile blood cells that are critical for hemostasis/thrombosis. Local platelet accumulation is a known contributor to proinflammation in various disease states. However, the anti-inflammatory/immunosuppressive potential of platelets has been poorly explored. Here, we uncovered, unexpectedly, desialylated platelets (dPLTs) down-regulated immune responses against both platelet-associated and -independent antigen challenges. Utilizing multispectral photoacoustic tomography, we tracked dPLT trafficking to gut vasculature and an exclusive Kupffer cell-mediated dPLT clearance in the liver, a process that we identified to be synergistically dependent on platelet glycoprotein Ibα and hepatic Ashwell–Morell receptor. Mechanistically, Kupffer cell clearance of dPLT potentiated a systemic immunosuppressive state with increased anti-inflammatory cytokines and circulating Cd4+ regulatory T cells, abolishable by Kupffer cell depletion. Last, in a clinically relevant model of hemophilia A, presensitization with dPLT attenuated anti-factor VIII antibody production after factor VIII ( infusion. As platelet desialylation commonly occurs in daily-aged and activated platelets, these findings open new avenues toward understanding immune homeostasis and potentiate the therapeutic potential of dPLT and engineered dPLT transfusions in controlling autoimmune and alloimmune diseases.

关键词： Platelet transfusion homeostasis

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Cyclic dinucleotide Self-Assembled Nanoparticles as a Carrier-Free delivery Platform for STING-Mediated Cancer Immunotherapy

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CCS Chemistry 2024年第1期6卷 177-195页

作者： lang Zhao Shao-Hua Zhuo Tian-Yang Wang Jun-Jun Wu Jing-Yun Su Wen-Hao Li Bo-dou Zhang Yan-Mei Li Key Lab of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084 Beijing Institute for Brain disorders Beijing 100069 Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084

Cyclic dinucleotides(CdNs)are natural agonists of the stimulator of interferon genes(STING),which is an attractive immunotherapy ***,CdNs and their derivatives are being investigated ***,the poor bioavailability of exogenous CdNs has limited their application in *** nanocarriers are widely used for cytosolic delivery of CdNs,their loading capacity is insufficient,and their complicated composition and purification process raises bio-compatibility ***,we report a super-simplified CdN self-assembly strategy for carrier-free delivery of *** the presence of excess K^(+),CdNs form oligomers which further self-assemble with divalent metal ions(such as Mn^(2+))to form nanoparticles(NPs)in aqueous *** demonstrate that the self-assembled CdN NPs promote cellular uptake of CdNs and enhance tumor immunogenicity by remodeling the tumor microenvironment,inducing immunogenic tumor cell death and increasing tumorinfiltrating lymphocytes,which is conducive to the generation of tumor neoantigen-specific T-cell *** also demonstrate that the use of CdN NPs alone or in combination with immune checkpoint blockades inhibits tumor growth,highlighting the fact that CdN NPs are a potent platform for cancer immunotherapy.

关键词： cyclic dinucleotide STING carrierfree delivery tumor immunogenicity cancer immunotherapy

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慢加急性肝衰竭动物模型研究现状

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临床肝胆病杂志 2024年第1期40卷 187-192页

作者：刘韦白浪四川大学华西医院感染性疾病中心成都610041

慢加急性肝衰竭病情复杂、进展快、病死率高,其发病机制、病因等仍有待进一步研究阐明。而通过慢加急性肝衰竭动物模型的建立,不仅能为慢加急性肝衰竭的发病机制研究提供良好的基础,而且能为临床治疗提供实验依据。通过对相关文献的梳理... 详细信息

慢加急性肝衰竭病情复杂、进展快、病死率高,其发病机制、病因等仍有待进一步研究阐明。而通过慢加急性肝衰竭动物模型的建立,不仅能为慢加急性肝衰竭的发病机制研究提供良好的基础,而且能为临床治疗提供实验依据。通过对相关文献的梳理,总结了目前常用的建立慢加急性肝衰竭动物模型的方法,包括CCl4联合脂多糖(LPS)/d-氨基半乳糖胺法、硫代乙酰胺联合LPS法、血清白蛋白法、胆管结扎术法等。通过分析各种动物模型的特点,为进一步探索更理想的动物模型提供文献基础和实验依据。

关键词：肝疾病慢加急性肝功能衰竭模型动物

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The synergistic interplay of artificial intelligence and digital twin in environmentally planning sustainable smart cities:A comprehensive systematic review

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Environmental Science and Ecotechnology 2024年第4期20卷 79-104页

作者： Simon Elias Bibri Jeffrey Huang Senthil Kumar Jagatheesaperumal john Krogstie Swiss Federal Institute of Technology Lausanne(EPFL) Institute of Computer and Communication Sciences(IINFCOM)School of ArchitectureCivil and Environmental Engineering(ENAC)Media and Design Laboratory(LDM)1015LausanneSwitzerland department of Electronics&Communication Engineering Mepco Schlenk Engineering CollegeSivakasi626005TamilnaduIndia department of Computer Science Norwegian University of Science and Technology(NTNU)TrondheimNorway

The dynamic landscape of sustainable smart cities is witnessing a significant transformation due to the integration of emerging computational technologies and innovative *** advancements are reshaping data-driven planning strategies,practices,and approaches,thereby facilitating the achievement of environmental sustainability *** transformative wave signals a fundamental shift d marked by the synergistic operation of artificial intelligence(AI),artificial intelligence of things(AIoT),and urban digital twin(UdT)*** previous research has largely explored urban AI,urban AIoT,and UdT in isolation,a significant knowledge gap exists regarding their synergistic interplay,collaborative integration,and collective impact on data-driven environmental planning in the dynamic context of sustainable smart *** address this gap,this study conducts a comprehensive systematic review to uncover the intricate interactions among these interconnected technologies,models,and domains while elucidating the nuanced dynamics and untapped synergies in the complex ecosystem of sustainable smart *** to this study are four guiding research questions:*** theoretical and practical foundations underpin the convergence of AI,AIoT,UdT,data-driven planning,and environmental sustainability in sustainable smart cities,and how can these components be synthesized into a novel comprehensive framework?*** does integrating AI and AIoT reshape the landscape of datadriven planning to improve the environmental performance of sustainable smart cities?*** can AI and AIoT augment the capabilities of UdT to enhance data-driven environmental planning processes in sustainable smart cities?*** challenges and barriers arise in integrating and implementing AI,AIoT,and UdT in data-driven environmental urban planning,and what strategies can be devised to surmount or mitigate them?Methodologically,this study involves a rigorous analysis and synthesis of studies publis

关键词： Sustainable smart cities Artificial intelligence Artificial intelligence of things Urban digital twin data-driven urban planning Environmental planning Environmental sustainability

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企业研发组合式税收优惠的政策一致性反思——以西部某国家级新区为例

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税收经济研究 2024年第4期29卷 47-52页

作者：宋朗西南政法大学商学院法商管理系

为激励企业开展研发活动,我国实施了多样化的税收优惠政策。科技创新型企业在特定区域内集聚并享受多项与研发相关的税收优惠政策是常态。从企业视角来看,激励效果取决于组合式税收优惠政策的叠加效应。以西部某国家级新区为例,该区域... 详细信息

为激励企业开展研发活动,我国实施了多样化的税收优惠政策。科技创新型企业在特定区域内集聚并享受多项与研发相关的税收优惠政策是常态。从企业视角来看,激励效果取决于组合式税收优惠政策的叠加效应。以西部某国家级新区为例,该区域内企业研发相关税收优惠政策依据激励方式内在逻辑的差异分为所得减少型与税率降低型两类。基于现有理论及文献观点的定性分析以及基于数理模型推导的定量分析,发现政策组合视角下二者的一致性偏弱。未来的企业研发税收优惠政策设计与实践,应充分发挥不同类型税收优惠的相对优势,并注重彼此间有效协同。

关键词：企业研发税收优惠类型化政策组合一致性

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damage evolution of rock-encased-backfill structure under stepwise cyclic triaxial loading

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 597-615页

作者： Xin Yu Yuye Tan Weidong Song john Kemeny Shengwen Qi Bowen Zheng Songfeng Guo Key Laboratory of Shale Gas and Geoengineering Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100089China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing100089China University of Chinese Academy of Sciences Beijing100049China School of Civil and Resources Engineering University of Science and Technology BeijingBeijing100083China Key Laboratory of High-Efficient Mining and Safety of Metal Mines(Ministry of Education of China) University of Science and Technology BeijingBeijing100083China department of Mining and Geological Engineering University of ArizonaTucsonAZ86721USA

Rock-encased-backfill(RB)structures are common in underground mining,for example in the cut-andfill and stoping *** understand the effects of cyclic excavation and blasting activities on the damage of these RB structures,a series of triaxial stepwise-increasing-amplitude cyclic loading experiments was conducted with cylindrical RB specimens(rock on outside,backfill on inside)with different volume fractions of rock(VF=0.48,0.61,0.73,and 0.84),confining pressures(0,6,9,and 12 MPa),and cyclic loading rates(200,300,400,and 500 N/s).The damage evolution and meso-crack formation during the cyclic tests were analyzed with results from stress-strain hysteresis loops,acoustic emission events,and post-failure X-ray 3d fracture *** results showed significant differences between cyclic and monotonic loadings of RB specimens,particularly with regard to the generation of shear microcracks,the development of stress memory and strain hardening,and the contact forces and associated friction that develops along the rock-backfill *** important finding is that as a function of the number of cycles,the elastic strain increases linearly and the dissipated energy increases ***,compared with monotonic loading,the cyclic strain hardening characteristics are more sensitive to rising confining pressures during the initial compaction *** finding is that compared with monotonic loading,more shear microcracks are generated during every reloading stage,but these microcracks tend to be dispersed and lessen the likelihood of large shear fracture *** transition from elastic to plastic behavior varies depending on the parameters of each test(confinement,volume fraction,and cyclic rate),and an interesting finding was that the transformation to plastic behavior is significantly lower under the conditions of 0.73 rock volume fraction,400 N/s cyclic loading rate,and 9 MPa *** the findings have important practical implications on t

关键词： Rock and backfill Triaxial cyclic loading Volume fraction damage evolution 3d visualization

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