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Pathogens causing diarrhoea among Bangladeshi children with malignancy: Results from two pilot studies

World Journal of Clinical Cases 2020年第2期8卷 276-283页

作者： Sabina Karim Ferdousi Begum Afiqul islam Monowar Ahmad Tarafdar Mamtaz Begum Md johirul islam Bushra Malik Md Shamim Ahsan Ameneh Khatami Harunor Rashid Department of Paediatric Haematology and Oncology National Institute of Cancer Research and HospitalMohakhaliDhaka 1212Bangladesh Department of Pediatric Hematology and Oncology Bangabandhu Sheikh Mujib Medical UniversityDhaka 1212Bangladesh Department of Community Medicine Z.H.Sikder Women’s Medical CollegeDhaka 1212Bangladesh Department of Cancer Epidemiology National Institute of Cancer Research and HospitalMohakhaliDhaka 1212Bangladesh National Centre for Immunisation Research and Surveillance The Children’s Hospital at WestmeadWestmeadNSW 2145Australia Medical Services Rangpur CantonmentRangpur 5400Bangladesh Department of Infectious Diseases and Microbiology The Children’s Hospital at WestmeadNSW 2145Australia Discipline of Child and Adolescent Health Faculty of Medicine and HealthUniversity of SydneyNSW 2145Australia

BACKGROUND Diarrhoea is a frequent symptom in children with cancer, and occurs due to a composite effect of underlying disease and immunosuppression consequent to therapy, malnutrition, and non-infective aetiologies such as mucositis. In a large proportion of cases, the aetiology of diarrhoea remains unknown but is often attributed to multiple pathogens including *** To identify and describe the pathogens causing diarrhoea in Bangladeshi children with *** Two cross-sectional pilot studies were conducted involving paediatric oncology patients with diarrhoea. Stool samples were collected from children who were hospitalised with or without being treated with chemotherapy during the study period, and had diarrhoea at any stage during their admission. In the first study,stool samples were tested by conventional microbiological methods and by polymerase chain reaction for parasites, and by immunoassays for Clostridium difficile. In the second study, conventional microbiology was conducted for bacteria and parasites including an enzyme-linked immunosorbent assay for Cryptosporidium antigen, and in a subset, immunoassays for Clostridium *** In the first study Giardia lamblia was detected in 68.5% of samples, Entamoeba histolytica in 13%, Cryptosporidium in 5.6%, non-toxigenic C. difficile in 22.4%, and other bacteria in 5.2%. In the second study, E. histolytica was detected in 10% of samples, Cryptosporidium in 4.3%, G. lamblia in 1.4%, C. difficile in 5.1%, and other bacteria in 5.7% of *** These pilot data suggest that parasites are important aetiologies of diarrhoea in Bangladeshi children with malignancy. While molecular diagnostic tools detect an array of stool pathogens with greater sensitivity, conventional diagnostic methods are also useful.

关键词： Bangladesh Cancer Child Cryptosporidium Gastroenteritis Parasite

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Neoadjuvant Chemotherapy Followed by Surgery versus Primary Surgery in Advanced Epithelial Ovarian Cancer: A Review of Outcomes at National Institute of Cancer Research Hospital in Bangladesh

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Journal of Cancer Therapy 2021年第11期12卷 621-633页

作者： Farhana Kalam Shahana Pervin K. M. Nazmul islam Joy johirul islam Annekathryn Goodman Gynaecological Oncology Department National Institute of Cancer Research & Hospital (NICRH) Dhaka Bangladesh Neurology Department SShMC Dhaka Bangladesh Cancer Epidemiology NICRH Dhaka Bangladesh Harvard Medical School Division Gynecologic Oncology Massachusetts General Hospital Boston USA

Introduction: This study evaluated the difference in operative and clinical outcomes for patients with advanced ovarian cancer after primary debulking surgery (PDS) versus neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) in Bangladesh. Methods: Sixty patients with advanced epithelial ovarian cancer presenting to the department of Gynaecological Oncology at the National Institute of Cancer Research and Hospital were prospectively enrolled. Thirty patients underwent primary debulking surgery and thirty patients received NACT followed by IDS. Results: In the PDS and IDS groups respectively, 56.7% and 50% of patients presented with stage IIIC and 67.7% and 56.7% respectively had serious papillary type histopathology. Duration of surgery, amount of blood loss and total hospital stay were significantly lower (p in

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