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Effects of rice straw on the cell viability, photosynthesis, and growth of Microcystis aeruginosa

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Chinese Journal of Oceanology and Limnology 2014年第1期32卷 120-129页

作者：苏文 johannes A.HAGSTR?M 贾育红卢亚萍孔繁翔 State Key Laboratory of Lake & Environment Science Nanjing Institute of Geography and LimnologyChinese Academy of Sciences University of Chinese Academy of Sciences Ecology and Evolution in Microbial Model Systems EEMiSSchool of Natural SciencesLinnaeus University

Rice straw is supposed to be an environment-friendly biomaterial for inhibiting the growth of harmful blooms of the cyanobacterium Microcystis aeruginosa. However, its potential mechanism is not well known. To explore this mechanism, the growth, cell viability(esterase activity, membrane potential, and membrane integrity), photosynthesis, and cell size of M. aeruginosa were determined using fl ow cytometry and Phyto-PAM after exposure to rice straw extracts(RSE). The results show that doses from 2.0 to 10.0 g/L of RSE effi ciently inhibited the alga for 15 days, while the physiologic and morphologic responses of the cyanobacteria were time-dependent. RSE interfered with the cell membrane potential, cell size, and in vivo chlorophyll- a fl uorescence on the fi rst day. After 7 days of exposure, RSE was transported into the cytosol, which disrupted enzyme activity and photosynthesis. The cyanobacteria then started to repair its physiology(enzyme activity, photosynthesis) and remained viable, suggesting that rice straw act as an algistatic agent.

关键词： esterase activity membrane potential Phyto-PAM rice straw Microcystis flow cytometry

Machine-learning driven global optimization of surface adsorbate geometries

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npj Computational Materials 2023年第1期9卷 1196-1203页

作者： Hyunwook Jung Lena Sauerland Sina Stocker Karsten Reuter johannes T.Margraf Fritz-Haber-Institut der Max-Planck-Gesellschaft Faradayweg 4-6D-14195 BerlinGermany

The adsorption energies of molecular adsorbates on catalyst surfaces are key descriptors in computational catalysis *** the relatively large reaction intermediates frequently encountered,e.g.,in syngas conversion,a multitude of possible binding motifs leads to complex potential energy surfaces(PES),*** implies that finding the optimal structure is a difficult global optimization problem,which leads to significant uncertainty about the stability of many *** tackle this issue,we present a global optimization protocol for surface adsorbate geometries which trains a surrogate machine learning potential *** approach is applicable to arbitrary surface models and adsorbates and minimizes both human intervention and the number of required DFT calculations by iteratively updating the training set with configurations explored by the *** demonstrate the efficiency of this approach for a diverse set of adsorbates on the Rh(111)and(211)surfaces.

关键词： optimization global implies

Scientific geodata infrastructures: challenges, approaches and directions

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International Journal of Digital Earth 2014年第7期7卷 613-633页

作者： Lars Bernard Stephan Mas Matthias Muller Christin Henzen johannes Brauner Department of Geosciences Faculty of Environmental SciencesTechnische Universitat DresdenDresdenGermany

Based on various experiences in developing Geodata Infrastructures(GDIs)for scientific applications,this article proposes the concept of a Scientific GDI that can be used by scientists in environmental and earth sciences to share and disseminate their research results and related analysis *** GDI is understood as an approach to tackle the science case in Digital Earth and to further enhance e-science for environmental *** Scientific GDI to support the research community in efficiently exchanging data and methods related to the various scientific disciplines forming the basis of environmental studies poses numerous challenges on today’s GDI *** paper summarizes requirements and recommendations on the publication of scientific geospatial data and on functionalities to be provided in Scientific *** practices and open issues for governance and policies of a Scientific GDI are discussed and are concluded by deriving a research agenda for the next decade.

关键词： scientific geodata infrastructure sharing environmental models geospatial cyberinfrastructure e-science spatial data infrastructure

The Combinatorial Approach to Asymmetric Hydrogenation: More Miles out of Monophos

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复旦学报（自然科学版） 2005年第5期44卷 829-830页

作者： johannes G. de Vries DSM Research DSM Pharma Chemicals-Advanced Synthesis Catalysis & Development P.O. Box 18 6160 MD Geleen The Netherlands.

In custom manufacturing time-to-market is of overriding importance. Thus, asymmetric hydrogenation will be applied only if an appropriate catalyst can be found in a very short period of time. For this reason we have build up a full-scale capability for High Throughput Experimentation, encompassing several robot systems. As ligand synthesis was the last remaining barrier we have explored, together with the University of Groningen, the use of simple monodentate ligands, such as MonoPhosTM. These ligands can be synthesised in two chemical steps, from BINOL, PCl3 and an ***, very high enantioselectivities can be obtained in the asymmetric hydrogenation of α-and β-dehydro-amino acids and esters, aromatic enamides, itaconic acid and ester[1]. See Scheme 1 and 2(at page 830).

关键词：加氢催化同质催化剂铑氨基磷酸脂

Contact tracing-Old models and new challenges

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Infectious Disease Modelling 2021年第1期6卷 222-231页

作者： johannes Müller Mirjam Kretzschmar Mathematical Institute Technical University of MunichBoltzmannstr.385748GarchingGermany Institute for Computational Biology Helmholtz Center Munich85764NeuherbergGermany Julius Center for Health Sciences and Primary Care University Medical Center UtrechtUtrecht UniversityHeidelberglaan 1003584CXUtrechtthe Netherlands

Contact tracing is an effective method to control emerging infectious *** the 1980’s,modellers are developing a consistent theory for contact tracing,with the aim to find effective and efficient implementations,and to assess the effects of contact tracing on the spread of an infectious *** the progress made in the area,there remain important open *** addition,technological developments,especially in the field of molecular biology(genetic sequencing of pathogens)and modern communication(digital contact tracing),have posed new challenges for the modelling *** the present paper,we discuss modelling approaches for contact tracing and identify some of the current challenges for the field.

关键词： Contact tracing Mathematical models

Effect of bed load supply on sediment transport in mountain streams

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International Journal of Sediment Research 2017年第2期32卷 240-252页

作者： johannes Kammerlander Bernhard Gems Daniel Kβler Markus Aufleger Unit of Hydraulic Engineering University of Innsbruck Austrian Research Centre for Forests Department of Natural Hazards 3. BERNARD Ingenieure ZT GmbH

Mountain streams with their tributary torrents build the upper part of the fluvial *** are important regarding the transfer of sediment from headwaters to lower *** are typically steep with wide grain size distributions,ranging from fine sand up to large boulders,and a stabilized bed *** streams often are supply-limited with respect to mobile bed load,which needs to be addressed when bed load transport equations are applied to such *** better understand supply limitation,laboratory experiments highlighting the effect of bed load supply on incipient motion and bed load transport rate are *** tests were done in which fine bed load was supplied to a previously armored channel bed,with flow conditions ranging from one-third to twice the critical discharge for the bed *** flows not exceeding the critical discharge,the time series of the bed load transport rate at the downstream model boundary featured consistent patterns which are attributed to distinct phases:(i) a temporal lag,(ii) an equilibrium state,and(iii) a post-supply *** load transport occurred even at flows distinctly below that for incipient motion of the bed ***,with the mass of total bed load outflow approaching the supply amount,the mass did not exclusively consist of supplied *** coarser the supplied bed load,the more sediment was mobilized from the bed *** higher flows,processes *** bed load outflow exceeded the supply amount and the break-up of the armor layer caused a refining of the bed surface.

关键词： Bed load transport Bed load supply Mountain stream Experimental modeling

Autoantibodies in primary sclerosing cholangitis

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World Journal of Gastroenterology 2008年第24期14卷 3781-3791页

作者： johannes Roksund Hov Kirsten Muri Boberg Tom H Karlsen Medical Department Rikshospitalet University Hospital

The aetiology of primary sclerosing cholangitis (PSC) is not known and controversy exists as to whether PSC should be denominated an autoimmune disease. A large number of autoantibodies have been detected in PSC patients,but the specifi city of these antibodies is generally low,and the frequencies vary largely between different studies. The presence of autoantibodies in PSC may be the result of a nonspecifi c dysregulation of the immune system,but the literature in PSC points to the possible presence of specifi c antibody targets in the biliary epithelium and in neutrophil granulocytes. The present review aims to give an overview of the studies of autoantibodies in PSC,with a particular emphasis on the prevalence,clinical relevance and possible pathogenetic importance of each individual marker.

关键词： Primary sclerosing cholangitis,Autoantibodies, Autoimmunity Antibodies againstcytoplasmic constituents of neutrophil, Tropomyosin

Predicting the next move: tracking the complexity of lung cancer evolution and metastasis

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3885-3887页

作者： Carina Lorenz Axel M.Hillmer johannes Brägelmann University of Cologne Faculty of Medicine and University Hospital CologneDepartment of Translational GenomicsCologneGermany University of Cologne Faculty of Medicine and University Hospital CologneMildred Scheel School of Oncology CologneCologneGermany University of Cologne Faculty of Medicine and University Hospital CologneCenter for Molecular Medicine CologneCologneGermany University of Cologne Faculty of Medicine and University Hospital CologneInstitute of PathologyCologneGermany

In a series of seven papers in Nature and Nature Medicine,the TRACERx study group presents multi-omic analyses of 421 non-small cell lung cancer(NSCLC)patients,which have yielded a comprehensive map of intratumor heterogeneity(ITH)and lung cancer evolutionary trajectories at an unprecedented level of detail.1–7 The in-depth molecular data,and their subsequent integrated analyses,hold the potential to not only shine light on lung cancer progression but also influence a broad spectrum of scientific disciplines,research fields,and clinical oncology,thereby enhancing our understanding of cancer in general.

关键词： lung cancer metastasis

Efficient training of ANN potentials by including atomic forces via Taylor expansion and application to water and a transition-metal oxide

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npj Computational Materials 2020年第1期6卷 1205-1218页

作者： April M.Cooper johannes Kästner Alexander Urban Nongnuch Artrith School of Chemistry University of St AndrewsSt AndrewsUK Institute for Theoretical Chemistry University of StuttgartStuttgartGermany Department of Chemical Engineering Columbia UniversityNew YorkNYUSA

Artificial neural network(ANN)potentials enable the efficient large-scale atomistic modeling of complex materials with near firstprinciples *** molecular dynamics simulations,accurate energies and interatomic forces are a prerequisite,but training ANN potentials simultaneously on energies and forces from electronic structure calculations is computationally ***,we introduce an efficient alternative method for the training of ANN potentials on energy and force information,based on an extrapolation of the total energy via a Taylor *** translating the force information to approximate energies,the quadratic scaling with the number of atoms exhibited by conventional force-training methods can be avoided,which enables the training on reference datasets containing complex atomic structures.

关键词： forces enable atomic