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Beneficial effects of hirudotherapy in a chronic case of complex regional pain syndrome

Journal of Integrative Medicine 2019年第5期17卷 383-386页

作者： Rebecca Kulbida Alexander Mathes johannes loeser Department of Anaesthesiology and Intensive Care Medicine University Clinic of Cologne

We report about hirudotherapy in a patient with chronic complex regional pain syndrome(CRPS) in the right hand. CRPS is a multifactorial disease associated with disabling pain as well as sensory and motor deficits. The optimal therapeutic management is based on personalized multimodal treatment approaches;however, hirudotherapy has not been described in the available literature. To date, we have completed five medicinal leech treatments. Altogether, hirudotherapy led to rapid and substantial relief of symptoms, especially with respect to pain intensity ratings and skin temperature asymmetries. In addition, the patient’s active and passive agility of the affected limb improved obviously.

关键词： Hirudotherapy Complex regional pain syndrome Chronic pain Medicinal leeches

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Hirudotherapy attenuates arthritic pain in patients with various chronic pain syndromes: A retrospective analysis

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Journal of Integrative Medicine 2020年第5期18卷 425-433页

作者： johannes loeser Brigitte Layer Christopher Plata Klaus-Maria Perrar Tim Hucho Rebecca Kulbida Department of Anaesthesiology and Intensive Care Medicine University Clinic of CologneKoeln 50937Germany Department of Palliative Care University Clinic of CologneKoeln 50937Germany

Objective: Osteoarthritis is a degenerative disease that affects synovial joints. Micro-injuries of articular structures initiate inflammatory processes, leading to persistent pain. Due to various risk factors,osteoarthritis is often diagnosed in multimorbid patients. This makes pain management one of the key challenges, with a consistent need for new therapeutic strategies. Hence, complementary and integrative methods such as hirudotherapy have become increasingly important, even though their mechanisms of action are not entirely understood.Methods: We retrospectively analyzed the longitudinal effect of a single leech application on osteoarthritic joints in a heterogenic cohort of 24 cases with various chronic pain syndromes. We assessed articular pain intensity ratings and movability of the treated joint after one-time leeching for up to 12 months.We further investigated the effect of hirudotherapy on the systemic pain status and multimodal treatment strategies of the patients.Results: There was a significant reduction in pain intensity ratings at the joint of leech application for up to 12 months after treatment. The improvements in pain intensities were independent of the form of osteoarthritis treated. In addition, we saw a considerable enhancement in local movability of the treated joint. Hirudotherapy did not seem to influence the systemic pain status as well as the previously established individualized multimodal treatment model of the patients.Conclusion: Leeching as an adjuvant therapy has a great potential especially in terms of safety and longterm outcome.

关键词： Hirudotherapy Medicinal leeching Chronic pain syndromes Pain management Osteoarthritis

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维普期刊数据库

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Millijoule ultrafast optical parametric amplification as replacement for high-gain regenerative amplifiers

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High Power Laser Science and Engineering 2023年第4期11卷 33-44页

作者： Yannik Zobus Christian Brabetz johannes Hornung Jonas BOhland Dirk Reemts Ji-Ping Zou Markus loeser Daniel Albach Ulrich Schramm Vincent Bagnoud Technische Universität Darmstadt DarmstadtGermany GSI Helmholtzzentrum für Schwerionenforschung GmbH DarmstadtGermany Laboratoire pour l’Utilisation des Lasers Intenses CNRSEcole PolytechniquePalaiseauFrance Helmholtz-Zentrum Dresden-Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany Helmholtz-Institut Jena JenaGermany

We report on the development of an ultrafast optical parametric amplifier front-end for the Petawatt High Energy Laser for heavy Ion eXperiments(PHELIX)and the Petawatt ENergy-Efficient Laser for Optical Plasma Experiments(PEnELOPE)facilities.This front-end delivers broadband and stable amplification up to 1 mJ per pulse while maintaining a high beam quality.Its implementation at PHELIX allowed one to bypass the front-end amplifier,which is known to be a source of pre-pulses.With the bypass,an amplified spontaneous emission contrast of 4.9×10^(−13)and a pre-pulse contrast of 6.2×10^(−11)could be realized.Due to its high stability,high beam quality and its versatile pump amplifier,the system offers an alternative for high-gain regenerative amplifiers in the front-end of various laser systems.

关键词： high-intensity laser temporal laser contrast ultrafast optical parametric amplification

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