检索结果-南通市图书馆

Encapsulation of Ru(II) Polypyridine Complexes for Tumor-Targeted Anticancer Therapy

在线全文

学校读者我要写书评

暂无评论

Biomedical Engineering Frontiers 2023年第1期4卷 52-65页

作者： johannes Karges Faculty of Chemistry and Biochemistry Ruhr-University BochumUniversitasstrasse 15044780 BochumGermany.

Ru(II)polypyridine complexes have attracted much attention as anticancer agents because of their unique photophysical,photochemical,and biological *** their promising therapeutic profile,the vast majority of compounds are associated with poor water solubility and poor cancer *** the different strategies employed to overcome these pharmacological limitations,many research efforts have been devoted to the physical or covalent encapsulation of the Ru(II)polypyridine complexes into *** article highlights recent developments in the design,preparation,and physicochemical properties of Ru(II)polypyridine complex-loaded nanoparticles for their potential application in anticancer therapy.

关键词： properties. pyridine complexes

13C analysis of cow tail hair and farm slurry can be used to implicitly distinguish between different dairy production systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ecological Processes 2023年第1期12卷 100-111页

作者： Friederike Sieve johannes Isselstein Manfred Kayser Department of Crop Science Grassland Science Georg-August University G?ttingen Geo-Lab University of Vechta

Background Public interest in the way food is produced on the farm and processed along the food-production chain is increasing. The analysis of isotopic signatures(13C) in cow tail hair provides a method to reconstruct the dietary proportion of maize in cow diets. Based on this, we further investigated whether there is a relationship between isotopic signatures in cow tail hair or farm slurry and the proportion of maize of the total utilized agricultural area per farm [%]. We did an on-farm survey on 17 dairy farms in coastal Northwest Germany and collected cow tail hair from dairy cows and slurry samples on each farm. The farms differed in their feeding regime（C3vs. C4plants）, their site conditions（sandy soil = ‘Geestland'; organic soil = ‘Peatland'; clayey soil = ‘Marshland'）, and in the area cultivated with maize as a proportion of the total utilized agricultural area per *** We found a positive relationship between δ13C values in both cow tail hair and slurry and the annual dietary proportion of maize（R2= 0.67; and R2= 0.63）. Furthermore, we confirmed that there was a relationship between δ13C values in cow tail hair and area of maize as a proportion of the total utilized agricultural area per farm（R2= 0.69）.Conclusion Our findings suggest a general applicability of using isotopic signatures(13C) along a wide gradient of site conditions and productions systems in practice.

关键词： Stable isotopes Natural 13 C abundance Environmental indicator Maize Dietary composition Traceability

Tribological mechanisms of slurry abrasive wear

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Friction 2023年第6期11卷 1079-1093页

作者： Yulong LI Paul SCHREIBER johannes SCHNEIDER Christian GREINER Institute for Applied Material(IAM) Karlsruhe Institute of Technology(KIT)Karlsruhe76131Germany KIT IAM-ZM MicroTribology Center(μTC) Karlsruhe76131Germany

Abrasive wear mechanisms—including two-body and three-body abrasion—dominate the performance and lifespan of tribological systems in many engineering fields,even of those operating in lubricated *** steel(100Cr6)pins and discs in a flat-on-flat contact were utilized in experiments together with 5 and 13 μm Al_(2)O_(3)-based slurries as interfacial media to shed light on the acting *** results indicate that a speed-induced hydrodynamic effect occurred and significantly altered the systems'frictional behavior in tests that were performed using the 5 μm *** experiments revealed that a speed-dependent hydrodynamic effect can lead to a 14% increase in film thickness and a decrease in friction of around 2/3,accompanied by a transition from two-body abrasion to three-body abrasion and a change in wear mechanism from microcutting and microploughing to fatigue ***,no correlation could be found between the total amount of wear and the operating state of the system during the experiment;however,the wear distribution over pin and disc was observed to change *** paper studies the influence of the hydrodynamic effect on the tribological mechanism of lubricated abrasive wear and also highlights the importance to not only consider a tribological systems'global amount of wear.

关键词： abrasive wear two-body abrasion three-body abrasion hydrodynamic effect steel

Combination of chemistry and material science to overcome health problems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biosafety and Health 2022年第2期4卷 64-65页

作者： johannes Karges Department of Chemistry and Biochemistry University of CaliforniaSan DiegoLa JollaCA 92093United States

Since its outbreak,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has strongly influenced the life of the general public around the *** on its fast spread and high mortality,there is a need for novel therapeutic treatments to overcome this global health *** medicinal chemistry is focused on the development of highly selective and affine inhibitors toward a specific target enzyme,material science is focused on the development of nanomaterials for selective drug *** on the individual strengths,these disciplines could synergistically act together and help overcome the limitations of the respective ***,the combination of medicinal chemistry with material science to overcome health problems with the example of SARS-CoV-2 is critically discussed.

关键词： Biomaterials Biosafety Biosafety materials COVID-19 Material science

Development of Texture Mapping Approaches for Additively Manufacturable Surfaces

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2022年第4期35卷 125-138页

作者： Bhupesh Verma Omid Zarei Song Zhang johannes Henrich Schleifenbaum Chair for Digital Additive Production RWTH Aachen University52074 AachenGermany

manufacturing(AM)technologies have been recognized for their capability to build complex components and hence have ofered more freedom to designers for a long *** ability to directly use a computer-aided design(CAD)model has allowed for fabricating and realizing complicated components,monolithic design,reducing the number of components in an assembly,decreasing time to market,and adding performance or comfort-enhancing *** of the features that can be introduced for boosting a component functionality using AM is the inclusion of surface texture on a given *** inclusion is usually a difcult task as creating a CAD model resolving fne details of a given texture is difcult even using commercial software *** paper develops a methodology to include texture directly on the CAD model of a target surface using a patch-based sampling texture synthesis algorithm,which can be manufactured using *** for the texture generation algorithm can be either a physical sample or an image with heightmap *** heightmap information from a physical sample can be obtained by 3D scanning the sample and using the information from the acquired point *** obtaining the required inputs,the patches are sampled for texture generation according to non-parametric estimation of the local conditional Markov random feld(MRF)density function,which helps avoid mismatched features across the patch *** generating the texture,a design constraint to ensure AM producibility is considered,which is essential when manufacturing a component using,e.g.,Fused Deposition Melting(FDM)or Laser Powder Bed Fusion(LPBF).The generated texture is then mapped onto the surface using the developed distance and angle preserving mapping *** implemented algorithms can be used to map the generated texture onto a mathematically defned *** paper maps the textures onto fat,curved,and sinusoidal surfaces for *** the texture m

关键词： Texture synthesis Design for additive manufacturing Image processing Textured surface generation Texture mapping

Evaluation of Transmission Losses of Various Battery Electric Vehicles

在线全文

学校读者我要写书评

暂无评论

Automotive Innovation 2022年第4期5卷 388-399页

作者： johannes Hengst Matthias Werra Ferit KüÇükay Institute of Automotive Engineering TU BraunschweigBraunschweigGermany

Transmission losses in battery electric vehicles have compared to internal combustion engine powertrains a larger share in the total energy consumption and play therefore a major ***,the power flows not only during propulsion through the transmissions,but also during recuperation,whereby efficiency improvements have a double *** investigation of transmission losses of electric vehicles thus plays a major *** this paper,three simulation models of the Institute of Automotive Engineering(the lossmap-based simulation model,the modular simulation model,and the 3D simulation model)are *** lossmap-based simulation model calculates transmission losses for electric and hybrid transmissions,where three spur gear transmission concepts for battery electric vehicles are *** transmission concepts include a single-speed transmission as a reference and two two-speed ***,the transmission lossmaps are integrated into the modular simulation model(backward simulation)and in the 3D simulation model(forward simulation),which improves the simulation *** modular simulation model calculates the optimal operation of the transmission concepts and the 3D simulation model represents the more realistic behavior of the transmission *** different transmission concepts are investigated in Worldwide Harmonized Light Vehicle Test Cycle and evaluated in terms of transmission losses as well as the total energy *** map-based simulation model allows the transmission losses to be broken down into the individual component losses,thus allowing transmission concepts to be examined and evaluated in terms of their efficiency in the early development stage to develop optimum powertrains for electric axle *** considering transmission losses in detail with a high degree of accuracy,less efficient concepts can be eliminated at an early development *** a result,only relevant concepts are built as prototypes,which reduce

关键词： Battery electric vehicle(BEV) Transmission losses Efficiency analysis WLTC Backward simulation Forward simulation Energy consumption

A Sub-element Adaptive Shock Capturing Approach for Discontinuous Galerkin Methods

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications on Applied Mathematics and Computation 2023年第2期5卷 679-721页

作者： johannes Markert Gregor Gassner Stefanie Walch Department for Mathematics and Computer Science University of CologneWeyertal 86-9050931 CologneGermany Department for Mathematics and Computer Science Center for Data and Simulation ScienceUniversity of CologneWeyertal 86-9050931 CologneGermany I.Physikalisches Institut Center for Data and Simulation ScienceUniversity of CologneZülpicher Str.7750937 CologneGermany

In this paper,a new strategy for a sub-element-based shock capturing for discontinuous Galerkin(DG)approximations is *** idea is to interpret a DG element as a col-lection of data and construct a hierarchy of low-to-high-order discretizations on this set of data,including a first-order finite volume scheme up to the full-order DG *** dif-ferent DG discretizations are then blended according to sub-element troubled cell indicators,resulting in a final discretization that adaptively blends from low to high order within a single DG *** goal is to retain as much high-order accuracy as possible,even in simula-tions with very strong shocks,as,e.g.,presented in the Sedov *** framework retains the locality of the standard DG scheme and is hence well suited for a combination with adaptive mesh refinement and parallel *** numerical tests demonstrate the sub-element adaptive behavior of the new shock capturing approach and its high accuracy.

关键词： High-order methods Discontinuous Galerkin spectral element method Finite volume method Shock capturing Astrophysics Stellar physics

Model of an iron ore sinter plant with selective waste gas recirculation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Carbon Resources Conversion 2022年第1期5卷 71-83页

作者： johannes Niel Bernd Weiss Walter Wukovits TU Wien Institute of ChemicalEnvironmental and Bioscience EngineeringGetreidemarkt 9/1661060 ViennaAustria Primetals Primetals Technologies Austria GmbHLinzAustria

The use of sinter influences hot metal production substantially and significantly affects an integrated steel mill’s total emissions. Sintering of iron ores is an enormousenergy-intensive and resources consuming process. Introducing a selective waste gas recirculation (SWGR) to the sintering process reduces the energy consumption,stack gas volume flow, and sulfur dioxide emissions of an iron sinter production. Simulating this complex process in flowsheet simulations of integrated iron andsteelworks is a fast and cost-effective opportunity to validate new operation settings. The implementation of a sinter plant in gPROMS ModelBuilder®characterizesthe sintering processes by three main sub-models. A burner model describes the gas combustion, a black-box model consider the main sintering processes, and a windbox model divides the total off-gas into a recycle gas and a stack gas. A specific temperature polynomial represents the temperature distribution across the wind boxesto allow detailed investigations on SWGR in complex flowsheet simulations. Implementing SWGR to the sintering process, the model shows a reduction of cokeconsumption, stack gas flow rate, and sulfur dioxide emissions by 11%, 27%, and 27%, respectively. In the SWGR scenario, the utilization rate of carbon monoxideincreases and less coke is consumed. The chlorine emissions of the sintering process differ with and without SWGR insignificantly.

关键词： dioxide monoxide consuming

Editorial for special issue on hydrogen metallurgy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2022年第10期29卷 1817-1819页

作者： Jianliang Zhang johannes Schenk Zhengjian Liu Kejiang Li School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Department of Metallurgy Chair of Ferrous MetallurgyMontanuniversität LeobenFranz-Josef Straße 188700 LeobenAustria

*** The carbon neutral strategy is promoting the transformation and upgrading of the traditional metallurgical industry,and the high-quality and low-carbon reform of the metallurgical industry is ***,as a clean energy... 详细信息

关键词： upgrading metallurgy industry