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Bone remodeling effect of a chitosan and calcium phosphate-based composite

Regenerative Biomaterials 2019年第4期6卷 241-247页

作者： Lilja Kjalarsdottir Arna Dyrfjord Atli Dagbjartsson Elin H.Laxdal Gissur Orlygsson johannes gislason Jon M.Einarsson Chuen-How Ng Halldor Jonsson Jr Department of Orthopaedic Surgery Landspı´tali University HospitalReykjavik 108Iceland Faculty of Medicine University of IcelandReykjavik 101Iceland Genis hf. Siglufjordur 580Iceland Department of Materials Biotechnology and EnergyInnovation Center IcelandReykjavik 112Iceland Department of Vascular Surgery Landspitali University HospitalReykjavik 108Iceland

Chitosan is a biocompatible polymer that has been widely studied for tissue engineering *** aim of this research was to assess bone regenerative properties of an injectable chitosan and calcium phosphate-based composite and identify optimal degree of deacetylation(%DDA)of the chitosan *** holes were generated on the left side of a mandible in Sprague-Dawley rats,and the hole was either left empty or filled with the *** animals were sacrificed at several time points after surgery(7–22 days)and bone was investigated using micro-CT and *** significant new bone formation was observed in the implants themselves at any time ***,substantial new bone formation was observed in the rat mandible further away from the drill *** changes indicating bone formation were found in specimens explanted on Day 7 in animals that received *** bone formation pattern was seen in control animals with an empty drill hole at later time points but not to the same extent.A second experiment was performed to examine if the%DDA of the chitosan polymer influenced the bone remodeling *** results suggest that chitosan polymers with%DDA between 50 and 70%enhance the natural bone remodeling mechanism.

关键词： bone remodeling bone implant bone defects chitosan degree of deacetylation micro-CT rat mandible

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