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Colon capsule endoscopy: Current status and future directions

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World Journal of Gastroenterology 2014年第44期20卷 16596-16602页

作者： Andrea O Tal johannes Vermehren J?rg G Albert Department of Internal Medicine I University Hospital Frankfurt

Colon capsule endoscopy(CCE; Pill Cam Colon; Given Imaging; Yoqneam, Israel) is a minimally invasive wireless technique for the visualization of the colon. With the recent introduction of the second generation colon capsule the diagnostic accuracy of CCE for polyp detection has significantly improved and preliminary data suggest it may be useful to monitor mucosal inflammation in patients with inflammatory bowel disease. Limitations include the inability to take biopsies and the procedural costs. However, given the potentially higher acceptance within an average risk colorectal cancer(CRC) screening population, its usefulness as a screening tool with regard to CRC prevention should be further evaluated.

关键词： Capsule endoscopy Endoscopy Colon capsule endoscopy Colonoscopy Colorectal cancer Colon Colonic capsule endoscopy Inflammatory bowel disease

Predicting the next move: tracking the complexity of lung cancer evolution and metastasis

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3885-3887页

作者： Carina Lorenz Axel M.Hillmer johannes Brägelmann University of Cologne Faculty of Medicine and University Hospital CologneDepartment of Translational GenomicsCologneGermany University of Cologne Faculty of Medicine and University Hospital CologneMildred Scheel School of Oncology CologneCologneGermany University of Cologne Faculty of Medicine and University Hospital CologneCenter for Molecular Medicine CologneCologneGermany University of Cologne Faculty of Medicine and University Hospital CologneInstitute of PathologyCologneGermany

In a series of seven papers in Nature and Nature Medicine,the TRACERx study group presents multi-omic analyses of 421 non-small cell lung cancer(NSCLC)patients,which have yielded a comprehensive map of intratumor heterogeneity(ITH)and lung cancer evolutionary trajectories at an unprecedented level of detail.1–7 The in-depth molecular data,and their subsequent integrated analyses,hold the potential to not only shine light on lung cancer progression but also influence a broad spectrum of scientific disciplines,research fields,and clinical oncology,thereby enhancing our understanding of cancer in general.

关键词： lung cancer metastasis

Efficient training of ANN potentials by including atomic forces via Taylor expansion and application to water and a transition-metal oxide

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npj Computational Materials 2020年第1期6卷 1205-1218页

作者： April M.Cooper johannes Kästner Alexander Urban Nongnuch Artrith School of Chemistry University of St AndrewsSt AndrewsUK Institute for Theoretical Chemistry University of StuttgartStuttgartGermany Department of Chemical Engineering Columbia UniversityNew YorkNYUSA

Artificial neural network(ANN)potentials enable the efficient large-scale atomistic modeling of complex materials with near firstprinciples *** molecular dynamics simulations,accurate energies and interatomic forces are a prerequisite,but training ANN potentials simultaneously on energies and forces from electronic structure calculations is computationally ***,we introduce an efficient alternative method for the training of ANN potentials on energy and force information,based on an extrapolation of the total energy via a Taylor *** translating the force information to approximate energies,the quadratic scaling with the number of atoms exhibited by conventional force-training methods can be avoided,which enables the training on reference datasets containing complex atomic structures.

关键词： forces enable atomic

Chronic peripheral inflammation: a possible contributor to neurodegenerative diseases

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Neural Regeneration Research 2021年第9期16卷 1711-1714页

作者： Patrick Süβ Addison J.Lana johannes C.M.Schlachetzki Department of Molecular Neurology Friedrich-Alexander-University Erlangen-NürnbergUniversity Hospital ErlangenErlangenGermany Department of Cellular and Molecular Medicine University of California San DiegoLa JollaCAUSA

The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding question. Sustained activation of the peripheral innate and adaptive immune systems occurs in the context of a broad array of disorders ranging from chronic infectious diseases to autoimmune and metabolic diseases. In addition, progressive systemic inflammation is increasingly recognized during aging. Peripheral immune cells could potentially modulate the cellular brain environment via the secretion of soluble molecules. There is an ongoing debate whether peripheral immune cells have the potential to migrate into the brain under certain permissive circumstances. In this perspective, we discuss the possible contribution of chronic peripheral inflammation to the pathogenesis of age-related neurodegenerative diseases with a focus on microglia, the resident immune cells of the brain parenchyma.

关键词： aging Alzheimer's disease inflammation innate immune system microglia neurodegeneration Parkinson's disease

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Experimental investigation on local shear stress and turbulence intensities over a rough non-uniform bed with and without sediment using 2D particle image velocimetry

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International Journal of Sediment Research 2020年第2期35卷 193-202页

作者： Petr Lichtneger Christine Sindelar johannes Schobesberger Christoph Hauer Helmut Habersack CD-Laboratory of Sediment Research and Management Institute of Water ManagementHydrology and Hydraulic EngineeringDepartment Water-Atmosphere-EnvironmentUniversity of Natural Resources and Life Sciences

The current work focuses on locally resolving velocities,turbulence,and shear stresses over a rough bed with locally non-uniform character.A nonporous subsurface layer and fixed interfacial sublayer of gravel and sand were water-worked to a nature-like bed form and additionally sealed in a hydraulic ***-dimensional Particle Image Velocimetry(2 D-PIV) was applied in the vertical plane of the experimental flume *** with clear water and weak sediment transport were done under slightly supercritical flow to ensure sediment transport conditions without formation of considerable sediment deposits or *** study design included analyzing the double-averaged flow parameters of the entire measurement domain and investigating the flow development at 14 consecutive vertical *** geometrical variabilities as well the presence of sediment were mainly reflected in the vertical velocity *** the vertical velocity decreased over the entire depth in presence of sediment transport,the streamwise velocity profile was reduced only within the interfacial *** the region with decelerating flow conditions,however,the streamwise velocity profile systematically increased along the entire depth *** increase in the main velocity(reduction of flow resistance)correlated with a decrease of the turbulent shear and main normal ***,effects of rough bed smoothening and drag force reduction were experimentally documented within the interfacial sublayer due to mobile ***,the current study leads to the conclusion that in nonuniform flows the maximum Reynolds stress values are a better predictor for the bed shear stress than the linearly extrapolated Reynolds stress *** is an important finding because,in natural flows,uniform conditions are rare.

关键词： Turbulence measurement Local bed shear stress Sediment transport and flow interaction Hydraulic flume experiment Particle image velocimetry

Association of inducible nitric oxide synthetase genotype and Helicobacter pylori infection gastric cancer risk may be due to faulty primer design

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World Journal of Gastroenterology 2013年第3期19卷 429-430页

作者： Amin Talebi Bezmin Abadi johannes G Kusters Department of Medical Microbiology University Medical Center Utrecht3584 CX UtrechtThe Netherlands

Rafiei et al recently described an association between the presence of the C150T polymorphism of the induc-ible nitric oxide synthase(iNOS)gene and Helicobacter pylori(***)induced gastric *** we used primer-BLAST to find the polymerase chain reaction (PCR)product that would be generated by the primers used by these authors no products against any of the sequences present in the GenBank database were *** analysis of the iNOS sequences present in the GenBank suggest that the result from their study might come from a faulty primer design and may thus represent an *** they may be correct and have identified a truly interesting explanation for the mechanism whereby *** induces gastric cancer but some additional experiments would be in order to exclude the possibility of a PCR artifact.

关键词： Helicobacter pylori Polymorphism Inducible nitric oxide synthase

Influence of rolling friction on single spout fluidized bed simulation

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Particuology 2012年第5期10卷 582-591页

作者： Christoph Goniva Christoph Kloss Niels G. Deen johannes A.M.Kuipers Stefan Pirker Christian-Doppler Laboratory on Particulate Flow Modelling Johannes Kepler UniversityLinz Austria DCS Computing GmbH Linz Austria Christian-Doppler Laboratory on Particulate Flow Modelling Johannes Kepler UniversityLinz Austria Department of Chemical Engineering and Chemistry Eindhoven University of TechnologyEindhovenThe Netherlands Department of Chemical Engineering and Chemistry Eindhoven University of TechnologyEindhovenThe Netherlands Christian-Doppler Laboratory on Particulate Flow Modelling Johannes Kepler UniversityLinzAustria Institute of Fluid Mechanics and Heat Transfer Johannes Kepler UniversityLinzAustria

In this paper we study the effect of rolling friction on the dynamics in a single spout fluidized bed using Discrete Element Method （DEM） coupled to Computational Fluid Dynamics （CFD）. In a first step we neglect rolling friction and show that the results delivered by the open source CFD-DEM framework applied in this study agree with previous simulations documented in literature. In a second step we include a rolling friction sub-model in order to investigate the effect of particle non-sphericity. The influence of particle-particle as well as particle-wall rolling friction on the flow in single spout fluidized bed is studied separately. Adequate rolling friction model parameters are obtained using first principle DEM simulations and data from literature. Finally, we demonstrate the importance of correct modelling of rolling friction for coupled CFD-DEM simulations of spout fluidized beds. We show that simulation results can be improved significantly when applying a rolling friction model, and that experimental data from literature obtained with Positron Emission Particle Trackin~ fPEPT） technique can be satisfactorily reoroduced.

关键词： CFD-DEMOpen sourceRolling frictionSpout fluidized bedNon-sphericity

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Drug-and Herb-Induced Liver Injury in Clinical and Translational Hepatology:Causality Assessment Methods, Quo Vadis?

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Journal of Clinical and Translational Hepatology 2013年第1期1卷 59-74页

作者： Rolf Teschke Axel Eickhoff johannes Schulze Department of Internal Medicine Ⅱ Division of Gastroenterology and Hepatology Klinikum Hanau Academic Teaching Hospital of the Medical Faculty Goethe University Frankfurt/Main Germany Institute of Industrial Environmental and Social Medicine Medical Faculty Goethe University Frankfurt/Main Germany

Drug-induced liver injury (DILI) and herb-induced liver injury (HILI) are typical diseases of clinical and translational hepatology. Their diagnosis is complex and requires an experienced clinician to translate basic science into clinical judgment and identify a valid causality algorithm. To pro-spectively assess causality starting on the day DILI or HILI is suspected, the best approach for physicians is to use the Council for International Organizations of Medical Sciences (CIOMS) scale in its original or preferably its updated version. The CIOMS scale is validated, liver-specific, structured, and quantitative, providing final causality grades based on scores of specific items for individual patients. These items include latency period, decline in liver values after treatment cessa-tion, risk factors, co-medication, alternative diagnoses, hepatotoxicity track record of the suspected product, and unintentional re-exposure. Provided causality is established as probable or highly probable, data of the CIOMS scale with all individual items, a short clinical report, and complete raw data should be transmitted to the regulatory agencies, manufacturers, expert panels, and possibly to the scientific community for further refinement of the causality evaluation in a setting of retrospective expert opinion. Good-quality case data combined with thorough CIOMS-based assessment as a standardized approach should avert subsequent necessity for other complex causality assessment methods that may have inter-rater problems because of poor-quality data. In the future, the CIOMS scale will continue to be the preferred tool to assess causality of DILI and HILI cases and should be used consistently, both prospectively by physicians, and retrospectively for subsequent expert opinion if needed. For comparability and international harmonization, all parties assessing causality in DILI and HILI cases should attempt this standardized approach using the updated CIOMS scale.

关键词： Drug-induced liver injury Drug hepatotoxicity Herb-induced liver injury Herbal hepatotoxicity Causality assessment

Soil temperature modifies effects of soil biota on plant growth

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Journal of Plant Ecology 2017年第5期10卷 808-821页

作者： johannes Heinze Sabine Gensch Ewald Weber Jasmin Joshi Department of Biodiversity Research/Botany Institute of Biochemistry and BiologyUniversity of PotsdamMaulbeerallee 1D-14469 PotsdamGermany Berlin-Brandenburg Institute of Advanced Biodiversity Research(BBIB) Altensteinstr.614195 BerlinGermany

Aims Plants directly and indirectly interact with many abiotic and biotic soil *** so far mostly focused on direct,indi-vidual abiotic or biotic effects on plant growth,but only few studies tested the indirect effects of abiotic soil factors on plant ***,we investigated how abiotic soil conditions affect plant performance,via changes induced by soil *** In a full-factorial experiment,we grew the widespread grass Dactylis glomerata either with or without soil biota and investigated the impact of soil temperature,fertility and moisture on the soil biota effects on plant *** measured biomass production,root traits and colonization by arbuscular mycorrhizal fungi as well as microbial *** Findings We found significant interaction effects between abiotic soil con-ditions and soil biota on plant growth for fertility,but especially for soil temperature,as an increase of 10°c significantly changed the soil biota effects on plant growth from positive to ***,if tested individually,an increase in soil temperature and fertility per se positively affected plant biomass production,whereas soil biota per se did not affect overall plant growth,but both influenced root *** affecting soil microbial activ-ity and root architecture,soil temperature might influence both mutualistic and pathogenic interactions between plants and soil *** soil temperature effects should be considered in soil feedback studies to ensure greater transferability of results from artificial and experimental conditions to natural environmental conditions.

关键词： plant-soil interaction soil biota abiotic soil factors root traits plant growth