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Open Journal of Anesthesiology 2020年第11期10卷 371-380页

作者： johanne Bangshoej Thomas Thougaard Hans Fjeldsøe-Nielsen Sandra Viggers Department of Anesthesiology Nykoebing Falster Hospital Nykoebing Falster Denmark

Introduction: Blind fascia iliaca compartment block (FICB) and ultrasound guided femoral nerve block (FNB) are two types of peripheral nerve blocks, commonly used in preoperative pain management in patients with hip fractures in Danish emergency departments. The aim of this study was to compare the efficacy in pain management of these two types of peripheral nerve blocks in the preoperative period in patients with hip fractures. Method: We performed a randomized controlled study. The primary outcome was the proportion of patients with a numeric rating scale (NRS) pain score equal to three or less at rest and after passive leg raise test three hours after block administration. Results: A total of 88 patients were included in the study and 67 patients in the statistical analysis with 33 in the FICB group and 34 in the FNB group. The results showed a significant reduction in the proportion of patients with an NRS score higher than three, three hours after administration of either FICB or FNB compared to at inclusion. There was no significant difference in pain scores between patients receiving FICB versus patients receiving FNB at rest or after passive leg raise (p = 0.25 and p = 0.86, respectively). Conclusion: Blind FICB and ultrasound guided FNB were effective in preoperative pain management in patients with hip fractures. The results showed that the two types of peripheral nerve blocks were equally efficient in providing pain management in the preoperative period.

关键词： Local Analgesia Peripheral Nerve Block Pain Control Preoperative Optimization

Characteristics and potential analysis of Madagascar hydrocarbon-bearing basins

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China Geology 2019年第1期2卷 56-66页

作者： Da-tian Wu johanne Iomimalala Ramaniraka Feng-ming Xu Jian-bo Shao Yong-heng Zhou Yuan-dong Zhao Bruno Ralison Shenyang Center China Geological SurveyMinistry of Natural ResourcesShenyang 110034China China University of Geosciences Wuhan 430074China Departement des Sciences de la Terre Faculte des SciencesUniversite d’AntananarivoAntananarivo 101Madagascar

Madagascar becomes a large isolated island after its dislocation from East Africa at its western part during the opening of the Mozambique Channel and its separation from India at its eastern part during the opening of the basin of the Mascarene. From a stratigraphic point of view, Karroo of Madagascar shares substantial similarities with the stratigraphic strata of East *** oil companies have taken a liking to the basins of East Africa, they also turn to the basins in the western part of Madagascar especially after the discovery of large oil fields at Tsimiroro and Bemolanga. According to the study of their geological history, the basins of Madagascar contain huge hydrocarbon potential. The western basins, which is more developed than the east coast of the island, have been the subject of many in-depth studies by numerous researchers. The cross-referencing of bibliographic data with geological studies, and knowledge of hydrocarbon formation and maturation stages, carried out in this study served to determine the nature of source rocks, reservoir rocks, bedrock and eventual trapping system of hydrocarbons in Madagascar. This study identified the properties of Madagascar source rocks, reservoir rocks, bedrock and the final oil and gas trap system by cross-referencing the literature and geological research, oil and gas formation and maturity stages, and shows that Madagascar has considerable hydrocarbon potential.

关键词： Madagascar Hydrocarbon-bearing basins Characteristics of Malagasy basins Potential analysis Geology and stratigraphy

Candidate genes of hypertension with defective environmental expression

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Cell Research 1995年第1期5卷 47-58页

作者： SUN YU LIN johanne TREMBLAY DEWEN KONG PMEL HAMET. (Centre de Recherche Hotel-Dieu de Montreal, Universite de Montrdal, Montrdal, Canada) Centre de Recherche Hôtel-Dieu de Montréal Université de Montréal Montréal Canada

Previous studies in our laboratory have demonstrated that the thermosensitivity locus cosegregates with blood pressure and that the elevated expression and restriction fragment length polymorphism of HSP70 gene are associ-ated with hypertension. Cell protection against environ-mental stressors such as heat and chemicals is often accom-panied by up-regulated expression of a wide spectrum of heat sliock genes(HSP). To further investigate the interre-lation between HSP expression and blood pressure regulation, we employed an effective method of cloning 2 poten-tial hypertension-related HSPs. Synthetic oligonucleotides corresponding either to a higbly-conserved region of the known HSP family or a repetitive sequence in the protein- encoding gene were used as target primers for polymerase chain reaction (PCR). cDNA prepared from heat-stressed and non-stressed vascular smooth muscle cells (VSMC) of Brown Norway rats (BN.1x) and spontaneously hyperten-sive rats (SHRp) respectively served as template in the reaction. The PCR products were subsequently analyzed in a single-stranded conformational polymorphism (SSCP) electrophoresing system. Differential gene expression in BN.1x and SHRp was seen on autoradiographs of SSCP gel by comparing the migration patterns of PCR-amplified DNA fragments. Using this technique, we also found that HSP27 and a new member of the large HSP gene family were differentially expressed in BN.1x and SHRp VSMC.

关键词： Hypertension genes defective expression polymerase chain reaction singlestranded conformational polymorphism

采用Mixolab和Rheometer研究含外源蛋白燕麦面团的热机械学和动态流变学特性

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食品科学 2009年第13期30卷 147-152页

作者：王凤黄卫宁刘若诗金亮秀周坚强 johanne Boisvert 江南大学食品科学与技术国家重点实验室江苏无锡214122 加拿大农业与农业食品部-国际科学合作局

通过酶流变分析仪(Mixolab)和动态流变仪(Pheometer)研究3种不同外源蛋白对燕麦面团体系热机械学和流变学特性的影响。Mixolab分析结果表明:大豆蛋白和面筋蛋白都使燕麦面团的吸水率增大,蛋清蛋白使吸水率显著下降。3种蛋白的添加都可... 详细信息

通过酶流变分析仪(Mixolab)和动态流变仪(Pheometer)研究3种不同外源蛋白对燕麦面团体系热机械学和流变学特性的影响。Mixolab分析结果表明:大豆蛋白和面筋蛋白都使燕麦面团的吸水率增大,蛋清蛋白使吸水率显著下降。3种蛋白的添加都可显著提高面团形成时间,其中面筋蛋白影响最大,大豆蛋白最小。面筋蛋白和蛋清蛋白都使燕麦面团的稳定时间显著增加,其中含10%面筋蛋白和15%蛋清蛋白的燕麦面团具有最好的稳定性。含蛋清蛋白的燕麦面团在淀粉糊化时获得最大的峰值扭矩和回值,且随着其添加量增加而有所增大,大豆蛋白则相反,面筋蛋白对相关参数影响较小。动态流变学实验显示:含面筋蛋白和大豆蛋白的燕麦面团具有较大的弹性模量(G')和黏性模量(G"),且随着添加量的增大而增加,含蛋清蛋白的面团则相反。采用DSC进一步分析面团的热力学特性显示:蛋清蛋白和大豆蛋白可显著提高燕麦面团的峰值温度和终止温度,并在一定程度上提高面团的热焓值;面筋蛋白则作用不明显。

关键词：燕麦面团外源蛋白酶流变分析仪热机械学特性流变学特性

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悬崖上的鲜花

大学英语 2008年第6期 11-13页

作者： johanne Mednick 李宛悦吉林通化师范学院

埃德温上大学时学的是理科。他爽快谨慎、忠厚勤奋，这些良好品质让索菲娅为之倾倒。他们一直热恋了三年才举行婚礼。

关键词：大学英语教学教学方法翻译方法范文《悬崖上的鲜花》

Reliability and sensitivity to change of IW-TSE versus DESS magnetic resonance imaging sequences in the assessment of bone marrow lesions in knee osteoarthritis patients: Longitudinal data from the Osteoarthritis Initiative (OAI) cohort

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Journal of Biomedical Science and Engineering 2013年第3期6卷 337-345页

作者： Jean-Pierre Raynauld Lukas Martin Wildi Francois Abram Thomas Moser Jean-Pierre Pelletier johanne Martel-Pelletier Osteoarthritis Research Unit University of Montreal Hospital Research Center(CRCHUM)MontrealCanada Department of Rheumatology University Hospital of ZurichZurichSwitzerland Imaging Research&Development ArthroLab Inc.MontrealCanada Department of Radiology University of Montreal Hospital Centre(CHUM)MontrealCanada

Background: Bone marrow lesions (BMLs) are associated with osteoarthritis (OA). We assessed the performance of two commonly used MRI sequences, IW-TSE and DESS, for reliability in the detection of BMLs and sensitivity to estimate change over time. We suggested that the IW-TSE would demonstrate higher sensitivity to change than DESS in the assessment of BML prevalence and change over time. This study was performed using a subset of the Osteoarthritis Initiative (OAI) cohort. Methods: A sub-group of 144 patients was selected from the OAI progression cohort who all had IW-TSE and DESS MRI acquisitions at baseline and 24 months. BMLs were assessed using a semi-quantitative scale in the global knee, medial and lateral compartments, and subregions. Intra-reader reliability was assessed on a subset of 51 patients. Results: Intra-reader reliability was substantial for the global knee ≥ 0.64, medial ≥ 0.70, and lateral ≥ 0.63 compartments for IW-TSE and DESS. The prevalence of BML detected at baseline was only slightly greater for IW-TSE compared to DESS. The mean BML score at baseline was significantly higher (p ≤ 0.006) for the IW-TSE than the DESS. However, mean change at 24 months was similar for both sequences for all regions except the medial compartment (p = 0.034) and medial femur (p = 0.015) where they were significantly higher for DESS than IW-TSE. Moreover, the prevalence of BML change at 24 months was similar in all regions except the global knee (p = 0.047) and the lateral tibial plateau (p = 0.031). Conclusion: This study does not suggest superior sensitivity to change of one sequence over the other for almost all the regions. The only difference is a higher BML mean change over time detected by the DESS sequence in the medial compartment and femur. These data bring into perspective that both sequences seem equivalent regarding their use for the assessment of BML in clinical trials.

关键词： Osteoarthritis Magnetic Resonance Imaging Bone Marrow Lesions

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HAAKEN美术馆

住区 2014年第6期 124-126页

作者： johanne Borthne Vilhelm Christensen Henriette Wold

Haaken美术馆位于奥斯陆的Tjuvholmen,是一个新兴艺术街区的一部分.室内设计受到现有空间的形式和大小的限制,现有的空间有两个标高,空间中布满了随机布置的柱子和多种角度的墙体,整个空间只有150m2.设计策略是希望通过加入新的空间元... 详细信息

Haaken美术馆位于奥斯陆的Tjuvholmen,是一个新兴艺术街区的一部分.室内设计受到现有空间的形式和大小的限制,现有的空间有两个标高,空间中布满了随机布置的柱子和多种角度的墙体,整个空间只有150m2.设计策略是希望通过加入新的空间元素使得各部分可以具有多种功能的可能性,同时提供更多的墙面来进行展陈.主要的元素有：1,楼梯,兼具储存功能;2,具有储存功能的展墙;3.用书架围成的办公（阅读）空间,同时也提供了展示和非正式会议的功能.现有的空间及其两个标高被解释为两个空间几何形式.较低的一层简化为矩形空间,较高的一层则处理成更加复杂的形式.围绕中间现状圆柱的曲面木质接待台是美术馆中唯一打断展览空间的地方.

关键词：美术馆展览空间非正式会议室内设计设计策略几何形式功能奥斯陆

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路线

住区 2014年第6期 131-134页

作者： johanne Borthne Vilhelm Christensen Mille MeeHerstad

挪威建筑事务所Spacegroup和Superunion凭借他们设计的“Lysning”方案赢得了桑内斯“Ruten”的设计竞赛.位于挪威桑内斯的“Ruten”是作为城市发展预期保留的缓冲区——与在纽约城市网格变密之前设立中央公园的作用相似.桑内斯的旧城... 详细信息

挪威建筑事务所Spacegroup和Superunion凭借他们设计的“Lysning”方案赢得了桑内斯“Ruten”的设计竞赛.位于挪威桑内斯的“Ruten”是作为城市发展预期保留的缓冲区——与在纽约城市网格变密之前设立中央公园的作用相似.桑内斯的旧城中心是一条沿着挪威最长购物街展开的小尺度建成区.滨水新区则是另外一种城市机理,在尺度上类似于旧工业区.为了联结这两个截然不同的城市文脉,“Ruten”的设计需要同时适应二者.我们建议“Ruten”应反映出城市的发展,把“Ruten”打造为一个自然中心,把桑内斯打造为具有强烈根基和当地历史自豪感的未来城市.我们设计的圆环连接并创建一个新的交通枢纽和一个轻质的统一屋顶下的公共空间.“Ruten”将成为新的中央公园——城市身份的创造者和桑内斯的地标.

关键词：城市发展设计竞赛建筑事务所公共空间交通枢纽未来城市挪威缓冲区

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伊斯坦布尔灾害预防和教育中心

住区 2014年第6期 127-130页

作者： johanne Borthne Vilhelm Christensen Pal Arnulf Trodahl Bjorn Andreassen

该项目是预防和教育中心（自然灾害研究和信息）的国际设计竞赛,位于伊斯坦布尔市区与阿塔图尔克国际机场之间.中心包括各式各样的基于经验的自然灾害模拟器,例如地震、森林火灾和山体滑坡等.这个项目提供了一个很好的机会来探索和实践... 详细信息

该项目是预防和教育中心（自然灾害研究和信息）的国际设计竞赛,位于伊斯坦布尔市区与阿塔图尔克国际机场之间.中心包括各式各样的基于经验的自然灾害模拟器,例如地震、森林火灾和山体滑坡等.这个项目提供了一个很好的机会来探索和实践景观建筑.我们把中心设计成悬停的平行板,通过四个支点支撑在地面上：除了一尊下跪的阿特拉斯（Atlas）雕塑以及两个双柱作为垂直支持,还有一条金色的楼梯作为主入口.楼梯通向一个开敞的、石灰材质（travertine）装饰的大厅,两侧分别为管理办公区和活动体验区.游览流线穿过不同大小和主题的体验空间,过程就像一部好莱坞的灾难大片.底层架空的形式可以确保这种半开放式的城市空间可以被进一步强化.

关键词：伊斯坦布尔教育中心灾害预防设计竞赛自然灾害国际机场城市空间景观建筑

Effect of Gastrointestinal Protease Digestion on Bioactivity of Marine Peptides

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Journal of Agricultural Science and Technology(B) 2014年第1期4卷 74-84页

作者： Ida-johanne Jensen Lisa Lystbek Andersen Carlo Gunnar Ossum Greta Jakobsen Cristian De Gobba Sabeena Farvin Koduvayur Habeebullah Inez Johansson Else Hoffmann Edel Oddny Elvevoll Flemming Jessen Henrik Hauch Nielsen Faculty of Bioscience Fisheries and Economics Norwegian College of FisheO Science UniversiO of Tromso Tromso 9037Norway Division ofIndustrial Food Research National Food Institute DTU-Food Technical University qf Denmark Lyngby DK-2800Denmark Department of Biology Cell and Developmental Biology Universitv of Copenhagen Copenhagen 2100 Denmark Marinova ApS Adelvej 11 Lem St. 6940 Denmark Department of Food Science University o[Copenhagen Frederiksberg C 1958 Denmark

Focus in nutritional science has turned towards components in, or added to, foods that may possess health beneficial activities beyond the classical nutritional value, namely functional food. Bioactive peptides are examples of such components. In vitro studies on bioactivities have mainly been executed without concerning subsequent digestion after intake and the aim of this work was hence to investigate how the in vitro antioxidative, antihypertensive and caspase activating activities of peptides are affected by digestion with gastrointestinal （GI） proteases. Five different fish protein hydrolysates were chosen to study the effect of in vitro digestion on bioactivity. The protein concentration decreased in all samples during digestion and the molecular weight distribution of the peptides shifted towards lower values. Thus, in vitro digestion with GI proteases resulted in a further degradation of the peptides obtained by hydrolysis. The antihypertensive effect increased in all samples after digestion with GI proteases whereas the antioxidative capacity decreased. The effect on the caspase activity depended on the proteases used in the preparation of hydrolysates. In conclusion, the caspase activity and antihypertensive activity are maintained during digestion with GI proteases, while the antioxidative capacity seems to be reduced.

关键词： Antioxidative ACE in vitro caspase bioactivity marine peptides.