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Additive Manufacturing of Ceramics from Liquid Feedstocks

Chinese Journal of Mechanical Engineering(Additive Manufacturing Frontiers) 2022年第1期1卷 16-27页

作者： Giorgia Franchin Hamada Elsayed Renata Botti Kai Huang johanna schmidt Giulio Giometti Alice Zanini Anna De Marzi Marco D’Agostini Paolo Scanferla Yurun Feng Paolo Colombo Dipartimento di Ingegneria Industriale Universitàdi Padovavia Marzolo 935131 PadovaItaly Refractories Ceramics and Building Materials DepartmentNational Research CentreEl Buhouth Str.12622 CairoEgypt Department of Materials Science and Engineering Pennsylvania State UniversityUniversity ParkPA 16802USA

In this review,we summarize the research activities carried out by our research group at the University of Padova on the additive manufacturing of ceramics from liquid ***,we evaluate the use of preceramic polymers,geopolymers,and sol-gel *** mainly focus on processing with liquid feedstocks because they have some advantages with respect to slurry-based feedstocks in which powders are ***,lower viscosity,enhanced transparency,and lack of scattering and sedimentation are advantageous features for vat photopolymerization processes,whereas the absence of particulates reduces clogging problems at the nozzle for extrusion-based ***,preceramic polymers and geopolymers have some limitations in terms of the range of ceramic compositions that can be obtained;sol-gel solutions are intrinsically unstable,whereas printed objects suffer from drying ***,we successfully produced high-quality parts using a variety of additive manufacturing techniques,some of which(e.g.,volumetric additive manufacturing)have been proposed for the fabrication of ceramic components for the first time.

关键词： Additive manufacturing Preceramic polymers SiOC

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Role of histone deacetylases in pancreas: Implications for pathogenesis and therapy

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World Journal of Gastrointestinal Oncology 2015年第12期7卷 473-483页

作者： Eckhard Klieser Stefan Swierczynski Christian Mayr johanna schmidt Daniel Neureiter Tobias Kiesslich Romana Illig Institute of Pathology Paracelsus Medical UniversitySalzburger Landeskliniken (SALK) 5020 Salzburg Austria Department of Surgery Paracelsus Medical University Salzburger Landeskliniken (SALK) 5020 SalzburgAustria Department of Internal Medicine I Paracelsus Medical University Salzburger Landes- kliniken (SALK) 5020 Salzburg Austria Laboratory for Tumour Biology and Experimental Therapies (TREAT) Institute of Physiology and Pathophysiology Paracelsus Medical University

In the last years, our knowledge of the pathogenesis in acute and chronic pancreatitis(AP/CP) as well as in pancreatic cancerogenesis has significantly diversified. Nevertheless, the medicinal therapeutic options are still limited and therapeutic success and patient outcome are poor. Epigenetic deregulation of gene expression is known to contribute to development and progression of AP and CP as well as of pancreatic cancer. Therefore, the selective inhibition of aberrantly active epigenetic regulators can be an effective option for future thera-pies. Histone deacetylases(HDACs) are enzymes that remove an acetyl group from histone tails, thereby causing chromatin compaction and repression of transcri-ption. In this review we present an overview of the currently available literature addressing the role of HDACs in the pancreas and in pancreatic diseases. In pancreatic cancerogenesis, HDACs play a role in the important process of epithelial-mesenchymal-transition, ubiquitin-proteasome pathway and, hypoxia-inducible-factor-1-angiogenesis. Finally, we focus on HDACs as potential therapeutic targets by summarizing currently available histone deacetylase inhibitors.

关键词： Pancreatitis Pancreatic cancer Epigenetics Histone

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Differential role of Hedgehog signaling in human pancreatic(patho-)physiology:An up to date review

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World Journal of Gastrointestinal Pathophysiology 2016年第2期7卷 199-210页

作者： Eckhard Klieser Stefan Swierczynski Christian Mayr Tarkan Jager johanna schmidt Daniel Neureiter Tobias Kiesslich Romana Illig Institute of Pathology Paracelsus Medical UniversitySalzburger Landeskliniken(SALK) Department of Surgery Paracelsus Medical UniversitySalzburger Landeskliniken(SALK) Department of Internal Medicine I Paracelsus Medical UniversitySalzburger Landeskliniken(SALK) Laboratory for Tumour Biology and Experimental Therapies(TREAT) Institute of Physiology and PathophysiologyParacelsus Medical University

Since the discovery of the Hedgehog(Hh)pathway in drosophila melanogaster,our knowledge of the role of Hh in embryonic development,inflammation,and cancerogenesis in humans has dramatically increased over the last *** is the case especially concerning the pancreas,however,real therapeutic breakthroughs are missing until *** general,Hh signaling is essential for pancreatic organogenesis,development,and tissue *** the case of acute pancreatitis,Hh has a protective role,whereas in chronic pancreatitis,Hh interacts with pancreatic stellate cells,leading to destructive parenchym fibrosis and atrophy,as well as to irregular tissue remodeling with potency of initiating *** vitro and in situ analysis of Hh in pancreatic cancer revealed that the Hh pathway participates in the development of pancreatic precursor lesions and ductal adenocarcinoma including critical interactions with the tumor *** application of specific inhibitors of components of the Hh pathway is currently subject of ongoing clinical trials(phases 1 and 2).Furthermore,a combination of Hh pathway inhibitors and established chemotherapeutic drugs could also represent a promising therapeutic *** this review,we give a structured survey of the role of the Hh pathway in pancreatic development,pancreatitis,pancreatic carcinogenesis and pancreatic cancer as well as an overview of current clinical trials concerning Hh pathway inhibitors and pancreas cancer.

关键词： Pancreatic cancer Hedgehog Pancreatitis Pancreas Development

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Insights into CODE-DE–Germany’s Copernicus data and exploitation platform

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Big Earth Data 2019年第4期3卷 338-361页

作者： Tobias Storch Christoph Reck Stefanie Holzwarth Bert Wiegers Nico Mandery Ulrich Raapea Christian Strobl Rouven Volkmann Martin Böttcher Andreas Hirner johanna Senft Nicolae Plesia Thomas Kukuk Stephan Meissl Jens-Rainer Felske Thomas Heege Vanessa Keuck Michael schmidt Helmut Staudenrausch Earth Observation Center(EOC) German Aerospace Center(DLR)WeßlingGermany T-Systems SfR GmbH BonnGermany Brockmann Consult GmbH GeesthachtGermany GAF AG MunichGermany EOX IT Services GmbH ViennaAustria Werum Software&Systems AG LüneburgGermany EOMAP GmbH&Co.KG SeefeldGermany Programme Strategy Space R&D German Aerospace Center(DLR)CologneGermany Space Administration German Aerospace Center(DLR)BonnGermany

This article presents and analyses the modular architecture and capabilities of CODE-DE(Copernicus Data and Exploitation Platform–Deutschland,***),the integrated German operational environment for accessing and processing Copernicus data and products,as well as the methodology to establish and operate the *** March 2017,CODE-DE has been online with access to Sentinel-1 and Sentinel-2 data,to Sentinel-3 data shortly after this time,and since March 2019 with access to Sentinel-5P *** products are available and accessed by 1,682 registered users as of March *** this period 654,895 products were downloaded and a global catalogue was continuously updated,featuring a data volume of 814 TByte based on a rolling archive concept supported by a reload mechanism from a long-term *** November 2017,the element for big data processing has been operational,where registered users can process and analyse data themselves specifically assisted by methods for value-added product *** 195,467 core and 696,406 memory hours,982,948 products of different applications were fully automatically generated in the cloud environment and made available as of March *** features include an improved visualization of available Sentinel-2 products,which are presented within the catalogue client at full 10 m resolution.

关键词： Big earth data big data processing online data access Sentinel Copernicus CODE-DE collaborative ground segment

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