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Cardiac Autonomic Control in Relation to Other Prognostic Markers in Idiopathic Dilated Cardiomyopathy

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World Journal of Cardiovascular Diseases 2015年第5期5卷 107-119页

作者： Satu Karkkainen Ari Puhakka Jan Fedacko Jarkko Magga Kati Miettinen Esko Vanninen johanna kuusisto Keijo J. Peuhkurinen Petri O. Tuomainen Department of Internal Medicine Kuopio University Hospital and University of Eastern Finland Kuopio Finland Heart Center Kuopio University Hospital and University of Eastern Finland Kuopio Finland Center of Preventive and Sports Medicine Safarik University and Pasteur Hospital Kosice Slovakia Department of Clinical Physiology and Nuclear Medicine Kuopio University Hospital and University of Eastern Finland Kuopio Finland

Objectives: We set out to study cardiac autonomic tone in patients with idiopathic dilated cardio-myopathy (IDC), and whether it correlates with other established markers of disease progression and patient ultimate outcome. Design: Fifty-one IDC patients in sinus rhythm underwent extensive non-invasive and invasive evaluation during a three-day hospitalization period. The control group consisted of thirty-eight apparently healthy subjects who underwent 24-hour ambulatory ECG recording. Results: Heart rate variability (HRV) and heart rate turbulence (HRT) correlated with many previously established prognostic markers of IDC and congestive heart failure, especially measures of cardiorespiratory performance capacity and circulating neurohumoral factors (p < 0.05 for all). Furthermore, attenuated HRV correlated with worse prognosis during a median follow-up of 6.8 years (range 5.1 - 8.1). Additionally, 24-hour time domain, low and high frequency components of frequency domain and non-linear HRV, excluding scaling exponents (α), were lower in IDC patients as compared with controls (p < 0.05 for all);however, HRT was not significantly different. Conclusions: The magnitude of impairment in cardiac autonomic control correlates well with other prognostic markers of IDC, and is associated with unfavorable outcome.

关键词： Heart Rate Variability Heart Rate Turbulence Cardiorespiratory Fitness Vasoactive Peptides Proinflammatory Cytokines

Thick Electrodes of a Self-Assembled MXene Hydrogel Composite for High-Rate Energy Storage

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Energy & Environmental Materials 2024年第4期7卷 255-261页

作者： Leiqiang Qin Jianxia Jiang Lintao Hou Fengling Zhang johanna Rosen Department of Physics Chemistry and Biology (IFM) Link?ping University Flexible Electronics Innovation Institute (FEII) Jiangxi Key Laboratory of Flexible Electronics Jiangxi Science and Technology Normal University Guangzhou Key Laboratory of Vacuum Coating Technologies and New Energy Materials Physics Department Jinan University

Supercapacitors based on two-dimensional MXene （Ti3C2Tz） have shown extraordinary performance in ultrathin electrodes with low mass loading,but usually there is a significant reduction in high-rate performance as the thickness increases,caused by increasing ion diffusion *** limitations include restacking of the nanosheets,which makes it challenging to realize the full potential of these electrode materials.

关键词： energy storage high-rate hydrogel MXene self-assemble

Mechanical upper bowel obstruction caused by a large trichobezoar in a young woman: A very unusual case report

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World Journal of Clinical Cases 2024年第4期12卷 777-781页

作者： Magdalena Scherrer Peter Kornprat Robert Sucher johanna Muehlsteiner Doris Wagner Department of Surgery Division for GeneralVisceral and Transplantation SurgeryMedical University of GrazGraz 8036Austria Department of Surgery Clinic RohrbachRohrbach 4150Austria

BACKGROUND Bezoars usually compile human fibers and debris.A special form of bezoar in case of psychologically altered individuals is the *** consists of voluntarily swallowed hair bulks and is normally removed via *** leading to ileus have rarely been *** SUMMARY A 24-year-old female patient presented to the emergency room with abdominal pain,nausea,and vomiting for 3 *** previous medical and psychiatric history was *** analysis showed iron deficiency anemia,leukocytosis,and elevated liver *** abdominal CT scan revealed a dense structure in the patients’stomach which turned out to be a huge trichobezoar completely obstructing the *** trichobezoar had to be removed *** her postoperative course,a subcutaneous seroma *** a single puncture,the rest of the recovery process was unremarkable,and the patient recovered *** A mechanical bowel obstruction is a potentially life-threatening event for every *** our case a young female was suffering from severe symptoms of an obstruction which might have resulted in serious harm without successful surgical management.

关键词： Rapunzel syndrome Hair ingestion Gastroscopy Bezoar Case report

Adverse Pregnancy Outcomes Following Cryotherapy, Thermal Ablation and Loop Electrosurgical Excision Procedure for Cervical Intraepithelial Neoplasia Treatment: A Pilot Study among Zambian Women

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Open Journal of Obstetrics and Gynecology 2024年第1期14卷 7-17页

作者： Victoria Mwiinga-Kalusopa johanna E. Maree Concepta Kwaleyela Patricia Katowa-Mukwato Department of Basic and Clinical Nursing University of Zambia Lusaka Zambia Department of Nursing Education University of Witwatersrand Johannesburg Gauteng South Africa School of Health Sciences Mulungushi University Kabwe Central Province Zambia

Background: Cervical Intraepithelial neoplasia treatments have become essential interventions to manage cervical lesions. Majority of the recipients of these treatments are women within the reproductive age group, who according to literature may be at risk of adverse pregnancy outcomes. This pilot study is part of a study investigating adverse pregnancy outcomes among women who received Cryotherapy, Thermal ablation and Loop Electrosurgical Excision Procedure compared to the untreated women in Zambia. Materials and Methods: This descriptive study analyzed records of 886 (n = 443 treated and n = 443 untreated) women aged 15 - 49 years. The women were either screened with Visual Inspection with Acetic Acid or treated for Cervical Intraepithelial neoplasia at the Adult Infectious Disease Centre between January 2010 and December 2020. Women meeting the criteria were identified using the Visual Inspection with Acetic Acid screening records and telephone interviews to obtain the adverse pregnancy outcome experienced. Data were analysed using STATA version 16 to determine the prevalence and obtain frequency distribution of outcomes of interest. Univariate and multivariable binary logistic regression estimated odds of adverse pregnancy outcomes across the three treatments. Results: The respondents were aged 15 to 49 years. Adverse pregnancy outcomes were observed to be more prevalent in the treatment group (18.5%) compared to the untreated group (5.4%). Normal pregnancy outcomes were lower in the treated (46.3%;n = 443) than the untreated (53.7%;n = 443). The treated group accounted for the majority of abortions (85.2%), prolonged labour (85.7%) and low birth weight (80%), whereas, the untreated accounted for the majority of still births (72.7%). Women treated with cryotherapy (aOR = 2.43, 95% CI = 1.32 - 4.49, p = 0.004), thermal ablation (aOR = 6.37, 95% CI = 0.99 - 41.2, p = 0.052) and Loop Electrosurgical Excision Procedure (aOR = 9.67, 95% CI = 2.17 - 43.1, p = 0.003)

关键词： Adverse Pregnancy Outcomes Cervical Intraepithelial Neoplasia Cryothera-py Thermal Ablation Loop Electrosurgical Excision Procedure Pilot Repro-ductive Age

Genomic selection in plant breeding:Key factors shaping two decades of progress

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Molecular Plant 2024年第4期17卷 552-578页

作者： Admas Alemu johanna Astrand Osval A.Montesinos-López Julio Isidro y Sanchez Javier Fernandez-Gónzalez Wuletaw Tadesse Ramesh R.Vetukuri Anders S.Carlsson Alf Ceplitis JoséCrossa Rodomiro Ortiz Aakash Chawade Department of Plant Breeding Swedish University of Agricultural SciencesAlnarpSweden Lantmannen Lantbruk SvalövSweden Facultad de Telematica University de ColimaColimaColima 28040Mexico Centro de Biotecnología y Genómica de Plantas(CBGP UPM-INIA)Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA)Campus de Montegancedo-UPM28223 MadridSpain International Center for Agricultural Research in the Dry Areas(ICARDA) RabatMorocco International Maize and Wheat Improvement Center(CIMMYT) Km 45Carretera México-VeracruzTexcocoMéxico 52640Mexico

Genomic selection,the application of genomic prediction(GP)models to select candidate individuals,has significantly advanced in the past two decades,effectively accelerating genetic gains in plant *** article provides a holistic overview of key factors that have influenced GP in plant breeding during this *** delved into the pivotal roles of training population size and genetic diversity,and their relationship with the breeding population,in determining GP *** emphasis was placed on optimizing training population *** explored its benefits and the associated diminishing returns beyond an optimum *** was done while considering the balance between resource allocation and maximizing prediction accuracy through current optimization *** density and distribution of single-nucleotide polymorphisms,level of linkage disequilibrium,genetic complexity,trait heritability,statistical machine-learning methods,and non-additive effects are the other vital *** wheat,maize,and potato as examples,we summarize the effect of these factors on the accuracy of GP for various *** search for high accuracy in GP—theoretically reaching one when using the Pearson’s correlation as a metric—is an active research area as yet far from optimal for various *** hypothesize that with ultra-high sizes of genotypic and phenotypic datasets,effective training population optimization methods and support from other omics approaches(transcriptomics,metabolomics and proteomics)coupled with deep-learning algorithms could overcome the boundaries of current limitations to achieve the highest possible prediction accuracy,making genomic selection an effective tool in plant breeding.

关键词： genomic selection genetic gain genomic prediction optimization deep learning training population optimization

Modeling Blood Flow in Veins of Uniform Properties (Giraffe Jugular Vein)

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Open Journal of Biophysics 2024年第2期14卷 132-153页

作者： Rogers Omboga Amenya johanna Kibet Sigey Geoffrey Moriaso Ole Maloiy David Mwangi Theuri Department of Mathematics and Physical Sciences Dedan Kimathi University of Technology Nyeri Kenya Department of Pure and Applied Mathematics School of Mathematical Sciences Jomo Kenyatta Unversity of Agriculture and Technology Kisii Kenya Institute of Animal Physiology and Biotechnology Research University of Nairobi Nairobi Kenya

This paper models the giraffe’s jugular veins as a uniform collapsible tube from a rigid skull. The equations governing one-dimensional steady flow through such a tube for various conditions have been developed. The effects of inertial and inclination angles that have not been discussed previously have been included. It has been shown that different flows for a uniform tube (vein) are possible. However, this flow matches that of a jugular vein which is supercritical, and the steady solution has been given by the balance between the driving forces of gravity and the viscous resistance to the flow at the right atrium of the heart must be sub-critical for a fixed right-atrium pressure which means that an elastic jump is required to return the flow to sub-critical from the supercritical flow upstream this type of relationship gives rise to flow limitation at the same time given any right atrium fixed pressure there exists a maximum flow rate which when exceeded the boundary conditions of the flow do not hold boundary conditions at the right atrium are not satisfied hence making the steady flow impossible this mechanism of flow limitation is slightly different from the other one in that causes airways through forced expiration from the observation made it is clearly shown that there is an intravascular pressure difference with a change in height.

关键词： Blood Flow Jugular Vein Cross-Sectional Area Supercritical Subcritical Jump

2024年工程师不可错过的AI主要发展趋势

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世界电子元器件 2024年第2期 23-24页

作者： johanna Pingel MathWorks AI

随着AI在各行各业的应用日益广泛,它将继续深刻影响着人类社会的发展和进步,并彻底改变技术和人类交互的方方面面。据Forrester预测,到2024年,企业AI计划有助于将工作效率和创造性问题解决能力提高50%。AI将对工程师和教育工作者等的工... 详细信息

随着AI在各行各业的应用日益广泛,它将继续深刻影响着人类社会的发展和进步,并彻底改变技术和人类交互的方方面面。据Forrester预测,到2024年,企业AI计划有助于将工作效率和创造性问题解决能力提高50%。AI将对工程师和教育工作者等的工作产生影响,即帮助他们节省时间,让他们有更多精力专注于推进科学和工程事业的其他项目。2024年推动AI持续发展的三大趋势:AI和仿真对于设计和开发工程系统至关重要随着AI在各行各业和应用中走向主流,不使用AI的复杂工程系统将显得格格不入。工程系统集多个领域的组件和子系统于一体,创建了能够感知和响应周围世界的智能系统。

关键词：智能系统创造性问题解决复杂工程系统 AI 主要发展趋势教育工作者工程师工作效率

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海蒂

英语画刊(高中版) 2024年第5期 3-5页

作者： johanna Spyri 翟红梅

《海蒂》是瑞士儿童文学作家约翰娜·斯比丽创作的长篇小说，讲述了小女孩海蒂的成长历程。小说中描述的动人细节和深厚情感，自十九世纪80年代首次出版以来，感动着一代又一代读者。本文为节选。海蒂跟着小姨蒂提爬上高山牧场找爷爷。...

《海蒂》是瑞士儿童文学作家约翰娜·斯比丽创作的长篇小说，讲述了小女孩海蒂的成长历程。小说中描述的动人细节和深厚情感，自十九世纪80年代首次出版以来，感动着一代又一代读者。本文为节选。海蒂跟着小姨蒂提爬上高山牧场找爷爷。蒂提打算将海蒂托付给老人，但是脾气古怪、离群索居的老人对她们下了逐客令。

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德国高校教学数字化的变革潜力

应用型高等教育研究 2024年第1期9卷 69-73页

作者： johanna Leifeld Tina Basner Tina Classen 陈颖高等教育发展中心德国居特斯洛33332 国际管理学院德国多特蒙德44227 不详

为了明确何为高质量的数字化辅助教学及其先决条件,一项调查研究对20位德国高校数字化教学奖获得者进行了定性访谈。在此调查研究的基础上,文章阐释了实施高质量数字化教学理念的具体策略和关键成功因素。调查结果揭示了促进教学创新的... 详细信息

为了明确何为高质量的数字化辅助教学及其先决条件,一项调查研究对20位德国高校数字化教学奖获得者进行了定性访谈。在此调查研究的基础上,文章阐释了实施高质量数字化教学理念的具体策略和关键成功因素。调查结果揭示了促进教学创新的必要条件,强调了线上和线下教学方式均衡结合的重要性。这些发现为高校教师提供了实践指导,并有助于推进具有前瞻性的高等教育发展。

关键词：数字化最佳实践范例高校教学教学创新