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Feline Hypertrophic cardiomyopathy Associated with the p.A31P Mutation in cMyBP-c Is caused by Production of Mutated cMyBP-c with Reduced Binding to Actin

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Open Journal of Veterinary Medicine 2013年第2期3卷 95-103页

作者： Mia T.N.Godiksen craig Kinnear Tina Ravnsborg Peter Hojrup Sara Granstrom Inga A.Laursen Paula L.Hedley johanna c.Moolman-Smook William J.McKenna Jorgen Koch Michael christiansen Department of clinical Biochemistry and Immunology Statens Serum InstitutCopenhagenDenmark Department of Small Animals Diseases Faculty of Life ScienceUniversity of CopenhagenCopenhagenDenmark MRc centre for Molecular and cellular Biology University of StellenboschCape TownSouth Africa Institute of Biochemistry and Molecular Biology University of Southern DenmarkOdenseDenmark Institute of cardiovascular Science The Heart HospitalUniversity College LondonLondonUK

Hypertrophic cardiomyopathy (HcM) is a myocardial disorder, with complications including heart failure, thromboemboli and sudden death. Human and feline HcM (fHcM) are clinically comparable, thus fHcM may serve as a spontaneous animal model. fHcM in Maine coon (Mc) cats is associated with the p.A31P mutation in the cMyBP-c protein. The mutation is located in the cMyBP-c c0-domain which is known to interact with actin. The presence and levels of the wild type and mutated protein in heart tissue from mutant and wild type Mc cats were examined by SDS-PAGE and mass spectrometry (MS). Quantitative yeast-2-hybrid (Y2H) protein-protein interaction analysis was used to assess the effect of the mutation on c0c1/actin interaction. The NMR-based structure of the c0 domain was used to calculate the energetic consequence of replacing alanine with a proline residue. In the homozygous Mc cat, the mutated cMyBP-c protein was present, and cMyBPc-c levels were not reduced compared to that of the wild type cat. However, the interaction of actin with mutant cMyBP-c c0c1 was reduced compared to that of wild type. This may be because the substitution of the alanine with proline in position 31 was energetically highly unfavorable and resulted in only one hydrogen bond within the anti-parallel beta-strand compared to two hydrogen-bonds for alanine, possibly destabilizing the structure of the actin-interacting domain. The p.A31P mutation is present in cardiac tissue and the most likely pathogenic mechanism is interference with contractility by reducing binding of the c0c1 domain of cMyBP-c to actin.

关键词： Feline HcM cMyBP-c Mutation Actin Y2H MSMS

金刚烷胺模拟废水Fenton氧化及其中间产物分析

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环境工程技术学报 2011年第6期1卷 455-459页

作者：曾萍宋永会 DRESELY johanna HOFFMANN Erhard 中国环境科学研究院城市水环境研究室北京100012 卡尔斯鲁厄理工大学德国卡尔斯鲁厄76128

采用Fenton试剂氧化法处理模拟金刚烷胺废水,研究不同反应条件下Fenton试剂对金刚烷胺的去除效果,确定反应的最佳条件。结果表明:当反应温度为常温(23～25℃),pH为4,H2O2投加量为3000mg/L,H2O2与Fe2+的质量比为1.28时,处理含金刚烷胺浓... 详细信息

采用Fenton试剂氧化法处理模拟金刚烷胺废水,研究不同反应条件下Fenton试剂对金刚烷胺的去除效果,确定反应的最佳条件。结果表明:当反应温度为常温(23～25℃),pH为4,H2O2投加量为3000mg/L,H2O2与Fe2+的质量比为1.28时,处理含金刚烷胺浓度为500mg/L废水,cODcr去除率为30%～80%,处理效果良好。因此,Fenton试剂可以有效降解金刚烷胺。通过Fenton反应,金刚烷胺废水的可生化性得到提高,B/c由0提高到0.1～0.4。对Fenton氧化金刚烷胺的中间产物的分析发现,Fenton氧化反应5min后,系统中没有检出金刚烷胺。反应30min后,中间产物已基本完全降解。

关键词： Fenton反应金刚烷胺制药废水高级氧化

QTL analysis for ascorbic acid content in strawberry fruit reveals a complex genetic architecture and association with GDP-L-galactose phosphorylase

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Horticulture Research 2023年第3期10卷 136-150页

作者： Pilar Muñoz cristina castillejo JoséAntonio Gómez Luis Miranda Silke Lesemann Klaus Olbricht Aurélie Petit Philippe chartier Annika Haugeneder johanna Trinkl Luca Mazzoni Agnieszka Masny Edward Zurawicz Freya Maria Rosemarie Ziegler Björn Usadel Wilfried Schwab Béatrice Denoyes Bruno Mezzetti Sonia Osorio JoséFSánchez-Sevilla Iraida Amaya centro IFAPA de Málaga Instituto Andaluz de Investigación y Formación Agraria y Pesquera(IFAPA)29140MálagaSpain PhD program in Advanced Biotechnology Universidad de Málaga29071MálagaSpain Finca el cebollar Centro IFAPA las Torres04745HuelvaSpain Hansabred GmbH&co.KG 01108DresdenGermany INVENIO 33800BordeauxFrance Biotechnology of Natural Products Technische Universität München85354FreisingGermany Dipartimento di Scienze Agrarie Alimentari e AmbientaliUniversitàPolitecnica delle Marche60131AnconaItaly Department of Horticultural crop Breeding the National Institute of Horticultural ResearchKonstytucji 3 Maja 1/396-100SkierniewicePoland Institute of Bio-and Geosciences Bioinformatics(IBG-4)Forschungszentrum Jülich GmbH52428JülichGermany Univ.Bordeaux INRAEBiologie du Fruit et PathologieUMR 1332F-33140France Departamento de Biología Molecular y Bioquímica Instituto de Hortofruticultura Subtropical y Mediterránea"La Mayora"Universidad de Málaga-Consejo Superior de Investigaciones CientíficasCampus de Teatinos29071 MálagaSpain Unidad Asociada de I+D+i IFAPA-cSIc Biotecnología y Mejora en Fresa 29010MálagaSpain.

Strawberry(Fragaria×ananassa)fruits are an excellent source of L-ascorbic acid(AsA),a powerful antioxidant for plants and *** the genetic components underlying AsA accumulation is crucial for enhancing strawberry nutritional ***,we unravel the genetic architecture of AsA accumulation using an F1 population derived from parental lines‘candonga’and‘Senga Sengana’,adapted to distinct Southern and Northern European *** account for environmental effects,the F1 and parental lines were grown and phenotyped in five locations across Europe(France,Germany,Italy,Poland and Spain).Fruit AsA content displayed normal distribution typical of quantitative traits and ranged five-fold,with significant differences among genotypes and *** content in each country and the average in all of them was used in combination with 6,974 markers for quantitative trait locus(QTL)*** stable QTLs for AsA content were detected in linkage group(LG)3A,LG 5A,LG 5B,LG 6B and LG *** genes were identified within stable QTL intervals and expression analysis in lines with contrasting AsA content suggested that GDP-L-Galactose Phosphorylase FaGGP(3A),and the chloroplast-located AsA transporter gene FaPHT4;4(7c)might be the underlying genetic factors for QTLs on LG 3A and 7c,*** show that recessive alleles of FaGGP(3A)inherited from both parental lines increase fruit AsA ***,expression of FaGGP(3A)was two-fold higher in lines with high *** here identified represent a useful resource for efficient selection of new strawberry cultivars with increased AsA content.

关键词： straw cultivar content

The Quadrennial Ozone Symposium 2016

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Advances in Atmospheric Sciences 2017年第3期34卷 283-288页

作者： Sophie GODIN-BEEKMANN Irina PETROPAVLOSKIKH Stefan REIS Paul NEWMAN Wolfgang STEINBREcHT Markus REX Michelle L. SANTEE Richard S. EcKMAN Xiandong ZHENG Matthew B. TULLY David S. STEVENSON Paul YOUNG John PYLE Mark WEBER johanna TAMMINEN Gina MILLS Alkis F. BAIS clare HEAVISIDE christos ZEREFOS Observatoire de Versailles Saint-Quentin en Yvelines Universite de Versailles Saint-Quentin-en-Yvelines CNRS 78280 Guyancourt France cIRES University of Colorado Boulder CO 80309 USA NERc centre for Ecology & Hydrology Edinburgh EH26 OQB UK Goddard Space Flight center NASA Greenbelt MD 20771 USA Hohenpeissenberg Meteorological Observatory Deutscher Wetterdienst 82383 Hohenpeissenberg Germany Alfred Wegener Institute 14401 Potsdam Germany Jet Propulsion Laboratory California Institute of Technology CA 91109 USA NASA Headquarters Earth Science Division Washington DC USA chinese Academy of Meteorological Sciences Beijing 100081 China Bureau of Meteorology Melbourne Victoria 3001 Australia University of Edinburgh School of GeoSciences Edinburgh EH9 3FE UK Lancaster Environment centre Lancaster University Lancaster LA1 4YQ UK University of cambridge Department of Chemistry Cambridge CB2 1EW UK University of Bremen Institute of Environmental Physics 28359 Bremen Germany Finnish Meteorological Institute Earth Observation FI-00101 Helsinki Finland NERc centre for Ecology and Hydrology Bangor Gwynedd LL57 2UW Wales UK Aristotle University of Thessaloniki ELKE AUTH Thessaloniki Greece Public Health England Centre for Radiation Chemical and Environmental Hazards London UK Research center for Atmospheric Physics & climatology Academy of Athens Athens 10680 Greece University of Exeter Medical School Truro TR1 3HD UK

1. Overview The 2016 Quadrennial Ozone Symposium （QOS-2016） was held on 4-9 September 2016 in Edinburgh, UK. The Symposium was organized by the International Ozone commission （IO3c）, the NERc centre for Ecology ＆ Hydrology and the University of Edinburgh, and was co-sponsored by the International Union of Geodesy and Geophysics, the International Association of Meteorology and Atmospheric Sciences, and the World Meteorological Organization.

关键词： NERc The Quadrennial Ozone Symposium 2016 UK USA

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三元层状材料结构调控及性能研究进展

无机材料学报 2023年第8期38卷 845-884页

作者：丁浩明李勉李友兵陈科肖昱琨周洁陶泉争 johanna ROSEN 尹航柏跃磊张毕堃孙志梅王俊杰张一鸣黄振莺张培根孙正明韩美康赵双王晨旭黄庆中国科学院宁波材料技术与工程研究所先进能源材料工程实验室宁波315201 中国科学院大学北京101408 宁波杭州湾新材料研究院宁波315336 林雪平大学物理、化学和生物学系瑞典林雪平SE-58183 哈尔滨工业大学特种环境复合材料技术国防科技重点实验室/复合材料与结构研究所哈尔滨150001 北京航空航天大学材料科学与工程学院北京100191 西北工业大学材料学院西安710072 北京交通大学机械与电子控制工程学院北京100044 东南大学材料科学与工程学院南京211189 复旦大学光电研究院和上海市智能光电与感知前沿科学研究基地上海200433 北京大学核物理与核技术国家重点实验室北京100871

MAX/MAB相是一类非范德华三元层状材料,具有丰富的元素组成和晶体结构,兼具陶瓷和金属的物理性质,在高温、强腐蚀、辐照等极端环境中极具应用潜力。近年来,由MAX/MAB相衍生的二维(2D)材料(MXene和MBene)在材料物理与材料化学领域引起了... 详细信息

MAX/MAB相是一类非范德华三元层状材料,具有丰富的元素组成和晶体结构,兼具陶瓷和金属的物理性质,在高温、强腐蚀、辐照等极端环境中极具应用潜力。近年来,由MAX/MAB相衍生的二维(2D)材料(MXene和MBene)在材料物理与材料化学领域引起了广泛兴趣,已经成为继石墨烯和过渡金属硫族化合物之后最受关注的二维范德华材料。MAX/MAB相材料结构调控不仅对这类非范德华层状材料本征性能产生重要影响,而且对其衍生的二维范德华材料结构功能特性研究也具有重要价值。本文归纳和总结了MAX/MAB相层状材料在结构调控、理论计算和应用基础研究等方向的最新科研进展,并展望了该类层状材料未来发展方向。

关键词： MAX相 MAB相二维过渡金属碳氮化物结构调控理论计算综述

养殖三疣梭子蟹体内哈维氏弧菌的分离与致病性鉴定

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应用海洋学学报 2013年第2期32卷 215-221页

作者：周永强李登峰彭姣 Ester johanna Shikongo 陈炯刘联国顾晓英宁波大学海洋学院浙江宁波315211

养殖的三疣梭子蟹(Portunus trituberculatus)秋、冬季常发生非典型症状的死亡.本研究取濒死的三疣梭子蟹内脏及体腔液进行细菌分离,经纯化传代获得1株优势菌***菌的革兰氏染色呈阴性,菌体呈杆状、弧形或逗点状,无荚膜,无芽孢,极生单鞭... 详细信息

养殖的三疣梭子蟹(Portunus trituberculatus)秋、冬季常发生非典型症状的死亡.本研究取濒死的三疣梭子蟹内脏及体腔液进行细菌分离,经纯化传代获得1株优势菌***菌的革兰氏染色呈阴性,菌体呈杆状、弧形或逗点状,无荚膜,无芽孢,极生单鞭毛,运动性强.生长特性和生化试验表明该菌生长需盐,最适生长的Nacl含量为30 mg/cm3;28℃下生长旺盛,能利用葡萄糖产酸但不产气,可以利用麦芽糖、蔗糖等糖类.测定了HY菌约930bp的16S rDNA序列,分类进化树显示其与哈维氏弧菌(Vibrio harveyi)Xc08001聚为一簇.综合形态、生化和16S rDNA序列分析结果确定HY菌为哈维氏弧菌.以2×106cfu/只(蟹)的HY菌悬液注射健康梭子蟹成蟹(平均体重为400±25 g/只),致死率为35%;菌液浸泡感染梭子蟹仔蟹的半数致死剂量(Lc50)为8.25×105cfu/cm3.上述结果表明分离的哈维氏弧菌对三疣梭子蟹具有致病性.

关键词：海洋微生物学三疣梭子蟹病原哈维氏弧菌分离鉴定

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争议之地：无家可归者与亚特兰大市中心公园

杭州师范大学学报（社会科学版） 2013年第4期35卷 96-105页

作者：唐纳德·c.雷泽斯蒂莫西·J.克里敏斯约翰娜·J.伯尔斯乔西·帕克李芸(译) 张卫良(校) 美国乔治亚州立大学社会学系上海200241 美国乔治亚州立大学历史系上海200241 美国乔治亚州立大学华东师范大学中文系上海200241 杭州师范大学城市学研究所浙江杭州310036

在此项研究中,我们调查了公园利益相关方超过20年控制无家可归者在市中心公园活动规模的举措,以及无家可归拥护者对付这些举措的一系列回应。我们发现,伍德拉夫公园的用途和价值伴随一天的不同时间、一周的不同日子和不同季节而变化。此... 详细信息

在此项研究中,我们调查了公园利益相关方超过20年控制无家可归者在市中心公园活动规模的举措,以及无家可归拥护者对付这些举措的一系列回应。我们发现,伍德拉夫公园的用途和价值伴随一天的不同时间、一周的不同日子和不同季节而变化。此外,公园利益相关方虽会随时间而变更,但当局使用的策略不一定必然会朝着某个始终如一的方向发展,或者按一种常规模式变化。最终,虽然无家可归的拥护者比起过去已很少看到,但他们仍然保护了公园内的无家可归者。案例研究认为,一个公园应该是一个基础空间,即作为共有地向所有人开放;也应该是一个典范空间,在这里,没有人会被看作是入侵者。

关键词：伍德拉夫公园城市空间无家可归者

Decline in subarachnoid haemorrhage volumes associated with the first wave of the cOVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo c Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi chandril chugh charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro Sc Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A cora Rotem Sivan-Hoffmann Roberto crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the cOVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and cOVID-19 were identified by prospective aneurysm databases or by International classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%cI−24.3%to−20.7%,pclined with 1170-1035 procedures,respectively,representing an 11.5%(95%cI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%cI−28.0%to−22.1%,pcrease in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%cI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the cOVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid