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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A maj.r unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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含气条件下水力旋流器的压力特性研究

石油机械 2004年第2期32卷 1-4页

作者：赵立新蒋明虎 A.Belaidi m.thew 刘峰哈尔滨工业大学大庆石油学院英国Bradford大学大庆石油管理局

针对固液分离水力旋流器 ,研究了结构参数及操作参数对压力特性的影响 ,得到了含气条件下水力旋流器的压力特性研究结果 ,并进行了能耗分析。实验结果表明 ,在含气条件下水力旋流器的溢流和底流压差都显著增加 ;在不含气条件下压降比... 详细信息

针对固液分离水力旋流器 ,研究了结构参数及操作参数对压力特性的影响 ,得到了含气条件下水力旋流器的压力特性研究结果 ,并进行了能耗分析。实验结果表明 ,在含气条件下水力旋流器的溢流和底流压差都显著增加 ;在不含气条件下压降比随着流量的增加而降低 ,但在含气时则基本保持不变 ;随着旋数的增加 ,压差增大 ,而压降比减小 ;随着气液比的加大 ,压差基本呈增加趋势 ,而压降比则无明显变化。最后指出 ,减少水力旋流器能量消耗的方法主要有降低流量、旋数或气液比 ,其中最可行的方法是降低水力旋流器入口处的气液比 ,即提高游离水脱除器等前端处理设备的除气效率。

关键词：水力旋流器含气条件压力特性压差压降比能耗分析

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a maj.r contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Deciphering Water Oxidation Catalysts: The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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NANO-mICRO LETTERS 2025年第1期17卷 1-15页

作者： An, Li Li, j.anyi Sun, Yuanmiao Zhu, j.amin Seow, j.stin Zhu Yeow Zhang, Hong Zhang, Nan Xi, Pinxian Xu, Zhichuan j. Yan, Chun-Hua Lanzhou Univ Frontiers Sci Ctr Rare Isotopes Key Lab Nonferrous Met Chem & Resources Utilizat G State Key Lab Appl Organ ChemColl Chem & Chem Eng Lanzhou 730000 Peoples R China Nanyang Technol Univ Sch Mat Sci & Engn Singapore 639798 Singapore Chinese Acad Sci Fac Mat Sci & Energy Engn Shenzhen Inst Adv Technol Inst Technol Carbon Neutral Shenzhen 518055 Peoples R China Yunnan Univ Natl Ctr Int Res Photoelect & Energy Mat Electron Microscopy Ctr Sch Mat & EnergyKey Lab Electromagnet Mat & Devic Kunming 650091 Peoples R China Baotou Res Inst Rare Earths State Key Lab Baiyunobo Rare Earth Resource Res & Baotou 014030 Peoples R China Peking Univ Beijing Natl Lab Mol Sci State Key Lab Rare Earth Mat Chem & Applicat PKU HKU Joint Lab Rare Earth Mat & Bioinorgan Chem Beijing 100871 Peoples R China

Demonstrate that the key factor to determine the activity of reconstructed surfaces is the surface chemistry, instead of reconstruction degree using the popular perovskite LaNi1-xFexO3 oxides as model *** content can influence both the surface reconstruction degree, the activation degree, and the activity of reconstructed *** oxygen evolution reaction activity of reconstructed catalysts is primarily governed by the chemistry of the reconstructed surface species. Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution reaction. The surface reconstruction has been widely observed in perovskite catalysts, and the reconstruction degree has been often correlated with the activity enhancement. Here, a systematic study on the roles of Fe substitution in activation of perovskite LaNiO3 is reported. The substituting Fe content influences both current change tendency and surface reconstruction degree. LaNi0.9Fe0.1O3 is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi1-xFexO3 (x = 0.00, 0.10, 0.25, 0.50, 0.75, 1.00) series. The reconstructed LaNi0.9Fe0.1O3 shows a higher intrinsic activity than most reported NiFe-based catalysts. Besides, density functional theory calculations reveal that Fe substitution can lower the O 2p level, which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term stability. Furthermore, it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction degree. The effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface reconstruction. This finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

Ribozymes and the mechanisms that underlie RNA catalysis

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Frontiers of Chemical Science and Engineering 2016年第2期10卷 178-185页

作者： Timothy j. Wilson Yij.n Liu David m. j. Lilley Cancer Research UK Nucleic Acid Structure Research Group MSI/WTB Complex The University of Dundee Dundee DD1 5EH UK

Ribozymes are widespread, and catalyze some extremely important reactions in the cell. mechanistically most fall into one of two classes, using either metal ions or general acid-base catalysis. The nucleolytic ribozymes fall into the latter class, mostly using nucleobases. A sub-set of these use a combination of guanine base plus adenine acid to catalyze the cleavage reaction. New ribozymes are still being discovered at regular intervals and we can speculate on the potential existence of ribozymes that catalyze chemistry beyond phosphoryl transfer reactions, perhaps using small-molecule coenzymes.

关键词： RNA catalysis RNA structure catalytic mechanism

The unusual life history of a southern Iberian Peninsula population of Torleya maj.r （Ephemeroptera： Ephemerellidae）

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Insect Science 2011年第5期18卷 583-589页

作者： m. j. Lopez-Rodriguez j. m. Tierno de Figueroa j. Alba-Tercedor Departamento de Biologia Animal Facultad de Ciencias Universidad de Granada Granada Spain

The nymphal biology of a population of Torleya maj.r （Klapalek） in southem Iberian Peninsula was studied. An atypical life cycle pattern is described, with eggs hatching in August producing a fast-developing cohort with adults emerging in autumn and a second slow-developing cohort with adults emerging in spring of the following year. Nymphal growth occurred primarily in summer-autumn （in the first cohort） and in spring （in the second）. The origin of such a life history is discussed. Nymphs were collector-gatherers, consuming mainly detritus. Although ontogenetic shifts on the use of trophic resources were detected, similar food was utilized during the months when both cohorts cohabited, eliminating the possibility that the rapid growth of the first cohort could be related to the utilization of different food resources.

关键词： collector-gatherer life cycle mayfly nymphal feeding southern Iberian Peninsula

A vestigial pathway for sex differences in immune regulation

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Cellular & molecular Immunology 2017年第7期14卷 578-580页

作者： Yun Liang j.michelle Kahlenberg johann E Gudj.nsson Department of Dermatology University of MichiganAnn ArborMI 48109USA Division of Rheumatology Department of Internal MedicineUniversity of MichiganAnn ArborMI 48109USA

Autoimmune diseases have a strikingly higher prevalence in women compared to men,with approximately 80%of individuals affected with autoimmune diseases being *** nature of this sex-bias has remained unclear,but sex hormones have previously been implicated as the leading underlying *** this research highlight,we discuss a recently identified transcription factor。

关键词： diseases autoimmune prevalence

Leader-following consensus control for networked multi-teleoperator systems with interval time-varying communication delays

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Chinese Physics B 2013年第7期22卷 96-103页

作者： m. j. Park S. m. Lee j. W. Son O. m. Kwon E. j. Cha School of Electrical Engineering Chungbuk National University School of Electronic Engineering Daegu University Division of IT-Convergence Daegu Gyeongbuk Institute of Science & Technology Department of Biomedical Engineering School of MedicineChungbuk National University

We study the leader-following consensus stability and stabilization of networked multi-teleoperator systems with interval time-varying communication delays. With the construction of a suitable Lyapunov–Krasovskii functional and the utilization of the reciprocally convex approach, novel delay-dependent consensus stability and stabilization conditions for the systems are established in terms of linear matrix inequalities, which can easily be solved by various effective optimization algorithms. One illustrative example is given to illustrate the effectiveness of the proposed methods.

关键词： multi-teleoperator systems interval time-varying delay leader–following consensus problem Lyapunov method