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Metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth

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The Innovation 2024年第2期5卷 107-114页

作者： johan Gustafsson fariba Roshanzamir Anders Hagnestål Sagar M.Patel Oseeyi I.Daudu Donald f.Becker Jonathan L.Robinson Jens Nielsen Department of Life Sciences Chalmers University of TechnologySE-41296 GothenburgSweden Hagnesia AB SE-43854 HindåsSweden Department of Biochemistry and Redox Biology Center University of Nebraska-LincolnLincolnNE 68588USA BioInnovation Institute DK2200 CopenhagenDenmark

The tumor microenvironment is composed of a complex mixture of different cell types interacting under conditions of nutrient deprivation,but the metabolism therein is not fully understood due to difficulties in measuring metabolic fluxes and exchange of metabolites between different cell types in ***-scale metabolic modeling enables estimation of such exchange fluxes as well as an opportunity to gain insight into the metabolic behavior of individual cell ***,we estimated the availability of nutrients and oxygen within the tumor microenvironment using concentration measurements from blood together with a metabolite diffusion *** addition,we developed an approach to efficiently apply enzyme usage constraints in a comprehensive metabolic model of human *** combined modeling reproduced severe hypoxic conditions and the Warburg effect,and we found that limitations in enzymatic capacity contribute to cancer cells’preferential use of glutamine as a substrate to the citric acid ***,we investigated the common hypothesis that some stromal cells are exploited by cancer cells to produce metabolites useful for the cancer *** identified over 200 potential metabolites that could support collaboration between cancer cells and cancer-associated fibroblasts,but when limiting to metabolites previously identified to participate in such collaboration,no growth advantage was *** work highlights the importance of enzymatic capacity limitations for cell behaviors and exemplifies the utility of enzyme-constrained models for accurate prediction of metabolism in cells and tumor microenvironments.

关键词： metabolism effect limitations

Enabling low-cost decentralized power reserves adopting carbon dioxide for green methane exchange in stabilized clathrate adsorbent

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Journal of Energy Chemistry 2024年第10期97卷 438-443页

作者： Lucas Hanssens Maarten Houlleberghs C.Vinod Chandran Geert Watson Sambhu Radhakrishnan Pascal Van Der Voort Joeri f.M.Denayer Christine E.A.Kirschhock johan A.Martens Eric Breynaert Centre for Surface Chemistry and Catalysis-Characterization and Application Team (COK-KAT) NMR/X-Ray Platform for Convergence Research (NMRCoRe) Centre for Ordered Materials Organometallics and Catalysis (COMOC) Department of Chemistry Ghent University Department of Chemical Engineering Vrije Universiteit Brussel

*** circular methane energy systems In recent decades,methane-based energy systems have rapidly gained traction across the globe because of the increasing availability of low-cost methane production ***,fossil methane... 详细信息

关键词： Long duration energy storage Green methane Carbon neutrality Confined clathrate hydrates CH4 /CO2 exchange Direct gas exchange ENERGY-STORAGE CONfINED NANOSPACE TO-METHANE GAS MECHANISMS ADSORPTION HYDROGEN

Colorectal anastomotic leakage: Aspects of prevention, detection and treatment

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World Journal of Gastroenterology 2013年第15期19卷 2293-2297页

作者： freek Daams Misha Luyer johan f.lange Department of Surgery Catharina Ziekenhuis5623 EJ EindhovenThe Netherland Department of Surgery Catharina Ziekenhuis5623 EJ EindhovenThe Netherlands Department of Surgery Erasmus Medical Center3015 CE RotterdamThe Netherlands

All colorectal surgeons are faced from time to time with anastomotic leakage after colorectal surgery. This complication has been studied extensively without a significant reduction of incidence over the last 30 years. New techniques of prevention, by innovative anastomotic techniques should improve results in the future, but standardization and "teachability" should be guaranteed. Risk scoring enables intra-operative decision-making whether to restore continuity or deviate. Early detection can lead to reduction in delay of diagnosis as long as a standard system is used. for treatment options, no firm evidence is available, but future studies could focus on repair and saving of the anastomosis on the one hand or anastomotical breakdown and definitive colostomy on the other hand.

关键词： Colorectal surgery Complications Postoperative care Anastomotic leakage Prevention

Economic overview of a two-agent process for underground coal gasification with fischer-Tropsch- based poly-generation

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Clean Energy 2019年第1期3卷 34-46页

作者： johan f.Brand johan C.van Dyk frans B.Waanders African Carbon Energy PO Box 450Standerton 2430South Africa Centre of Excellence in Carbon-based fuels North-West UniversityPotchefstroom 2520South Africa African Carbon Energy PO Box 254SasolburgSouth Africa

Underground Coal Gasification(UCG)is a mining-gasification process that produces synthesis gas from in situ coal by injecting air(or oxygen and steam)and extracting the produced gas via *** resulting synthesis gas(‘syngas’)produced by UCG can be used directly as a fuel-gas or deep-cleaned to produce many other products like chemicals,liquid fuels,hydrogen and synthetic natural *** has significant environmental,safety and practical advantages over conventional coal mining and utilization,foremost being cost and emissions *** South Africa,facilities of an industrial-scale fischer-Tropsch(fT)have been operating for decades on coal-to-liquid and gas-to-liquid ***-blown UCG produces syngas,which contains a mixture of carbon monoxide(CO)and hydrogen,and these molecules can be conditioned to serve as feed for synthetic-crude-oil(‘syncrude’)conversion technologies based on the fT *** Carbon Energy(Pty)Ltd.(Africary)completed a study integrating its UCG technology with mini gas-to-liquids *** from Africary’s Theunissen Underground Coal Gasification(TUCG)project will be used for power production and synthesis of liquid fuels in a unique poly-generation *** TUCG process will consist of two parallel gasifiers,operated on different agents,making the component parts of UCG and coal-to-(any product)(CtX)tightly linked and interdependent,but reducing both cost and ***-CtX offers a lower capital investment to conventional underground mining and surface gasification due to the removal of the surface gasifier and coal-mine *** gas clean-up systems will remove undesirable components from each gasifier and blend the cleaned syngas for H2:CO ratio control and provide implementation of carbon capture and *** study has minimized the complexity and optimized the process flow to provide own-use electricity and about 4000 barrels/day equivalent fuels at a capital cost estimate(2017)of

关键词： underground coal gasification fischer-Tropsch coal to liquids gas to liquids CCS UCG fT LNG CtX economic study South Africa

Integrated approach to colorectal anastomotic leakage: Communication, infection and healing disturbances

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World Journal of Gastroenterology 2016年第32期22卷 7226-7235页

作者： Cloe L Sparreboom Zhou-Qiao Wu Jia-fu Ji johan f.lange Department of Surgery Erasmus University Medical Center 3015 CN Rotterdam. The NEthelands Department of Gastrointestinal Surgery Peking University Cancer Hospital and Institute Haidian District Beijing 100142 China

Colorectal anastomotic leakage(CAL) remains a major complication after colorectal surgery. Despite all efforts during the last decades, the incidence of CAL has not decreased. In this review, we summarize the available strategies regarding prevention, prediction and intervention of CAL and categorize them into three categories: communication, infection and healing disturbances. These three major factors actively interact during the onset of CAL. We aim to provide an integrated approach to CAL based on its etiology. The intraoperative air leak test, intraoperative endoscopy, radiological examinations and stoma construction mainly aim to detect and to prevent communication between the intra- and extra-luminal content. Other strategies including postoperative drainage, antibiotics, and infectious-parameter evaluation are intended to detect and prevent anastomotic or peritoneal infection. Most currently available interventions for CAL focus on the control of communication and infection, while strategies targeting the healing disturbances such as lifestyle changes, oxygen therapy and evaluation of metabolic biomarkers still lack wide clinical application. This simplified categorization may contribute to an integrated understanding of CAL. We strongly believe that this integrated approach should be taken into consideration during clinical practice. An integrated approach to CAL could contribute to a better understanding of the etiology of CAL and eventually better patient outcome.

关键词： Colorectal anastomotic leakage Integrated approach Prevention Prediction Intervention

Successful management of therapy-refractory pseudoachalasia after Ivor Lewis esophagectomy by bypassing colonic pull-up:A case report

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World Journal of Clinical Cases 2021年第16期9卷 3971-3978页

作者： Sven flemming johan f Lock Mohammed Hankir Stanislaus Reimer Bernhard Petritsch Christoph-ThomasGermer florian Seyfried Department of General VisceralTransplantationVascular and Pediatric SurgeryUniversity Hospital of WuerzburgWürzburg 97080Germany Department of Internal Medicine II Section of GastroenterologyUniversity Hospital of WuerzburgWürzburg 97080Germany Department of Diagnostic and Interventional Radiology University Hospital of WuerzburgWürzburg 97080Germany

BACKGROUND Gastric pull-up after esophagectomy is still a demanding surgical procedure and associated with considerable morbidity such as anastomotic leaks,fistulas or *** complications are usually managed by endoscopy,but in extreme cases multidisciplinary management including reoperations may be ***,we report managing therapy-refractory pseudoachalasia after Ivor Lewis esophagectomy by bypassing colonic *** SUMMARY A 70-year-old male with dysphagia and regurgitation after esophagectomy with gastric pull-up reconstruction was transferred to our tertiary *** endoscopic approaches including balloon dilatation and stenting failed,retrosternal colonic pull-up with Roux-en-Y reconstruction was performed with no subsequent adverse *** Secondary colonic pull-up is a demanding but successful surgical procedure in patients suffering from therapy-refractory complaints after esophagectomy with gastric pull-up reconstruction.

关键词： Pseudoachalasia Ivor Lewis esophagectomy Dysphagia Colonic pull-up Esophageal stenting Case report

Long-term experimental study on gravitational sedimentation of water aluminum oxide nanofluid at different volumetric concentrations

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International Journal of Sediment Research 2023年第3期38卷 303-315页

作者： Mario Misale johan Augusto Bocanegra Annalisa Marchitto DIME-Department of Mechanics Energetics Management and Transportation Thermal Engineering and Environmental Conditioning Division University of Genoa

The stability of nanofluids is critical in engineering applications. The sedimentation of the nanoparticles in the base fluid limits the stability of the nanofluid. By measuring the absorbance of a visible laser through water aluminum oxide nanofluids it is possible to observe the evolution of the sedimentation process. A simple experimental setup consisting of a thin closed test cavity（0.8 mm or 1.5 mm thickness）filled with nanofluid and a set of laser diodes-photodiodes pairs was used in the experiments to determine the absorbance and the local volumetric concentration. The evolution of the local volumetric concentration of the nanofluid was measured at 13 height positions along the test cavity. five initial volumetric concentrations of aluminum oxide（Al2O3; 0.5%, 1.0%, 1.5%, 2.0%, 3.0% and 4.0%） were considered. Data and digital photos were acquired for a total time lapse of 260 days. The results were independent of the container thickness. The same general trend was consistent for all the initial volumetric concentrations, i.e., the sedimentation rate decreases in time. The time evolution of the volumetric concentration was compared with results from a modified Mason-Weaver model. The comparison was possible by setting a variable sedimentation velocity in the model, suggesting that the sedimentation is affected by the dynamics of nanoparticle clusters with diverse sizes produced by agglomeration.

关键词： Pure nanofluid Aluminum oxide Nanoscale alumina particles Colloid sedimentation Nanoparticle settling Mason-Weaver model

Prediction and diagnosis of colorectal anastomotic leakage: A systematic review of literature

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World Journal of Gastrointestinal Surgery 2014年第2期6卷 14-26页

作者： freek Daams Zhouqiao Wu Max Jef Lahaye johannus Jeekel johan frederik lange Department of Surgery Catharina ZiekenhuisPostbus 1350 5602 ZA Eindhoven The Netherlands Department of Surgery Erasmus Medical Center Postbus 2040 3000 CA Rotterdam The Netherlands Department of Radiology Maastricht University Medical Centre Postbus 5800 6202 AZ Maastricht The Netherlands Department of Neuroscience Erasmus Medical Center Postbus 2040 3000 CA Rotterdam The Netherlands

Although many studies have focused on the preoperative risk factors of anastomotic leakage after colorectal surgery(CAL), postoperative delay in diagnosis is common and harmful. This review provides a systematic overview of all available literature on diagnostic tools used for CAL. A systematic search of literature was undertaken using Medline, Embase, Cochrane and Webof-Science libraries. Articles were selected when a diagnostic or prediction tool for CAL was described and tested. Two reviewers separately assessed the eligibility and level of evidence of the papers. Sixty-nine articles were selected(clinical methods: 11, laboratory tests: 12, drain fluid analysis: 12, intraoperative techniques:22, radiology: 16). Clinical scoring leads to early awareness of probability of CAL and reduces delay of diagnosis. C-reactive protein measurement at postoperative day 3-4 is helpful. CAL patients are characterized by elevated cytokine levels in drain fluid in the very early postoperative phase in CAL patients. Intraoperative testing using the air leak test allows intraoperative repair of the anastomosis. Routine contrast enema is not recommended. If CAL is clinically suspected, rectal contrast-computer tomography is recommended by a few studies. In many studies a "no-test" control group was lacking, furthermore no golden standard for CAL is available. These two factors contributed to a relatively low level of evidence in the majority of the papers. This paper provides a systematic overview of literature on the available tools for diagnosing CAL. The study shows that colorectal surgery patients could benefit from some diagnostic interventions that can easily be performed in daily postoperative care.

关键词： Colorectal Anastomosis Leakage Diagno-sis Prediction

Discovering Mathematics with Maple: An interactive exploration for mathematicians, engineers and econometricians 1

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