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A prospective longitudinal study shows putamen volume is associated with moderate amphetamine use and resultant cognitive impairments

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Psychoradiology 2021年第1期1卷 3-12页

作者： Keith M.Kendrick joerg daumann Daniel Wagner Philip Koester Marc Tittgemeyer Qiang Luo Euphrosyne Gouzoulis-Mayfrank Benjamin Becker The Clinical Hospital of Chengdu Brain Science Institute Key Laboratory for NeuroinformationCenter for Information in MedicineSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengduChina Department of Psychiatry and Psychotherapy University of CologneGermany Max-Planck Institute for Neurological Research CologneGermany Institute of Science and Technology for Brain-Inspired Intelligence Ministry of Education Key Laboratory of Computational Neuroscience and Brain-Inspired IntelligenceFudan UniversityShanghaiPR China LVR Clinics of Cologne CologneGermany

Background:Amphetamine-type stimulants(ATS)have become a critical public health *** models have indicated a clear neurotoxic potential of *** humans,chronic use has been associated with cogni-tive deficits and structural brain ***,cross-sectional retrospective designs in chronic users cannot truly determine the causal direction of the ***:To prospectively determine effects of occasional ATS use on cognitive functioning and brain ***:In a prospective longitudinal study design,cognitive functioning and brain structure were assessed at baseline and at 12-month follow-up in occasional ATS users(cumulative lifetime use<10 units at baseline).Results:Examination of change scores between the initial examination and follow-up revealed declined verbal memory performance and putamen volume in users with high relative to low interim ATS *** the entire sample,interim ATS use,memory decline,and putamen volume reductions were strongly ***:The present findings support the hypothesis that ATS use is associated with deficient dorsal stri-atal morphology that might reflect alterations in dopaminergic *** importantly,these findings strongly suggest that even occasional,low-dose ATS use disrupts striatal integrity and cognitive functioning.

关键词： amphetamines brain volume dorsal striatum MDMA prospective stimulants

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