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含MUCI的一组免疫组化标记可有助于区分宫颈内膜和子宫内膜黏液腺癌

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临床与实验病理学杂志 2007年第1期23卷 24-24页

作者： khoury T Tan D Wang J 杨小兵（摘译）赵建华（审校）不详南京医科大学附属南京第一医院病理科南京210006

由于宫颈内膜腺癌(ECA)和子宫内膜腺癌的治疗和预后不同,所以区别二者有重要的临床意义。当肿瘤累及子宫下段或宫颈上段,或在分段诊刮或刮宫标本中时均有肿瘤,而且没有原位部分存在时,形态学上区分这2种肿瘤是很困难的。黏液腺癌时由于... 详细信息

由于宫颈内膜腺癌(ECA)和子宫内膜腺癌的治疗和预后不同,所以区别二者有重要的临床意义。当肿瘤累及子宫下段或宫颈上段,或在分段诊刮或刮宫标本中时均有肿瘤,而且没有原位部分存在时,形态学上区分这2种肿瘤是很困难的。黏液腺癌时由于缺乏间质,二者的区分更加困难。为了探讨免疫组化在ECA和子宫内膜黏液腺癌(EMMA)鉴别诊断中的价值,作者应用一组免疫组化抗体(MUC1、p16、ER、PR和vimentin)检测了32例病人。32例病人中ECal4例,EMMal8例。结果发现MUCI在大部分EMMA中表达阳性(78%,14/18),阳性表达部位位于顶端/胞质(A/C),而仅有14%ECA(2/14)呈A/C表达;p16在71%ECA(10/14)中表达阳性,而4/18例EMMA中(22%)p16表达阳性;17/18例EMMA中(94%)ER表达阳性,而21%ECA(3/14)阳性;PR在EMMA和ECA中阳性率分别为89%(16/18)和21%(3/14);vimentin在EMMA中阳性率为50%(9/18),ECA为7%(1/14)。[第一段]

关键词：免疫组化标记子宫内膜腺癌黏液腺癌宫颈内膜 vimentin p16表达阳性表达 ECA

Cancer stem cells in Helicobacter pylori infection and aging: Implications for gastric carcinogenesis

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World Journal of Gastrointestinal Pathophysiology 2014年第3期5卷 366-372页

作者： Edi Levi Paula Sochacki Nabiha khoury Bhaumik B Patel Adhip PN Majumdar Department of Veterans Affairs John D Dingell VA Medical Center Wayne State University Detroit MI 48201 United States Pathology Wayne State University Detroit MI 48201 United States Karmanos Cancer Center Wayne State University Detroit MI 48201 United States Departments of Internal Medicine Wayne State University Detroit MI 48201 United States

AIM: To demonstrated the combined effects of aging and carcinogen treatment on cancer stem/stem-like cells(CSCs) of gastric mucosa in an animal model. METHODS: In this study we investigated the effects of aging and Helicobacter pylori(H. pylori) inflammation as a model for inflammation induced carcinogenesis in human and rat gastric mucosa samples. In aging studies, we compared 4-mo old(young) with 22 mo(aged) old Fischer-344 rats. For human studies, gastric biop-sies and resection specimens representing normal mucosa or different stages of H. pylori gastritis and gastric adenocarcinomas were used for determining the expression of stem cell markers CD166, alDH1 and LGR5. In addition we performed immunofluorescent double labeling for B-catenin and Lgr5 in both rat and human gastric tissues to examine the status of Wnt signaling in these cells. RESULTS: CSC markers alDH1, LGR5, and CD166 were expressed in very low levels in normal human gastric mucosa or young rat gastric mucosa. In contrast, level of expression for all three markers significantly increased in H. pylori gastritis and gastric adenocarcinomas as well as in normal gastric mucosa in aged rats. We also observed cytoplasmic B-catenin staining in both aged rat and human H. pylori inflamed gastric mucosa, which were found to be colocalized with Lgr5 immunoreactive cells. The increased number of alDH1, CD166 and LGR5 positive cells in H. pylori gastritis indicates that increased number of stem-like cells in gastric mucosa is an early event, and may constitute an important step in the progression to neoplasia. CONCLUSION: Our observation of the age-related increase in cancer stem/stem-like cells in the gastric mucosa may explain the increased incidence of gastric cancer during aging. Combination of aging and H. pylori infection may have additive effects in progression to neoplasia.

关键词： Cancer stem cells Aging CD166 alDH1 LGR5 Gastric cancer Helicobacter pylori

无地域限制的STRokEDOC无线电视医疗系统可靠性的前瞻性研究

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 61-61页

作者： Meyer B.C. Lyden P.D. al-khoury L. 朱光明 Department of Neurosciences UCSD School of MedicineStroke Center (8466) 200 West Arbor Drive San DiegoCA92103-8466United States Dr.

The authors evaluated a site-independent telemedicine *** may be limited by the need for fixed *** and site-independent te chnologies eliminate this ***-five stroke patients underwent eval uations by remote and bedside examiners. Ten of 15 (67%) NIH Stroke Scale and 9 of 11 (82%) Modified NIH Stroke Scale items showed excellent interrater reliab ility. Spearman correlations were ≥0.93. This Internet system is reliable and v alid. Further studies should assess its use in acute stroke.

关键词：地域限制系统可靠性 STRokEDOC 急性脑卒中评分项目证实有效国际系统程及连接设备

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完全埋于皮下的静脉通路系统

国外医学.护理学分册 1986年第4期07卷 160-160页

作者： khoury 朱光第

长时间的化疗使癌症患者可用的外周血管很快硬化。为解决癌症患者的静脉通路问题已曾用过静脉瘘、血管移植及中心静脉插管等法。本文介绍另一种方法:完全埋于皮下的静脉通路系统。它由注射港(injection port)和与之相连的上腔静脉插管... 详细信息

长时间的化疗使癌症患者可用的外周血管很快硬化。为解决癌症患者的静脉通路问题已曾用过静脉瘘、血管移植及中心静脉插管等法。本文介绍另一种方法:完全埋于皮下的静脉通路系统。它由注射港(injection port)和与之相连的上腔静脉插管所组成。作者已在68例缺少合适外周静脉的癌症患者中使用。方法与材料将Ommaya 囊用于本法,此囊系硅橡胶制成,1963年Ommaya 氏最初用此于脑脊液的分流术。其组成包括:(1)单腔贮液囊(即作为注射港——译者注),(2)内径1mm 的直接管,(3)内径1.3mm 末端有裂隙活瓣(单向阀门——译者)的导管。在手术室无菌条件下埋置此系统,大多数病例在门诊用局麻进行。埋置前用肝素——盐水溶液灌洗该

关键词：静脉通路中心静脉导管阻塞癌症患者

Incidence and prevalence of hepatitis B and hepatitis C viruses in hemodialysis patients in Lebanon

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World Journal of Nephrology 2016年第1期5卷 101-107页

作者： Antoine Abou Rached Lara El khoury Talal El Imad Abdallah S Geara Josette Jreijiry Walid Ammar National Hepatitis Program Ministry of Public HealthBeirut 1106 9800Lebanon Department of Internal Medicine Division of GastroenterologyLebanese UniversityBeirut 2903 1308Lebanon Faculty of Medical Sciences Lebanese UniversityBeirut 2903 1308Lebanon School of Medicine West Virginia UniversityMorgantownWV 26506-9100United States Ministry of Public Health Beirut 1106 9800Lebanon

AIM: To determine the incidence and the prevalence of hepatitis B and C viral infections in patients on hemodialysis(HD) across ***: We reviewed the data registry at the Lebanese Ministry of Public Health where records of monthly hepatitis B surface antigen(HBs Ag) and hepatitis C virus(HCV) serology are reported from 60 affiliated HD centers across Lebanon. all patients who were on HD or who started HD between October 2010 and July 2012 were included in the study. Patients from seven HD centers were excluded due to inadequate and incomplete results reporting. During the selected period, HBs Ag and HCV serology were available for 3769 patients from 53 HD centers distributed at all Lebanese governorates. The prevalence was calculated by dividing the number of patients with positive HBs Ag or HCV serology to the total number of patients. The Incidence was calculated by dividing the number of newly acquired infection to number of patients-years(p-y). Incidence rates at different governorates were compared to each other using two tailed Z test and a P value of alence of hepatitis B virus(HBV) and HCV in HD patients across Lebanon was 1.6%, and 4.7%, respectively. The comparison of prevalence according to geographic distribution could not be done accurately due to the frequent shift of patients between dialysis centers at different governorates. The incidence rate was 0.27 per 100 p-y for HBV and 0.37 per 100 p-y for HCV. There was no significant difference concerning the incidence of HBV between HD centers at different governorates(all P values > 0.1), but this difference was highly significant concerning the incidence rates of HCV which occurred predominantly in the southern centers(1.47 per 100 p-y) with a P value of 0.00068 and 0.00374 when compared to Mount Lebanon(0.21 per 100 p-y) and

关键词：肝炎病毒感染治疗方法临床分析

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近期干旱和气候变化下的西班牙森林的恢复力

气象科技进展 2020年第5期10卷 176-176页

作者： khoury S Coomes D 侯美亭(编译) 不详

由于土地被遗弃和木材需求减少,地中海北部森林的森林覆盖率正在大范围增加,但气候变化背景下这些次生林的恢复能力仍然不确定。为此,英国剑桥大学的khoury等使用卫星遥感植被指数(NDVI)获得的18年树冠绿度时间序列来评估气候变化对西... 详细信息

由于土地被遗弃和木材需求减少,地中海北部森林的森林覆盖率正在大范围增加,但气候变化背景下这些次生林的恢复能力仍然不确定。为此,英国剑桥大学的khoury等使用卫星遥感植被指数(NDVI)获得的18年树冠绿度时间序列来评估气候变化对西班牙森林的影响。具体而言,他们利用从3100个森林像素中提取的月时间序列,分为十种森林类型,分析了气候水分平衡(即标准化降水蒸散指数,SPEI)对NDVI的影响。森林的叶面积指数平均每年增加0.01(从2000年的1.7增加到了2017年的1.9),但与气候水分平衡有关的年际变化很大。

关键词：时间序列木材需求恢复力水分平衡气候变化恢复能力森林覆盖率叶面积指数

CT血管成像在鉴别急性脑卒中后真假颈部颈内动脉(ICA)闭塞的应用:准确性、组间及组内观察者一致性的研究

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国际医学放射学杂志 2018年第3期 348-348页

作者： A.Diouf R.Fahed M.Gaha M.Chagnon N.khoury M.Kotowski 吕晓虹 Department of Radiology Centre Hospitalier del ’Université de Montréal -CHUM Notre -Dame Hospital

摘要目的评估CT血管成像(CTA)鉴别真性颈部颈内动脉(ICA)闭塞和伪闭塞(阻止血流上升的孤立的颅内血栓)的准确性和可靠性。材料与方法本回顾性研究共纳入了行

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恶性血管神经肌瘤的临床病理学及免疫组化特点:病例报道和文献综述

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世界核心医学期刊文摘（皮肤病学分册） 2006年第1期2卷 25-25页

作者： khoury T Balos L McGrath B 党倩丽

Malignant glomus tumor (MGT) is a rare, recently described neoplasm that recapitulates the appearance of the modified smooth cells of the normal glomus body. We report a case of MGT of the hand of a 48-year-old woman. Magnetic resonance imaging (MRI) showed a 2.8-cm, well circumscribed, enhancing mass on the volar aspect of the thenar region of the right hand in immediate continuity with the ulnar artery and nerve. Computed tomography scan (CT-Scan) of the chest was nor mal. Histologic evaluation revealed a multilobular lesion with prominent branchi ng capillary vasculature and perivascular arrangement of sheets of tumor cells. The tumor cells were round, relatively uniform in size with distinct cell border s and perinuclear cytoplasmic clearing. They were of intermediate to high nuclea r grade and showed significant mitotic activity. A wide local excision with nega tive margins was performed. Multiple lung metastases were evident at 8-month fo llow-up. To date, forty-five cases of MGT of skin and soft issue have been rep orted in the literature. Twelve of the forty-five cases developed metastasis. I n this report, we emphasize the differential diagnosis of MGT in the skin and de ep soft tissue.

关键词：血管神经肌瘤免疫组化特点临床病理学文献综述血管球体深部软组织鉴别诊断掌面强性道中

急性脑卒中患者静脉内对比剂使用与急性肾脏疾病的关联:基于人群的研究

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中华高血压杂志 2017年第3期25卷 231-231页

作者：刘莉叶鹏 Demel SL Grossman AW khoury JC Moomaw CJ alwell K Kissela BM Woo D Flaherty ML Ferioli S Mackey J De Los Riosla Rosa F Martini S Adeoye O Kleindorfer DO

计算机断层血管造影和常规血管造影为脑卒中患者提供即时的血管解剖学信息。然而，碘化对比剂可能引起急性肾损伤（acutekidneyinjury，AKI）。在一个大型、包括两个族裔的人群中，研究人员检查了脑卒中患者住院期间新发或恶化的肾脏病... 详细信息

计算机断层血管造影和常规血管造影为脑卒中患者提供即时的血管解剖学信息。然而，碘化对比剂可能引起急性肾损伤（acutekidneyinjury，AKI）。在一个大型、包括两个族裔的人群中，研究人员检查了脑卒中患者住院期间新发或恶化的肾脏病的发病率，及其与静脉内给对比剂的相关性。方法：纳入大辛辛那提／北肯塔基州2010年急诊住院的急性缺血性脑卒中或脑出血的所有成年居民。在确定接受或未接受静脉注射对比剂的两组患者中，确定急诊问诊时未察觉到的肾脏疾病的发生率及人院后AKI发生率。

关键词：静脉内对比剂脑卒中患者急性肾损伤肾脏疾病人群计算机断层血管造影急性缺血性脑卒中常规血管造影