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Disagreement between symptom-reflux association analysis parameters in pediatric gastroesophageal reflux disease investigation

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World Journal of Gastroenterology 2010年第19期16卷 2401-2406页

作者： Samuel C lüthold Mascha K Rochat Peter Bhler Division of Gastroenterology Departement of Pediatrics Hospital of Fribourg CH-1708 Fribourg Switzerland Asthma and Allergy Research Group University of Munich Lindwurmstrasse 4 D 80337 Munich Germany

AIM: To assess the agreement within 3 commonly used symptom-reflux association analysis (SAA) parameters investigating gastroesophageal reflux disease (GERD) in infants. METHODS: Twenty three infants with suspected GERD were included in this study. Symptom index (SI), Symptom sensitivity index (SSI) and symptom association probability (SAP) related to cough and irritability were calculated after 24 h combined pH/multiple intraluminal impedance (MII) monitoring. Through defined cutoff values, SI, SSI and SAP values are differentiated in normal and abnormal, whereas abnormal values point towards gastroesophageal reflux (GER) as the origin of symptoms. We analyzed the correlation and the concordance of the diagnostic classification of these 3 SAA ***: Evaluating the GER-irritability association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 39.2% of the infants. When irritability was taken as a symptom, there was only a poor inter-parameter association between SI and SSI, and between SI and SAP (Kendall’s tau b = 0.37, P ll’s tau b = 0.36, P ly). Evaluating the GER-cough association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 52.2% of the patients. When cough was taken as a symptom, only SI and SSI showed a poor inter-parameter association (Kendall’s tau b = 0.33, P lUSION: In infants investigated for suspected GERD with pH/MII-monitoring, SI, SSI and SAP showed a poor inter-parameter association and important dis-agreements in diagnostic classification. These limitations must be taken into consideration when interpreting the results of SAA in infants.

关键词： Gastroesophageal reflux disease Infant Symptom-reflux association analysis Intraluminal impedance monitoring pH

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Phylogenetic relationships of Cypriniformes and plasticity of pharyngeal teeth in the adaptive radiation of cyprinids

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Science China(life Sciences) 2019年第4期62卷 553-565页

作者： Wenjing Tao lei Yang Richard l.Mayden Shunping He Key laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences Institute of Hydrobiology Chinese Academy of Sciences Key laboratory of Freshwater Fish Reproduction and Development (Ministry of Education) Key Laboratory of Aquatic Science of Chongqing School of Life Sciences Southwest University Florida Museum of Natural History University of Florida Department of Biology Saint Louis University CAS Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences

The Cypriniformes comprise approximately 4,200 species accounting for 25% of the diversity of all freshwater fish, which is widely distributed across the world's continents except Antarctica, South America, and Australia. The highest species diversity is found in Southeastern Asia. Despite its remarkable species diversity and broad-scale geographic patterns of distribution, the evolutionary history of this major freshwater fish group remains largely unresolved. To gain insight of the evolutionary history of Cypriniformes, we present a phylogeny of this group using 1 mitochondrial gene and 15 nuclear genes comprising a total of14,061 bp. Bayesian inference using all gene fragments yielded a well resolved phylogeny, which is mostly consistent with topologies obtained from Maximum likelihood analyses. Our results further confirmed the monophyly of Cypriniformes and seven constituent subclades including Cyprinidae, Catostomidae, Gyrinocheilidae, Balitoridae, Cobitidae, Nemacheilidae, and Botiidae. Bayesian divergence time analysis indicated that the origin of the Cypriniformes was about 193 Mya during the early Jurassic, coinciding with the onset of the Pangaea breakup. The basal divergence of Cypriniformes is 154 Mya during the late Jurassic. Our findings from molecular divergence and biogeographical analysis indicate the most likely initial geographical range of the ancient Cypriniformes was both East and South Asia(Southeastern area of Mesozoic laurasia). Moreover, the burst in species diversity in Cyprinidae afforded by the nearly worldwide colonization is possibly in response to the plasticity of pharyngeal dentition. The present study demonstrates that the Cypriniformes was about 193 Mya during the early Jurassic,coinciding with the onset of the Pangaea breakup. The plasticity of pharyngeal dentition of cyprinids might contribute to the burst and radiation of this lineage. The phylogenetic and biogeographic analyses in this study help to improve our understanding

关键词： phylogeny biogeographic analyses Cypriniformes pharyngeal teeth adaptive radiation

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The Impact of Topography on Social Factors,a Case Study of Montenegro

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Journal of Mountain Science 2014年第1期11卷 131-141页

作者： TElBISZ Tamás BOTTlIK Zsolt MARI lászló KOSZEGI Margit Department of Physical Geography Eotvos University Department of Regional Science Eotvos University

Relationships between environmental and social factors have long been studied by ***,GIS-aided statistical analysis provides new tools to explore these *** order to detect the impact of topography on social factors,we selected the country of Montenegro as a case example due to its high topographic *** compared the spatial pattern of population,settlements and ethnic minorities to physical geographic factors,especially to topography,but lithology and land cover data were also taken into *** found that certain factors are closely correlated,*** settlement density linearly decreases with elevation,while the characteristic settlement area shows an exponential increase *** population density is not related to absolute elevation,but it is in close correlation with height(*** relative to the local minimum).Population change and illiteracy are also topography-related social *** the contrary,the variable ethnic pattern of Montenegro is influenced by historical,political and economic effects rather than by environmental factors or topographic *** a conclusion we state that in the scale of a country or a region,the environment can strongly impact some social factors.

关键词： Human-environment relations Dinarides GIS Settlements Population Ethnic groups

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建筑现象学视域下澳门普济禅院空间认知研究

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城市建筑 2024年第9期21卷 183-190页

作者：吕竞轩王松涛李孟顺澳门城市大学创新设计学院中国澳门

目前对于澳门普济禅院的研究往往停留于建筑材质与历史沿革方面,与之密切相关的空间与人的关系方面的研究涉猎较少,进而导致对空间认知的片面化。文章通过实地调研,分析建筑现象学视野下普济禅院的空间格局与人的知觉感受之间的“对话... 详细信息

目前对于澳门普济禅院的研究往往停留于建筑材质与历史沿革方面,与之密切相关的空间与人的关系方面的研究涉猎较少,进而导致对空间认知的片面化。文章通过实地调研,分析建筑现象学视野下普济禅院的空间格局与人的知觉感受之间的“对话”关系。以空间形态、行为路径、场域范围为载体,理清普济禅院空间“现象域”特质,并分析现象域对人产生知觉感受的机制,解析现象学背景下普济禅院的空间价值。在解释普济禅院现象域“纵向”与“横向”两种属性成因的同时归纳其属性特质,为普济禅院及澳门地区本地类似的寺庙建筑的研究与建筑遗产的发展提供一定启示。

关键词：建筑现象学普济禅院场域行为路径知觉感受身体

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Resonant Effects of FPl and SPP for light Transmitting through Subwavelength Metallic Gratings

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Communications in Theoretical Physics 2011年第10期56卷 727-732页

作者：马佑桥周骏何苗 l.Petti P.Mormile Department of Physics Faculty of ScienceNingbo University Photonics Research Centre School of Electronic and Communications EngineeringDublin Institute of Technology Institute of Optoelectronic Materials & Technology South China Normal University Institute of Cybernetics of CNR Via Campi Flegrei 3480072-PozzuoliItaly

A new model is proposed to explain the physical mechanism of the extraordinary transmission enhancement in subwavelength metallic *** extraordinary transmission enhancement is described by the co-operation of Fabry-Perot-like(FPl) resonance and the surface plasmon polariton(SPP) *** rigorous coupled-wave analysis(RCWA) and the finite difference time domain(FDTD) method are employed to illustrate the model by calculating the transmission and the field distributions in the subwavelength metallic grating,*** the numerical calculations show that transmission enhancement is achieved when the coupling resonance of the incident light,the surface plasmon polariton mode and the Fabry-Perot-like mode is happened,which are in good agreement with the proposed model.

关键词： gratings subwavelength structures optics at surfaces surface plasmons

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我国无花果供给侧市场规模评估及建议

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中国果树 2024年第2期 130-133页

作者：殷丹丹王达吕毅张禹威海市农业农村事务服务中心山东264200 中华全国供销合作总社济南果品研究所威海市农业科学院

为进一步促进我国无花果产业高质量发展,以国内学者现有研究成果为基础,结合海关进出口数据,从供给侧的角度对我国无花果市场规模进行了趋势评估。结果显示,2015—2022年,我国无花果鲜果市场规模从约21.70万t快速增长到约63.00万t,且仍... 详细信息

为进一步促进我国无花果产业高质量发展,以国内学者现有研究成果为基础,结合海关进出口数据,从供给侧的角度对我国无花果市场规模进行了趋势评估。结果显示,2015—2022年,我国无花果鲜果市场规模从约21.70万t快速增长到约63.00万t,且仍呈高速增长态势,保鲜贮藏运输难和自主培育品种匮乏已成为阻碍我国无花果进一步发展的主要因素。据此提出积极培育无花果地方特色品种、推进无花果规模化与产业化发展、强化保鲜贮藏技术研发、提升出口产业竞争力等方面的建议。

关键词：无花果供给侧市场规模评估建议

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口腔鳞状细胞癌患者血清NGAl、YKl-40水平及其诊断、预后价值

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口腔颌面外科杂志 2024年第5期34卷 365-370页

作者：赵媛吕继连叶克强林楠裴飞郑州大学附属郑州中心医院口腔颌面外科郑州450007

目的:探讨口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)患者血清中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAl)、甲壳质酶蛋白40(chitinase protein 40,YKl-40)的水平在诊断和预后中的价值。方法:选取本院2017年3月—2020年9月间收治的114例OSCC患者作为研究对象(OSCC组),另选取同期118例本院良性肿瘤病变者作为对照组,酶联免疫吸附试验(enzyme-linked immunosorbent assay,ElISA)检测2组受试者血清NGAl、YKl-40的水平;通过受试者工作特征(receiver operating characteristic,ROC)曲线分析血清NGAl、YKl-40水平在OSCC中的诊断价值;并收集OSCC患者出院后3年内的预后情况,使用Kaplan-Meier法分析OSCC患者血清NGAl、YKl-40水平与其3年预后的关系;采用Cox比例风险回归模型分析影响OSCC患者出院3年预后的危险因素。结果:OSCC组血清NGAl、YKl-40水平显著高于对照组(Pl、YKl-40及二者联合诊断OSCC的曲线下面积(area under the curve,AUC)分别为0.716、0.744、0.791,其中联合诊断的AUC优于单独检测(P=0.008、0.047);不同年龄、性别、吸烟史、发病部位的OSCC患者血清NGAl、YKl-40表达水平比较,差异无统计学意义(P>0.05);TNM分期Ⅲ~Ⅳ期、肿瘤直径≥3 cm、有淋巴结转移患者血清NGAl、YKl-40表达水平显著高于TNM分期Ⅰ~Ⅱ期、肿瘤直径l低表达患者的3年生存率高于NGAl高表达患者,YKl-40低表达患者3年生存率高于YKl-40高表达患者(Pl、YKl-40是影响OSCC患者预后的危险因素(Pl、YKl-40水平均升高,二者对OSCC有一定的诊断价值,并且与患者预后有关。

关键词：口腔鳞状细胞癌中性粒细胞明胶酶相关脂质运载蛋白甲壳质酶蛋白40 诊断预后价值

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Breakup of Cavitation Bubbles within the Diesel Droplet

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Chinese Journal of Mechanical Engineering 2014年第1期27卷 198-204页

作者： l Ming NING Zhi YAN Kai FU Juan SONG Yunchao SUN Chunhua College of Mechanical and Electrical Engineering Beijing Jiaotong University

Supercavitation in the diesel nozzle increases the instability of droplets in part due to the two-phase mixture, while the effect of cavitation bubbles on the instability of drops is still unclear. In order to investigate the breakup of cavitation bubbles within the diesel droplet, a new mathematical model describing the disturbance growth rate of the diesel bubble instability is developed. The new mathematical model is applied to predict the effects of fluids viscosity on the stability of cavitation bubbles. The predicted values reveal that the comprehensive effect of fluids viscosity makes cavitation bubbles more stable. Compared with the viscosities of air and cavitation bubble, the diesel droplet＇s viscosity plays a dominant role on the stability of cavitation bubbles. Furthermore, based on the modified bubble breakup criterion, the effects of bubble growth speed, sound speed, droplet viscosity, droplet density, and bubble-droplet radius ratio on the breakup time and the breakup radius of cavitation bubbles are studied respectively. It is found that a bubble with large bubble-droplet radius ratio has the initial condition for breaking easily. For a given bubble-droplet radius ratio （0.2）, as the bubble growth speed increases （from 2 m/s to 60 m/s）, the bubble breakup time decreases（from 3.59 gs to 0.17 ps） rapidly. Both the greater diesel droplet viscosity and the greater diesel droplet density result in the increase of the breakup time. With increasing initial bubble-droplet radius ratio （from 0.2 to 0.8）, the bubble breakup radius decreases （from 8.86 trn to 6.23 tm）. There is a limited breakup radius for a bubble with a certain initial bubble-droplet radius ratio. The mathematical model and the modified bubble breakup criterion are helpful to improve the study on the breakup mechanism of the secondary diesel droplet under the condition of supercavitation.

关键词： supercavitation instability diesel droplet cavitation bubbles secondary breakup

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Vascularization in interconnected 3D printed Ti-6Al-4V foams with hydrogel matrix for biomedical bone replacement implants

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Science China Materials 2018年第4期61卷 565-578页

作者： Victor l.Correa Kristine M.Garza lawrence E.Murr Department of Metallurgical Materials and Biomedical Engineering University of Texas at El Paso Department of Biological Sciences University of Texas at El Paso

Vascularization on newly implanted metal orthopedic implants has remained a challenge in the field of tissue engineering. To address this challenge, in this research,an interconnected foam structure of Ti-6 Al-4 V was microfabricated by electron beam melting(EBM) technique. The foam in question has a density of 1.77 g cm-3 with 60% porosity and a tensile strength of 18 GPa. An extracellular matrix based hydrogel was added as an aqueous matrix to the *** mimetic stress has been closely related to many wound healing biomedical applications as it increases survival and proliferation molecular signals. To that end, increased expression of hypoxia-inducible factor-1α(Hif-1α) and vascular endothelial growth factor(VEGF) in the aqueous hydrogel matrix was achieved by the addition of a hypoxia mimetic deferoxamine mesylate(DFM). In this study, the formation of an endothelial network was achieved in a hydrogel matrix in the presence of the before mentioned 3 D printed metal foam. Cellular viability, fluorescent microscopy and scanning electron microscopy imaging analysis demonstrate that pre-osteoblasts undergo proliferation and also attach efficiently to the foam when exposed to DFM. Human umbilical vascular endothelial cells(HUVECs) were grown in an extracellular matrix-like 3 D hydrogel and a hypoxia-like stress was achieved. This research demonstrates that pre-osteoblast cells undergo cell differentiation and increase the production of hydroxyapatite on exposure to the hypoxia mimetic molecule. This proposed approach encompasses an ideal prototype for a completely living implanted structure for future orthopedic implants.

关键词： Ti-6Al-4V electron beam melting angiogenesis deferoxamine mesylate hydrogel vascularization

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商用车电控空气干燥器系统仿真分析及应用

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汽车工程师 2024年第1期 30-36页

作者：吕征李淼张炼马明武李法兵东风商用车技术中心武汉430056 一汽解放汽车有限公司长春130011

为提升商用车气制动系统安全性及智能化控制水平,分析了电控干燥器的工作原理,提出以空气再生气耗比作为干燥效能评价指标,通过建立干燥器整车仿真模型,研究了机械干燥器和电控干燥器的干燥效能差异,结合车辆贮气筒压缩空气的露点降实... 详细信息

为提升商用车气制动系统安全性及智能化控制水平,分析了电控干燥器的工作原理,提出以空气再生气耗比作为干燥效能评价指标,通过建立干燥器整车仿真模型,研究了机械干燥器和电控干燥器的干燥效能差异,结合车辆贮气筒压缩空气的露点降实测结果验证了电控干燥器的性能优势,分析了电控干燥器在预防制动管路结冰、节省燃油、预见性维修保养方面的技术优势。

关键词：气压制动电控干燥器再生气耗比干燥效能

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