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1999～2006年急性冠脉综合征患者死亡及心力衰竭发生率降低

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美国医学会杂志（中文版） 2007年第6期26卷 323-330页

作者： Keith A. A. Fox Philippe Gabriel Steg Kim A. Eagle Shaun G. Goodman Frederick A. Anderson Christopher B. Granger marcus D. Flather Andrzej Budaj Ann Quill joel m. Gore 康俊萍（译）马长生（校） Cardiovascular Research Division of Medical and Radiological Sciences The University of Edinburgh Edinburgh Scotland Hospital Bichat Paris France University of michigan Health System Ann Arbor Canadian Heart Research Centre and Terrence Donnelly Heart Centre Division of Cardiology St Michael＇s Hospital University of Toronto Toronto Ontario University of massachusetts medical School Worcester Royal Brompton ＆ Harefield NHS Trust London England Postgraduate medical School Grochowski Hospital Warsaw Poland Duke University medical Center Durham NC 不详

背景：有关药物和介入治疗对ST段抬高型和非ST段抬高型急性冠脉综合征（non—ST-segment elevation acute coronary syndrome，NSTE ACS）患者的作用，随机试验已经提供了足够的证据，但是是否已经转化为相应的临床变化还不清楚。目的... 详细信息

背景：有关药物和介入治疗对ST段抬高型和非ST段抬高型急性冠脉综合征（non—ST-segment elevation acute coronary syndrome，NSTE ACS）患者的作用，随机试验已经提供了足够的证据，但是是否已经转化为相应的临床变化还不清楚。目的：确定ST段抬高型心肌梗死（ST-segment elevation myocardial infarction，STEmI）和NSTE ACS患者的院内治疗改变是否伴随临床结果的改善。设计、地点及患者：全球急性冠脉事件注册研究（Global Registry of Acute Coronary Events，GRACE）是一项多国家队列研究。自1999年7月1日至2006年12月31日，该研究共入选并随访了来自14个国家、113家医院的44372例ACS患者。主要观测指标：当前循证药物和介入治疗应用的趋势及患者预后（死亡、充血性心力衰竭、肺水肿、心源性休克、卒中和心肌梗死）。结果：随着研究时间的进展，相关药物的应用增加（β-受体阻滞剂、他汀类药物、血管紧张素转换酶抑制剂、行或未行经皮冠状动脉介入治疗[percutaneous coronary intervention，PCI]患者应用噻氯毗啶、糖蛋白Ⅱb／Ⅲa抑制剂和低分子肝素；P〈0．001）。STEmI患者药物再灌注治疗下降了22个百分点（95％可信区间[confidence interval，CI]，-27～-17），而直接PCI增加了37个百分点（95％CI，33—41）。在NSTEmI患者中，PCI的比例显著升高了18个百分点（95％CI，15～20）。充血性心力衰竭和肺水肿在STEmI患者中降低了9个百分点（95％CI，-12～-6），在NSTEACS患者中降低了6．9个百分点（95％CI，-8．4～-4．7）。STEmI患者的院内死亡率降低了18个百分点（95％CI，-5．3～-1．9），心源性休克降低了24个百分点（95％CI，-4．3～-0．5）。校正了危险评分后，NSTEACS患者的院内死亡率降低了0．7个百分点（95％CI，-1．7～0．3）；STEmI患者6个月随访时卒中发生率降低了0．8个百分点（95％CI，-1．7～0．1），心肌梗死发生率降低了2．8个百分点（95％CI，-6．4～0．9）。NSTEACS患者6个月死亡率降低了1．6个百分点（95％CI，-3．0～-0．1），卒中发生率降低了0．7个百分点（95％CI，-1．4～0．1）。结论：在本项多国家观察性研究中，ACS患者治疗的改善与6个月新发心力衰竭、死亡率、卒中和心肌梗死发生率显著降低相关。

关键词：充血性心力衰竭急性冠脉综合征院内死亡率发生率经皮冠状动脉介入治疗血管紧张素转换酶抑制剂糖蛋白Ⅱb/Ⅲa抑制剂非ST段抬高型

Global prevalence of hepatitis B virus serological markers among healthcare workers:A systematic review and meta-analysis

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World Journal of Hepatology 2021年第9期13卷 1190-1202页

作者： Gadji mahamat Sebastien Kenmoe Etheline W Akazong Jean Thierry Ebogo-Belobo Donatien Serge mbaga Arnol Bowo-Ngandji Joseph Rodrigue Foe-Essomba marie Amougou-Atsama Chavely Gwladys monamele Chris Andre mbongue mikangue Ginette Irma Kame-Ngasse Jeannette Nina magoudjou-Pekam Cromwel Zemnou-Tepap Dowbiss meta-Djomsi martin maidadi-Foudi Sabine Aimee Touangnou-Chamda Audrey Gaelle Daha-Tchoffo Abdel Aziz Selly-Ngaloumo Rachel Audrey Nayang-mundo Jacqueline Felicite Yengue Jean Bosco Taya-Fokou Lorraine K m Fokou Raoul Kenfack-momo Dimitri Tchami Ngongang Efietngab Atembeh Noura Herve Raoul Tazokong Cynthia Paola Demeni Emoh Cyprien Kengne-Nde Jean joel Bigna Onana Boyomo Richard Njouom Department of microbiology The University of Yaounde IYaounde 00237Cameroon Department Centre Pasteur of CameroonYaounde 00237Cameroon Department of Biochemistry University of DschangDschang 00237Cameroon medical Research Centre Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Department of mycobacteriology Centre Pasteur of CameroonYaounde 00237Cameroon Centre de Recherche sur les maladies Emergentes et Re-Emergentes Institut de Recherches Medicales et d'Etudes des Plantes MedicinalesYaounde 00237Cameroon Department of Biochemistry The University of Yaounde IYaounde 00237Cameroon Department of medical Biochemistry The University of Yaounde IYaounde 00237Cameroon Department of microbiology Protestant University of Central AfricaYaounde 00237Cameroon Department of Animals Biology and Physiology The University of Yaounde IYaounde 00237Cameroon Evaluation and Research Unit National AIDS Control CommitteeYaounde 00237Cameroon Department of Epidemiology and Public Health Centre Pasteur of CameroonYaounde 00237Cameroon

BACKGROUND The hepatitis B virus(HBV)infection is a global public health concern that affects about 2 billion people and causes 1 million people deaths *** is a bloodborne disease and healthcare workers(HCWs)are a high-risk group because of occupational hazard to patients’*** regions of the world show a highly variable proportion of HCWs infected and/or immunized against *** data on serologic markers of HBV infection and immunization in HCWs are very important to improve strategies for HBV *** To determine the worldwide prevalence of HBV serological markers among *** In this systematic review and meta–analyses,we searched Pubmed and Excerpta medica Database(Embase)to identify studies published between 1970 and 2019 on the prevalence of HBV serological markers in HCWs *** also manually searched for references of relevant *** independent investigators selected studies and included those on the prevalence of each of the HBV serological markers including hepatitis B surface antigen(HBsAg),hepatitis e antigen(HBeAg),immunoglobulin m anti-HBc,and *** quality of eligible studies was assessed and random-effect model meta-analysis resulted in the pooled prevalence of HBV serological markers HBV infection in ***(I²)was assessed using theχ²test on Cochran’s Q statistic and H ***’sources were explored through subgroup and metaregression *** study is registered with PROSPERO,number *** We reviewed 14059 references,out of which 227 studies corresponding to 448 prevalence data among HCWs(224936 HCWs recruited from 1964 to 2019 in 71 countries)were included in this *** pooled seroprevalences of current HBsAg,current HBeAg,and acute HBV infection among HCWs were 2.3%[95% confidence interval(CI):1.9-2.7],0.2%(95%CI:0.0-1.7),and 5.3%(95%CI:1.4-11.2),*** pooled seroprevalences of total immunity against HBV and immu

关键词： Healthcare workers Hepatitis B virus Seroprevalence Hepatitis B surface antigen Hepatitis e antigen

Higher IL-8 Response to <i>mycobacterium tuberculosis</i>Antigens in Women above 40 Years

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Journal of Tuberculosis Research 2021年第4期9卷 266-275页

作者： marielle Leboueny Priscillia Virginie Liesse mbourou mensah Paulin N. Essone Anicet Christel maloupazoa Siawaya Amel Kévin Alame-Emane Amandine mveang Nzoghe Dimitri Ulrich Essamazokou Carene Anne Ndong Sima Sima Ofilia mvoundza Ndjindji Guy-Stéphane Padzys Joseph Privat Ondo Brigitte Gicquel joel Fleury Djoba Siawaya Service Laboratoire Centre Hospitalier Universitaire Mère Enfant Fondation Jeanne EBORI Libreville Gabon Département de chimie Faculté des Sciences Université des Sciences et Techniques de Masuku Franceville Gabon Centre de Recherches médicales de Lambaréné BP 242 Lambaréné Gabon Unité des Recherche et de Diagnostic Spécialisé Laboratoire National de Santé Publique Libreville Gabon Department of Biomedical Sciences Division of Molecular Biology and Human Genetics Faculty of Medicine and Health Sciences Stellenbosch University Stellenbosch South Africa Département de Biologie Faculté des Sciences Université des Sciences et Techniques de Masuku Franceville Gabon Unité de Génétique mycobactérienne Institut Pasteur Paris France

Objective: Circulating levels of sex hormones vary with age. moreover, there is emerging evidence supporting that sex hormones have an influence on the immune response of women. Here, we investigated age-associated le... 详细信息

Objective: Circulating levels of sex hormones vary with age. Moreover, there is emerging evidence supporting that sex hormones have an influence on the immune response of women. Here, we investigated age-associated levels of sex hormones and Mycobacterium tuberculosis (Mtb) specific cytokines response in women. Design: Using immunoassay methods, we have measured and compared secretion levels of E2, P4 and Mtb specific secretion of 11 cytokines including Granulocyte-macrophage colony-stimulating factor (GM-CSF), Interferon gamma (IFN-γ), Interleukin 1 beta (IL-1βmily:Verdana;">), IL-10, IL-12 (p70

关键词： IL-8 mycobacterium tuberculosis Estradiol (E2) Progesterone (P4)

柴达木盆地大红沟剖面新生代地层磁组构特征及构造意义

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柴达木盆地大红沟剖面新生代地层磁组构特征及构造意义

Unveiling the global reach of African anthrax research:a bibliometric study

2016中国地球科学联合学术年会

作者：苏庆达聂军胜 joel E.Saylor Brian K.Horton meredith A.Bush 陈文汉兰州大学资源环境学院西部环境教育部重点实验室 Department of Earth and Atmospheric Sciences University of Houston Department of Geological Sciences and Institute for Geophysics Jackson School of Geosciences University of Texas at Austin Department of Geological Sciences Jackson School of Geosciences University of Texas at Austin USA

研究表明柴达木盆地新生代沉积物磁化率各向异性能够有效记录印度-欧亚板块碰撞的应力场方向,然而过去对该盆地磁组构研究主要集中在始新世下干柴沟组和中新世下油砂山组,因此不能有效界定应力场方向发生变化的年代。本文对柴达木盆地... 详细信息

研究表明柴达木盆地新生代沉积物磁化率各向异性能够有效记录印度-欧亚板块碰撞的应力场方向,然而过去对该盆地磁组构研究主要集中在始新世下干柴沟组和中新世下油砂山组,因此不能有效界定应力场方向发生变化的年代。本文对柴达木盆地北缘大红沟剖面沉积岩进行了详细的磁组构分析,获得了新生代较高分辨率(平均6～10m)的磁化率各向异性数据。结果表明,下干柴沟组、上干柴沟组、下油砂山组和上油砂山组及狮子沟组磁面理发育较为明显,磁化率椭球体呈压扁状,具有较强

关键词：磁组构新生代地层大红沟柴达木盆地构造意义

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Science in One Health

Science in One Health 2024年第1期3卷 108-117页

作者： Ishaku Leo Elisha Arieri Onikisateinba Ganih Saidu joel Pam Dachung Luka Barde Israel Joshua Shuaibu Hafsat Jagab Rabi Ahmed Habibu Haliru Sa’adatu Aliyu Abubakar Sunday makama Ngulukun Samuel Sati maryam muhammad National Veterinary Research Institute Vom P.M.B.01 VomPlateau StateNigeria State Key Laboratory for Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of ScienceChina Department of Biosecurity National Biosafety Management AgencyAbujaNigeria National Reference Laboratory Nigeria Centre for Disease Control and PreventionAbujaNigeria

Anthrax is a zoonotic bacterial disease caused by Bacillus *** poses significant threat to humans through contact with infected animals or their *** arise from its long-lasting spore viability and lethality,fuelling its biowarfare *** anthrax outbreaks across multiple African nations prompted this bibliometric *** aim of the study was to assess the contributions of African countries,institutions,authors,research funding,and collaborations,while identifying research trends and *** conducted an extensive bibliometric analysis of anthrax-related research publications in Africa from 1923 to 2023,utilizing the Scopus database and *** study covered 364 publications from 32 African countries,accumulating 5,636 citations at an average of 15.5 citations per article,with research articles comprising 88.5%of the *** publication growth rate from 1923 to 2023 was modest at 8.3%,indicating gradual ***,there was a significant surge in publications between 2011 and 2023,accounting for 73.1%of total *** African research contributions,were categorized into five thematic focuses:ecological dynamics and host interactions,human-livestock anthrax interface,molecular insights into bacterial activity and treatment strategies,collaborative approaches for zoonotic disease prevention,and antibody response and vaccination *** institutional contributors included the University of Pretoria and the University of *** extended globally to 35 non-African countries,with significant involvement from the United States,United Kingdom,and *** African partnerships,especially between Kenya,Nigeria,and South Africa,*** top 10 cited papers explored diverse aspects,including disease impact on wildlife and innovative control strategies,underscoring the importance of multidisciplinary *** Africa played a prominent role,contributing 95 publications

关键词： Africa Anthrax Bibliometrics Collaborations Global impacts Outbreaks

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新卫城博物馆

城市环境设计 2016年第1期 154-167页

作者： Bernard Tschumi joel Rutten Adam Dayem Jane Kim Aristotelis Dimitrakopoulos Eva Sopeoglou Kim Starr Anne Save de Beaurecueil joel Aviles Valentin Bontjes van Beek Jonathan Chace Allis Chee Thomas Goodwill Robert Holton Liz Kim Daniel Holguin michaela metcalfe Justin moore Georgia Papadavid Kriti Siderakis Véronique Descharrèires Cristina De Vizzi Kate Linker

项目位于卫城山脚下,处于雅典炎热的气候之中和地震带之上。拥有约21 000m2建筑面积的博物馆包括了约8 000m2的馆藏展示空间、一些临时画廊、可容纳180人的会堂、餐厅加咖啡厅、礼品店、接待和咨询处、策展和行政办公室以及文物保护工... 详细信息

项目位于卫城山脚下,处于雅典炎热的气候之中和地震带之上。拥有约21 000m2建筑面积的博物馆包括了约8 000m2的馆藏展示空间、一些临时画廊、可容纳180人的会堂、餐厅加咖啡厅、礼品店、接待和咨询处、策展和行政办公室以及文物保护工作室。

关键词：博物馆建筑面积雅典博物院文化机构希腊卫城帕特农神庙

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鲁昂音乐厅及展览中心

城市环境设计 2016年第1期 114-119页

作者： Bernard Tschumi Peter Cornell megan miller joel Rutten Kim Starr Roderick Villafranca Robert Holton Véronique Descharrèires Alex Reid Christina Devizzi Laurane Ponsonnet Kevin Collins

这座音乐厅及展览中心被视为促进鲁昂区经济文化发展的重要市政设施。它坐落于城市的门户地带,距离巴黎只有一个半小时的车程。7 000个座席的音乐厅、面积达7 000m2的展厅以及一系列开放空间构成了富有冲击力的当代形象,为区域经济文化... 详细信息

这座音乐厅及展览中心被视为促进鲁昂区经济文化发展的重要市政设施。它坐落于城市的门户地带,距离巴黎只有一个半小时的车程。7 000个座席的音乐厅、面积达7 000m2的展厅以及一系列开放空间构成了富有冲击力的当代形象,为区域经济文化的复苏添砖加瓦。声学上的要求促成了音乐厅双层表皮的建筑语言。内

关键词：鲁昂展览中心公共建筑音乐厅建筑物

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美三大律师解读美知识产权策略

Fluctuating temperature modifies heat-mortality association around the globe

国际法学 2005年第5期

作者： Louis S·mastriani joel E·Lutzker Tom m·Schaumberg

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The Innovation 2022年第2期3卷 65-72页

作者： Yao Wu Bo Wen Shanshan Li Antonio Gasparrini Shilu Tong Ala Overcenco Ales Urban Alexandra Schneider Alireza Entezari Ana maria Vicedo-Cabrera Antonella Zanobetti Antonis Analitis Ariana Zeka Aurelio Tobias Barrak Alahmad Ben Armstrong Bertil Forsberg CarmenÍñiguez Caroline Ameling César De la Cruz Valencia ChristoferÅström Danny Houthuijs Do Van Dung Dominic Royé Ene Indermitte Eric Lavigne Fatemeh mayvaneh Fiorella Acquaotta Francesca de’Donato Francesco Sera Gabriel Carrasco-Escobar Haidong Kan Hans Orru Ho Kim Iulian-Horia Holobaca Jan Kyselý Joana madureira joel Schwartz Klea Katsouyanni magali Hurtado-Diaz martina SRagettli masahiro Hashizume mathilde Pascal micheline de Sousa Zanotti Stagliorio Coélho Noah Scovronick Paola michelozzi Patrick Goodman Paulo Hilario Nascimento Saldiva Rosana Abrutzky Samuel Osorio Tran Ngoc Dang Valentina Colistro Veronika Huber Whanhee Lee Xerxes Seposo Yasushi Honda michelle L.Bell Yuming Guo Department of Epidemiology and Preventive medicine School of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Department of Public Health Environments and SocietyLondon School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre for Statistical methodology London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre on Climate Change&Planetary Health London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Shanghai Children’s medical Centre Shanghai Jiao Tong UniversityShanghai 200025China School of Public Health Institute of Environment and Human HealthAnhui Medical UniversityHefei 230032China Center for Global Health Nanjing Medical UniversityNanjing 211166China School of Public Health and Social Work Queensland University of TechnologyBrisbane 4000Australia National Agency for Public Health of the ministry of Health Labour and Social Protection of the Republic of MoldovaChisinau MD-2009Republic of Moldova Institute of Atmospheric Physics Czech Academy of SciencesPrague 14100Czech Republic Faculty of Environmental Sciences Czech University of Life SciencesPrague 16500Czech Republic Institute of Epidemiology Helmholtz Zentrum M€unchen-German Research Center for Environmental HealthNeuherberg 85747Germany Faculty of Geography and Environmental Sciences Hakim Sabzevari UniversitySabzevar ***Iran Institute of Social and Preventive medicine University of BernBern 3012Switzerland Oeschger Center for Climate Change Research University of BernBern 3012Switzerland Department of Environmental Health Harvard T.H.Chan School of Public HealthHarvard UniversityBostonMA 02115USA Department of Hygiene Epidemiology and Medical StatisticsNational and Kapodistrian University of AthensAthens 11527Greece Institute for Environment Healthand SocietiesBrunel University LondonLondon UB83PNUK Institute of Environmental Assessment and

Studies have investigated the effects of heat and temperature variability(TV)on ***,few assessed whether TV modifies the heat-mortality *** on daily temperature and mortality in the warm season were collected from 717 locations across 36 *** was calculated as the standard deviation of the average of the same and previous days’minimum and maximum temperatures.

关键词： deviation modif heat