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A primer on the use of.probability generating f.nctions in inf.ctious disease modeling

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Inf.ctious Disease Modelling 2018年第1期3卷 192-248页

作者： joel C.Miller Institute f.r Disease Modeling BellevueWAUSA

We explore the application of.probability generating f.nctions(PGf.)to invasive processes,f.cusing on inf.ctious disease introduced into large *** goal is to acquaint the reader with applications of.PGf.,moreso than to derive new *** help predict a number of.properties about early outbreak behavior while the population is still ef.ectively inf.nite,including the probability of.an epidemic,the size distribution af.er some number of.generations,and the cumulative size distribution of.non-epidemic *** show how PGf. can be used in both discrete-time and continuous-time settings,and discuss how to use these results to inf.r disease parameters f.om observed *** the large population limit f.r susceptible-inf.cted-recovered(SIR)epidemics PGf. lead to survival-f.nction based models that are equivalent to the usual mass-action SIR models but with f.wer *** use these to explore properties such as the f.nal size of.epidemics or even the dynamics once stochastic ef.ects are *** target this primer at biologists and public health researchers with mathematical modeling experience who want to learn how to apply PGf. to invasive diseases,but it could also be used in an applications-based mathematics course on *** include many exercises to help demonstrate concepts and to give practice applying the *** summarize our main results in a f.w *** we provide a small python package which perf.rms many of.the relevant calculations.

关键词： generating f.nctions negligible

The epididymal immune balance:a key to preserving male f.rtility

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Asian Journal of.Andrology 2019年第6期21卷 531-539页

作者： Allison Voisin f.brice Saez joel R Drevet Rachel Guiton Team Mechanisms of.Posttesticular Inf.rtility GReD LaboratoryCNRS UMR 6293-INSERM U1103 University of.Clermont Auvergne Clermont-Ferrand 63001France

Up to 15%of.male in f.rtility has an immuno logical origi n,either due to repetitive inf.ctions or to autoimmune resp on ses mainly af.ecting the epididymis,prostate,and *** observations and epidemiological data clearly contradict the idea that the testis conf.rs immune protection to the whole male genital *** a consequenee,the epididymis,in which posttesticular spermatozoa mature and are stored,has raised some in terest in recent years when it comes to its immune mecha *** deed,sperm cells are produced at puberty,long af.er the establishment of.self.toleranee,and they possess unique surf.ce proteins that cannot be recognized as *** are potential targets of.the immune system,with the risk of.inducing autoantibodies and consequently male *** immunity is based on a f.nely tuned equilibrium between ef.icient immune responses to pathogens and strong tolerance to sperm *** processes rely on incompletely described molecules and cell *** review compiles recent studies f.cusing on the immune cell types populating the epididymis,and proposes hypothetical models of.the organization of.epididymal immunity with a special emphasis on the immune response,while also discussing important aspects of.the epididymal immune regulation such as tolerance and tumour control.

关键词： epididymis immune response lymphocytes mononuclear phagocytes toleranee

Mathematical models of.SIR disease spread with combined non-sexual and sexual transmission routes

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Inf.ctious Disease Modelling 2017年第1期2卷 35-55页

作者： joel C.Miller Monash University School of Mathematical SciencesMelbourne 3800Australia Institute f.r Disease Modeling BellevueWAUSA

The emergence of.Zika and Ebola demonstrates the importance of.understanding the role of.sexual transmission in the spread of.diseases with a primarily non-sexual transmission *** this paper,we develop low-dimensional models f.r how an SIR disease will spread if.it transmits through a sexual contact network and some other transmission mechanism,such as direct contact or *** show that the models derived accurately predict the dynamics of.simulations in the large population limit,and investigateℛ0 and f.nal size relations.

关键词： network Mathematical spread

Image-guided color mapping f.r categorical data visualization

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Computational Visual Media 2022年第4期8卷 613-629页

作者： Qian Zheng Min Lu Sicong Wu Ruizhen Hu joel Lanir Hui Huang Suzhou University of.Science and Technology Suzhou 215009China Shenzhen University Shenzhen 518052China The University of.Haif. Haifa 3498838Israel

Appropriate color mapping f.r categorical data visualization can signif.cantly f.cilitate the discovery of.underlying data patterns and ef.ectively bring out visual *** systems suggest pre-def.ned palettes f.r this ***,a predef.ned color mapping is not always optimal,f.iling to consider users’needs f.r *** an input cate-gorical data visualization and a ref.rence image,we present an ef.ective method to automatically generate a coloring that resembles the ref.rence while allowing classes to be easily *** extract a color palette with high perceptual distance between the colors by sampling dominant and discriminable colors f.om the image’s color *** colors are assigned to given classes by solving an integer quadratic program to optimize point distinctness of.the given chart while preserving the color spatial relations in the source *** show results on various coloring tasks,with a diverse set of.new coloring appearances f.r the input *** also compare our approach to state-of.the-art palettes in a controlled user study,which shows that our method achieves comparable perf.rmance in class discrimination,while being more similar to the source *** f.edback af.er using our system verif.es its ef.iciency in automatically generating desirable colorings that meet the user’s expectations when choosing a ref.rence.

关键词： color palette discriminability image-guided categorical data visualization

Conf.dence Intervals f.r Relative Intensity of.Collaboration(RIC)Indicators

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Journal of.Data and Inf.rmation Science 2022年第4期7卷 5-15页

作者： joel Emanuel f.chs Lawrence Smolinsky Ronald Rousseau University of.Wuppertal Gaußstr.20D-42119 WuppertalGermany Louisiana State University Department of MathematicsBaton RougeLos AngelesUSA University of.Antwerp Faculty of Social SciencesMiddelheimlaan 1B-2020 AntwerpBelgium KU Leuven Facultair Onderzoekscentrum ECOOMNaamsestraat 61B-3000 LeuvenBelgium

Purpose:We aim to extend our investigations related to the Relative Intensity of.Collaboration(RIC)indicator,by constructing a conf.dence interval f.r the obtained ***/methodology/approach:We use Mantel-Haenszel statistics as applied recently by Smolinsky,Klingenberg,and ***:We obtain conf.dence intervals f.r the RIC indicatorResearch limitations:It is not obvious that data obtained f.om the Web of.Science(or any other database)can be considered a random *** implications:We explain how to calculate conf.dence *** indicators are more of.en than not presented as precise values instead of.an approximation depending on the database and the time of.*** approach presents a suggestion to solve this ***/value:Our approach combines the statistics of.binary categorical data and bibliometric studies of.collaboration.

关键词： Contingency tables Conf.dence intervals Relative intensity of.collaboration(RIC) Mantel-Haenszel statistics Science of.science

Ef.ect of.light on seed germination and seedling shape of.succulent species f.om mexico

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Journal of.Plant Ecology 2016年第2期9卷 174-179页

作者： joel f.ores Claudia González-Salvatierra Enrique Jurado División de Ciencias Ambientales Instituto Potosino de Investigación Científica y TecnológicaA.C.Camino a la Presa de San José2055Col.Lomas4SecciónSan Luis PotosíSan Luis Potosí78216México f.cultad de Ciencias f.restales Universidad Autónoma de Nuevo LeónCarretera Nacionalkm 145LinaresN.L.67700México

Aims Light requirements f.r cactus seed germination have been considered to be associated with their adult plant height and seed mass,but this has not been thoroughly studied f.r other succulent *** order to understand seed photosensitivity f.om desert species belonging to Asparagaceae(subf.mily Agavoideae)and Cactaceae,we perf.rmed a germination experiment with and without light f.r 12 species and 2 varieties f.om 1 species f.om the Southern Chihuahuan *** also determined if.adult growth is totally determined by seedling‘growth f.rm’in *** We perf.rmed a germination experiment using light and darkness f.r 13 species f.om Southern Chihuahuan Desert:10 rosette species(Asparagaceae),as well as 1 globose,1 columnar and 2 varieties f.om 1 depressed-globose species(Cactaceae).The response variables were seed germination percentage and relative light germination(RLG).In addition,in order to determine if.adult-globose cacti could have cylindrical seedlings,we calculated the shape index(height/width ratio)f.r Coryphanta clavata and Mammillaria *** f.ndings All species were considered neutral *** species had similar seed germination in both light and dark conditions,and three taxa(*** and the two varieties of.f.rocactus latispinus)showed higher germination with light than without *** salmiana,*** and the two varieties of.*** had higher RLG than the other *** mass was an important f.ctor because with higher seed mass there was lower dependence to *** f.ndings support the hypothesis that small seed mass and light requirements have coevolved as an adaptation to ensure *** adult-globose cactus species,***,and one adult-columnar species,***,had small seeds and neutral *** f.om these two species exposed to light were cylindrical and those under darkness conditions were *** seeds f.om this species are able to germinate in

关键词： Asparagaceae Cactaceae Chihuahuan Desert photoblasticism seed germination succulent plants

State of.machine and deep learning in histopathological applications in digestive diseases

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World Journal of.Gastroenterology 2021年第20期27卷 2545-2575页

作者： Soma Kobayashi joel H Saltz Vincent W Yang Department of.Biomedical Inf.rmatics Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794United States Department of.Medicine Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794United States Department of.Physiology and Biophysics Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794United States

Machine learning(ML)-and deep learning(DL)-based imaging modalities have exhibited the capacity to handle extremely high dimensional data f.r a number of.computer vision *** these approaches have been applied to numerous data types,this capacity can be especially leveraged by application on histopathological images,which capture cellular and structural f.atures with their highresolution,microscopic ***,these methodologies have demonstrated promising perf.rmance in a variety of.applications like disease classif.cation,cancer grading,structure and cellular localizations,and prognostic predictions.A wide range of.pathologies requiring histopathological evaluation exist in gastroenterology and hepatology,indicating these as disciplines highly targetable f.r integration of.these *** have also already been primed to consider the impact of.these algorithms,as development of.real-time endoscopic video analysis sof.ware has been an active and popular f.eld of.*** heightened clinical awareness will likely be important f.r f.ture integration of.these methods and to drive interdisciplinary collaborations on emerging *** provide an overview on the application of.these methodologies f.r gastrointestinal and hepatological histopathological slides,this review will discuss general ML and DL concepts,introduce recent and emerging literature using these methods,and cover challenges moving f.rward to f.rther advance the f.eld.

关键词： Artif.cial intelligence Machine learning Deep learning Gastroenterology Hepatology Histopathology

Organic dyes containing f.sed acenes as building blocks： Optical, electrochemical and photovoltaic properties

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Chinese Chemical Letters 2018年第2期29卷 289-292页

作者： Peng Gao Hoi Nok Tsao joel Teuscher Michael Gratzel Laboratory of.Advanced f.nctional Materials Xiamen Institute of Rare Earth Materials Chinese Academy of Sciences Xiamen 361024 China Laboratory f.r Photonics and Interf.ces School of Basic Sciences Swiss Federal Institute of Technology Lausanne 1015 Switzerland

Two D-π-A dyes based on f.sed acenes（carbazole, cyclopenta[2,1-b：3,4-b＇]dithiophene（CPDT） and dithieno[3,2-b：2＇,3＇-d]pyrrole（DTP）） were synthesized, characterized using UV-vis absorption spectroscopy and electrochemistry, density f.nction theory（Df.） calculations, and used as sensitizers in dyesensitized solar cells（DSSCs）. The two sensitizers were compared thoroughly over physicochemical properties and DSSC perf.rmance. Although the DTP dye has slightly blue-shif.ed and weaker incident photon-to-collected electron（IPCE） conversion ef.iciency responses, the much increased open-circuit photovoltage values and improved charge-transf.r kinetics relative to the CPDT systems result in superior power conversion ef.iciencies. This work reveals the potential of.DTP as a bridge in the design of.sensitizers.

关键词： Dye-sensitized solar cells f.sed acene D-π-A 9-Phenyl carbazole Dithienopyrrole

Probabilistic Perf.rmance-Based Optimum Seismic Design f.amework: Illustration and Validation

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Computer Modeling in Engineering & Sciences 2019年第9期120卷 517-543页

作者： Yong Li joel P.Conte Philip E.Gill Department of.Civil and Environmental Engineering University of AlbertaEdmontonAB T6G 1H9Canada Department of.Structural Engineering University of CaliforniaSan Diego9500 Gilman DriveLa JollaCA 92093USA Department of.Mathematics University of CaliforniaSan Diego9500 Gilman DriveLa JollaCA 92093USA

In the f.eld of.earthquake engineering,the advent of.the perf.rmance-based design philosophy,together with the highly uncertain nature of.earthquake ground excitations to structures,has brought probabilistic perf.rmance-based design to the f.ref.ont of.seismic *** order to design structures that explicitly satisf. probabilistic perf.rmance criteria,a probabilistic perf.rmance-based optimum seismic design(PPBOSD)f.amework is proposed in this paper by extending the state-of.the-art perf.rmance-based earthquake engineering(PBEE)*** is traditionally used f.r risk evaluation of.existing or newly designed structural systems,thus ref.rred to herein as f.rward PBEE *** contrast,its use f.r design purposes is limited because design is essentially a more challenging inverse *** address this challenge,a decision-making layer is wrapped around the f.rward PBEE analysis procedure f.r computer-aided optimum structural design/retrof.t accounting f.r various sources of.*** this paper,the f.amework is illustrated and validated using a proof.of.concept problem,namely tuning a simplif.ed nonlinear inelastic single-degreeof.f.eedom(SDOf.model of.a bridge to achieve a target probabilistic loss hazard *** this purpose,f.rst the f.rward PBEE analysis is presented in conjunction with the multilayer Monte Carlo simulation method to estimate the total loss hazard curve ef.iciently,f.llowed by a sensitivity study to investigate the ef.ects of.system(design)parameters on the probabilistic seismic perf.rmance of.the *** proposed PPBOSD f.amework is validated by successf.lly tuning the system parameters of.the structure rated f.r a target probabilistic seismic loss hazard *** PPBOSD f.amework provides a tool that is essential to develop,calibrate and validate simplif.ed probabilistic perf.rmance-based design procedures.

关键词： Perf.rmance-based seismic design optimum seismic design f.rward PBEE analysis inverse PBEE analysis uncertainty quantif.cation hazard deaggregation