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Acute heart failure in elderly patients:a review of invasive and non-invasive management

Journal of Geriatric Cardiology 2021年第7期18卷 560-576页

作者： Gregorio Tersalvi Alessio Gasperetti Marco Schiavone Jeroen Dauw Cecilia Gobbi Marialessia Denora joel daniel krul Giacomo Maria Cioffi Gianfranco Mitacchione Giovanni B.Forleo Department of Internal Medicine Hirslanden Klinik St.AnnaLucerneSwitzerland Cardiology Unit ASST-Fatebenefratelli SaccoLuigi Sacco University HospitalMilanItaly Department of Cardiology Ziekenhuis Oost-LimburgGenkBelgium Doctoral School for Medicine and Life Sciences Hasselt UniversityDiepenbeekBelgium Institut Cardiovasculaire de Caen Hôpital PrivéSaint MartinCaenFrance Division of Cardiology Fondazione Cardiocentro TicinoLuganoSwitzerland Division of Cardiology Heart CenterLuzerner KantonsspitalLucerneSwitzerland

Acute heart failure(AHF)is a major cause of unplanned hospitalisations in the elderly and is associated with high *** prevalence has grown in the last years due to population aging and longer life expectancy of chronic heart failure *** international societies have provided guidelines for the management of AHF in the general population,scientific evidence for geriatric patients is often lacking,as these are underrepresented in clinical *** have a different risk profile with more comorbidities,disability,and frailty,leading to increased morbidity,longer recovery time,higher readmission rates,and higher ***,therapeutic options are often limited,due to unfeasibility of invasive strategies,mechanical circulatory support and cardiac ***,the in-hospital management of AHF should be tailored to each patient's clinical situation,cardiopulmonary condition and geriatric *** care should be considered in some cases,in order to avoid unnecessary diagnostics and/or *** discharge,a strict follow-up through outpatient clinic or telemedicine is can improve quality of life and reduce rehospitalisation *** aim of this review is to offer an insight on current literature and provide a clinically oriented,patient-tailored approach regarding assessment,treatment and follow-up of elderly patients admitted for AHF.

关键词： patients mortality invasive

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Application of near-infrared spectroscopy for fast germplasm analysis and classification in multi-environment using intact-seed peanut(Arachis hypogaea L.)

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Oil Crop Science 2024年第2期9卷 132-141页

作者： Fentanesh Chekole Kassie Gilles Chaix Hermine Bille Ngalle Maguette Seye Coura Fall Hodo-Abalo Tossim Aissatou Sambou Olivier Gibert Fabrice Davrieux Joseph Martin Bell Jean-Francois Rami daniel Fonceka joel Romaric Nguepjop Department of Plant Biology and Physiology Faculty of SciencesUniversity of Yaounde IYaoundeP.O.Box 337Cameroon Department of Plant Science College of AgricultureWolaita Sodo UniversitySodoP.O.Box 138Ethiopia CIRAD UMR AGAP InstitutMontpellierFrance AGAP Institut Univ MontpellierCIRADINRAEInstitut AgroMontpellierFrance ChemHouse Research Group MontpellierFrance Centre D’Etudes Regional Pour L’Amelioration de L’Adaptation a La Secheresse(CERAAS/ISRA) Route de KhomboleThiesBP 3320Senegal Dispositif de Recherche et de Formation en Partenariat Innovation et Amelioration Varietale en Afrique de L’Ouest(IAVAO)CERAASRoute de KhomboleThiesBP 3320Senegal CIRAD UMR QUALISUDSaint PierreFrance

Peanut is a worldwide oilseed crop and the need to assess germplasm in a non-destructive manner is important for seed nutritional *** this study,Near Infrared Spectroscopy(NIRS)was applied to rapidly assess germplasm variability from whole seed of 699 samples,field-collected and assembled in four genetic and environmentbased sets:one set of 300 varieties of a core-collection and three sets of 133 genotypes of an interspecific population,evaluated in three environments in a large spatial scale of two countries,Mbalmayo and Bafia in Cameroon and Nioro in Senegal,under rainfed *** elemental spectra were gathered on six subsets of seeds of each sample,after three rotation scans,with a spectral resolution of 16 cm-1over the spectral range of867 nm to 2530 *** were then processed by principal component analysis(PCA)coupled with Partial least squares-discriminant analysis(PLS-DA).As results,a huge variability was found between varieties and genotypes for all NIR wavelength within and between *** magnitude of genetic variation was particularly observed at 11 relevant wavelengths such as 1723 nm,usually related to oil content and fatty acid *** yielded the most chemical attributes in three significant PCs(i.e.,eigenvalues>10),which together captured 93%of the total variation,revealing genetic and environment structure of varieties and genotypes into four clusters,corresponding to the four samples *** pattern of genetic variability of the interspecific population covers,remarkably half of spectrum of the core-collection,turning out to be the ***,a PLS-DA model was developed and a strong accuracy of 99.6%was achieved for the four sets,aiming to classify each seed sample according to environment *** confusion matrix achieved for the two sets of Bafia and Nioro showed 100%of instances classified correctly with 100%at both sensitivity and specificity,confirming that their seed quality was different f

关键词： Groundnut Oilseed Near infrared spectroscopy Germplasm analysis Environment Nutritional Breeding

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Review of additive manufactured tissue engineering scaffolds:relationship between geometry and performance

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Burns & Trauma 2018年第3期6卷 167-182页

作者： Andrew Gleadall Dafydd Visscher Jing Yang daniel Thomas joel Segal Wolfson School of Mechanical and Manufacturing Engineering Loughborough UniversityLoughboroughLeicestershire LE11 3TUUK Department of Plastic Reconstructive and Hand SurgeryVU University Medical CenterAmsterdam Movement SciencesAmsterdamThe Netherlands Faculty of Science School of PharmacyUniversity of NottinghamUniversity ParkNottingham NG7 2RDUK 3Dynamic Systems Heol Ty Gwyn Industrial EstateBridgend CF34 0BQUK Advanced Manufacturing Technology Research Group Faculty of EngineeringUniversity of NottinghamUniversity ParkNottingham NG7 2RDUK.

Material extrusion additive manufacturing has rapidly grown in use for tissue engineering research since its adoption in the year 2000. It has enabled researchers to produce scaffolds with intricate porous geometries that were not feasible with traditional manufacturing processes. Researchers can control the structural geometry through a wide range of customisable printing parameters and design choices including material, print path, temperature, and many other process parameters. Currently, the impact of these choices is not fully understood. This review focuses on how the position and orientation of extruded filaments, which sometimes referred to as the print path, lay-down pattern, or simply'scaffold design', affect scaffold properties and biological performance. By analysing trends across multiple studies, new understanding was developed on how filament position affects mechanical properties. Biological performance was also found to be affected by filament position, but a lack of consensus between studies indicates a need for further research and understanding. In most research studies, scaffold design was dictated by capabilities of additive manufacturing software rather than free-form design of structural geometry optimised for biological requirements. There is scope for much greater application of engineering innovation to additive manufacture novel geometries. To achieve this, better understanding of biological requirements is needed to enable the effective specification of ideal scaffold geometries.

关键词： Fused deposition modelling Bioprinting 3D printing Scaffold architecture Tissue engineering constructs Regenerative medicine

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Characteristics and distinct prognostic determinants of individuals with hepatosplenic T-cell lymphoma over the past two decades

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World Journal of Clinical Oncology 2024年第6期15卷 745-754页

作者： Ayrton Bangolo Pierre Fwelo Shraboni Dey Tanni Sethi Sowmya Sagireddy Jawaria Chatta Ashish Goel Sneha Nagpaul Eric Pin-Shiuan Chen Chiranjeeve Saravanan Sheeja Gangan joel Thomas Sarah Potiguara Vignesh K Nagesh daniel Elias Charlene Mansour Prajakta H Ratnaparkhi Priyanshu Jain Midhun Mathew Taylor Porter Shadiya Sultan Shailaja Abbisetty Linh Tran Megha Chawla Abraham Lo Simcha Weissman Christina Cho Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Epidemiology Human Geneticsand Environmental SciencesUTHealth School of Public HealthHoustonTX 77030United States Department of Medicine Palisades Medical CenterNorth BergenNJ 07047United States Stem Cell Transplantation and Cellular Therapy John Theurer Cancer CenterHackensackNJ 07601United States

BACKGROUND Hepatosplenic T-cell lymphoma(HSTCL)is a rare and aggressive peripheral T-cell lymphoma with historically dismal outcomes,representing less than one percent of non-Hodgkin *** its rarity,the true incidence of HSTCL is unknown and most data have been extrapolated through case *** the best of our knowledge,the largest and most up to date study addressing the epidemiology and outcomes of patients with HSTCL in the United States covered a period from 1996 to 2014,with a sample size of 122 *** To paint the most updated epidemiological picture of *** A total of 186 patients diagnosed with HSTCL,between 2000 and 2017,were ultimately enrolled in our study by retrieving data from the Surveillance,Epidemiology,and End Results *** analyzed demographics,clinical characteristics,and overall mortality(OM)as well as cancer-specific mortality(CSM)of *** with a P value<0.01 in the univariate Cox regression were incorporated into the multivariate Cox model to determine the independent prognostic factors,with a hazard ratio of greater than 1 representing adverse prog-nostic *** Overall,the outlook for this rare malignancy is very *** this retrospective cohort study of the United States population,non-Hispanic blacks and the elderly had a higher *** data highlights the need for larger prospective studies to investigate factors associated with worse prognosis in one ethnic group,such as treatment delays,which have been shown to increase mortality in this racial/ethnic group for other cancers.

关键词： Extra nodal lymphoma Mortality Survival Racial disparity Age

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Diffraction Pattern of a Rotated Grating

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Journal of Applied Mathematics and Physics 2019年第8期7卷 1870-1876页

作者： Pirooz Mohazzabi daniel J. Mattson joel Ambriz Ponce Jr Department of Mathematics and Physics University of Wisconsin-Parkside Kenosha USA

Diffraction patterns of a rotated grating are investigated from both theoretical and experimental points of view. It is shown that as the grating rotates, the angle of deviation of each diffracted line relative to the incident light goes through a minimum, and that the angle between any two successive diffracted lines goes through a minimum value which is the same for all adjacent diffracted lines. It is also shown that the angle between diffraction lines with n=1 and n=-1 is not sensitive to small variations of the grating from being normal to the incident light. Finally, a method is suggested for determining the line distance of a diffraction grating with high accuracy.

关键词： Diffraction Pattern Rotated Grating Angle of Deviation

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Use of blood-based biomarkers for early diagnosis and surveillance of colorectal cancer

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World Journal of Gastrointestinal Oncology 2014年第4期6卷 83-97页

作者： Ganepola AP Ganepola joel Nizin John R Rutledge David H Chang Center for Cancer Research and Genomic Medicine The Daniel and Gloria Blumenthal Cancer Center Department of Surgery The Valley Hospital

Early screening for colorectal cancer(CRC) holds the key to combat and control the increasing global burden of CRC morbidity and mortality. However, the current available screening modalities are severely inadequate because of their high cost and cumbersome preparatory procedures that ultimately lead to a low participation rate. People simply do not like to have colonoscopies. It would be ideal, therefore, to develop an alternative modality based on blood biomarkers as the first line screening test. This will allow for the differentiation of the general population from high risk individuals. Colonoscopy would then become the secondary test, to further screen the high risk segment of the population. This will encourage participation and therefore help to reach the goal of early detection and thereby reduce the anticipated increasing global CRC incidence rate. A blood-based screening test is anappealing alternative as it is non-invasive and poses minimal risk to patients. It is easy to perform, can be repeated at shorter intervals, and therefore would likely lead to a much higher participation rate. This review surveys various blood-based test strategies currently under investigation, discusses the potency of what is available, and assesses how new technology may contribute to future test design.

关键词： Colorectal neoplasms Early detection of cancer Colonoscopy Biological markers Blood Messenger RNA MicroRNA Long non-coding RNA DNA methylation Microsatellite instability Loss of heterozygosity High-throughput nucleotide sequencing Mass spectrometry Real-time polymerase chain reaction Microarray analysis

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数字狂徒

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汽车生活 2011年第12期 54-55页

作者： joel Leung daniel Ho

从21世纪开始,我们就半自愿半被迫地被推进数位的世界,一切原本连绵温暖的东西忽然间被分断成疏离的存在,菲林、黑胶唱片、信件等都被电脑里一连串的零一零一零一数字取代。芸芸众生之中,唯一不被数码攻陷的,便是高级腕表的世界。在这里... 详细信息

从21世纪开始,我们就半自愿半被迫地被推进数位的世界,一切原本连绵温暖的东西忽然间被分断成疏离的存在,菲林、黑胶唱片、信件等都被电脑里一连串的零一零一零一数字取代。芸芸众生之中,唯一不被数码攻陷的,便是高级腕表的世界。在这里,如果你戴着一枚数码跳字腕表,是会惹来鄙夷目光的。

关键词：世界数码腕表

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Connecting supplier and DoD blockchains for transparent part tracking

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Blockchain(Research and Applications) 2021年第3期2卷 17-30页

作者： Francis Asuncion Adam Brinckman Dwayne Cole Jeffrey Curtis Matt Davis Timothy Dunlevy Calvin Farmer Andrew Harrison daniel P.Johnson Joshua Joyce Chris Klubertanz Jonathan Lane John Martin Jarek Nabrzyski joel Neidig Deysi Olivares Gregory Robinson Gabriel Rodriguez Chris Root Karen Rowand Al Salour Jeff Score David Scott Ian Taylor Chandler Thompson Huy Truong Xiqun Wang Dale Warren NAVAIR USA SIMBA Chain PlymouthIN46563USA Center for Research Computing University of Notre DameNotre DameIN46556USA Indiana Technology and Manufacturing Companies(ITAMCO) PlymouthIN46563USA Boeing Company USA Naval Systems Inc.USA

Blockchains have been around for more than ten years,and since 2015,a plethora of systems have been launched to target more flexible use *** recently,several enterprise blockchain systems,such as Consensys Quorum and Hyperledger Fabric,have been launched to make blockchain simpler to apply in complex organizational *** this paper,we identify a specific Department of Defense use case,extrapolate requirements,and perform a thorough assessment of the different layers of the blockchain stack to identify the existing state of the art and undertake a gap analysis of the technology for this *** describe a platform that meets many of these challenges and show how we architected,designed,and implemented a solution for this use case for deployment at *** solution connects transactions from two separate blockchain systems,Consensys Quorum and Hyperledger Fabric,by using a graph-based approach that preserves privacy while enabling full transparency across the military and supplier networks.

关键词： Blockchain Smart contracts Supply chain Department of defense(DoD) GraphQL Enterprise blockchain systems

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Comparison of open and closed hyperthermic intraperitoneal chemotherapy: Results from the United States hyperthermic intraperitoneal chemotherapy collaborative

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World Journal of Gastrointestinal Oncology 2020年第7期12卷 756-767页

作者： Jennifer L Leiting Jordan M Cloyd Ahmed Ahmed Keith Fournier Andrew J Lee Sophie Dessureault Seth Felder Jula Veerapong joel M Baumgartner Callisia Clarke Harveshp Mogal Charles A Staley Mohammad Y Zaidi Sameer H Patel Syed A Ahmad Ryan J Hendrix Laura Lambert daniel E Abbott Courtney Pokrzywa Mustafa Raoof Christopher J LaRocca Fabian M Johnston Jonathan Greer Travis E Grotz Division of Hepatobiliary and Pancreas Surgery Mayo ClinicRochesterMN 55901United States Division of Surgical Oncology Department of SurgeryThe Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Surgical Oncology University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Gastrointestinal Oncology Moffitt Cancer CenterDepartment of Oncologic SciencesMorsani College of MedicineTampaFL 33612United States Division of Surgical Oncology Department of SurgeryUniversity of CaliforniaSan DiegoCA 92093United States Division of Surgical Oncology Department of SurgeryMedical College of WisconsinMilwaukeeWI 53226United States Division of Surgical Oncology Winship Cancer InstituteEmory UniversityAtlantaGA 30322United States Department of Surgery University of Cincinnati College of MedicineCincinnatiOH 45267United States Division of Surgical Oncology Department of SurgeryUniversity of Massachusetts Medical SchoolWorcesterMA 01655United States Peritoneal Surface Malignancy Program Section of Surgical Oncology Huntsman Cancer InstituteUniversity of UtahSalt Lake CityUT 84112United States Division of Surgical Oncology Department of SurgeryUniversity of WisconsinMadisonWI 53792United States Christopher La Rocca Division of Surgical OncologyDepartment of SurgeryCity of Hope National Medical CenterDuarteCA 91010United States Department of Surgery Johns Hopkins UniversityBaltimoreMD 21287United States

BACKGROUND Cytoreductive surgery(CRS)with hyperthermic intraperitoneal chemotherapy(HIPEC)for peritoneal carcinomatosis can be performed in two ways:Open or closed abdominal *** To evaluate the impact of HIPEC method on post-operative and long-term survival *** Patients undergoing CRS with HIPEC from 2000-2017 were identified in the United States HIPEC collaborative ***-operative,recurrence,and overall survival outcomes were compared between those who received open vs closed *** Of the 1812 patients undergoing curative-intent CRS and HIPEC,372(21%)patients underwent open HIPEC and 1440(79%)underwent closed *** was no difference in re-operation or severe complications between the two *** HIPEC had higher rates of 90-d readmission while open HIPEC had a higher rate of 90-d *** multi-variable analysis,closed HIPEC technique was not a significant predictor for overall survival(hazards ratio:0.75,95%confidence interval:0.51-1.10,P=0.14)or recurrence-free survival(hazards ratio:1.39,95%confidence interval:1.00-1.93,P=0.05)in the entire *** findings remained consistent in the appendiceal and the colorectal *** In this multi-institutional analysis,the HIPEC method was not independently associated with relevant post-operative or long-term *** technique may be left to the discretion of the operating surgeon.

关键词： Mucinous appendiceal carcinoma Cytoreductive surgery Multi-institutional

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A tabletop X-ray tomography instrument for nanometer-scale imaging: reconstructions

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Microsystems & Nanoengineering 2023年第2期9卷 249-259页

作者： Zachary H.Levine Bradley K.Alpert Amber L Dagel Joseph W.Fowler Edward S.Jimenez Nathan Nakamura daniel S.Swetz Paul Szypyt Kyle R.Thompson joel N.Ulom National Institute of Standards and Technology GaithersburgMD 20899USA National Institute of Standards and Technology BoulderCO 80305USA Sandia National Laboratories AlbuquerqueNM 87123USA Department of Physics University of ColoradoBoulderCO 80309USA

We show three-dimensional reconstructions of a region of an integrated circuit from a 130 nm copper *** reconstructions employ x-ray computed tomography,measured with a new and innovative high-magnification x-ray *** instrument uses a focused electron beam to generate x-rays in a 100 nm spot and energy-resolving x-ray detectors that minimize backgrounds and hold promise for the identification of materials within the *** x-ray generation target,a layer of platinum,is fabricated on the circuit wafer itself.A region of interest is imaged from a limited range of angles and without physically removing the region from the larger *** reconstruction is consistent with the circuit's design file.

关键词： process removing platinum

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