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Characteristics and distinct prognostic determinants of individuals with hepatosplenic T-cell lymphoma over the past two decades

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World Journal of Clinical Oncology 2024年第6期15卷 745-754页

作者： Ayrton Bangolo Pierre Fwelo Shraboni Dey Tanni Sethi Sowmya Sagireddy Jawaria Chatta Ashish Goel Sneha Nagpaul Eric Pin-Shiuan Chen Chiranjeeve Saravanan Sheeja Gangan joel thomas Sarah Potiguara Vignesh K Nagesh Daniel Elias Charlene Mansour Prajakta H Ratnaparkhi Priyanshu Jain Midhun Mathew Taylor Porter Shadiya Sultan Shailaja Abbisetty Linh Tran Megha Chawla Abraham Lo Simcha Weissman Christina Cho Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Epidemiology Human Geneticsand Environmental SciencesUTHealth School of Public HealthHoustonTX 77030United States Department of Medicine Palisades Medical CenterNorth BergenNJ 07047United States Stem Cell Transplantation and Cellular Therapy John Theurer Cancer CenterHackensackNJ 07601United States

BACKGROUND Hepatosplenic T-cell lymphoma(HSTCL)is a rare and aggressive peripheral T-cell lymphoma with historically dismal outcomes,representing less than one percent of non-Hodgkin *** its rarity,the true incidence of HSTCL is unknown and most data have been extrapolated through case *** the best of our knowledge,the largest and most up to date study addressing the epidemiology and outcomes of patients with HSTCL in the United States covered a period from 1996 to 2014,with a sample size of 122 *** To paint the most updated epidemiological picture of *** A total of 186 patients diagnosed with HSTCL,between 2000 and 2017,were ultimately enrolled in our study by retrieving data from the Surveillance,Epidemiology,and End Results *** analyzed demographics,clinical characteristics,and overall mortality(OM)as well as cancer-specific mortality(CSM)of *** with a P value<0.01 in the univariate Cox regression were incorporated into the multivariate Cox model to determine the independent prognostic factors,with a hazard ratio of greater than 1 representing adverse prog-nostic *** Overall,the outlook for this rare malignancy is very *** this retrospective cohort study of the United States population,non-Hispanic blacks and the elderly had a higher *** data highlights the need for larger prospective studies to investigate factors associated with worse prognosis in one ethnic group,such as treatment delays,which have been shown to increase mortality in this racial/ethnic group for other cancers.

关键词： Extra nodal lymphoma Mortality Survival Racial disparity Age

Review of additive manufactured tissue engineering scaffolds:relationship between geometry and performance

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Burns & Trauma 2018年第3期6卷 167-182页

作者： Andrew Gleadall Dafydd Visscher Jing Yang Daniel thomas joel Segal Wolfson School of Mechanical and Manufacturing Engineering Loughborough UniversityLoughboroughLeicestershire LE11 3TUUK Department of Plastic Reconstructive and Hand SurgeryVU University Medical CenterAmsterdam Movement SciencesAmsterdamThe Netherlands Faculty of Science School of PharmacyUniversity of NottinghamUniversity ParkNottingham NG7 2RDUK 3Dynamic Systems Heol Ty Gwyn Industrial EstateBridgend CF34 0BQUK Advanced Manufacturing Technology Research Group Faculty of EngineeringUniversity of NottinghamUniversity ParkNottingham NG7 2RDUK.

Material extrusion additive manufacturing has rapidly grown in use for tissue engineering research since its adoption in the year 2000. It has enabled researchers to produce scaffolds with intricate porous geometries that were not feasible with traditional manufacturing processes. Researchers can control the structural geometry through a wide range of customisable printing parameters and design choices including material, print path, temperature, and many other process parameters. Currently, the impact of these choices is not fully understood. This review focuses on how the position and orientation of extruded filaments, which sometimes referred to as the print path, lay-down pattern, or simply'scaffold design', affect scaffold properties and biological performance. By analysing trends across multiple studies, new understanding was developed on how filament position affects mechanical properties. Biological performance was also found to be affected by filament position, but a lack of consensus between studies indicates a need for further research and understanding. In most research studies, scaffold design was dictated by capabilities of additive manufacturing software rather than free-form design of structural geometry optimised for biological requirements. There is scope for much greater application of engineering innovation to additive manufacture novel geometries. To achieve this, better understanding of biological requirements is needed to enable the effective specification of ideal scaffold geometries.

关键词： Fused deposition modelling Bioprinting 3D printing Scaffold architecture Tissue engineering constructs Regenerative medicine

Wheat zinc finger protein TaZF interacts with both the powdery mildew AvrPm2 protein and the corresponding wheat Pm2a immune receptor

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Plant Communications 2024年第5期5卷 25-41页

作者： Beatrice Manser Helen Zbinden Gerhard Herren joel Steger Jonatan Isaksson Stephanie Braunlich thomas Wicker Beat Keller Department of Plant and Microbial Biology University of ZurichZollikerstrasse 1078008 ZurichSwitzerland Agroscope Route de Duillier 501260 NyonSwitzerland BIOREBA AG Christoph Merian-Ring 74153 ReinachSwitzerland

Plant defense responses to pathogens are induced after direct or indirect perception of effector proteins or their activity on host *** fungal–plant interactions,relatively little is known about whether,in addi-tion to avirulence effectors and immune receptors,other proteins contribute to specific *** nucleotide-binding leucine-rich repeat(NLR)immune receptor Pm2a in wheat recognizes the fungal pow-dery mildew effector *** found that the predicted wheat zincfinger TaZF interacts with both the fungal avirulence protein AvrPm2 and the wheat NLR *** further demonstrated that the virulent AvrPm2-H2 variant does not interact with *** silencing in wheat resulted in a reduction but not a loss of Pm2a-mediated powdery mildew *** studies showed that the leucine-rich repeat domain of Pm2a is the mediator of the interaction with *** recruits both Pm2a and AvrPm2 from the cytosol to the nucleus,resulting in nuclear localization of Pm2a,TaZF,and AvrPm2 in *** propose that TaZF acts as a facilitator of Pm2a-dependent AvrPm2 effector *** highlight the importance of identifying effector host targets for characterization of NLR-mediated effector recognition.

关键词： plant immunity plant-fungal interactions pathogen effectors nucleotide-binding leucine-rich repeat immune receptor NLR wheat powdery mildew

A call to action on World Kidney Day,8 March 2007

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肾脏病与透析肾移植杂志 2007年第1期16卷 1-2页

作者： William G Couser Sudhir Shah joel Kopple Paul Beerkens Anne Wilson John Feehally thomas Reiser Miguel Riella President International Society of Nephrology MD Department of MedicineDivision of NephrologyUniversity of Washington16050 169th Avenue NEWoodinvilleWashington 98072USA President International Federation of Kidney Foundations For the joint International Society of Nephrology/International Federation of Kidney Foundations World Kidney Day 2007 Steering Committee MD IFKF Executive Member MD IFKF President-Elect IFKF Secretary Treasurer ISN Secretary General MD ISN Executive Director ISN Committee Chair MD

William G Couser,MD1President,International Society of NephrologySudhir Shah,MD President,International Federation of Kidney Foundations For the joint International Society of Nephrology/International Federation of Kidney ABSTRACT:World Kidney Day,a joint initiative of the International Society of Neph-rology(ISN) and the International Federation of Kidney Foundations(IFKF),aims to spread the crucial message that kidney disease is common,harmful,and treatable.

关键词：肾脏生命 “世界肾脏日” 疾病预防

Crop phenotyping in a context of global change:What to measure and how to do it

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Journal of Integrative Plant Biology 2022年第2期64卷 592-618页

作者： Jose Luis Araus Shawn Carlisle Kefauver Omar Vergara-Díaz Adrian Gracia-Romero Fatima Zahra Rezzouk joel Segarra Maria Luisa Buchaillot Melissa Chang-Espino thomas Vatter Rut Sanchez-Bragado JoséArmando Fernandez-Gallego Maria Dolores Serret Jordi Bort Integrative Crop Ecophysiology Group Plant Physiology SectionFaculty of BiologyUniversity of BarcelonaBarcelonaSpain AGROTECNIO Center LleidaSpain Plant Ecophysiology and Metabolism Lab ITQB NovaPlant Sciences DivisionOeirasPortugal Programa de Ingeniería Electrónica Facultad de IngenieríaUniversidad de IbaguéIbaguéColombia

High-throughput crop phenotyping,particularly under field conditions,is nowadays perceived as a key factor limiting crop genetic *** not only facilitates conventional breeding,but it is necessary to fully exploit the capabilities of molecular breeding,and it can be exploited to predict breeding targets for the years ahead at the regional level through more advanced simulation models and decision support *** terms of phenotyping,it is necessary to determined which selection traits are relevant in each situation,and which phenotyping tools/methods are available to assess such *** sensing methodologies are currently the most popular approaches,even when lab-based analyses are still relevant in many *** top of that,data processing and automation,together with machine learning/deep learning are contributing to the wide range of applications for *** review addresses spectral and red-green-blue sensing as the most popular remote sensing approaches,alongside stable isotope composition as an example of a lab-based tool,and root phenotyping,which represents one of the frontiers for field ***,we consider the two most promising forms of aerial platforms(unmanned aerial vehicle and satellites)and some of the emerging data-processing *** review includes three Boxes that examine specific case studies.

关键词： crop phenotyping deep learning models photosynthesis platforms remote sensing roots satellites sensors stable isotopes

Sonohysterography: Principles, technique and role in diagnosis of endometrial pathology

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World Journal of Radiology 2013年第3期5卷 81-87页

作者： thomas Yang Amit Pandya Leonardo Marcal Ronald O Bude joel F Platt Deepak G Bedi Khaled M Elsayes Department of Radiology University of Texas MD Anderson Cancer Center Houston Department of Radiology University of Michigan

Sonohysterography (SHG), which provides enhanced endometrial visualization during standard transvaginal ultrasonography, is a relatively safe procedure for the evaluation of endometrial pathology. It can be used to evaluate patients with abnormal vaginal bleeding or infertility. This modality offers real time imaging of the endometrium without exposure to ionizing radiation. SHG is typically used in patients for whom standard transvaginal ultrasonography does not show the endometrium well, show a potential abnormality for which further imaging is required, or in patients without endometrial pathology defined on routine transvaginal imaging but in whom there is a strong clinical suspicion of an abnormality. This article will discuss the utility of the sonohysterogram in evaluation of various endometrial pathologies. Imaging examples of these pathological entities will be illustrated as well.

关键词： Sonohysterography Endometrial pathology Vaginal bleeding Infertility

Illegal Wildlife Trade: Trade Flows of Wildlife Products and Facilitation Methods in the Ruaha Landscape, Tanzania

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Open Journal of Ecology 2022年第9期12卷 585-603页

作者： Hillary thomas Mrosso Rose Peter Kicheleri Japhet joel Kashaigili Pantaleo Munishi Reuben Mpuya Joseph Kadigi Charles Peter Mgeni Michael Honorati Kimaro College of Forestry Wildlife and Tourism Management Sokoine University of Agriculture Morogoro Tanzania Tanzania Research and Conservation Organization Morogoro Tanzania College of Economics and Business Studies Sokoine University of Agriculture Morogoro Tanzania GELIFES Institute University of Groningen Groningen Netherlands

Tanzania’s Ruaha landscape is prominent for its potential wildlife resources, which play a key role in sustaining the economy and livelihoods of the people. However, most of these resources are illegally obtained and traded in different places within and outside the Ruaha landscape. Due to its illegal nature, most of the important information regarding the trade is poorly documented. Therefore, the current study aimed first, to explore the origin and destination of wildlife products;second, to assess the relationship between hunters and buyers or customers;third, to assess the means used to transport wildlife products;and lastly, to assess who influences people to engage in illegal hunting and trade activities. In addition, we assess the materials used in the exchange of wildlife products. Semi-structured questionnaires and face-to-face interviews were used to collect information from 123 respondents. Social network analysis was used to indicate the origin and destination of wildlife products. The findings show that 70% of wildlife products originate from the Ruaha National Park and MBOMIPA wildlife management areas, with the remaining 30% originating from villages. The majority of respondents (65%) reported transporting wildlife products by foot and bicycle as the primary modes of transportation. Suppliers of wildlife products are reported to have close and long-term relationships with their customers and traders, with most of whom being friends and relatives. We found most poachers to be influenced by their friends and relatives in terms making decision to engage in illegal wildlife trade. In addition, crops like maize and rice were the most popular products used to exchange with wildlife products in the Ruaha landscape. Therefore, in order to combat illegal trade in wildlife products at the local level, alternative income-generating activities need to be promoted accompanied by not only well-funded anti-poaching programmes but also more effective surveillance pla

关键词： Wildlife Products Illegal Trade Ruaha Landscape

Influence of Halide Choice on Formation of Low-Dimensional Perovskite Interlayer in Efficient Perovskite Solar Cells

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Energy & Environmental Materials 2022年第2期5卷 670-682页

作者： Xueping Liu thomas Webb Linjie Dai Kangyu Ji joel A.Smith Rachel C.Kilbride Mozhgan Yavari Jinxin Bi Aobo Ren Yuanyuan Huang Zhuo Wang Yonglong Shen Guosheng Shao Stephen J.Sweeney Steven Hinder Hui Li David G.Lidzey Samuel D.Stranks Neil C.Greenham S.Ravi P.Silva Wei Zhang State Center for International Cooperation on Designer Low-carbon&Environmental Materials(CDLCEM) Zhengzhou UniversityZhengzhou 450001China Advanced Technology Institute Department of Electrical and Electronic EngineeringUniversity of SurreyGuildford GU27XHUK Cavendish Laboratory University of CambridgeCambridge CB30HEUK Department of Chemical Engineering and Biotechnology University of CambridgeCambridge CB30ASUK Department of Physics and Astronomy University of SheffieldSheffield S37RHUK Department of Physics University of OxfordClarendon LaboratoryOxford OX13PUUK Advanced Technology Institute and Department of Physics University of SurreyGuildford GU27XHUK The Surface Analysis Laboratory Department of Mechanical Engineering SciencesUniversity of SurreyGuildford GU27XHUK Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China

Recent advances in heterojunction and interfacial engineering of perovskite solar cells(PSCs)have enabled great progress in developing highly efficient and stable ***,the effect of halide choice on the formation mechanism,crystallography,and photoelectric properties of the lowdimensional phase still requires further detailed *** this work,we present key insights into the significance of halide choice when designing passivation strategies comprising large organic spacer salts,clarifying the effect of anions on the formation of quasi-2D/3D *** demonstrate the importance of halide influences,we employ novel neo-pentylammonium halide salts with different halide anions(neoPAX,X=I,Br,or Cl).We find that regardless of halide selection,iodide-based(neoPA)_(2)(FA)_((n-1))PbnI_((3n+1))phases are formed above the perovskite substrate,while the added halide anions diffuse and passivate the perovskite *** addition,we also find the halide choice has an influence on the degree of dimensionality(n).Comparing the three halides,we find that chloride-based salts exhibit superior crystallographic,enhanced carrier transport,and extraction compared to the iodide and bromide *** a result,we report high power conversion efficiency in quasi-2D/3D PSCs,which are optimal when using chloride salts,reaching up to 23.35%,and improving long-term stability.

关键词： carrier dynamics halide anions(I Br Cl) neo-pentylammonium halides perovskite solar cells quasi-2D/3D heterojunction

Cardiovascular Risk Factors in the Civil Service of Oyo State, South-Western Nigeria: An Epidemic with an Unmatched Response

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World Journal of Cardiovascular Diseases 2020年第8期10卷 587-607页

作者： Olaniyan Akintunde Babatunde Sunday Olakunle Olarewaju Adeleye Abiodun Adeomi joel Olufunminiyi Akande Sunday thomas Sola Adenike Iyanuoluwa Olugbenga-Bello James O. Bamidele Department of Community Medicine Ladoke Akintola University of Technology Ogbomoso Oyo State Nigeria Oriire Local Government Health Authority Ikoyi-Ile Oyo State Nigeria Department of Community Medicine Osun State University Osogbo Osun State Nigeria Department of Community Medicine Obafemi Awolowo University Ile-Ife Osun State Nigeria Department of Chemical Pathology BOWEN University Teaching Hospital Ogbomoso Oyo State Nigeria Nigeria Field Epidemiology and Laboratory Training Programme Asokoro Abuja Nigeria Department of Community Medicine Ekiti State University Ado-Ekiti Ekiti State Nigeria

Background: Worldwide, the burden of cardiovascular (CV) risk factors is rising with devastating impacts on the productive workforce. In developing nations, it has further led to an unstable population pyramid as a result of premature deaths of her workforce leading to the continued tapering of the pyramidal apex. Inspite of this, many studies were conducted among the general population neglecting the local government civil servants who are seen as policy implementers. Therefore, the study assessed the pattern of CV risk factors in South-western Nigeria. Methods: A cross-sectional study was conducted among 260 local government workers selected by multistage sampling technique from July to September 2017. A pretested, interviewer-administered questionnaire was administered to obtain socio-demographic and behavioural information. Lipid analysis, anthropometric, blood pressure, fasting blood glucose measurements were done according to protocols. Data were analyzed using IBM SPSS version 25;bivariate analysis was done using Chi-square. Level of significance was at 5%. Results: The mean age of respondents was 46.0 ± 6.7 years. The proportion of participants with good knowledge of risk factors was 57.7%. The proportion of respondent with hypertension, visceral obesity, general obesity, diabetes, smoking and physical inactivity was 40.4%, 35.0%, 52.2%, 38.2%, 5.8% and 75.8% respectively. The prevalence of elevated total cholesterol (↑TC), raised low-density lipoprotein (