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Gastroesophageal reflux following per-oral endoscopic myotomy:Can we improve outcomes?

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World Journal of Gastroenterology 2024年第22期30卷 2834-2838页

作者： Inian samarasam Raj Kumar joel Anna B Pulimood Department of surgery Upper Gastrointestinal Surgery UnitChristian Medical College&HospitalVellore 632004TamilnaduIndia Department of Cardiothoracic surgery Christian Medical College&HospitalVellore 632004TamilnaduIndia Department of Gastrointestinal sciences Christian Medical College and HospitalVellore 632004Tamil NaduIndia

This editorial is an analysis the review article by Nabi et al recently published in this *** Cardia is a disease whose pathophysiology is still *** is known that there is inflammation of unknown aetiology leading to loss of ganglion cells in the muscularis *** end result is lower oesophageal sphincter spasm,loss of receptive relaxation,decreased oesophageal peristalsis,all leading on to varying degrees of *** treatment of this condition is palliative in nature,performed by myotomy of the lower oesophagus either surgically or *** reflux disease(GERD)has been associated with the myotomy performed,particularly with the Peroral Endoscopic Myotomy(POEM)*** et al have provided an excellent overview of the latest developments in predicting,preventing,evaluating,and managing GERD subsequent to *** on this theme,this review article explores the concept of using histology of the oesophageal muscle layer,to grade the disease and thereby help tailoring the length/type of myotomy performed during the POEM *** the future,will a histology based algorithm available preoperatively,help modify the POEM procedure,thereby decreasing the incidence of GERD associated with POEM?

关键词： Achalasia cardia Peroral endoscopic myotomy Laparoscopic Heller’s myotomy Histopathology Histologic grading

The “Dead Universe” Theory: Natural separation of Galaxies Driven by the Remnants of a supermassive Dead Universe

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Natural science 2024年第6期16卷 65-101页

作者： joel Almeida Department of Theology and Metaphysics UniFil University Curitiba Brazil

This article explores the dead universe theory as a novel interpretation for the origin and evolution of the universe, suggesting that our cosmos may have originated from the remnants of a preceding universe. This perspective challenges the conventional Big Bang theory, particularly concerning dark matter, the expansion of the universe, and the interpretation of phenomena such as gravitational waves.

关键词： Dead Universe Theory Heat Death of the Universe Big Bang Theory Universe’s Ultimate Fate Universe Expansion Big Freeze Universe Cosmological Models End of Universe Theories Natural Galaxy Drift Future of the Universe Universe Cooling Down Cosmology and Entropy

Further Analysis of Machine Tool Dimensional Accuracy and Thermal stability under Varying Floor Temperature

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World Journal of Engineering and Technology 2024年第2期12卷 258-273页

作者： joel Arumun shadrack Abiola Department of Control systems and Instrumentation University of Huddersfield Huddersfield UK

Machining is as old as humanity, and changes in temperature in both the machine’s internal and external environments can be of great concern as they affect the machine’s thermal stability and, thus, the machine’s dimensional accuracy. This paper is a continuation of our earlier work, which aimed to analyze the effect of the internal temperature of a machine tool as the machine is put into operation and vary the external temperature, the machine floor temperature. some experiments are carried out under controlled conditions to study how machine tool components get heated up and how this heating up affects the machine’s accuracy due to thermally induced deviations. Additionally, another angle is added by varying the machine floor temperature. The parameters mentioned above are explored in line with the overall thermal stability of the machine tool and its dimensional accuracy. A Robodrill CNC machine tool is used. The CNC was first soaked with thermal energy by gradually raising the machine floor temperature to a certain level before putting the machine in operation. The machine was monitored, and analytical methods were deplored to evaluate thermal stability. secondly, the machine was run idle for some time under raised floor temperature before it was put into operation. Data was also collected and analyzed. It is observed that machine thermal stability can be achieved in several ways depending on how the above parameters are joggled. This paper, in conclusion, reinforces the idea of machine tool warm-up process in conjunction with a carefully analyzed and established machine floor temperature variation for the approximation of the machine tool’s thermally stability to map the long-time behavior of the machine tool.

关键词： Dimensional Accuracy Machine Tool Machine Floor Thermal stability Temperature Thermal Deviation

A cross-sectional study to assess medication safety,knowledge,attitude,and practices regarding nutrition and medication among pregnant women

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Asian pacific Journal of Reproduction 2024年第3期13卷 115-119页

作者： Gauthami R Bipin shaji Twinkle MJs Krishnapriya Radhakrishnan Reshma Kolar Juno Jerold joel Nitte(Deemed to be University) NGSM Institute of Pharmaceutical Sciences(NGSMIPS)Department of Pharmacy PracticeDeralakatteMangaluruIndia Nitte(Deemed to be University) KS Hegde Medical Academy(KSHEMA)Department of Obstetrics and GynaecologyDeralakatteMangaluruIndia AJ Institute of Medical sciences and Research Centre Department of Community MedicineMangaluruKarnatakaIndia

Objective:To assess pregnant women's knowledge,attitude,and practice regarding nutrition and medication usage,analyse the prescribing pattern,and categorize them based on the Food and Drug Administration(FDA)***:A cross-sectional study was conducted with 264 pregnant women in the obstetrics and gynaecology department of a tertiary care hospital from October 2022 to August 2023.A knowledge,attitude,and practice(KAP)questionnaire was prepared in English language by the researchers and validated by an expert panel consisting of 12 *** validated questionnaire was then translated into regional languages,Kannada and *** reliability of the questionnaire was assessed with test-retest method with a representative sample population of 30 subjects(10 subjects for each language).The subjects'knowledge,attitude,and practice were evaluated using the validated KAP *** safety of the medication was assessed using the FDA drug safety classification for ***:The mean scores for nutritional and medication usage knowledge,attitude,and practice were 4.14±1.15,4.50±1.09,and 3.00±1.47,*** 30 prescribed medications,3 belong to category A(no risk in human studies),8 belong to category B(no risk in animal studies),18 belong to category C(risk cannot be ruled out)and 1 drug is not classified.A significant association was observed between medication knowledge and practice(r=0.159,P=0.010).Conclusions:Most of the study population knows the need to maintain good dietary and medication practices during *** pregnant women regarding diet and medication usage is crucial in maternal care.

关键词： Pregnancy Nutrition Medication Knowledge Practice safe medication

Quantum-mechanical effects in photoluminescence from thin crystalline gold films

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Light(science & Applications) 2024年第4期13卷 783-794页

作者： Alan R.Bowman Alvaro Rodríguez Echarri Fatemeh Kiani Fadil Iyikanat Ted V.Tsoulos joel D.Cox Ravishankar sundararaman F.Javier García de Abajo Giulia Tagliabue Laboratory of Nanoscience for Energy Technologies(LNET) STIÉcole Polytechnique Fédérale de Lausanne(EPFL)LausanneSwitzerland ICFO–Institut de Ciencies Fotoniques The Barcelona Institute of Science and TechnologyCastelldefels(Barcelona)Spain. MBI–Max-Born-Institut BerlinGermany. POLIMA–Center for Polariton-driven Light–Matter Interactions University of Southern DenmarkOdense MDenmark. Danish Institute for Advanced study University of Southern DenmarkOdense MDenmark. Department of Materials science&Engineering Rensselaer Polytechnic InstituteTroyNYUSA. Department of Physics Applied Physicsand AstronomyRensselaer Polytechnic InstituteTroyNYUSA. ICREA–Institucio Catalana de Recerca i Estudis Avancats BarcelonaSpain

Luminescence constitutes a unique source of insight into hot carrier processes in metals,including those in plasmonic nanostructures used for sensing and energy ***,being weak in nature,metal luminescence remains poorly understood,its microscopic origin strongly debated,and its potential for unraveling nanoscale carrier dynamics largely ***,we reveal quantum-mechanical effects in the luminescence emanating from thin monocrystalline gold ***,we present experimental evidence,supported by first-principles simulations,to demonstrate its photoluminescence origin(i.e.,radiative emission from electron/hole recombination)when exciting in the interband *** model allows us to identify changes to the measured gold luminescence due to quantum-mechanical effects as the gold film thickness is ***,such effects are observable in the luminescence signal from flakes up to 40 nm in thickness,associated with the out-of-plane discreteness of the electronic band structure near the Fermi *** qualitatively reproduce the observations with first-principles modeling,thus establishing a unified description of luminescence in gold monocrystalline flakes and enabling its widespread application as a probe of carrier dynamics and light-matter interactions in this *** study paves the way for future explorations of hot carriers and charge-transfer dynamics in a multitude of material systems.

关键词： luminescence quantum crystalline

Allying interfacial engineering of 2D carbon nanosheet-,graphene-,and graphdiyne-based heterostructured electrocatalysts toward hydrogen evolution and overall water splitting

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Electron 2024年第1期2卷 106-163页

作者： Wuwei Mo joel Jie Foo Wee‐Jun Ong school of Energy and Chemical Engineering Xiamen University MalaysiaSepangSelangor Darul EhsanMalaysia Center of Excellence for NaNo Energy&Catalysis Technology(CONNECT) Xiamen University MalaysiaSepangSelangor Darul EhsanMalaysia state Key Laboratory of Physical Chemistry of solid surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamenChina Gulei Innovation Institute Xiamen UniversityZhangzhouChina shenzhen Research Institute of Xiamen University ShenzhenChina

Electrochemical hydrogen evolution reaction(HER)and overall water splitting(OWs)for renewable energy generation have recently become a highly promising and sustainable strategy to tackle energy crisis and global warming arising from our overreliance on fossil ***,tremendous research breakthroughs have been made in 2D carbon-based heterostructured electrocatalysts in this *** heterostructures are distinguished by their remarkable electrical conductivity,exposed active sites,and mechanical ***,with fundamental mechanisms of electrocatalytic OWs summarized,our review critically emphasized on state-of-the-art 2D carbon nanosheet-,graphene-,and graphdiyne-based heterostructured electrocatalysts in HER and OWs since ***,the three emerging carbonaceous substrates tend to be incorporated with metal carbides,phosphides,dichalcogenides,nitrides,oxides,nanoparticles,single atom catalysts,or layered double ***,fascinating structural engineering and facile synthesis strategies were also unraveled to establish the structure-activity relationship,which will enlighten future electrocatalyst developments toward ameliorated HER and OWs ***,computational results from density functional theory simulations were highlighted as well to better comprehend the synergistic effects within the ***,current stages and future recommendations of this brand-new electrocatalyst type were concluded and discussed for advanced catalyst designs and future practical applications.

关键词： 2D carbon-based heterostructures electrocatalysis hydrogen evolution reaction interfacial engineering overall water splitting

Multimodal comparison of plasma proteins associated with blood-brain barrier impairment in Alzheimer’s disease

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Aging Communications 2024年第1期6卷 1-9页

作者： Elisa Giunti Roberto Collu joel Reisman Jong soo Lee Noureddine Melikechi Weiming Xia Geriatric Research Education and Clinical Center Bedford VA Healthcare SystemBedfordMA 01730U.S.A Department of Pharmacology Physiology and BiophysicsBoston University Chobanian&Avedisian School of MedicineBostonMA 02118U.S.A Center for Healthcare Organization and Implementation Research Bedford VA Healthcare SystemBedfordMA 01730U.S.A Kennedy College of science University of Massachusetts LowellLowellMA 01854U.S.A.

Background:Vascular impairment is one of the major contributors to *** aimed to identify blood biomarkers suggestive of potential impairment of the blood-brain barrier(BBB)in subjects with Alzheimer’s disease(AD).Methods:We used administrative data from the VA Informatics and Computing Infrastructure Resource Center to study both inpatients and outpatients with *** samples from healthy control and AD individuals were analyzed using enzyme-linked immunosorbent assay and proteomics approaches to identify differentially expressed *** analysis was applied to explore significantly enriched ***:In the same cohort of patients with AD,we found twice number of subjects with cerebral amyloid angiopathy in the two-year period after the onset of AD,compared to the number of subjects with cerebral amyloid angiopathy in the two-year period prior to AD *** pathways related to BBB,like cell adhesion,extracellular matrix organization and Wnt signaling,were activated and differentially expressed proteins such as ADAM22,PDGFR-α,DKK-4,Neucrin and RsOP-1 were ***,matrix metalloproteinase-9,which is implicated in causing degradation of basal lamina and BBB disruption,was significantly increased in the plasma of AD ***:Alteration of proteins found in AD subjects could provide new insights into biomarkers regulating permeability and BBB integrity.

关键词： Alzheimer’s disease blood-brain barrier peripheral biomarkers matrix metalloproteinases cerebral amyloid angiopathy

Beta-HCG Levels and Ovarian Ultrasonography Results among Non-Pregnant Women of Reproductive Age in Port Harcourt, Nigeria: A Cross-sectional study

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Journal of Biosciences and Medicines 2024年第5期12卷 233-241页

作者： Celine C. Agonsi Francis Anacletus joel Aluko Chinemerem Eleke Joy C. samuel African Centre of Public Health and Toxicological Research (ACE-PUTOR) University of Port Harcourt Choba Nigeria Department of Nursing science University of Port Harcourt Choba Nigeria

Background: Certain ovarian cancers that were previously common in postmenopausal women are now increasingly observed in women of reproductive age. The research on using β-HCG as a diagnostic biomarker for ovarian cancer in women of reproductive age is ongoing. Aim: This study assessed the level of serum β-HCG in non-pregnant women of reproductive age and determined its potential association with suspicious ovarian ultrasonography results. Methods: The study was conducted in Port Harcourt, Nigeria. This study adopted a cross-sectional design on a quota sample of 224 case notes of women aged 18 - 40 years obtained from eight diagnostic centres. A data extraction form was used for data collection. Data analysis employed descriptive statistics, Chi-square, Fisher’s exact test, and Odds Ratio at 95% confidence and 5% significance levels. Results: About 5.8% of the participants exhibited detectable levels of serum β-HCG above 5 IU/L (World Health Organization reference) at a mean concentration of 5.87 (±1.75) IU/L. About 4.0% of the participants had suspicious ovarian lesions identified through ultrasonography. Participants with elevated serum β-HCG levels above the WHO reference were 59 times more likely to have suspicious ovarian lesions (Odds ratio: 59.4, 95%CI: 12.3 - 287.8, p β-HCG level and age (p = 0.041) as well as parity (p Conclusion: serum β-HCG levels above the WHO reference in non-pregnant women were associated with suspicious ovarian lesions. More rigorous primary research, systematic reviews, and meta-analyses are needed to confirm the findings of this study.

关键词： Biomarkers Ovarian Cancer Pregnancy Ultrasonography

美国放射学院适宜性标准:肩关节置换术后影像学检查(续)

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中华肩肘外科电子杂志 2017年第4期5卷 299-304页

作者：张晓萌陈建海 soterios Gyftopoulos Zehava s.Rosenberg Catherine C.Roberts Jenny T.Bencardino Marc Appel steven J.Baccei R.Carter Cassidy Eric Y.Chang Michael G.Fox Bennett s.Greenspan Mary G.Hochman Jon A.Jacobson Douglas N.Mintz joel s.newman Nehal A.shah Kirstin M.small Barbara N.Weissman 北京大学人民医院创伤骨科 100044 纽约大学医疗中心纽约市纽约关节病医院纽约市梅奥诊所亚利桑那州凤凰城纽约大学医学院纽约市 James J.Peters VA医疗中心纽约市马萨诸塞大学医疗中心伍斯特英国医疗脊柱和全关节服务列克星敦 VA圣地亚哥医疗系统圣地亚哥弗吉尼亚卫生系统夏洛茨维尔奥古斯塔大学佐治亚州医学院奥古斯塔贝斯以色列女执事医疗中心波士顿密歇根大学医疗中心安娜堡纽约特种外科医院纽约市新英格兰浸信会医院波士顿布列根和妇女医院波士顿

过去的20年里,在美国实施的肩关节置换术的数量迅速增长,其中包括部分或全肱骨头表面置换术、半肩置换术、全肩关节置换术和反式全肩关节置换术。影像学检查在诊断这些肩关节置换术引起的并发症方面起到了重要作用。本综述分为两个部分... 详细信息

过去的20年里,在美国实施的肩关节置换术的数量迅速增长,其中包括部分或全肱骨头表面置换术、半肩置换术、全肩关节置换术和反式全肩关节置换术。影像学检查在诊断这些肩关节置换术引起的并发症方面起到了重要作用。本综述分为两个部分。第一部分阐述了对各种影像学检查模式的总体探讨,包括X线片、计算机断层扫描、核磁共振成像、超声、核医学以及它们提供有益的以治疗为导向的信息时所发挥的作用。第二部分重点研究最佳影像学方法的选择,用于肩关节置换术的并发症,包括无菌性松动、感染、骨折、肩袖肌腱撕裂和神经损伤。在本报告中所提供的美国放射学院适宜性标准循证指南,是通过广泛分析来自同行评审期刊的现有医学文献,并应用行之有效的方法学而完成的(兰德/加州大学洛杉矶分校的适宜性方法以及推荐评价、发展和评估分级),它们用于特殊临床情况下的影像学检查和治疗措施的适宜性评价。多学科专家小组对指南进行了进一步的分析和审查。由于用于推荐合适成像算法的数据会出现不足或模棱两可,在这种情况下,专家意见可能对现有证据进行补充。为此,将美国《放射学院适宜性标准:肩关节置换术后影像学检查》翻译成中文,供同道参考。

关键词：全肩关节置换术美国放射学院影像学检查适宜性标准核磁共振成像计算机断层扫描循证指南