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npj Computational Materials 2023年第1期9卷 1469-1481页

作者： Kate L.M.Elder joel Berry Aurélien Perron Brandon Bocklund jibril Shittu Connor j.Rietema Hunter B.Henderson Scott K.McCall joseph T.McKeown Materials Science Division Lawrence Livermore National LaboratoryLivermoreCA 94550USA.✉

Here the discovery of refractory multi-principal element alloys(MPEAs)with high-temperature strength and stability is pursued within a constrained and application-relevant design space.A comprehensive approach is developed and applied to explore all 165 ternary systems in the Al-Ce-Fe-Hf-Mo-Nb-Ta-Ti-V-W-Zr family.A subset of ternary systems that contain large areas in composition–temperature space with high strength and robust BCC phase stability is *** sets of high-performing alloys are identified,each set optimized for one combination of phase constraint,optimization target,and temperature *** mechanical tests support the viability of the *** work highlights the importance of considering phase stability,exploring non-equiatomic regions of composition space,and applying application-relevant *** I and II provide three down-selection techniques for identifying high-performing BCC refractory MPEAs,design guidelines,and many candidates predicted to have BCC phase stability and strengths 2–3 times higher than any reported to date.

关键词： alloys element ternary

Downregulating activated epidermal growth factor receptor has no effect on RBM5 expression

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Chinese Medical journal 2012年第13期125卷 2378-2381页

作者： Twinkle j. Masilamani Nina D. Rintala-maki WANG Ke Leslie C. Sutherland Tumor Biology Group Regional Cancer Program of the Sudbury Regional Hospital Sudbury Ontario Canada P3E 5J1 Biomolecular Sciences Program Laurentian University Sudbury Ontario Canada P3E 5J1 Departments of Chemistry/Biochemistry and Biology Laurentian University Sudbury Ontario Canada P3E 5J1 Department of Respiratory Medicine Second Affiliated Hospital ofJilin University Changchun Jilin 130000 China Medical Sciences Division Northern Ontario School of Medicine Laurentian and Lakehead Universities Canada Faculty of Medicine University of Ottawa Canada

Background We were interested in determining how the tumor suppressor gene RBM5 is regulated in lung cancers. Previous studies suggested that the gene expression is related to histological subtype and smoking exposure, since in small cell lung cancers the RBM5 gene is deleted whereas in non-small cell lung carcinomas （NSCLC） RBM5 expression is reduced. Of particular interest was the recent finding that in lung adenocarcinomas, a histological subtype of NSCLC, smoking exposure correlated with mutational activity in the transforming growth factor alpha （TGF-c~） signaling pathway. Lung adenocarcinomas from smokers were associated with activating KRAS mutations, whereas lung adenocarcinomas from never-smokers were associated with activating epidermal growth factor receptor （EGFR） mutations. We hypothesized that inhibition of RBM5 in lung adenocarcinomas is achieved indirectly via these activating mutations. The objective of the research described herein was to determine if EGFR activation and RBM5 expression are negatively correlated. Methods EGFR expression in the lung adenocarcinoma cell line NCI-H1975 was inhibited using small interfering RNA. RBM5 expression was examined by real-time quantitative polymerase chain reaction and Western blotting. Results Reduced EGFR expression did not correlate with any change in RBM5 expression at either the RNA or protein level. Conclusion These results suggest that RBM5 expression is not directly regulated by EGFR in non-smoker related lung adenocarinomas, and that some other mechanism operates to inhibit either the expression or function of this potential tumour suppressor in lung cancers that retain the RBM5 gene.

关键词： adenocarcinoma epidermal growth factor receptor RBM5 gene expression

Textiles from non-wood feedstocks: Challenges and opportunities of current and emerging fiber spinning technologies

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journal of Bioresources and Bioproducts 2024年第4期9卷 410-432页

作者： Ryen M.Frazier Mariana Lendewig Ramon E.Vera Keren A.Vivas Naycari Forfora Ivana Azuaje Autumn Reynolds Richard Venditti joel j.Pawlak Ericka Ford Ronalds Gonzalez Department of Forest Biomaterials North Carolina State UniversityRaleighNC 27695USA Department of Textile Engineering Chemistry and ScienceThe Nonwovens InstituteNorth Carolina State UniversityRaleighNC 27695USA

As the global population continues growing, the demand for textiles also increases, putting pres- sure on cotton manufacturers to produce more natural fiber from this already undersupplied resource. Synthetic fibers such as polyester (PET) can be manufactured quickly and cheaply, but these petroleum-based products are detrimental to the environment. With increased efforts to encourage transparency and create a more circular textile economy, other natural alternatives must be considered. This article discusses the existing condition and future possibilities for man- made cellulosic fibers (MMCFs), with an emphasis on using non-woody alternative feedstocks as a starting material. This work focuses on conversion technology suitable for producing textile- grade fibers from non-wood-based dissolving pulp, which may be different in nature from its woody counterpart and therefore behave differently in spinning processes. Derivatization and dissolution methods are detailed, along with spinning techniques and parameters for these pro- cesses. Existing research related to the spinning of non-woody-based dissolving pulp is covered, along with suggestions for the most promising feedstock and technology combinations. In addi- tion, an emerging method of conversion, in which textile fibers are spun from a hydrogel made of an undissolved nano/micro-fibrillated fiber suspension, is briefly discussed due to its unique po- tential. Methods and concepts compiled in this review relate to utilizing alternative feedstocks for future fibers while providing a better understanding of conventional and emerging fiber spinning processes for these fibers.

关键词： Non-wood Residue Regenerated cellulose Fibrillated cellulose Biobased fiber Textile Man-made cellulosic fiber

High-power,electronically controlled source of user-defined vortex and vector light beams based on a few-mode fiber amplifier

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Photonics Research 2021年第5期9卷 856-864页

作者： DI LIN joel CARPENTER YUTONG FENG YONGMIN jUNG SHAIF-UL ALAM DAVID j.RICHARDSON Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK School of Information Technology and Electrical Engineering The University of QueenslandBrisbaneQLD 4072Australia

Optical angular momentum(OAM)-based structured light beams provide an additional degree of freedom for practical applications ranging from optical communication to laser-based material processing. Many techniques exist for generating such beams within laser sources and these primarily rely upon the use of specially designed optical components that limit laser power scaling and ready tunability of the topological charge and polarization of the output OAM beams. Here we show that some of these limitations can be overcome by employing a computer controlled reflective phase-only spatial light modulator to adaptively tailor the input(and subsequent output) beam wavefront and polarization in a few-mode fiber amplifier. In this way modal-coupling-induced beam distortion within the fiber amplifier can be mitigated and we are able to generate at will any desired supported spatial mode guided in the fiber, including conventional linearly polarized(LP) modes, scalar OAM modes, and cylindrical vector modes, at average powers >10 W and with a peak power of >11 kW. Our results pave the way to the realization of practical high-power structured laser sources with tunable chirality and polarization.

关键词： amplifier fiber power

Synthesis and Crystal Structure of tert-Butyl(((2R,3R,6R)-3-hydroxy-6-(nitromethyl)-3,6-dihydro-2H-pyran-2-yl)methyl)carbonate

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Chinese journal of Structural Chemistry 2021年第9期40卷 1205-1212,1110页

作者： FENG Yong-Kui SU Hua-Lan MUKULA OTUKOL Billy joel ZHANG Xue-Qing YAO Hui HUANG Nian-Yu Hubei Key Laboratory of Natural Products Research and Development Key Laboratory of Functional Yeast(China National Light Industry)College of Biological and Pharmaceutical SciencesChina Three Gorges UniversityTichangHubei 443002China

In this paper,aβ-C-pyranogalactoside(Ⅸ)was synthesized from D-galactose through a nine-step reaction with a total yield of 32%under the palladium catalyst,and its structure was characterized by nuclear magnetic resonance(NMR)and high-resolution electrospray ionization mass spectrometry(HR-ESI-MS).The absolute configuration of this pyranogalactoside was confirmed with a Flack parameter of–0.01(6)by X-ray crystallography using a Cu radiation ***(Ⅸ),C_(12)H_(19)NO_(7),crystal data:monoclinic system,space group P2_(1)2_(1)2_(1),a=8.53480(10),b=9.4207(2),c=18.1308(3)A,V=1457.79(4)A^(3),Z=4,F(000)=616,Dc=1.318 g/cm^(3),μ=0.931 mm^(-1),R=0.0294 and wR=0.0752 for 2875 independent reflections(R_(int)=0.0163)and 2857 observed ones(I>2σ(I)).

关键词： X-ray diffraction crystal structure absolute configuration β-C-pyranogalactoside α-glucosidase inhibitory activity

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Management of Acute Skin Trauma

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中国运动医学杂志 2010年第2期29卷 221-224页

作者： joel W. Beam EdD LAT ATC University of North Florida Brooks College of Health

Acute skin trauma(ie,abrasions,avulsions,blis-ters,incisions,lacerations,and punctures)is common among individuals involved in work,recreational,and athletic *** management of these wounds is important to promote heal... 详细信息

关键词：运动医学皮肤损伤临床运动损伤

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耐热/耐磨烧结合金发展趋势

粉末冶金技术 2011年第5期29卷 386-393页

作者： Hideaki Kawata Kunio maki 韩凤麟日本日立粉末冶金(株) 亍270-2295松户市稔台520 不详

粉末冶金的一个特殊优势是合金设计自由度高,因此,烧结合金广泛用于耐热与耐磨零件。主要产品对象是气门导管、阀座圈(VSI)及发动机排气系统的零件。近年来,为回应环境问题,发动机的使用性能在不断提高,这些零件的使用环境随之越益严苛... 详细信息

粉末冶金的一个特殊优势是合金设计自由度高,因此,烧结合金广泛用于耐热与耐磨零件。主要产品对象是气门导管、阀座圈(VSI)及发动机排气系统的零件。近年来,为回应环境问题,发动机的使用性能在不断提高,这些零件的使用环境随之越益严苛,因此,就日益要求改进材料的耐磨性与其它性能。论述了近年来耐热/耐磨烧结材料的技术发展趋势,特别着重于材料发展趋势。

关键词：耐热性耐磨性切削性固体润滑剂阀系零件硬质颗粒

Wheat zinc finger protein TaZF interacts with both the powdery mildew AvrPm2 protein and the corresponding wheat Pm2a immune receptor

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Plant Communications 2024年第5期5卷 25-41页

作者： Beatrice Manser Helen Zbinden Gerhard Herren joel Steger jonatan Isaksson Stephanie Braunlich Thomas Wicker Beat Keller Department of Plant and Microbial Biology University of ZurichZollikerstrasse 1078008 ZurichSwitzerland Agroscope Route de Duillier 501260 NyonSwitzerland BIOREBA AG Christoph Merian-Ring 74153 ReinachSwitzerland

Plant defense responses to pathogens are induced after direct or indirect perception of effector proteins or their activity on host *** fungal–plant interactions,relatively little is known about whether,in addi-tion to avirulence effectors and immune receptors,other proteins contribute to specific *** nucleotide-binding leucine-rich repeat(NLR)immune receptor Pm2a in wheat recognizes the fungal pow-dery mildew effector *** found that the predicted wheat zincfinger TaZF interacts with both the fungal avirulence protein AvrPm2 and the wheat NLR *** further demonstrated that the virulent AvrPm2-H2 variant does not interact with *** silencing in wheat resulted in a reduction but not a loss of Pm2a-mediated powdery mildew *** studies showed that the leucine-rich repeat domain of Pm2a is the mediator of the interaction with *** recruits both Pm2a and AvrPm2 from the cytosol to the nucleus,resulting in nuclear localization of Pm2a,TaZF,and AvrPm2 in *** propose that TaZF acts as a facilitator of Pm2a-dependent AvrPm2 effector *** highlight the importance of identifying effector host targets for characterization of NLR-mediated effector recognition.

关键词： plant immunity plant-fungal interactions pathogen effectors nucleotide-binding leucine-rich repeat immune receptor NLR wheat powdery mildew

Informatics: The Frontier of Innovation in Health and Healthcare

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Engineering 2016年第1期2卷 37-39页

作者： Molly joel Coye Network for Excellence in Health Innovation

The purpose of public health and healthcare is to create healthier populations. The purpose of innovation in healthcare is to accelerate the transformation of the work processes and economic models required to improve health. The use of infor- mation technology and telecommunications, and especially of health informatics, is critically important to these goals. It is an inspiring and highly productive frontier for engineering, science, and human behavior, and is the most direct path to unleashing transformative and beneficial innovations in healthcare. I believe, however, that it is under-appreciated in terms of its potential.

关键词：医疗保健信息学健康公共卫生经济模式工作流程信息技术人的行为

Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice

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World journal of Gastroenterology 2010年第6期16卷 703-712页

作者： Nathalie E Ruyssers Benedicte Y De Winter joris G De Man Natacha D Ruyssers Ann j Van Gils Alex Loukas Mark S Pearson joel V Weinstock Paul A Pelckmans Tom G Moreels Laboratory of Experimental Medicine and Pediatrics Division of GastroenterologyUniversity of Antwerp Division of Infectious Diseases and Immunology Queensland Institute of Medical Research 4006 Brisbane Division of Gastroenterology-Hepatology Tufts New England Medical Center

AIM:To investigate the therapeutic effect of Schistosoma mansoni(***) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with *** *** were performed 5 d after TNBS *** quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal *** activity of distal colonic segments was studied in vitro using a modified Trendelenburg *** profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe *** with *** proteins significantly ameliorated colonic inflammation after 5 *** did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of *** with *** proteins ameliorated these in vivo and in vitro motility *** addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a *** protein effect was no longer observed at this time point. CONCLUSION:Treatment with *** proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis.

关键词： Schistosoma mansoni Helminth proteins Colitis Peristalsis Crohn’s disease Gastrointestinal motility Trinitrobenzene sulphate