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Predictors of clinical outcomes after non-operative management of symptomatic full-thickness rotator cuff tears

World journal of Orthopedics 2021年第4期12卷 223-233页

作者： Christopher Bush joel j gagnier james Carpenter Asheesh Bedi Bruce Miller Department of Orthopaedic Surgery University of MichiganAnn ArborMI 48106United States

BACKGROUND Previous studies have shown that non-surgical management can be an effective treatment strategy for many patients with rotator cuff *** the prevalence of rotator cuff disease,few studies have examined the patient and tear related factors that predict outcomes of nonsurgical management in this cohort of *** To identify factors that are associated with changes in patient reported outcomes over time in individuals with full-thickness rotator cuff tears treated without *** A cohort of 59 patients who underwent non-surgical management of full thickness rotator cuff tears with a minimum of 1-year follow-up were identified from our institutional *** demographics,comorbidities and tear characteristics were collected at initial *** measures were collected at baseline and at each clinical follow-up,which included Western Ontario Rotator Cuff(WORC)index,American Shoulder and Elbow Surgeons score,Visual Analog Scale for pain and Single Assessment Numerical ***-and univariate regression analyses were used to determine the impact of each patient and tear related variable on final WORC scores and change in WORC scores throughout the *** In this non-surgical cohort,all patient-reported outcome measures significantly improved compared to baseline at 1 and 2-year *** was no significant difference in outcomes between 1 and 2 *** average improvement surpassed the published minimal clinically important differences values for WORC,American Shoulder and Elbow Surgeons,Visual Analog Scale pain and Single Assessment Numerical Evaluation *** analysis identified female gender(β=-19.88,P=0.003),smoking(β=-29.98,P=0.014)and significant subscapularis fatty infiltration(β=-15.35,P=0.024)as predictors of less favorable WORC scores at 1 year,and female gender(β=-19.09,P=0.015)alone as a predictor of lower WORC scores at 2 *** with symptom duration greater than 1

关键词： Rotator cuff tear Conservative treatment Patient reported outcome measures Shoulder injuries Shoulder pain

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改进实效型试验的报告质量：CONSORT声明的扩充（1）

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英国医学杂志中文版 2009年第2期12卷 108-111页

作者： Merrick Zwarenstein Shaun Treweek joel j gagnier Douglas G Altman Sean Tunis Brian Haynes Andrew D Oxman David Moher 汪谋岳(译) Health Services Sciences Sunnybrook Hospital Toronto Ontario Canada Institute for Clinical Evaluative Sciences Toronto Depamnent of Health Policy Management and Evaluation University of Toronto Toronto Division of International Health (IHCAR) Karolinska Institute Stockholm Sweden Clinical and Population Sciences and Education University of Dundee Dundee Norwegian Knowledge Centre for the Health Services Oslo Norway Faculty of Medicine University of Toronto Centre for Statistics in Medicine University of Oxford Oxford Center for Medical Technology Policy Baltimore MD USA Division of General Internal Medicine Johns Hopkins School of Medicine Baltimore MD Center for Heahhcare Policy Stanford University School of Medicine Palo Alto CA USA Department of Clinical Epidemiology and Biostatistics and Department of Medicine McMaster University Faculty of Health Sciences Hamilton ON Canada Clinical Epidemiology Program Ottawa Health Research Institute Ottawa Canada Department of Epidemiology and Community Medicine Faculty of Medicine University of Ottawa Ottawa 中华医学杂志英文版编辑部

实效型试验旨在为临床实践决策提供依据，但报告得不好会降低其实用性。CONSORT和Practihc小组描述了对CONSORT指南的修改，帮助读者评估研究结果的适用性。

关键词： CONSORT声明报告质量试验临床实践适用性

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改进实效型试验的报告质量：CONSORT声明的扩充（2）

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英国医学杂志中文版 2009年第3期12卷 174-179页

作者： Merrick Zwarenstein Shaun Treweek joel j gagnier Douglas G Altman Sean Tunis Brian Haynes Andrew D Oxman David Moher 汪谋岳(译) Health Services Sciences Surmybrook Hospital Toronto Ontario Canada Insdtute for Clinical Evaluative Sciences Toronto Department of Health Policy Management and Evaluation University of Tomato Toronto Division of International Health (IHCAR) Karolinska Institute Stockholm Sweden Clinical and Population Sciences and Education University of Dundee Dundee Norwegian Centre for Services Oslo Norway Faculty of Medicine University of Tomato Centre for Statistics in Medicine University of Oxford Oxford Center for Medical Technology Policy Baltimore MD USA Division of General Internal Medicine Johns Hopkins School of Medicine Baltimore MD Center for Healthcare Policy Stanford University School of Medicine Palo Alto CA USA Department of Medicine McMastor University Faculty of Health Sciences Hamilton ON Canada Clinical Epidemiology Program Ottawa Health Research institute Ottawa Canada Department of Epidemiology and Community Medicine Faculty of Medicine University of Ottawa Ottawa 中华医学杂志英文版编辑部

关键词： CONSORT声明报告质量试验临床实践适用性

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提高实效性临床试验报告的质量——《CONSORT声明》的扩展

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中西医结合学报 2009年第4期7卷 392-397页

作者： Merrick Zwarenstein Shaun Treweek joel j gagnier Douglas G Altman Sean Tunis Brian Haynes Andrew D Oxman David Moher 吴宇峰刘建平 Health Services Sciences Sunnybrook HospitalToronto Institute for Clinical Evaluative Sciences Toronto Department of Health PolicyManagement and EvaluationUniversity of Toronto Division of International Health(IHCAR) Karolinska InstituteStockholm Clinical and Population Sciences and Education University of Dundee Norwegian Knowledge Centre for the Health Services Faculty of Medicine University of TorontoToronto Centre for Statistics in Medicine University of Oxford Center for Medical Technology Policy Balti more Department of Clinical Epidemiology and Biostatistics and Department of Medicine McMaster University Faculty of Health SciencesHamilton Clinical Epidemiology Program Ottawa Health Research Institute Department of Epidemiology and Community Medicine Faculty of MedicineUniversity of Ottawa 北京中医药大学循证医学中心

近年来实效性临床试验受到更多重视,尤其在传统医学临床评价研究领域。为了提高实效性临床试验报告的质量,CONSORT声明组和医疗保健体系中的实效性随机对照临床试验(pragmatic randomized controlled trials in health care systems,PRA... 详细信息

近年来实效性临床试验受到更多重视,尤其在传统医学临床评价研究领域。为了提高实效性临床试验报告的质量,CONSORT声明组和医疗保健体系中的实效性随机对照临床试验(pragmatic randomized controlled trials in health care systems,PRACTIHC)小组对《CONSORT声明》进行了修改,以帮助读者评估试验质量和结果的可靠性。实效性试验报告指南,作为《CONSORT声明》的一个特殊扩展,能在报告、评价和应用实效性试验方面帮助编辑、系统评价者、试验设计者和决策者评估实效性试验报告中的信息,判定其结论是否适用,以及干预措施是否可行、可否被接受。2005年1月和2008年3月,在加拿大多伦多分别举行了为期两天的会议来探讨提高随机对照试验对卫生保健决策贡献的方法,焦点集中于实效性试验。2005年会,后扩展版草案修订清单发送至编写组成员,经过几次修订,编写组起草了一份摘要草案。在2008年讨论并修改了这一草案。这份草案发给CONSORT声明组以供修改并发表。这份声明的扩展版提出了对8个条目的补充。及时向国内读者和临床试验研究人员介绍该指南有重要的现实意义和学术价值。北京中医药大学循证医学中心刘建平教授等在短时间内翻译了该指南。本刊希望通过介绍中文版"提高实效性临床试验报告的质量——《CONSORT声明》的扩展"以提高国内实效性临床试验报告的质量,相信也有助于改进试验设计的方法学质量。

关键词： CONSORT声明临床试验报告试验质量实效性随机对照临床试验医疗保健体系临床评价传统医学

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ON THE ALGORITHMIC COMPLEXITY OF STATIC STRUCTURES

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journal of Systems Science & Complexity 2010年第6期23卷 1037-1053页

作者： joel RATSABY j. CHASKALOVIC joel RATSABY Dept. of Electrical and Electronics Engineering Ariel University Center of Samaria Ariel Israel Department of Mathematics Ariel University Center of Samaria Ariel Israel and IJLRDA University Pierre and Marie Curie-Paris VI France.

This paper provides a first indication that this is true for a system comprised of a static structure described by hyperbolic partial differential equations and is subjected to an external random input force. The system deforms the randomness of an input force sequence in proportion to its algorithmic complexity. The authors demonstrate this by numerical analysis of a one-dimensional vibrating elastic solid （the system） on which we apply a maximally-random force sequence （input）. The level of complexity of the system is controlled via external parameters. The output response is the field of displacements observed at several positions on the body. The algorithmic complexity and stochasticity of the resulting output displacement sequence is measured and compared against the complexity of the system. The results show that the higher the system complexity, the more random-deficient the output sequence.

关键词： Data compression descriptional complexity randomness static structure.

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Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens

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journal of Animal Science and Biotechnology 2020年第4期11卷 1245-1260页

作者： joel j.Maki Elizabeth A.Bobeck Matthew j.Sylte Torey Looft Food Safety and Enteric Pathogens Research Unit National Animal Disease CenterAgricultural Research ServiceUS Department of Agriculture1920 Dayton AveAmesIA 50010USA Interdepartmental Microbiology Graduate Program Iowa State University|AmesIA 50011USA Oak Ridge Institute for Science and Education ARS Research Participation ProgramOak RidgeTN 37830USA Department of Animal Science Iowa State UniversityAmesIA 50011USA.

Background: The initial intestinal microbiota acquired from different sources has profound impacts on animal health and productivity. In modern poultry production practices, the source(s) of the establishing microbes and their overall contribution during development of gastrointestinal tract communities are still unclear. Using fertilized eggs from two independent sources, we assessed the impact of eggshell-and environmental-associated microbial communities on the successional processes and bacterial community structure throughout the intestinal tract of chickens for up to 6 weeks ***: Culturing and sequencing techniques identified a viable, highly diverse population of anaerobic bacteria on the eggshell. The jejunal, ileal, and cecal microbial communities for the egg-only, environment-only, and conventionally raised birds generally displayed similar successional patterns characterized by increasing community richness and evenness over time, with strains of Enterococcus, Romboutsia, and unclassified Lachnospiraceae abundant for all three input groups in both trials. Bacterial community structures differed significantly based on trial and microbiota input with the exception of the egg-exposed and conventional birds in the jejunum at week 1 and the ileum at week 6. Cecal community structures were different based on trial and microbiota input source, and cecal short-chain fatty acid profiles at week 6 highlighted functional differences as ***: We identified distinct intestinal microbial communities and differing cecal short-chain fatty acid profiles between birds exposed to the microbiota associated with either the eggshell or environment, and those of conventionally hatched birds. Our data suggest the eggshell plays an appreciable role in the development of the chicken intestinal microbiota, especially in the jejunum and ileum where the community structure of the eggshellonly birds was similar to the structure of conventionally hatched birds

关键词： 16S rRNA gene Eggshell microbiota Environmental microbiota Hatching Intestinal colonization SCFA Succession

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Exercise intolerance in heart failure with preserved ejection fraction： more than a heart problem

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journal of Geriatric Cardiology 2015年第3期12卷 294-304页

作者： Bharathi Upadhya Mark j Haykowsky joel Eggebeen Dalane W Kitzman Cardiology and Geriatrics Wake Forest School of Medicine Medical Center Blvd Winston Salem NC USA Faculty of Rehabilitation Medicine University of Alberta Edmonton AB Canada

Heart failure （HF） with preserved ejection fraction （HFpEF） is the most common form of HF in older adults, and is increasing in preva- lence as the population ages. Furthermore, HFpEF is increasing out of proportion to HF with reduced EF （HFrEF）, and its prognosis is worsening while that of HFrEF is improving. Despite the importance of HFpEF, our understanding of its pathophysiology is incomplete, and optimal treatment remains largely undefined. A cardinal feature of HFpEF is reduced exercise tolerance, which correlates with symptoms as well as reduced quality of life. The traditional concepts of exercise limitations have focused on central dysfimction related to poor cardiac pump function. However, the mechanisms are not exclusive to the heart and lungs, and the understanding of the pathophysiology of this dis- ease has evolved. Substantial attention has focused on defining the central versus peripheral mechanisms underlying the reduced functional capacity and exercise tolerance among patients with HF. In fact, physical training can improve exercise tolerance via peripheral adaptive mechanisms even in the absence of favorable central hemodynamic function. In addition, the drug trials performed to date in HFpEF that have focused on influencing cardiovascular function have not improved exercise capacity. This suggests that peripheral limitations may play a significant role in HF limiting exercise tolerance, a hallmark feature of HFpEF.

关键词： Exercise intolerance Heart failure Perioheral limitations Skeletal muscle

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Guest editorial: Network architectures and communication protocols for smart industrial IoT applications

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Digital Communications and Networks 2023年第2期9卷 293-295页

作者： Fazlullah Khan joel j.P.C.Rodrigues Mian Ahmad jan Department of Computer Science Abdul Wali Khan University Mardan23200Khyber PakhtunkhwaPakistan Federal University of Piauí(UFPI) Brazil Instituto de TelecomunicaçoesPortugal

The rapid growth in hardware technologies and the fourth industrial revolution-Industry 4.0 have enabled the Internet of Things(IoT)to be *** of the main drivers in Industry 4.0 is smart and secured Industrial IoT(IIoT)[1].The IIoT results from the widespread use of computers and the interconnectedness of *** has made software a crucial tool for almost every industry,from bakeries and arts to manufacturing facilities and healthcare systems[2].The IIoT devices can be mobile and geographically distributed over a long distance,which exposes them to network disturbances,Quality of Service(QoS)degradation,and security *** addition,the IIoT is a complex network at a large scale,and there is a dire need for network architecture and protocol design to accommodate these diverse domains and competencies and handle the increasing levels of ***,in this special issue,we aim to focus on the challenges of network architectures and communication protocol design in the context of the smart *** special issue has attracted numerous high-quality research articles and has accepted fourteen research papers[3–16].

关键词： IoT network communication

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Modified activated carbon with interconnected fibrils of iron-oxyhydroxides using Mn^(2+) as morphology regulator, for a superior arsenic removal from water

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journal of Environmental Sciences 2019年第2期31卷 403-414页

作者： Cesar Nieto-Delgado joel Gutiérrez-Martínez j.Rene Rangel-Méndez Environmental Sciences Division Potosino Institute of Scientific and Technological ResearchIPICyT

The arsenic removal efficiency of iron-modified activated carbons depends greatly on the number of available iron oxide surface sites, which are given by the surface area of the anchored particles. In this sense, aiming the generation of an adsorbent with superior arsenic adsorption capacity, we developed a protocol to anchor interconnected fibrils of iron oxyhydroxides, using Mn^(2+) as a morphology regulator. The protocol was based on a microwave-assisted hydrothermal method, using bituminous based activated carbon and both Fe^(2+) and Mn^(2+) ions in the hydrolysis solution. The elemental analysis of modified carbons revealed that Mn does not anchor to the carbon. However, when Mn is included in the hydrolysis solution, the iron content in the activated carbon increased up to 3.5 wt%,without considerable decreasing the adsorbent surface area. Under specific hydrothermal conditions, the Mn^(2+) promoted the formation of iron oxide nanoparticles shaped as interconnected fibrils. This material showed a superior arsenic adsorption capacity in comparison to similar iron modified activated carbons(5 mg As/g carbon, at 2 mg As/L),attributed to the increase in quantity and availability of active sites located on the novel interconnected fibrils of iron oxyhydroxides nanostructures.

关键词： Iron oxide nanostructures Hydrothermal synthesis Microwave Adsorption capacity Kinetics

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Adult celiac disease with acetylcholine receptor antibody positive myasthenia gravis

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World journal of Gastroenterology 2009年第38期15卷 4741-4744页

作者： Hugh j Freeman Helen R Gillett Peter M Gillett joel Oger Department of Medicine (Gastroenterology and Neurology) University of British Columbia

Celiac disease has been associated with some autoimmune disorders. A 40-year-old competitive strongman with celiac disease responded to a gluten-free diet, but developed profound and generalized motor weakness with acetylcholine receptor antibody positive myasthenia gravis, a disorder reported to occur in about 1 in 5000. This possible relationship between myasthenia gravis and celiac disease was further explored in serological studies. Frozen stored serum samples from 23 acetylcholine receptor antibody positive myasthenia gravis patients with no intestinal symptoms were used to screen for celiac disease. Both endomysial and tissue transglutaminase antibodies were examined. One of 23 (or, about 4.3%) was positive for both IgA-endomysial and IgA tissue transglutaminase antibodies. Endoscopic studies subsequently showed duodenal mucosal scalloping and biopsies confirmed the histopathological changes of celiac disease. Celiac disease and myasthenia gravis may occur together more often than is currently appreciated. The presence of motor weakness in celiac disease may be a clue to occult myasthenia gravis, even in the absence of intestinal symptoms.

关键词： Acetylcholine receptor antibodies Celiacdisease Myasthenia gravis Transglutaminase antibodies

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