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Integrins and their potential roles in mammalian pregnancy

Journal of Animal Science and Biotechnology 2024年第1期15卷 1-19页

作者： Gregory A.Johnson Robert C.Burghardt Fuller W.Bazer Heewon Seo joe.W.Cain Department of Veterinary Integrative Biosciences School of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843‑4459USA Department of Animal Science College of Agriculture and Life SciencesTexas A&M UniversityCollege StationTX 77843‑2471USA

Integrins are a highly complex family of receptors that, when expressed on the surface of cells, can mediate reciprocal cell-to-cell and cell-to-extracellular matrix(ECm) interactions leading to assembly of integrin adhesion complexes(IACs) that initiate many signaling functions both at the membrane and deeper within the cytoplasm to coordinate processes including cell adhesion, migration, proliferation, survival, differentiation, and metabolism. All metazoan organisms possess integrins, and it is generally agreed that integrins were associated with the evolution of multicellularity, being essential for the association of cells with their neighbors and surroundings, during embryonic development and many aspects of cellular and molecular biology. Integrins have important roles in many aspects of embryonic development, normal physiology, and disease processes with a multitude of functions discovered and elucidated for integrins that directly influence many areas of biology and medicine, including mammalian pregnancy, in particular implantation of the blastocyst to the uterine wall, subsequent placentation and conceptus(embryo/fetus and associated placental membranes) development. This review provides a succinct overview of integrin structure, ligand binding, and signaling followed with a concise overview of embryonic development, implantation, and early placentation in pigs, sheep, humans, and mice as an example for rodents. A brief timeline of the initial localization of integrin subunits to the uterine luminal epithelium(LE) and conceptus trophoblast is then presented, followed by sequential summaries of integrin expression and function during gestation in pigs, sheep, humans, and rodents. As appropriate for this journal, summaries of integrin expression and function during gestation in pigs and sheep are in depth, whereas summaries for humans and rodents are brief. Because similar models to those illustrated in Fig. 1, 2, 3, 4, 5 and 6 are present throughout the sc

关键词： Humans Implantation Integrins Pigs Pregnancy Rodents Sheep

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John 5给初学者与专业吉他手的实用建议

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乐器 2024年第7期 110-111页

作者： joe.Bosso Slowly(译) 不详

John 5是一位精通多种风格的吉他大师,曾与Lynyrd Skynyrd、David Lee Roth、Rick Springf ield合作演出,现在更是加入到m?tley Crüe,他为乐手提供的指导远不止练习方法这么简单。任何能将乡村风格的chicken pickin'技法与金属速弹相... 详细信息

John 5是一位精通多种风格的吉他大师,曾与Lynyrd Skynyrd、David Lee Roth、Rick Springf ield合作演出,现在更是加入到m?tley Crüe,他为乐手提供的指导远不止练习方法这么简单。任何能将乡村风格的chicken pickin'技法与金属速弹相结合的吉他手,绝不仅仅是“一招吃天下”。在他的职业生涯中,John 5将多样性作为自己的一张名片,他提供的吉他服务受到了众多艺术家的青睐,其中包括***、marilyn manson、Wilson Phillips、Lynyrd Skynyrd、David Lee Roth、Rick Springfield、Salt-N-Pepa等。

关键词：吉他手合作演出实用建议乡村风格练习方法多种风格职业生涯

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Surgical intervention combined with weight-bearing walking training promotes recovery in patients with chronic spinal cord injury:a randomized controlled study

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Neural Regeneration Research 2024年第12期19卷 2773-2784页

作者： Hui Zhu James D.Guest Sarah Dunlop Jia-Xin Xie Sujuan Gao Zhuojing Luo joe.E.Springer Wutian Wu Wise Young Wai Sang Poon Song Liu Hongkun Gao Tao Yu Dianchun Wang Libing Zhou Shengping Wu Lei Zhong Fang Niu Xiaomei Wang Yansheng Liu Kwok-Fai So Xiao-ming Xu Kunming Tongren Hospital KunmingYunnan ProvinceChina Neurological Surgery and the Miami Project to Cure ParalysisMiller School of MedicineUniversity of MiamiMiamiFLUSA School of Biological Sciences The University of Western AustraliaPerthWAAustralia minderoo Foundation PerthWAAustralia Clinical Center for Spinal Cord Injury Kunming General Hospital of Chengdu Military CommandKunmingYunnan ProvinceChina Department of Biostatistics and Health Data Science Indiana University School of MedicineIndianapolisINUSA Department of Orthopedic Spinal Surgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Spinal Cord and Brain Injury Research Center Department of Physical Medicine and RehabilitationUniversity of Kentucky College of MedicineLexingtonKYUSA Guangdong-HongKong-macao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina W.m.Keck Center for Collaborative Neuroscience Rutgers UniversityPiscatawayNJUSA Neurosurgery Department Chinese University of Hong KongPrince of Wales HospitalHong Kong Special Administration RegionChina Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA

For patients with chronic spinal cord injury,the co nventional treatment is rehabilitation and treatment of spinal cord injury complications such as urinary tract infection,pressure sores,osteoporosis,and deep vein *** is rarely perfo rmed on spinal co rd injury in the chronic phase,and few treatments have been proven effective in chronic spinal cord injury *** of effective therapies fo r chronic spinal co rd injury patients is *** conducted a randomized controlled clinical trial in patients with chronic complete thoracic spinal co rd injury to compare intensive rehabilitation(weight-bearing walking training)alone with surgical intervention plus intensive *** clinical trial was registered at ***(NCT02663310).The goal of surgical intervention was spinal cord detethering,restoration of cerebrospinal fluid flow,and elimination of residual spinal cord *** found that surgical intervention plus weight-bearing walking training was associated with a higher incidence of American Spinal Injury Association Impairment Scale improvement,reduced spasticity,and more rapid bowel and bladder functional recovery than weight-bearing walking training ***,the surgical procedures and intensive rehabilitation were *** Spinal Injury Association Impairment Scale improvement was more common in T7-T11 injuries than in T2-T6 *** combined with rehabilitation appears to have a role in treatment of chronic spinal cord injury patients.

关键词： chronic spinal cord injury intensive rehabilitation locomotor training neurological recovery surgical intervention weightbearing walking training

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An Imbalanced Dataset and Class Overlapping Classification model for Big Data

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Computer Systems Science & Engineering 2023年第2期44卷 1009-1024页

作者： mini Prince P.m.joe.Prathap Department of Information Technology St.Peter’s College of Engineering and TechnologyChennai600054TamilnaduIndia Department of Information Technology R.M.D Engineering CollegeChennai601206TamilnaduIndia

most modern technologies,such as social media,smart cities,and the internet of things(IoT),rely on big *** big data is used in the real-world applications,two data challenges such as class overlap and class imbalance *** dealing with large datasets,most traditional classiﬁers are stuck in the local optimum *** a result,it’s necessary to look into new methods for dealing with large data *** solutions have been proposed for overcoming this *** rapid growth of the available data threatens to limit the usefulness of many traditional *** such as oversampling and undersampling have shown great promises in addressing the issues of class *** all of these techniques,Synthetic minority Oversampling TechniquE(SmOTE)has produced the best results by generating synthetic samples for the minority class in creating a balanced *** issue is that their practical applicability is restricted to problems involving tens of thousands or lower instances of *** this paper,we have proposed a parallel mode method using SmOTE and mapReduce strategy,this distributes the operation of the algorithm among a group of computational nodes for addressing the aforementioned *** proposed solution has been divided into three ***ﬁrst stage involves the process of splitting the data into different blocks using a mapping function,followed by a pre-processing step for each mapping block that employs a hybrid SmOTE algo-rithm for solving the class imbalanced *** each map block,a decision tree model would be ***,the decision tree blocks would be com-bined for creating a classiﬁcation *** have used numerous datasets with up to 4 million instances in our experiments for testing the proposed scheme’s *** a result,the Hybrid SmOTE appears to have good scalability within the framework proposed,and it also cuts down the processing time.

关键词： Imbalanced dataset class overlapping SmOTE mapReduce parallel programming oversampling

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A Novel Approach to Design Distribution Preserving Framework for Big Data

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Intelligent Automation & Soft Computing 2023年第3期35卷 2789-2803页

In several fields like financial dealing,industry,business,medicine,et cetera,Big Data(BD)has been utilized extensively,which is nothing but a collection of a huge amount of ***,it is highly complicated along with time-consuming to process a massive amount of ***,to design the Distribution Preserving Framework for BD,a novel methodology has been proposed utilizing manhattan Distance(mD)-centered Partition Around medoid(mD–PAm)along with Conjugate Gradient Artificial Neural Network(CG-ANN),which undergoes various steps to reduce the complications of ***,the data are processed in the pre-processing phase by mitigating the data repetition utilizing the map-reduce function;subsequently,the missing data are handled by substituting or by ignoring the missed *** that,the data are transmuted into a normalized ***,to enhance the classification performance,the data’s dimensionalities are minimized by employing Gaussian Kernel(GK)-Fisher Discriminant Analysis(GK-FDA).Afterwards,the processed data is submitted to the partitioning phase after transmuting it into a structured *** the partition phase,by utilizing the mD-PAm,the data are partitioned along with grouped into a ***,by employing CG-ANN,the data are classified in the classification phase so that the needed data can be effortlessly retrieved by the *** analogize the outcomes of the CG-ANN with the prevailing methodologies,the NSL-KDD openly accessible datasets are *** experiential outcomes displayed that an efficient result along with a reduced computation cost was shown by the proposed *** proposed work outperforms well in terms of accuracy,sensitivity and specificity than the existing systems.

关键词： Big data artiﬁcial neural network ﬁsher discriminant analysis distribution preserving framework manhattan distance

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Physicochemical properties of silver carp(Hypophthalmichthys molitrix)mince sausages as influenced by washing and frozen storage

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Aquaculture and Fisheries 2023年第4期8卷 403-409页

作者： Kaveh Rahmanifarah joe.m.Regenstein mehdi Nikoo Department of Pathobiology and Quality Control Artemia and Aquaculture Research InstituteUrmia UniversityUrmiaWest Azerbaijan57179-44514Iran Department of Food Science Cornell UniversityIthacaNY14853-7201USA

Frozen storage of emulsion-type sausages may be one approach to avoid or reduce the use of sodium nitrite,which is associated with health *** carp(Hypophthalmichthys molitrix)mince(m_(0))was washed for 1(m_(1))or 3(m_(3))times and the impact of washing on the properties frozen storage(−18℃)during 4 months were determined and results were compared to those of conventional silver carp sausages(mt).Lipid oxidation,as evidenced by changes in thiobarbituric acid reactive substances and FFAs,took place during storage in the order of m_(0)>m_(1)=m_(3)=mt with m_(0)being highly oxidized(P≤0.05).Total volatile base nitrogen formed during storage and the ranking for the quality loss was as follows m_(0)>m_(1)>m_(3)=***(m_(1)=m_(3))led to less hardness(P≤0.05).mt had better redness,while m_(1)and m_(3)led to higher expressible moisture,water release and lightness(P≤0.05).Results indicated the lower sensory and consumer-liking properties of frozen m_(1)and m_(3)***,washing and frozen storage influenced silver carp mince sausages.

关键词： Frozen storage Emulsion-type sausages Hypophthalmichthys molitrix minced fish

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Dual-shell silicate and alumina coating for long lasting and high capacity lithium ion batteries

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Journal of Energy Chemistry 2022年第5期31卷 314-323页

作者： marcos Lucero Tucker m.Holstun Yudong Yao Ryan Faase maoyu Wang Alpha T.N’Diaye David P.Cann joe.Baio Junjing Deng Zhenxing Feng School of Chemical Biologicaland Environmental EngineeringOregon State UniversityCorvallisOR 97331United States Advanced Photon Source Argonne National LaboratoryArgonneIllinois 60439United States Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720United States materials Science School of MechanicalIndustrialand Manufacturing EngineeringOregon State UniversityCorvallisOR 97331United States

Here we demonstrate a theory-driven, novel dual-shell coating system of Li_(2)SrSiO_(4) and Al_(2)O_(3), achieved via a facile and scalable sol-gel technique on LiCoO_(2) electrode particles. The optimal thickness of each coating can lead to increased specific capacity(~185 m Ah/g at 0.5 C-rate) at a cut-off potential of 4.5 V, and greater cycling stability at very high C rates(up to 10 C) in half-cells with lithium metal. The mechanism of this superior performance was investigated using a combination of X-ray and electron characterization methods. It shows that the results of this investigation can inform future studies to identify still better dual-shell coating schemes, achieved by such industrially feasible techniques, for application on similar, nickel-rich cathode materials.

关键词： Lithium cobalt oxide Surface coating Sol-gel Silicate Alumina X-ray absorption spectroscopy

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A stochastic approach for integrating market and technical uncertainties in economic evaluations of petroleum development

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Petroleum Science 2009年第3期6卷 319-326页

作者： Changhyup Park joe.m. Kang Taewoong Ahn BK21 Research Division for Energy Resources Seoul National University Division of Energy Systems Engineering Seoul National University

The paper presents a stochastic and economic analysis for petroleum development under uncertain market and technical environments. mean-reversion with jumps for price forecasting is used to consider market uncertainty, while various scenarios for the reservoir properties and cost are employed to consider technical uncertainty. monte Carlo simulation is carried out to obtain the feasible range of net present values and internal rates of return. The influence of stochastic parameters is examined through correlation coefficients. The stochastic approach yields more reliable evaluation and effectively investigates the characteristics of development. The integration of uncertainties and contractual terms results in an irregular tendency in the future cash flow and reveals that a larger reserve does not guarantee a greater profit. The reserve and the well rate affect the economic values whereas the parameters for price prediction don＇t. The research confirms the necessity of qualifying uncertainties for realistic decision-making at the initial stage of development.

关键词： Uncertainty petroleum development decision-making stochastic approach mean reversion with jumps

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Alcohol,inflammation,and gut-liver-brain interactions in tissue damage and disease development

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World Journal of Gastroenterology 2010年第11期16卷 1304-1313页

作者： H joe.Wang Samir Zakhari m Katherine Jung Division of metabolism and Health Effects National Institute on Alcohol Abuse and Alcoholism National Institutes of Health

Chronic inflammation is often associated with alcoholrelated medical conditions. The key inducer of such inflammation, and also the best understood, is gut microflora-derived lipopolysaccharide (LPS). Alcohol can significantly increase the translocation of LPS from the gut. In healthy individuals, the adverse effects of LPS are kept in check by the actions and interactions of multiple organs. The liver plays a central role in detoxifying LPS and producing a balanced cytokine milieu. The central nervous system contributes to anti-inflammatory regulation through neuroimmunoendocrine actions. Chronic alcohol use impairs not only gut and liver functions, but also multi-organ interactions, leading to persistent systemic inflammation and ultimately, to organ damage. The study of these interactions may provide potential new targets for therapeutic intervention.

关键词： Chronic alcohol use Chronic inflammation Li- popolysaccharides Pro-inflammatory and anti-inflammatory cytokines Kupffer cells monocytes Tumor necrosis factor α Interleukin-10 Neuroendocrine Hypothalamo-pituitary-adrenal axis Glucocorticoid

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Control and Stability of Large-scale Power System with Highly Distributed Renewable Energy Generation:Viewpoints from Six Aspects

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CSEE Journal of Power and Energy Systems 2023年第1期9卷 8-14页

作者： Qing-Hua Wu Anjan Bose Chanan Singh joe.H.Chow Gang mu Yuanzhang Sun Zhaoxi Liu Zhigang Li Yang Liu School of Electric Power Engineering South China University of TechnologyGuangzhou 510640China School of Electrical Engineering&Computer Science Washington State UniversityPullmanWA 99164USA Department of Electrical and Computer Engineering Texas A&M UniversityCollege StationTX 77843USA Department of Electrical Computer and Systems EngineeringRensselaer Polytechnic Institute(RPI)TroyNYUSA Key Laboratory of modern Power System Simulation and Control&Renewable Energy Technology Ministry of Education(Northeast Electric Power University)Jilin 132012China School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China

Power systems are moving toward a low-carbon or carbon-neutral future where high penetration of renewables is *** conventional fossil-fueled synchronous generators in the transmission network being replaced by renewable energy generation which is highly distributed across the entire grid,new challenges are emerging to the control and stability of large-scale power *** analysis and control methods are needed for power systems to cope with the ongoing *** the CSEE JPES forum,six leading experts were invited to deliver keynote speeches,and the participating researchers and professionals had extensive exchanges and discussions on the control and stability of power ***,potential changes and challenges of power systems with high penetration of renewable energy generation were introduced and explained,and advanced control methods were proposed and analyzed for the transient stability enhancement of power grids.

关键词： Distributed energy resources high converter penetration power system control renewable energy generation stability control transient stability

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