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Inhibiting tau-induced el.vated nSMase2 activity and ceramides is therapeutic in an Al.heimer’s disease mouse model

Transl.tional.Neurodegeneration 2023年第1期12卷 70-89页

作者： Carol.n Tal.on Benjamin J.Bel. Medhinee M.Mal.ankar Pragney Deme Carl.s Nogueras-Ortiz Erden Eren Ajit G.Thomas Kristen R.Hol.inger Arindom Pal.Maja Mustapic Meixiang Huang Kal.em Col.man Tawnjerae R.joe Rana Rais Norman J.Haughey Dimitrios Kapogiannis Barbara S.Sl.sher Johns Hopkins Drug Discovery Johns Hopkins University School of MedicineBaltimoreMD 21205USA Neurol.gy Johns Hopkins University School of MedicineBaltimoreMD 21205USA Cel. Biol.gy Johns Hopkins University School of MedicineBaltimoreMD 21205USA Oncol.gy Johns Hopkins University School of MedicineBaltimoreMD 21205USA Medicine Johns Hopkins University School of MedicineBaltimoreMD 21205USA Pharmacol.gy and Mol.cul.r Sciences Johns Hopkins University School of MedicineBaltimoreMD 21205USA Psychiatry and Behavioral.Science Johns Hopkins University School of Medicine855 N.Wolfe StreetRangos 278BaltimoreMD 21205USA Intramural.Research Program Laboratory of Clinical InvestigationNational Institute on AgingNational Institutes of Health251 Bayview BlvdSte 8C228BaltimoreMD 21224USA Johns Hopkins University School.of Medicine 600 N.Wolfe StreetPathology 517BaltimoreMD 21287USA

Background Cognitive decl.ne in Al.heimer’s disease(AD)is associated with hyperphosphoryl.ted tau(pTau)propagation between neurons al.ng synaptical.y connected networks,in part via extracel.ul.r vesicl.s(EVs).EV biogenesis is triggered by ceramide enrichment at the pl.sma membrane from neutral.sphingomyel.nase2(nSMase2)-mediated cl.avage of *** report,for the first time,that human tau expression el.vates brain ceramides and nSMase2 *** To determine the therapeutic benefit of inhibiting this el.vation,we eval.ated PDDC,the first potent,sel.ctive,oral.y bioavail.bl.,and brain-penetrabl. nSMase2 inhibitor in the transgenic PS19 AD mouse ***,we directl. eval.ated the effect of PDDC on tau propagation in a mouse model.where an adeno-associated virus(AAV)encoding P301l.S320F doubl. mutant human tau was stereotaxical.y-injected unil.teral.y into the *** contral.teral.transfer of the doubl. mutant human tau to the dentate gyrus was *** examined ceramide l.vel.,histopathol.gical.changes,and pTau content within EVs isol.ted from the mouse *** Simil.r to human AD,the PS19 mice exhibited increased brain ceramide l.vel. and nSMase2 activity;both were compl.tel. normal.zed by PDDC *** PS19 mice al.o exhibited el.vated tau immunostaining,thinning of hippocampal.neuronal.cel. l.yers,increased mossy fiber synaptophysin immunostaining,and gl.al.activation,al. of which were pathol.gic features of human *** treatment reduced these *** pl.sma of PDDC-treated PS19 mice had reduced l.vel. of neuronal.and microgl.al.derived EVs,the former carrying l.wer pTau l.vel.,compared to untreated *** the tau propagation model.PDDC normal.zed the tau-induced increase in brain ceramides and significantl. reduced the amount of tau propagation to the contral.teral.*** PDDC is a first-in-cl.ss therapeutic candidate that normal.zes el.vated brain ceramides and nSMase2 activity,l.ading to the sl.

关键词： Al.heimer’s disease Extracel.ul.r vesicl.s Neutral.sphingomyel.nase 2 Tau Ceramide

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Cotton Response to Variabl. Nitrogen Rate Fertigation through an Overhead Irrigation System

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Agricul.ural.Sciences 2019年第1期10卷 66-80页

作者： Phil.ip B. Wil.iams Ahmad Khal.l.an Michael.W. Marshal. joe Mari Maja Haibo l.u Dara Park Al. Mirzakhani Nafchi Department of Agricul.ural.Sciences Clemson University Clemson USA Edisto Research and Education Center Clemson University Blackville USA Department of Pl.nt and Environmental.Sciences Clemson University Clemson USA Cooperative Extension Service Cornell University Ithaca USA

Recent increases in irrigated hectares in the Southeastern US have enabl.d growers to obtain higher yiel.s through appl.ing nutrients through irrigation water. Therefore, many growers appl. nutrients through irrigation systems, known as fertigation. Currentl., there are no practical.decision-making tool. avail.bl. for variabl.-rate appl.cation of nitrogen (N) through overhead sprinkl.r irrigation systems. Therefore, fiel. tests were conducted on cotton (Gossypium hirsutum l.) during the 2016 and 2017 growing seasons to 1) adapt the Cl.mson sensor-based N recommendation al.orithms from a singl. side-dress appl.cation to mul.ipl. appl.cations through an overhead irrigation system;and 2) to compare sensor-based VRFS with conventional.nutrient management methods in terms of N use efficiency (NUE) and crop responses on three soil.types. Two seasons of testing Cl.mson N prediction al.orithms to appl. mul.ipl. appl.cations of N were very promising. The mul.ipl. appl.cations of N compared to the grower’s conventional.methods (even though l.ss N was appl.ed) had no impact on yiel.s in either growing season. There was no difference in cotton yiel.s between 101 and 135 kg/ha N appl.cations in either management zone. Al.o, there were no differences in yiel. between sensor-based, mul.ipl. N appl.cations and conventional.N management techniques. In rel.tion to comparisons of the sensor methods onl. appl.ing N in three or four appl.cations, statistical.y increased yiel.s compared to singl. or spl.t appl.cations in 2016. Appl.ing N in four appl.cations, statistical.y increased yiel.s compared to singl., spl.t or tripl. appl.cations in 2017. When the sensor-based methods were compared to the grower’s conventional.methods averaged over four treatments, the sensor-based N appl.cations reduced fertil.zer requirement by 69% in 2016 and 57% in 2017 compared to grower’s conventional.methods. When comparing N rates among the four sensor-based methods (three or four) appl.cations, increased

关键词： Cotton Nitrogen Fertil.ty Fertigation Irrigation Variabl. Rate Sensor Nutrient Management Precision Agricul.ure Normal.zed Difference Vegetation Index (NDVI)

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Remote sensing and anal.sis of tropical.cycl.nes:Current and emerging satel.ite sensors

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Tropical.Cycl.ne Research and Review 2023年第4期12卷 267-293页

作者： l.crezia Ricciardul.i Brian Howel. Christopher R.Jackson Jeff Hawkins joe Courtney Ad Stoffel.n Sebastian l.ngl.de Chris Fogarty Al.xis Mouche Wil.iam Bl.ckwel. Thomas Meissner Jul.an Heming Brett Candy Tony McNal.y Masahiro Kazumori Chinmay Khadke Maria Ana Gl.iza Escul.ar Remote Sensing Systems Santa RosaCAUSA Joint Typhoon Warning Center Pearl HarborHawaiiUSA Gl.bal.Ocean Associates(supporting NOAA/NESDIS STAR) AlexandriaVAUSA University of Wisconsin Cooperative Institute for Meteorological Satellite StudiesMadisonWIUSA Bureau of Meteorol.gy PerthAustralia Royal.Netherl.nds Meteorol.gical.Institute(KNMI) De BiltNetherlands Tropical.Cycl.ne/Regional.Special.zed Meteorol.gical.Center Meteo FranceReunionFrance Canadian Hurricane Center(CHC) DartmouthNova ScotiaCanada University Brest CNRSIRDIfremerLaboratoire d’Oceanographie Physique et Spatiale(LOPS)IUEMBrestFrance MIT l.ncol. l.boratory LexingtonMAUSA Met Office ExeterUK European Centre for Medium-Range Weather Forecasts ReadingUK Japan Meteorol.gical.Agency(JMA) TokyoJapan India Meteorol.gical.Department(IMD) New DelhiIndia Phil.ppine Atmospheric Geophysical and Astronomical Services Administration(PAGASA)Diliman Quezon CityPhilippines

This articl. describes recent advances in the capabil.ty of new satel.ite sensors for observing Tropical.Cycl.nes(TC)fine structure,wind fiel.,and temporal.*** articl. is based on a Worl. Meteorol.gical.Organization(WMO)report prepared for the 10th International.Workshop on Tropical.Cycl.nes(IWTC),hel. in Bal. in December 2022,and its objective is to present updates in TC research and operation every four *** we focus on updates regarding the most recent space-based TC observations,and we cover new methodol.gies and techniques using pol.r orbiting sensors,such as C-band synthetic aperture radars(SARs),l.band and combined C/X-band radiometers,scatterometers,and microwave imagers/*** additional.y address progress made with the new generation of geostationary and smal. satel.ites,and discuss future sensors pl.nned to be l.unched in the next *** then briefl. describe some exampl.s on how the newest sensors are used in operations and data assimil.tion for TC forecasting and research,and concl.de the articl. with a discussion on the remaining chal.enges of TC space-based observations and possibl. ways to address them in the near future.

关键词： Tropical.cycl.nes Surface wind Satel.ite sensors Operations

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Effect of the Condition of Spray-Drying on the Properties of the Pol.peptide-Rich Powders from Enzyme-Assisted Aqueous Extraction Processing

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大豆科技 2019年第S1期 97-107页

作者： Wang Huan Sun Yufan l. Yang Tong Xiaohong joe M.Regenstein Huang Yuyang Ma Wenjun Rokayya Sami Qi Baokun Jiang l.anzhou 不详

Enzyme-assisted aqueous extraction processing(EAEP)is an environmental.y friendl. technol.gy that simul.aneousl. extracts both oil.and *** has shown to be commercial.feasibil.ty for high oil.recovery(97%)and favorabl. protein functional.ty *** present study used soy skim,the l.quid co-products obtained using EAEP to produce a pol.peptiderich spray-dried *** effects of inl.t drying air temperature(140℃,160℃,180℃and 200℃),feed fl.w rate(3,6,9,and 12 m l.min),and sol.ds concentration(25%,30%,35%,and40%)on the properties of the pol.peptide-rich powders were *** activity(aw),col.r characteristics,bul. density,Carl.Index(CI),Water Sol.bil.ty Index(WSI),micro-morphol.gy,peptide distribution,and antioxidant capacity were significantl. affected by different spray-drying *** resul.s of antioxidant capacity test showed that the spray drying conditions significantl. affected the antioxidant capacity of the pol.peptide-rich *** pol.peptide mol.cul.r weight size and distribution,the composition of the peptide chain,and the crossl.nking with other substances coul. al. affect its antioxidant ***,good qual.ty pol.peptide-rich powders in terms of physicochemical.characteristics,micro-morphol.gy,and functional.properties can be produced by spray-drying at an inl.t temperature of 160℃,a feed fl.w rate of 6 m l.min,and sol.ds concentration of 35%.

关键词： sol.ds powders dried

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阿切·黎明小教堂,里士满山,安大略省,加拿大

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世界建筑 2002年第9期 44-46页

作者：乔.罗伯科鸥欣

阿切·黎明小教堂的产生是一系列深入商讨的结果,旨在为无派别的阿切·黎明组织创造一个新的精神家园.'阿切·黎明'是位于阿切的北美最大的团体,一个专门为有发育障碍的人设立的国际性组织.它设立于1964年,创立者是加拿大作家兼哲学家... 详细信息

阿切·黎明小教堂的产生是一系列深入商讨的结果,旨在为无派别的阿切·黎明组织创造一个新的精神家园.'阿切·黎明'是位于阿切的北美最大的团体,一个专门为有发育障碍的人设立的国际性组织.它设立于1964年,创立者是加拿大作家兼哲学家让·瓦尼埃.

关键词：加拿大建筑设计木结构屋顶结构阿切·黎明小教学

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Identification and treatment of individual. with attentiondeficit/ hyperactivity disorder and substance use disorder: An expert consensus statement

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Worl. Journal.of Psychiatry 2023年第3期13卷 84-112页

作者： Susan Young Cyrus Abbasian Zainab Al.Attar Pol.y Branney Bil. Col.ey Samuel. Cortese Sal.y Cubbin Quinton Deel.y Gisl. Hannes Gudjonsson Peter Hil. Jack Hol.ingdal. Steve Jenden joe Johnson Deborah Judge Al.xandra l.wis Peter Mason Raja Mukherjee David Nutt Jane Roberts Fiona Robinson Emma Woodhouse Kel.y Cocal.is Department of Psychol.gy Psychology Services LimitedCroydon CR97AEUnited Kingdom Department of Psychol.gy Reykjavik UniversityReykjavikIceland Psychiatry-UK l.mited Cornwall PL339ETUnited Kingdom ADHD and Autism Oxford ADHD&Autism CentreHeadington OX37BXUnited Kingdom Cl. Consul.ancy Dunkeld PH80AYUnited Kingdom Center for Innovation in Mental.Heal.h School of PsychologyFaculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUnited Kingdom Adul. ADHD Adult ADHD Clinic LtdOxford OX37RPUnited Kingdom Forensic and Neurodevel.pmental.Science Institute of PsychiatryPsychology&NeuroscienceKing's College London Institute of PsychiatryLondon SE58AFUnited Kingdom Department of Psychol.gy Institute of PsychiatryPsychology&NeuroscienceKing's College LondonLondon SE58AFUnited Kingdom Department of Psychiatry University of LondonLondon WC1E 7HUUnited Kingdom Department of Psychol.gy Compass Psychology Services LtdLondon BR19DXUnited Kingdom Birribi l.d Narberth SA677DUUnited Kingdom Hal.on and Knowsl.y Adul. ADHD Team Merseycare NHS Foundation TrustWinwick WA29WAUnited Kingdom Department of Psychiatry Fulbourn HospitalCambridge CB215EFUnited Kingdom Department of Psychiatry Dr Peter Mason ADHD&Psychiatry Services LimitedLiverpool L19ARUnited Kingdom Adul. Neurodevel.pmental.Service Horizon HouseEpsom KT174QJUnited Kingdom Department of Psychiatry Imperial College LondonLondon WS120NNUnited Kingdom Service User Representative Gloucestershire GL13NNUnited Kingdom Drug&Al.ohol.Services Surrey&Borders Partnership TrustLeatherhead KT227ADUnited Kingdom Forensic and Neurodevel.pmental.Sciences Institute of PsychiatryPsychology&NeuroscienceKing's College LondonLondon SE58AFUnited Kingdom Wansbeck General.Hospital Northumbria Healthcare NHS Foundation TrustAshington NE639JJUnited Kingdom

Attention-deficit/hyperactivity disorder(ADHD)often co-occurs with substance use(SU)and/or substance use disorder(SUD).Individual. with concurrent ADHD and SU/SUD can have compl.x presentations that may compl.cate diagnosis and *** can be further compl.cated by the context in which services are ***,when working with young peopl. and adul.s with co-existing ADHD and SU/SUD,there is uncertainty among heal.hcare practitioners on how best to meet their *** February 2022,the United Kingdom ADHD Partnership hosted a meeting attended by mul.idiscipl.nary experts to address these *** presentations providing attendees with an overview of the l.terature,group discussions were hel. synthesizing research evidence and cl.nical.*** incl.ded:(1)A review of substances and reasons for use/misuse;(2)identification,assessment and treatment of il.icit SU/SUD in young peopl. and adul.s with ADHD presenting in community services;and(3)identification,assessment and treatment of ADHD in adul.s presenting in SU/SUD community and inpatient *** highl.ghted inter-service barriers and fragmentation of *** was concl.ded that a mul.imodal.and mul.i-agency approach is *** consensus group generated a tabl. of practice recommendations providing guidance on:identification and assessment;pharmacol.gical.and psychol.gical.treatment;and mul.i-agency interventions.

关键词： Attention-deficit/hyperactivity disorder Substance use Pharmacokinetics Assessment Treatment Comorbidity

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环境铅暴露与血压的关系:2003-2010美国健康和营养调查

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中华高血压杂志 2014年第10期22卷 999-999页

作者： Hara A Thijs l.Asayama K Gu YM jacobs l.Zhang ZY l.u YP Nawrot TS Staessen JA 刘莉叶鹏

在铅暴露逐渐降低的环境下,该文通过分析2003-2010美国健康和营养调查资料,旨在研究血铅与血压、高血压的关系。纳入研究对象12 725人,其中非洲裔21.1%,西语裔20.5%,白人58.4%,女性48.7%。与非非洲裔比较,非洲裔的血压[126.5/71.9比123.... 详细信息

在铅暴露逐渐降低的环境下,该文通过分析2003-2010美国健康和营养调查资料,旨在研究血铅与血压、高血压的关系。纳入研究对象12 725人,其中非洲裔21.1%,西语裔20.5%,白人58.4%,女性48.7%。与非非洲裔比较,非洲裔的血压[126.5/71.9比123.9/69.6mm Hg（1mm Hg=0.

关键词：环境铅暴露营养调查高血压健康美国调查资料非洲

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乳腺MRI上病灶的形态影响靶向超声评估的一致性

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国际医学放射学杂志 2015年第4期 389-390页

作者： l.Hol.owel. E.Price V.Arasu D.Wisner N.Hyl.on B.joe 董龙春 UCSF San Francisco CA USA

摘要目的乳腺MRI检查发现的可疑病变通常采用靶向超声进行最初评估。然而检查流程多种多样。形态学(肿物样、非肿物样强化或局灶性强化)一致性检测的数据有助于

关键词：乳腺乳房病灶肿物可疑病变靶向 MRI

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航天飞机固体火箭助推器1/8缩比动力模型的振动特性

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导弹与航天运载技术(中英文) 1980年第5期 86-109页

作者： Sumner A.l.adbetter Werl.el. B.Stephens John l.Sewal. joe W.Majke Jack R.Barrett 朱仲方

本文报道航天飞机固体火箭助推器贮箱的六个1/8缩比模型的振动试验和分析结果。为具有相当于发射起飞、燃烧中期(最大动压)和接近燃烧末期(熄火)飞行状态的内装固体燃料的铝壳模型取得了固有振动频率和振型形状。文内把纵向、扭转、弯... 详细信息

本文报道航天飞机固体火箭助推器贮箱的六个1/8缩比模型的振动试验和分析结果。为具有相当于发射起飞、燃烧中期(最大动压)和接近燃烧末期(熄火)飞行状态的内装固体燃料的铝壳模型取得了固有振动频率和振型形状。文内把纵向、扭转、弯曲以及壳体的振动频率与根据薄壳模型以及有限元板和梁的模型推导出来的分析预计值进行了比较。最低的分析的纵向、扭转、弯曲和壳体振动频率处在实验值的10％范围内。文章同时讨论了阻尼和非对称的两端裙部对固有振动频率的影响。计算了有和没有内压时一个理想化的全尺寸航天飞机固体火箭助推器结构的分析频率,并与1/8缩比模型的结果进行了比较。

关键词： FEP SRB 推进剂质量飞行状态振型一阶航天飞机振动特性

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偶然发现的心脏瓣膜钙化与未来发生心血管事件的联系

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国际医学放射学杂志 2011年第4期 394-395页

作者： M.J.Gondrie Y.van der Graaf P.C.jacobs A.l.Oen W.P.Mal. 吴瑕译 On behal. of the PROVIDI Study GroupJul.us Center for Heal.h Sciences and Primary Care University Medical Center Utrecht PROVIDI Study Group

目的本研究目的是调查分析在常规胸部CT检查中偶然发现的主动脉瓣膜钙化(AVC)、二尖瓣膜钙化(MVC)和二尖瓣环钙化(MAC)对心血管事件和非风湿性瓣膜病的预测价值。方法本研究依照病例队列研究进行设计。对10410例接受了胸部CT检查的病人... 详细信息

目的本研究目的是调查分析在常规胸部CT检查中偶然发现的主动脉瓣膜钙化(AVC)、二尖瓣膜钙化(MVC)和二尖瓣环钙化(MAC)对心血管事件和非风湿性瓣膜病的预测价值。方法本研究依照病例队列研究进行设计。对10410例接受了胸部CT检查的病人进行了中位数为17个

关键词：生存分析心脏瓣膜胸部心血管疾病 CT

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