检索结果-南通市图书馆

Temporal changes in inflammatory mitochondria-enriched microRNAs following traumatic brain injury and effects of miR-146a nanoparticle delivery

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第3期16卷 514-522页

作者： Wang-Xia Wang Paresh Prajapati Hemendra J.Vekaria Malinda Spry Amber L.Cloud Patrick G.Sullivan joe e.springer Sanders Brown Center on Aging University of KentuckyLexingtonKYUSA Spinal Cord and Brain Injury Research Center University of KentuckyLexingtonKYUSA Department of Pathology&Laboratory Medicine University of KentuckyLexingtonKYUSA Department of Neuroscience University of KentuckyLexingtonKYUSA

MicroRNAs(miRNAs)are small non-coding RNA molecules that regulate post-transcriptional gene expression and contribute to all aspects of cellular *** previously reported that the activities of several mitochondria-enriched miRNAs regulating inflammation(i.e.,miR-142-3p,miR-142-5p,and miR-146a)are altered in the hippocampus at 3–12 hours following a severe traumatic brain *** the present study,we investigated the temporal expression profile of these inflammatory miRNAs in mitochondria and cytosol fractions at more chronic post-injury times following severe controlled cortical impact injury in *** addition,several inflammatory genes were analyzed in the cytosol *** analysis showed that while elevated levels were observed in cytoplasm,the mitochondria-enriched miRNAs,miR-142-3p and miR-142-5p continued to be significantly reduced in mitochondria from injured hippocampi for at least 3 days and returned to near normal levels at 7 days *** not statistically significant,miR-146a also remained at reduced levels for up to 3 days following controlled cortical impact injury,and recovered by 7 *** contrast,miRNAs that are not enriched in mitochondria,including miR-124a,miR-150,miR-19b,miR-155,and miR-223 were either increased or demonstrated no change in their levels in mitochondrial fractions for 7 *** one exception was that miR-223 levels were reduced in mitochondria at 1 day following *** major alterations were observed in sham operated *** temporal pattern was unique to mitochondria-enriched miRNAs and correlated with injury-induced changes in mitochondrial bioenergetics as well as expression levels of several inflammatory *** observations suggested a potential compartmental re-distribution of the mitochondria-enriched inflammatory miRNAs and may reflect an intracellular mechanism by which specific miRNAs regulate injury-induced inflammatory *** test this,we utilized a novel peptide-based

关键词： cell permeable peptide-delivery controlled cortical impact inflammatory pathway mitochondria-associated microRNA nanoparticle nuclear factor-kappa B traumatic brain injury

Surgical intervention combined with weight-bearing walking training promotes recovery in patients with chronic spinal cord injury:a randomized controlled study

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第12期19卷 2773-2784页

作者： Hui Zhu James D.Guest Sarah Dunlop Jia-Xin Xie Sujuan Gao Zhuojing Luo joe e.springer Wutian Wu Wise Young Wai Sang Poon Song Liu Hongkun Gao Tao Yu Dianchun Wang Libing Zhou Shengping Wu Lei Zhong Fang Niu Xiaomei Wang Yansheng Liu Kwok-Fai So Xiao-Ming Xu Kunming Tongren Hospital KunmingYunnan ProvinceChina Neurological Surgery and the Miami Project to Cure ParalysisMiller School of MedicineUniversity of MiamiMiamiFLUSA School of Biological Sciences The University of Western AustraliaPerthWAAustralia Minderoo Foundation PerthWAAustralia Clinical Center for Spinal Cord Injury Kunming General Hospital of Chengdu Military CommandKunmingYunnan ProvinceChina Department of Biostatistics and Health Data Science Indiana University School of MedicineIndianapolisINUSA Department of Orthopedic Spinal Surgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Spinal Cord and Brain Injury Research Center Department of Physical Medicine and RehabilitationUniversity of Kentucky College of MedicineLexingtonKYUSA Guangdong-HongKong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina W.M.Keck Center for Collaborative Neuroscience Rutgers UniversityPiscatawayNJUSA Neurosurgery Department Chinese University of Hong KongPrince of Wales HospitalHong Kong Special Administration RegionChina Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA

For patients with chronic spinal cord injury,the co nventional treatment is rehabilitation and treatment of spinal cord injury complications such as urinary tract infection,pressure sores,osteoporosis,and deep vein *** is rarely perfo rmed on spinal co rd injury in the chronic phase,and few treatments have been proven effective in chronic spinal cord injury *** of effective therapies fo r chronic spinal co rd injury patients is *** conducted a randomized controlled clinical trial in patients with chronic complete thoracic spinal co rd injury to compare intensive rehabilitation(weight-bearing walking training)alone with surgical intervention plus intensive *** clinical trial was registered at ***(NCT02663310).The goal of surgical intervention was spinal cord detethering,restoration of cerebrospinal fluid flow,and elimination of residual spinal cord *** found that surgical intervention plus weight-bearing walking training was associated with a higher incidence of American Spinal Injury Association Impairment Scale improvement,reduced spasticity,and more rapid bowel and bladder functional recovery than weight-bearing walking training ***,the surgical procedures and intensive rehabilitation were *** Spinal Injury Association Impairment Scale improvement was more common in T7-T11 injuries than in T2-T6 *** combined with rehabilitation appears to have a role in treatment of chronic spinal cord injury patients.

关键词： chronic spinal cord injury intensive rehabilitation locomotor training neurological recovery surgical intervention weightbearing walking training

Targeting the mitochondrial permeability transition pore in traumatic central nervous system injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第8期13卷 1338-1341页

作者： joe e. springer Pareshkumar Prajapati Patrick G. Sullivan Spinal Lord and Brain Injury Research Center Department of Neuroscience University of Kentucky Lexington KY USA

The mitochondrion serves many functions in the central nervous system （CNS） and other organs beyond the well-recognized role of adenosine triphosphate （ATP） production. This includes calcium-dependent cell signaling, regulation of gene expression, synthesis and release of cytotoxic reactive oxygen species, and the release of cytochrome c and other apoptotic cell death factors. Traumatic injury to the CNS results in a rapid and, in some cases, sustained loss of mitochondrial function. One consequence of compromised mitochondrial function is induction of the mitochondrial permeability transition （mPT） state due to formation of the cyclosporine A sensitive permeability transition pore （mPTP）. In this mini-review, we summarize evidence supporting the involvement of the mPTP as a mediator of mitochondrial and cellular demise following CNS traumatic injury and discuss the beneficial effects and limitations of the current ex- perimental strategies targeting the mPTP.

关键词： mitochondrial permeability transition cyclophilin-D cyclosporine A NIM811 spinal cord injury traumatic brain injury secondary injury functional recovery

Antioxidant effect of Herbs and Spices on Copper Mediated Oxidation of Lower and Very Low Density Lipoprotein

在线全文

学校读者我要写书评

暂无评论

中国天然药物 2010年第2期8卷 114-120页

作者： Gabriel A.Agbor joe A.Vinson Julius e.Oben Jeanne Y.Ngogang CRPMT Institute of Medical Research and Medicinal Plants StudiesP.O Box 6163Yaoundé Cameroon Department of Chemistry University of ScrantonScrantonPennsylvania18510 USA Department of Biochemistry University of YaoundéICameroon Department of Physiological Sciences Faculty of Medicine and Biomedical SciencesUniversity of YaoundéICameroon

AIM:The present study investigates the antioxidant effect of two extracts(hydrolyzed and non-hydrolyzed)of five herbs and eight spices in the prevention of LDL+VLDL oxidation promoted by cupric ***:The polyphenolic concentrations of these extracts were measured using Folin-Ciocalteu *** antioxidant quality was analyzed by the determination of lag-time,concentration of polyphenol that will inhibit 50%of oxidation of LDL+VLDL(IC50)and phenol antioxidant index(PAOXI). ReSULTS:The hydrolyzed extracts had significant higher polyphenol concentration,longer lag-time,lower IC50 and higher PAOXI than the non-hydrolyzed extracts(Ped extract contains better quantity and quality polyphenolic antioxidant than the non-hydrolyzed *** hydrolyzed and non-hydrolyzed extracts were better antioxidants than Vitamin e in the inhibition of LDL+VLDL ***:The reaction rate and concentration of conjugated diene formed suggested that all the extracts had similar reaction mechanism in the prevention of copper mediated LDL+VLDL oxidation.

关键词：抗氧化剂药草水解多酚

An index method to evaluate growers' pesticide use for identifying on-farm innovations and effective alternative pest management strategies:a case study of winegrape in Madera County,California

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第3期12卷 226-246页

作者： Wen-juan LI Zhi-hao QIN Ming-hua ZHANG joe BROWDe Institute of Agro-Resources and Regional Planning Chinese Academy of Agricultural Sciences Beijing 100081 China Internatinal Institute for earth System Sciences Nanjing University Nanjing 210093 China Department of Land Air and Water Resources University of California Davis CA 95616 USA California Association of Winegrape Growers Sacramento CA 95825 USA

Winegrape is an important perennial crop in California,*** year California winegrape farming consumes about 20 million kilograms of pesticides that have been a pollutant source to the fresh water systems of the *** variation of pesticide use among winegrape growers has been *** has been observed that some growers have developed effective ways to reduce pesticide use,yet control pests efficiently to ensure ***-tification of the growers with low and high pesticide use is very helpful to extension programs that aim on reducing pesticide environmental *** this study,an index approach is proposed to quantitatively measure pesticide use intensity at grower *** integrated pesticide use index is developed by taking pesticide quantity and toxicity into *** additive formula and a multiplying formula were used to calculate the pesticide use index,i.e.,PUI and *** was found that both PUI and PUIM were capable of identifying the low and high pesticide users while PUI was slightly more conservative than *** pesticides used in California winegrape farming were taken into account for calculating the *** County,one of the largest winegrape producers in California,was taken as an example to test the proposed *** year 2000,among the total 208 winegrape growers,28 with PUI≤10 and 34 with 10ere identified as low pesticide users who were characterized with both low quantity and low toxicity of pesticide *** of the growers had small-sized vineyards,i.e.,one field and small planted ***,they had very low pesticide use intensity,used only 1-2 types of pesticides(mainly fungicides) ,applied few pesticides(1-3 only) ,and emphasized the use of low toxicity ***,19 growers with PUI>60,identified as high pesticide users,had large-sized vineyards,i.e.,more fields and large planted *** used all types of pesticides and many compounds,which indicated that their pest controls he

关键词： Pesticide use index Toxicity Compound Pesticide environmental risk California

Biotic resistance limits the invasiveness of the western flower thrips, Frankliniella occidentalis （Thysanoptera： Thripidae）, in Florida

在线全文

学校读者我要写书评

暂无评论

Insect Science 2016年第2期23卷 175-182页

作者： joe Funderburk Galen Frantz Charles Mellinger Kara Tyler-Julian Mrittunjai Srivastava North Florida Research and education Center University of Florida Florida 32351 USA Glades Crop Care Inc. Jupiter Florida 33458 USA

The spread of the western flower thrips, Frankliniella occidentalis （Pergande）, has resulted in the world-wide destabilization of established integrated pest management programs for many crops. It is hypothesized that frequent exposure to insecticides in intensive agriculture selected for resistant populations, which allowed invasive populations in the eastern USA to overcome biotic resistance from the native community of species. Research conducted in Florida to understand the role of biotic factors in limiting the abundance of the western flower thrips is reviewed. Orius spp. （Hemiptera： Anthocoridae） are effective predators that suppress populations of thrips on crop and non-crop hosts in southern and northern Florida. Orius are more effective predators of the western flower thrips than the native flower thrips, e tritici （Fitch） and e bispinosa （Morgan）. The native species are competitors of the western flower thrips. excessive fertilization and the use of broad-spectrum insecticides in crop fields further enhances populations of the western flower thrips. Interactions with native species clearly limit the abundance of western flower thrips in Florida, but populations are abundant in fertilized crop fields where application of insecticides excludes predators and competitor species.

关键词： disturbed habitat integrated pest management managing pest invasion resistance to invasion thrips pests

Online Pattern Recognition and Data Correction of PMU Data Under GPS Spoofing Attack

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean energy 2020年第6期8卷 1240-1249页

作者： Ancheng Xue Feiyang Xu Jingsong Xu joe H.Chow Shuang Leng Tianshu Bi State Key Laboratory of Alternate electrical Power System with Renewable energy Sources North China Electric Power UniversityBeijing 102206China State Grid Ningxia Yinchuan electric Power Company Yinchuan 750001China the Department of electrical Computerand Systems EngineeringRensselaer Polytechnic Institute(RPI)TroyNY 12180USA

Smart grids are increasingly dependent on data with the rapid development of communication and *** one of the important data sources of smart grids,phasor measurement unit(PMU)is facing the high risk from *** with cyber attacks,global position system(GPS)spoofing attacks(GSAs)are easier to implement because they can be exploited by portable devices,without the need to access the physical ***,this paper proposes a novel method for pattern recognition of GSA and an additional function of the proposed method is the data correction to the phase angle difference(PAD)***,this paper analyzes the effect of GSA on PMU measurement and gives two common patterns of GSA,i.e.,the step attack and the ramp ***,the method of estimating the PAD deviation across a transmission line introduced by GSA is proposed,which does not require the line *** obtaining the estimated PAD deviations,the pattern of GSA can be recognized by hypothesis tests and correlation coefficients according to the statistical characteristics of the estimated PAD ***,with the case studies,the effectiveness of the proposed method is demonstrated,and the success rate of the pattern recognition and the online performance of the proposed method are analyzed.

关键词： global position system(GPS) GPS spoofing attack(GSA),phasor measurement,pattern recognition,data correction,line parameter

Sturgeon and paddlefish:Review of research on broodstock and early life stage management

在线全文

学校读者我要写书评

暂无评论

Aquaculture and Fisheries 2024年第6期9卷 871-882页

作者： Victor P.Lobanov joe Pate Alyssa Joyce Department of Marine Sciences University of GothenburgGothenburg40530Sweden Regen Aquaculture WaltonKY41094USA

Sturgeon aquaculture has taken a parallel yet unique path relative to other teleost *** of the driving factors has been the fact that virtually all extant species are facing extinction;thus,laws concerning the transport and processing of sturgeon are *** a result,most sturgeon companies vertically integrate the farming process from hatchery to harvest,in contrast to the production of other commercial fish species(e.g.,trout,sea bass,salmon),where farmers tend to purchase fry from producers specialized only in the production of that life stage and sell product to unaffiliated fish *** aquaculture is furthermore unique in the extremely high value of the main product(caviar).The secondary product(meat)also surpasses other finfish aquaculture products’average price per *** expensive outputs reveal the greatest challenge in production-an exceptionally long time to market from larvae to harvestable *** all their rigor and robustness as juveniles and adults,sturgeon species are highly fragile during larval *** to the unique legal framework around sturgeon cultivation,aquaculturists often specialize in regional species,although some hybrids have achieved global *** lends to a heterogenous swath of literature on best cultivation and management practices,especially at early growth ***,the role of aquaculture as both a food source and restocking program to thwart further extinction of sturgeon species has hardly been fully *** light of the many challenges,this review examines recent advances in sturgeon farming with an emphasis on broodstock and early life-stage management to summarize studies that can help researchers and farmers assess the industry’s current state.

关键词： Sturgeon Paddlefish Sturgeon aquaculture Sturgeon fishery

On the mechanism and control for the ultra-low frequency oscillation in NY Power Grid with large-scale hydropower

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Control Theory and Technology 2019年第3期17卷 241-251页

作者： Ancheng XUe Jiawei WANG Chao ZHeNG joe H.CHOW Tianshu BI State Key Laboratory of Alternate electrical Power System with Renewable energy Source (North China electric Power University) Changping District Beijing 102206 China China electric Power Research Institute Haidian District Beijing 100192 China Department of electrical Computer and Systems Engineering Rensselaer Polytechnic Institute Troy 12180 New York State U.S.A.

The power grid with large proportion of hydropower may engage the ultra-low frequency oscillation (ULFO),which threatening the operation of *** the NY Power Grid system,whose dimension is over thousands,this paper reveals the cause of ULFO with the phase portrait method,i.e.,lies in the saturation of the different limits of the governor system of the generators,in other words,the occurrence of limit cycle is due to the non-smooth *** furthermore,it proposes two methods to suppress ULFO with the philosophy of destroying the condition of non-smooth *** detail,first,the phenomenon of ULFO in NY Power Grid,the damping characteristics and the limits in the governor system of the hydropower units are ***,based on the non-smooth bifurcation theory,the mathematical basis of the oscillation in the non-smooth system caused by the saturation of limits is *** then,the non-oscillation and oscillation dynamic of the system corresponding to without/with limits in the governor system are ***,it discusses the influence of the saturation of single limit on the characteristics of ULFO with the phase ***,the phase portraits of the ULFO under different faults is analyzed,and it shows that the limiting saturation occurs with a large enough ***,the ULFO is resulting from the negative damping of generation and the saturation of multiple limits under a large enough *** addition,according to the above mechanism,two strategies to suppress the ULFO,i.e.,the governor parameters tuning and the fault strength relief are *** simulation shows the effectiveness of proposed strategies.

关键词： Ultra -low frequency oscillatio n gover nor system limit no rnsmooth bifurcation limit cycle