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Insights on the molecular mechanism of neuroprotection exerted by edible bird’s nest and its bioactive constituents

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Food Science and Human Wellness 2023年第4期12卷 1008-1019页

作者： Weiyi Chu Chia Wei Phan Seng joe Lim Abdul Salam Babji Department of Pharmaceutical Life Sciences Faculty of PharmacyUniversiti MalayaKuala Lumpur 50603Malaysia Clinical Investigation Centre University Malaya Medical CentreLembah Pantai Kuala Lumpur 59100Malaysia Mushroom research Centre Universiti MalayaKuala Lumpur 50603Malaysia Department of Food Sciences Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaUKM BangiSelangor 43600Malaysia Innovation Centre for Confectionery Technology(MANIS) Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaUKM BangiSelangor 43600Malaysia

Neurodegenerative diseases are often associated with the accumulation of oxidative stress and *** bird’s nest(eBN)is a glycoprotein(sialylated mucin glycopeptides)found to be beneficial against neurodegenerative ***,anti-inflammatory,and anti-apoptotic properties of eBN in preserving neuronal cells were widely researched using in vitro and in vivo *** effects of eBN are often linked to its great number of antioxidants and anti-inflammatory *** compounds in eBN,especially sialic acid,add value to neurotrophic potential of eBN and contribute to neuronal repair and *** studies reporting the neuroprotective effects of eBN,their molecular mechanisms,and neuroactive composition were gathered in this review to provide better insights on the neuroprotective effects of eBN.

关键词： Antioxidant Composition edible bird nest Neurodegenerative disease Neuroprotection Sialylated mucin glycopeptide

Molecular cloning and comparative analysis of transcripts encoding chemosensory proteins from two plant bugs, Lygus lineolaris and Lygus hesperus

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Insect Science 2020年第3期27卷 404-424页

作者： J.joe Hull Omaththage P.Perera Mei-Xian Wang USDA-ArS Arid Land Agricultural research Center MaricopaArizonaUSA USDA-ArS Southern Insect Management Research UnitStonevilleMississippiUSA College of Animal Sciences Zhejiang UniversityHangzhouChina

Chemosensory proteins(CSPs)are soluble carrier proteins typically characterized by a six‐helix bundle structure joined by two disulfide bridges and a conserved Cys spacing pattern(C1‐X6‐8‐C2‐X16‐21‐C3‐X2‐C4).CSPs are functionally diverse with reported roles in chemosensation,immunity,development,and *** expand our molecular understanding of CSP function in plant bugs,we used recently developed transcriptomic resources for Lygus lineolaris and Lygus hesperus to identify 17 and 14 CSP‐like sequences,*** Lygus CSPs are orthologous and share significant sequence identity with previously annotated *** of the CSPs are predicted to deviate from the typical CSP structure with either five or seven helical segments rather than *** seven helix CSP is further differentiated by an atypical C3‐X3‐C4 Cys spacing *** transcriptase PCr‐based profiling of CSP transcript abundance in adult *** tissues revealed broad expression for most of the CSPs with antenna specific expression limited to a subset of the *** sequence analyses and homology modeling suggest that variations in the amino acids that comprise the Lygus CSP binding pockets affect the size and nature of the ligands accommodated.

关键词： chemosensation chemosensory protein homology modeling Lygus plant bug mired transcriptome

A Clearinghouse for Genome-edited Crops and Field Testing

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Molecular Plant 2021年第1期14卷 3-5页

作者： Angela Fernando Michael Selvaraj Paul Chavarriaga Sandra Valdes joe Tohme The Alliance of Bioversity International and International Center for Tropical Agriculture(CIAT) Km 17 Recta Cali-PalmiraApartado Aereo 6713763537 CaliColombia

Latin America was commonly called"sleeping giant"for its humid tropics and land base relative to its population *** International Center for Tropical Agriculture(ClAT,*** Spanish acronym)was initiated in 1967 to serve three important zones-coastal plains,savannahs,and“hot,humid jungles.”In line,the research areas were organized to be fitted as appropriate into these important ecological *** the 50 years,CIAT has been a forerunner in developing and disseminating improved crop varieties and agricultural technologies,including its pioneering approaches in the tropics.

关键词： initiated fitted plain

Histogram Matched Chest X-rays Based Tuberculosis Detection Using CNN

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Computer Systems Science & engineering 2023年第1期44卷 81-97页

作者： joe Louis Paul Ignatius Sasirekha Selvakumar Kavin Gabriel joe Louis Paul Aadhithya B.Kailash S.Keertivaas S.A.J.Akarvin raja Prajan Department of Information Technology Sri Sivasubramaniya Nadar College of EngineeringRajiv Gandhi Salai(OMR)KalavakkamChennai603110Tamil NaduIndia Gullas College of Medicine-University of Visayas BaniladMandaue City6014CebuPhilippines

Tuberculosis(TB)is a severe infection that mostly affects the lungs and kills millions of people’s lives every *** can be diagnosed using chest X-rays(CXr)and data-driven deep learning(DL)*** of its better automated feature extraction capability,convolutional neural net-works(CNNs)trained on natural images are particularly effective in image cate-gorization.A combination of 3001 normal and 3001 TB CXr images was gathered for this study from different accessible public *** different deep CNNs(resnet50,resnet101,resnet152,InceptionV3,VGG16,VGG19,DenseNet121,DenseNet169,DenseNet201,MobileNet)are trained and tested for identifying TB and normal *** study presents a deep CNN approach based on histogram matched CXr images that does not require object segmenta-tion of interest,and this coupled methodology of histogram matching with the CXrs improves the accuracy and detection performance of CNN models for TB ***,this research contains two separate experiments that used CXr images with and without histogram matching to classify TB and non-TB CXrs using deep *** was able to accurately detect TB from CXr images using pre-processing,data augmentation,and deep CNN *** histogram matching the best accuracy,sensitivity,specificity,precision and F1-score in the detection of TB using CXr images among ten models are 99.25%,99.48%,99.52%,99.48%and 99.22%*** histogram matching the best accuracy,sensitivity,specificity,precision and F1-score are 99.58%,99.82%,99.67%,99.65%and 99.56%*** proposed meth-odology,which has cutting-edge performance,will be useful in computer-assisted TB diagnosis and aids in minimizing irregularities in TB detection in developing countries.

关键词： Tuberculosis detection chest x-ray(CXr) convolutional neural networks(CNNs) transfer learning histogram matching

The biological stress of early weaned piglets

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Journal of Animal Science and Biotechnology 2013年第2期4卷 124-127页

作者： Joy M Campbell joe D Crenshaw Javier Polo APC Inc. 2425 SE Oak Tree CourtAnkenyIA USA

Pigs experience biological stress such as physiological, environmental, and social challenges when weaned from the sow. The process of weaning is one of the most stressful events in the pig＇s life that can contribute to intestinal and immune system dysfunctions that result in reduced pig health, growth, and feed intake, particularly during the first week after weaning. Technological improvements in housing, nutrition, health, and management have been used to minimize some of the adverse effects of weaning stress, but a greater understanding of the biological impact of stress is needed to improve strategies to overcome weaning stress. The focus of this review paper is to briefly describe how the biological stress associated with weaning impacts intestinal morphology, structure, physiology, and intestinal immune responses that can impact subsequent production efficiencies such as growth, intake, morbidity, and mortality.

关键词： Biological stress Intestine Pig Weaning

An index method to evaluate growers' pesticide use for identifying on-farm innovations and effective alternative pest management strategies:a case study of winegrape in Madera County,California

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第3期12卷 226-246页

作者： Wen-juan LI Zhi-hao QIN Ming-hua ZHANG joe BrOWDe Institute of Agro-resources and regional Planning Chinese Academy of Agricultural Sciences Beijing 100081 China Internatinal Institute for earth System Sciences Nanjing University Nanjing 210093 China Department of Land Air and Water Resources University of California Davis CA 95616 USA California Association of Winegrape Growers Sacramento CA 95825 USA

Winegrape is an important perennial crop in California,*** year California winegrape farming consumes about 20 million kilograms of pesticides that have been a pollutant source to the fresh water systems of the *** variation of pesticide use among winegrape growers has been *** has been observed that some growers have developed effective ways to reduce pesticide use,yet control pests efficiently to ensure ***-tification of the growers with low and high pesticide use is very helpful to extension programs that aim on reducing pesticide environmental *** this study,an index approach is proposed to quantitatively measure pesticide use intensity at grower *** integrated pesticide use index is developed by taking pesticide quantity and toxicity into *** additive formula and a multiplying formula were used to calculate the pesticide use index,i.e.,PUI and *** was found that both PUI and PUIM were capable of identifying the low and high pesticide users while PUI was slightly more conservative than *** pesticides used in California winegrape farming were taken into account for calculating the *** County,one of the largest winegrape producers in California,was taken as an example to test the proposed *** year 2000,among the total 208 winegrape growers,28 with PUI≤10 and 34 with 10ere identified as low pesticide users who were characterized with both low quantity and low toxicity of pesticide *** of the growers had small-sized vineyards,i.e.,one field and small planted ***,they had very low pesticide use intensity,used only 1-2 types of pesticides(mainly fungicides) ,applied few pesticides(1-3 only) ,and emphasized the use of low toxicity ***,19 growers with PUI>60,identified as high pesticide users,had large-sized vineyards,i.e.,more fields and large planted *** used all types of pesticides and many compounds,which indicated that their pest controls he

关键词： Pesticide use index Toxicity Compound Pesticide environmental risk California

Molecular and genetic insights into an infantile epileptic encephalopathy - CDKL5 disorder

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Frontiers in Biology 2017年第1期12卷 1-6页

作者： Ailing Zhou Song Han Zhaolan joe Zhou Jiaozhou People's Hospital Jiaozhou Shangdong 266300 China Department of Genetics University of Pennsylvania Perelman School of Medicine Philadelphia PA 19104 USA

BackGrOUND： The discovery that mutations in cyclin-dependent kinase-like 5 （CDKLS） gene are associated with infantile epileptic encephalopathy has stimulated world-wide research effort to understand the molecular and genetic basis of CDKL5 disorder. Given the large number of literature published thus far, this review aims to summarize current genetic studies, draw a consensus on proposed molecular functions, and point to gaps of knowledge in CDKL5 research. MeTHODS： A systematic review process was conducted using the PubMed search engine focusing on CDKL5 studies in the recent ten years. We analyzed these publications and summarized the findings into four sections： genetic studies, CDKL5 expression patterns, molecular functions, and animal models. We also discussed challenges and future directions in each section. reSULTS： On the clinical side, CDKL5 disorder is characterized by early onset epileptic seizures, intellectual disability, and stereotypical behaviors. On the research side, a series of molecular and genetic studies in human patients, cell cultures and animal models have established the causality of CDKL5 to the infantile epileptic encephalopathy, and pointed to a key role for CDKL5 in regulating neuronal function in the brain. Mouse models of CDKL5 disorder have also been developed, and notably, manifest behavioral phenotypes, mimicking numerous clinical symptoms of CDKL5 disorder and advancing CDKL5 research to the preclinical stage. CONCLUSIONS： Given what we have learned thus far, future identification of robust, quantitative, and sensitive outcome measures would be the key in animal model studies, particularly in heterozygous females. In the meantime, molecular and cellular studies of CDKL5 should focus on mechanism-based investigation and aim to uncover druggable targets that offer the potential to rescue or ameliorate CDKL5 disorder-related phenotypes.

关键词： CDKL5 disorder childhood epilepsy intellectual disability mouse model outcome measure

Numerical Simulation of Compositional Flow in Porous Media under Gravity

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Communications in Computational Physics 2006年第5期1卷 827-846页

作者： Zhangxin Chen Guoqiang(joe)Zhou Dan Carruthers Center for Scientific Computation Southern Methodist UniversityDallasTX 75275-0156USA research Center for Science Xi’an Jiaotong UniversityXi’an 710049P.R.China Center for Advanced reservoir Modeling and Simulation College of EngineeringPeking UniversityP.R.China The Permedia research Group 577 Somerset St.W.OttawaOntario K1R 5K1Canada

This paper is concerned with the numerical simulation of multiphase,multi-component flow in porous *** model equations are based on compositional flow with mass interchange between *** compositional model consists of Darcy’s law for volumetric flow velocities,mass conservation for hydrocarbon components,ther-modynamic equilibrium for mass interchange between phases,and an equation of state for ***-accurate finite volume methods on unstructured grids are used to discretize the model governing *** emphasis is placed on studying the influence of gravitational effects on the overall displacement *** particular,free and forced convections,diffusions,and dispersions are studied in separate and com-bined cases,and their interplays are intensively analyzed for gravitational *** numerical experiments are presented to validate the numerical study under consideration.

关键词： Compositional model reservoir simulation finite volume method unstructured grids gravitational effect free and forced convections diffusions dispersions numerical experiments

Biotic resistance limits the invasiveness of the western flower thrips, Frankliniella occidentalis （Thysanoptera： Thripidae）, in Florida

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Insect Science 2016年第2期23卷 175-182页

作者： joe Funderburk Galen Frantz Charles Mellinger Kara Tyler-Julian Mrittunjai Srivastava North Florida research and education Center University of Florida Florida 32351 USA Glades Crop Care Inc. Jupiter Florida 33458 USA

The spread of the western flower thrips, Frankliniella occidentalis （Pergande）, has resulted in the world-wide destabilization of established integrated pest management programs for many crops. It is hypothesized that frequent exposure to insecticides in intensive agriculture selected for resistant populations, which allowed invasive populations in the eastern USA to overcome biotic resistance from the native community of species. research conducted in Florida to understand the role of biotic factors in limiting the abundance of the western flower thrips is reviewed. Orius spp. （Hemiptera： Anthocoridae） are effective predators that suppress populations of thrips on crop and non-crop hosts in southern and northern Florida. Orius are more effective predators of the western flower thrips than the native flower thrips, e tritici （Fitch） and e bispinosa （Morgan）. The native species are competitors of the western flower thrips. excessive fertilization and the use of broad-spectrum insecticides in crop fields further enhances populations of the western flower thrips. Interactions with native species clearly limit the abundance of western flower thrips in Florida, but populations are abundant in fertilized crop fields where application of insecticides excludes predators and competitor species.

关键词： disturbed habitat integrated pest management managing pest invasion resistance to invasion thrips pests