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A Novel Approach to Design Distribution Preserving Framework for Big Data

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Intelligent Automation & Soft Computing 2023年第3期35卷 2789-2803页

作者： Mini Prince P.M.joe Prathap Department of Information Technology St.Peter’s College of Engineering and TechnologyChennai600054TamilnaduIndia Department of Information Technology R.M.D Engineering CollegeChennai601206TamilnaduIndia

In several fields like financial dealing,industry,business,medicine,et cetera,Big Data(BD)has been utilized extensively,which is nothing but a collection of a huge amount of ***,it is highly complicated along with time-consuming to process a massive amount of ***,to design the Distribution Preserving Framework for BD,a novel methodology has been proposed utilizing Manhattan Distance(MD)-centered Partition Around Medoid(MD–PAM)along with Conjugate Gradient Artificial Neural Network(CG-ANN),which undergoes various steps to reduce the complications of ***,the data are processed in the pre-processing phase by mitigating the data repetition utilizing the map-reduce function;subsequently,the missing data are handled by substituting or by ignoring the missed *** that,the data are transmuted into a normalized ***,to enhance the classification performance,the data’s dimensionalities are minimized by employing Gaussian Kernel(GK)-Fisher Discriminant Analysis(GK-FDA).Afterwards,the processed data is submitted to the partitioning phase after transmuting it into a structured *** the partition phase,by utilizing the MD-PAM,the data are partitioned along with grouped into a ***,by employing CG-ANN,the data are classified in the classification phase so that the needed data can be effortlessly retrieved by the *** analogize the outcomes of the CG-ANN with the prevailing methodologies,the NSL-KDD openly accessible datasets are *** experiential outcomes displayed that an efficient result along with a reduced computation cost was shown by the proposed *** proposed work outperforms well in terms of accuracy,sensitivity and specificity than the existing systems.

关键词： Big data artiﬁcial neural network ﬁsher discriminant analysis distribution preserving framework manhattan distance

Wet Pressing Models to reduce energy Consumption in Papermaking

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Paper And Biomaterials 2019年第1期4卷 1-6页

作者： J.David McDonald richard J.Kerekes joe r.Zhao JDMcD Consulting Inc. Vaudreuil-Dorion Quebec J7V 0G1 Canada Pulp and Paper Centre the University of British Columbia Vancouver BC V6T 1Z4 Canada Tri-Y environmental research Institute Vancouver BC V5M 3H9 Canada

Improved wet pressing reduces the need for drying and consequently energy needed in papermaking. Accordingly, it is desirable to optimize wet pressing, but the process is very complex with many interacting variables. It is therefore desirable to employ a mathematical model that accounts for the major variables to estimate the effects of changes in equipment and operating variables. This paper descibes such a model called the Decreasing Permeability Model (DPM). Mill and pilot plant applications over a wide range of basis weights for paper and paper board are described.

关键词： wet pressing Decreasing Permeability Model (DPM) papermaking water removal rewet mathemeitical model

Natural killer cells in pancreatic cancer stroma

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World Journal of Gastroenterology 2021年第24期27卷 3483-3501页

作者： rachel elizabeth Ann Fincham Francesca romana Delvecchio Michelle r Goulart joe Poe Sheng Yeong Hemant M Kocher Barts Cancer Institute-CrUK Centre of excellence Queen Mary University of LondonLondon EC1M 6BQUnited Kingdom Institute of Molecular and Cellular Biology Agency for ScienceTechnology and ResearchSingapore 138673Singapore Centre for Tumour Biology Barts Cancer Institute-CRUK Centre of ExcellenceQueen Mary University of LondonLondon EC1M 6BQUnited Kingdom

Pancreatic cancer remains one of medicine’s largest areas of unmet *** five-year survival rates of<8%,little improvement has been made in the last 50 *** presenting with advance stage disease,treatment options are **... 详细信息

Pancreatic cancer remains one of medicine’s largest areas of unmet *** five-year survival rates ofe improvement has been made in the last 50 *** presenting with advance stage disease,treatment options are *** date,surgery remains the only potentially curative option,however,with such late disease presentation,the majority of patients are ***,new therapeutic options and a greater understanding of the complex stromal interactions within the tumour microenvironment are sorely needed to revise the dismal outlook for pancreatic cancer *** killer(NK)cells are crucial effector units in cancer *** used as a prognostic biomarker in a range of malignancies,NK cells have received much attention as an attractive target for immunotherapies,both as cell therapy and as a pharmaceutical *** this interest,the role of NK cells in pancreatic cancer remains poorly ***,increasing evidence of the importance of NK cells in this dismal prognosis disease is beginning to come to ***,we review the role of NK cells in pancreatic cancer,examine the complex interactions of these crucial effector units within pancreatic cancer stroma and shed light on the increasingly attractive use of NK cells as therapy.

关键词： Pancreatic cancer Natural killer cells Tumour microenvironment Pancreatic cancer stroma Stromal cells

Multidisciplinary management of patients with post-inflammatory pancreatic necro

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 1-3页

作者： Santhalingam Jegatheeswaran joe Geraghty Ajith K Siriwardena regional Hepato-Pancreato-Biliary Surgery Unit Manchester Royal InfirmaryOxford RoadManchester M139WLUK Department of Gastroenterology Manchester Royal InfirmaryOxford RoadManchester M139WLUK Faculty of Biology Medicine and HealthUniversity of ManchesterManchester M139PLUK

Current knowledge of the pathophysiology of acute pancreatitis indicates that pancreatic injury originates at the acinar cell level and then extends through a spectrum of damage ranging from mild peri-acinar inflammatory infiltration and edema to extensive pancreatic parenchymal and peri-pancreatic necrosis[1,2].Clinical acute pancreatitis correlates closely with this range of injury with the majority of patients experiencing mild disease,some having transient organ dysfunction which typically recovers after adequate resuscitation(moderate acute pancreatitis)and a variable minority exhibiting sustained organ failure together with radiological evidence of pancreatic necrosis(severe acute pancreatitis)[2,3].Worldwide,the management of this latter category of patients with severe acute pancreatitis remains a *** is no effective direct medical treatment and there is no role for early pancreatic debridement[3,4].This article provides a concise summary of current multidisciplinary management of patients with post-inflammatory pancreatic necrosis.

关键词： acute patients sustained

evaluation of seismic potential in a longwall mine with massive sandstone roof under deep overburden

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International Journal of Mining Science and Technology 2018年第1期28卷 115-119页

作者： Mark A.Van Dyke Wen H.Su joe Wickline Ground Control Branch NIOSHPittsburgh15236 PAUSA Coronado Coal LLC BeckleyWVUSA

A recent seismic event was recorded by a deep longwall mine in Virginia at 3.7 ML on the local magnitude scale and 3.4 MMS by the United States Geological Survey(USGS) in *** investigations by the National Institute for Occupational Safety and Health(NIOSH) and Coronado Coal researchers have shown that this event was associated with geological features that have also been associated with other, similar seismic events in *** mapping and geological exploration in the mining area has made it possible to forecast possible locations for future seismic *** order to use the geology as a forecaster of mining-induced seismic events and their energy potential, two primary components are *** first component is a long history of recorded seismic events with accurately plotted *** second component is a high density of geologic data within the mining *** this case, 181 events of 1.0 MLor greater were recorded by the mine's seismic network between January, 2009, and October, *** the mining area, 897 geophysical logs, 224 core holes, and 1031 fiberscope holes were examined by mine *** this information, it was found that overburden thickness, sandstone thickness, and sandstone quality contributed greatly to seismic *** the data was analyzed, a pattern became apparent indicating that the majority of seismic events occurred under specific *** forecast maps were created based on geology of previous seismic *** forecast maps have shown an accuracy of within 74%–89% when compared to the recorded 181 events that were1.0 MLor greater when considering three major geological criteria of overburden thickness of 579.12 m or greater, 6.096–12.192 m of sandstone within 15.24 m of the Pocahontas number 3 seam, and a longwall caving height of 4.572 m or less.

关键词： Seismic Mapping Deep overburden Massive sandstone

Application of the coal mine floor rating(CMFr)to assess the floor stability in a Central Appalachian Coal Mine

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International Journal of Mining Science and Technology 2021年第1期31卷 83-89页

作者： Sena Cicek Ihsan Berk Tulu Mark Van Dyke Ted Klemetti joe Wickline Department of Mining engineering West Virginia UniversityMorgantownWV 26505USA National Institute for Occupational Safety and Health Pittsburgh Mining Research DivisionPittsburghPA 15236USA Coronado Global resources Inc. BeckleyWV 25801USA

estimating the overall floor stability in a coal mine using deterministic methods which require complex engineering properties of floor strata is desirable,but generally it is impractical due to the difficulty of gathering essential input ***,applying a quantitative methodology to describe floor quality with a single number provides a practical estimate for preliminary assessment of floor *** coal mine floor rating(CMFr)system,developed by the University of New South Wales(UNSW),is a rockmass classification system that provides an indicator for the competence of floor *** most significant components of the CMFr are uniaxial compressive strength and discontinuity intensity of floor *** addition to the competence of the floor,depth of cover and stress notch angle are input parameters used to assess the preliminary floor *** this study,CMFr methodology was applied to a Central Appalachian Coal Mine that intermittently experienced floor *** drill core data,overburden maps,and mine plans were utilized for the ***,qualitative data(failure/non-failure)on floor conditions of the mine entries near the core holes was collected and analyzed so that the floor quality and its relation to entry stability could be estimated by statistical *** was found that the current CMFr classification system is not directly applicable in assessing the floor stability of the Central Appalachian Coal *** order to extend the applicability of the CMFr classification system,the methodology was modified.A calculation procedure of one of the CMFr classification system’s components,the horizontal stress rating(HSr),was changed and new parameters were added to the HSr.

关键词： rock mass classification Coal mine floor rating(CMFr) Floor heave Floor failure Buckling failure mechanism

Prediction of Typhoon Tracks Using Dynamic Linear Models

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Advances in Atmospheric Sciences 2003年第3期20卷 379-384页

作者： Keon-Tae SOHN H.joe KWON Ae-Sook SUH Pusan KongjuMeteorological Research Institute//KMA National UniversityPusan609-735KoreaNational UniversityKonju314-701KoreaSeoul156-010Korea

This paper presents a study on the statistical forecasts of typhoon tracks. Numerical models have their own systematic errors, like a bias. In order to improve the accuracy of track forecasting, a statistical model called DLM (dynamic linear model) is applied to remove the systematic error. In the analysis of typhoons occurring over the western North Pacific in 1997 and 2000, DLM is useful as an adaptive model for the prediction of typhoon tracks.

关键词： typhoon track forecast systematic error dynamic linear model

Temporal changes in inflammatory mitochondria-enriched microrNAs following traumatic brain injury and effects of mir-146a nanoparticle delivery

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Neural regeneration research 2021年第3期16卷 514-522页

作者： Wang-Xia Wang Paresh Prajapati Hemendra J.Vekaria Malinda Spry Amber L.Cloud Patrick G.Sullivan joe e.Springer Sanders Brown Center on Aging University of KentuckyLexingtonKYUSA Spinal Cord and Brain Injury research Center University of KentuckyLexingtonKYUSA Department of Pathology&Laboratory Medicine University of KentuckyLexingtonKYUSA Department of Neuroscience University of KentuckyLexingtonKYUSA

MicrorNAs(mirNAs)are small non-coding rNA molecules that regulate post-transcriptional gene expression and contribute to all aspects of cellular *** previously reported that the activities of several mitochondria-enriched mirNAs regulating inflammation(i.e.,mir-142-3p,mir-142-5p,and mir-146a)are altered in the hippocampus at 3–12 hours following a severe traumatic brain *** the present study,we investigated the temporal expression profile of these inflammatory mirNAs in mitochondria and cytosol fractions at more chronic post-injury times following severe controlled cortical impact injury in *** addition,several inflammatory genes were analyzed in the cytosol *** analysis showed that while elevated levels were observed in cytoplasm,the mitochondria-enriched mirNAs,mir-142-3p and mir-142-5p continued to be significantly reduced in mitochondria from injured hippocampi for at least 3 days and returned to near normal levels at 7 days *** not statistically significant,mir-146a also remained at reduced levels for up to 3 days following controlled cortical impact injury,and recovered by 7 *** contrast,mirNAs that are not enriched in mitochondria,including mir-124a,mir-150,mir-19b,mir-155,and mir-223 were either increased or demonstrated no change in their levels in mitochondrial fractions for 7 *** one exception was that mir-223 levels were reduced in mitochondria at 1 day following *** major alterations were observed in sham operated *** temporal pattern was unique to mitochondria-enriched mirNAs and correlated with injury-induced changes in mitochondrial bioenergetics as well as expression levels of several inflammatory *** observations suggested a potential compartmental re-distribution of the mitochondria-enriched inflammatory mirNAs and may reflect an intracellular mechanism by which specific mirNAs regulate injury-induced inflammatory *** test this,we utilized a novel peptide-based

关键词： cell permeable peptide-delivery controlled cortical impact inflammatory pathway mitochondria-associated microrNA nanoparticle nuclear factor-kappa B traumatic brain injury

Towards Transgenic Primates:What can we learn from mouse genetics?

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Science China(Life Sciences) 2009年第6期52卷 506-514页

作者： WANG Phillip L. TSIeN joe Z. Brain and Behavior Discovery Institute School of MedicineMedical College of Georgia Yunnan Banna Primate Disease Model research Center and Shanghai Institute of Brain Functional GenomicsKey Laboratory of Brain Functional GenomicsMOE & STCSMEast China Normal University

Considering the great physiological and behavioral similarities with humans,monkeys represent the ideal models not only for the study of complex cognitive behavior but also for the preclinical research and development of novel therapeutics for treating human *** powerful genetic tech-nologies initially developed for making mouse models are being explored for generating transgenic primate *** review the latest genetic engineering technologies and discuss the potentials and limitations for systematic production of transgenic primates.

关键词： Non-human primate Mouse Transgene Genetics Learning Memory disease model