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Targeting the mitochondrial permeability transition pore in traumatic central nervous system injury

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Neural Regeneration Research 2018年第8期13卷 1338-1341页

作者： joe E. Springer Pareshkumar Prajapati Patrick G. Sullivan Spinal lord and Brain Injury Research center Department of Neuroscience University of Kentucky Lexington KY USA

The mitochondrion serves many functions in the central nervous system （cNS） and other organs beyond the well-recognized role of adenosine triphosphate （ATP） production. This includes calcium-dependent cell signaling, regulation of gene expression, synthesis and release of cytotoxic reactive oxygen species, and the release of cytochrome c and other apoptotic cell death factors. Traumatic injury to the cNS results in a rapid and, in some cases, sustained loss of mitochondrial function. One consequence of compromised mitochondrial function is induction of the mitochondrial permeability transition （mPT） state due to formation of the cyclosporine A sensitive permeability transition pore （mPTP）. In this mini-review, we summarize evidence supporting the involvement of the mPTP as a mediator of mitochondrial and cellular demise following cNS traumatic injury and discuss the beneficial effects and limitations of the current ex- perimental strategies targeting the mPTP.

关键词： mitochondrial permeability transition cyclophilin-D cyclosporine A NIM811 spinal cord injury traumatic brain injury secondary injury functional recovery

Bone mineral density and disorders of mineral metabolism in chronic liver disease

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World Journal of Gastroenterology 2009年第28期15卷 3516-3522页

作者： joe George Hosahithlu k Ganesh Shrikrishna Acharya Tushar R Bandgar Vyankatesh Shivane Anjana karvat Shobna J Bhatia Samir Shah Padmavathy S Menon Nalini Shah Department of Endocrinology Seth G.S. Medical College and KEM Hospital Department of Gastroenterology Seth G.S Medical College and KEM Hospital Department of Gastroenterology Jaslok Hospital

AIM： To estimate the prevalence and identify the risk factors for metabolic bone disease in patients with cirrhosis. METHODS： The study was performed on 72 Indian patients with cirrhosis （63 male, 9 female; aged 〈 50 years）. Etiology of cirrhosis was alcoholism （n = 37）, hepatitis B （n = 25） and hepatitis c （n = 10）. Twenty-three patients belonged to child class A, while 39 were in class B and 10 in class c. Secondary causes for metabolic bone disease and osteoporosis were ruled out. Sunlight exposure, physical activity and dietary constituents were calculated. complete metabolic profiles were derived, and bone mineral density （BMD） was measured using dual energy X ray absorptiometry. low BMD was defined as a Z score below -2. RESULTS： low BMD was found in 68% of patients. Lumbar spine was the most frequently and severely affected site. Risk factors for low BMD included low physical activity, decreased sunlight exposure, and low lean body mass. calcium intake was adequate, with unfavorable calcium： protein ratio and calcium： phosphorus ratio. Vitamin D deficiency was highly prevalent （92%）. There was a high incidence of hypogonadism （41%）. Serum estradiol level was elevated significantly in patients with normal BMD. Insulin-like growth factor （IGF） 1 and IGF binding protein 3 levels were below the age-related normal range in both groups. IGF-1 was significantly lower in patients with low BMD. Serum osteocalcin level was low （68%） and urinary deoxypyridinoline to creatinine ratio was high （79%）, which demonstrated low bone formation with high resorption. cONcLUSION： Patients with cirrhosis have low BMD. contributory factors are reduced physical activity, low lean body mass, vitamin D deficiency and hypogonadism and low IGF-1 level.

关键词： Bone mineral density Liver disease chronic disease cirrhosis Bone mineral metabolism Hepatic osteodystrophy

cellular factors involved in the hepatitis c virus life cycle

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World Journal of Gastroenterology 2021年第28期27卷 4555-4581页

作者： Hui-chun Li chee-Hing Yang Shih-Yen lo Department of Biochemistry Tzu Chi UniversityHualien 970Taiwan Department of Laboratory Medicine and Biotechnology Tzu Chi UniversityHualien 970Taiwan Department of Laboratory Medicine Buddhist Tzu Chi General HospitalHualien 970Taiwan

The hepatitis c virus(HcV),an obligatory intracellular pathogen,highly depends on its host cells to propagate *** HcV life cycle can be simply divided into several stages including viral entry,protein translation,RNA replication,viral assembly and *** of cellular factors involved in the HcV life cycle have been identified over more than thirty years of *** of these cellular factors has provided extensive insight into HcV replication *** of these cellular factors are targets for anti-HcV *** this review,we summarize the well-characterized and recently identified cellular factors functioning at each stage of the HcV life cycle.

关键词： Hepatitis c virus cellular factor Viral entry Translation Replication Assembly Release

Life made easy:simplifying reconstruction for dual portal veins in adult right lobe live donor liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2010年第5期9卷 547-549页

作者： Albert c.Y.chan chung Mau lo kenneth S.H.chok See ching chan Sheung Tat Fan Department of Surgery The University of Hong KongQueen Mary Hospital

In live donor liver transplantation, anatomical anomalies of the portal vein are more frequently encountered in right lobe than left lobe grafts. Of these, a dual portal vein is one of the most common anatomical anomalies encountered. We hereby report our method of using a recipient portal vein patch after venoplasty for reconstruction in a right lobe graft with separate anterior and posterior portal vein branches.

关键词： live donor liver transplantation portal vein reconstruction dual portal vein

粉煤灰地聚合物固封cr^3＋的FTIR和XPS研究

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光谱学与光谱分析 2008年第1期28卷 67-71页

作者：刘斯凤王培铭李宗津 Irene M.-c.lo 同济大学先进土木工程材料教育部重点实验室材料科学与工程学院上海200092 香港科技大学土木系中国香港

采用傅里叶变换红外光谱(FTIR)和X射线光电子能谱分析(XPS)研究了粉煤灰地聚合物固封cr3+的机理。含cr的污泥由人工合成,主要成分是cr(OH)3。浸出试验采用IcP-AES方法,测试了固封cr3+前后,粉煤灰地聚合物中Al和Si的浸出量;研究结果表明... 详细信息

采用傅里叶变换红外光谱(FTIR)和X射线光电子能谱分析(XPS)研究了粉煤灰地聚合物固封cr3+的机理。含cr的污泥由人工合成,主要成分是cr(OH)3。浸出试验采用IcP-AES方法,测试了固封cr3+前后,粉煤灰地聚合物中Al和Si的浸出量;研究结果表明,掺入含cr的污泥后,粉煤灰地聚合物中Si和Al元素的浸出量较不掺污泥时减少了,且浸出Si元素减少的幅度比浸出Al元素降低的幅度要大。FTIR结果显示,cr3+的掺入削弱了粉煤灰地聚合物主峰的强度,增加了Si—O—Si和Al—O—Si的振动波数;XPS测试结果表明,O(1s),Si(2p)和cr(2p)的结合能都有不同程度的改变,而Al(2p)的结合能几乎没有发生变化;结果揭示cr3+参与了粉煤灰地聚合物中硅酸结构的聚合,粉煤灰地聚合物固封cr3+,不仅仅只是物理性的包裹作用,而且主要是化学反应的结果。

关键词：地聚合物粉煤灰固封三价铬 FTIR XPS

Assessing the Efficacy of Lemongrass (cymbopogon citratus ) and Sambong (Blumea balsamifera ) Extracts in combating Black Pod Disease: Sustainable Solutions for controlling Phytophthora megakarya in cameroon’s cocoa Plantations

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The Near-contact Binary FU Ara:New Observations,a Photometric Study and Preliminary Elements

American Journal of Plant Sciences（美国植物学期刊） 2024年第7期 519页

作者： Gertrude Membang James Michel Tchotet Tchoumi Godswill Ntsomboh Ntsefong Emmanuel Yvan Mba Ela Sylvere Landry lontsi Dida Ludovic Tchuenkam Tsango Pascal loïc Ekango Mbondjo Fritz Oben Tabi

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chinese Journal of Astronomy and Astrophysics 2008年第6期8卷 707-713页

作者： A. Paschke F. Acerbi c. Barani Weierstr 30 8630 Rueti Switzerland Via Zoncada 51 26845 Codogno （LO） Italy Via Molinetto 35 26845 Triulza di Codogno （LO） Italy

A new ccD （V） light curve is presented for the semi-detached binary system FU Ara. The light curve, obtained in 2007, is the first one since the last 50 years. With our data we were able to determine six new times of minimum light and refined the period of the system to 0.8645049 days. A Wilson-Devinney analysis leads to a solution of a semi- detached configuration, composed of a main-sequence primary component of spectral type F5, fractionally smaller than its Roche lobe, and an evolved secondary component of spectral type k1 which fills its Roche lobe, and which is overluminous and oversized as compared with the main-sequence. The two components of FU Ara differ considerably in effective temperature. It is classified as an FO Virginis type of near-contact binary system. Assuming a reasonable value for the mass of the primary component, an estimate of the absolute elements of FU Ara has been made, on the assumption that the primary has a mass corresponding to its spectral type according to Svechnikov ＆ Taidakova.

关键词： binaries: eclipsing stars: fundamental parameters stars: individual:FU Ara

consequences of dysthyroidism on the digestive tract and viscera

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World Journal of Gastroenterology 2009年第23期15卷 2834-2838页

作者： Ronald Daher Thierry Yazbeck joe Bou Jaoude Bassam Abboud Department of General Surgery Hotel Dieu de France Hospital Faculty of Medicine Saint-Joseph University Beirut 16-6830 Lebanon Department of Gastroenterology Hotel Dieu de France Hospital Faculty of Medicine Saint-Joseph University Beirut 16-6830 Lebanon

Thyroid hormones def ine basal metabolism throughout the body, particularly in the intestine and viscera. Gastrointestinal manifestations of dysthyroidism are numerous and involve all portions of the tract. Thyroid hormone action on motility has been widely studied, but more complex pathophysiologic mechanisms have been indicated by some studies although these are not fully understood. Both thyroid hormone excess and def iciency can have similar digestive manifestations, such as diarrhea, although the mechanism is different in each situation. The liver is the most affected organ in both hypo-and hyperthyroidism. Specifi c digestive diseases may be associated with autoimmune thyroid processes, such as Hashimoto's thyroiditis and Grave's disease. Among them, celiac sprue and primary biliary cirrhosis are the most frequent although a clear common mechanism has never been proven. Overall, thyroid-related digestive manifestations were described decades ago but studies are still needed in order to conf irm old concepts or elucidate undiscovered mechanisms. All practitioners must be aware of digestive symptoms due to dysthyroidism in order to avoid misdiagnosis of rare but potentially lethal situations.

关键词： Hypothyroidism Hyperthyroidism Gastroin-testinal motility Intestine Liver Viscera

Management of fulminant hepatic failure at Queen Mary Hospital

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chinese Medical Journal 1997年第6期110卷 84-86页

作者： S.T.Fan c.M.lo R.J.W.lo k.Y.Fung W.Wei Y.B.chen c.L.Lai I.O.L.Ng k.Y.Yuen Johnchan JohnWong Department of Surgery The University of Hong Kong Queen Mary Hospital Hong Kong Department of Anaesthesiology The University of Hong Kong Queen Mary Hospital Hong Kong Department of Medicine The University of Hong Kong Queen Mary Hospital Hong Kong Department of Pathology The University of Hong Kong Queen Mary Hospital Hong Kong Department of Microbiology The University of Hong Kong Queen Mary Hospital Hong Kong Department of Radiology The University of Hong Kong Queen Mary Hospital Hong Kong

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关键词： LIVER-TRANSPLANTATION cHARcOAL