检索结果-南通市图书馆

COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history

Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith Tiffany M.Zúñiga Forrest l.Baker Helena Batatinha Charles R.Pedlar Shane C.Burgess Michael P.Gustafson Emmanuel Katsanis Richard J.simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 Exercise immunology SARS-CoV-2 T-Cells Vaccine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unveiling a novel metal-to-metal transition in luH_(2):Critically challenging superconductivity claims in lutetium hydrides

引用

Matter and Radiation at Extremes 2024年第3期9卷 65-73页

作者： Dong Wang Ningning Wang Caoshun Zhang Chunsheng Xia Weicheng Guo Xia Yin Kejun Bu Takeshi Nakagawa Jianbo Zhang Federico Gorelli Philip Dalladay-simpson Thomas Meier Xujie lü liling Sun Jinguang Cheng Qiaoshi Zeng Yang Ding Ho-kwang Mao Center for High-Pressure Science and Technology Advanced Research Beijing 100094China Beijing National laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China Shanghai Key laboratory of Material Frontiers Research in Extreme Environments(MFree) Shanghai Advanced Research in Physical Sciences(SHARPS)Shanghai 201203China

Following the recent report by Dasenbrock-Gammon et al.[Nature 615,244–250(2023)]of near-ambient superconductivity in nitrogendoped lutetium trihydride(luH_(3-δ)N_(ε)),significant debate has emerged surrounding the composition and interpretation of the observed sharp resistance ***,we meticulously revisit these claims through comprehensive characterization and *** definitively identify the reported material as lutetium dihydride(luH_(2)),resolving the ambiguity surrounding its *** similar conditions(270–295 K and 1–2 GPa),we replicate the reported sharp decrease in electrical resistance with a 30%success rate,aligning with the observations by Dasenbrock-Gammon et ***,our extensive investigations reveal this phenomenon to be a novel pressure-induced metal-to-metal transition intrinsic to luH_(2),distinct from ***,nitrogen doping exerts minimal impact on this *** work not only elucidates the fundamental properties of luH_(2)andluH_(3),but also critically challenges the notion of superconductivity in these lutetium hydride *** findings pave the way for future research on lutetium hydride systems,while emphasizing the crucial importance of rigorous verification in claims of ambient-temperature superconductivity.

关键词： resistance hydride superconductivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nitrate reduction capacity of the oral microbiota is impaired in periodontitis:potential implications for systemic nitric oxide availability

引用

International Journal of Oral Science 2024年第1期16卷 52-61页

作者： Bob T.Rosier William Johnston Miguel Carda-Diéguez Annabel simpson Elena Cabello-Yeves Krystyna Piela Robert Reilly Alejandro Artacho Chris Easton Mia Burleigh Shauna Culshaw Alex Mira Department of Genomics and Health FISABIO FoundationCenter for Advanced Research in Public HealthValenciaSpain Department of Biological and Biomedical Sciences Glasgow Caledonian UniversityGlasgowUK Oral Sciences University of Glasgow Dental SchoolSchool of MedicineDentistry and NursingCollege of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowUK Sport and Physical Activity Research Institute University of the West of ScotlandBlantyreScotland Instituto de Biomedicina de Valencia Consejo Superior de Investigaciones Científicas(IBV-CSIC)ValenciaSpain CIBER Center for Epidemiology and Public Health MadridSpain

The reduction of nitrate to nitrite by the oral microbiota has been proposed to be important for oral health and results in nitric oxide formation that can improve cardiometabolic conditions. Studies of bacterial composition in subgingival plaque suggest that nitrate-reducing bacteria are associated with periodontal health, but the impact of periodontitis on nitrate-reducing capacity(NRC)and, therefore, nitric oxide availability has not been evaluated. The current study aimed to evaluate how periodontitis affects the NRC of the oral microbiota. First, 16S rRNA sequencing data from five different countries were analyzed, revealing that nitratereducing bacteria were significantly lower in subgingival plaque of periodontitis patients compared with healthy individuals(P ll five datasets with n = 20–82 samples per dataset). Secondly, subgingival plaque, saliva, and plasma samples were obtained from 42 periodontitis patients before and after periodontal treatment. The oral NRC was determined in vitro by incubating saliva with 8 mmol/l nitrate(a concentration found in saliva after nitrate-rich vegetable intake) and compared with the NRC of 15healthy individuals. Salivary NRC was found to be diminished in periodontal patients before treatment(P lthy levels 90 days post-treatment. Additionally, the subgingival levels of nitrate-reducing bacteria increased after treatment and correlated negatively with periodontitis-associated bacteria(P l treatment on the baseline saliva and plasma nitrate and nitrite levels was found, indicating that differences in the NRC may only be revealed after nitrate intake. Our results suggest that an impaired NRC in periodontitis could limit dietary nitrate-derived nitric oxide levels, and the effect on systemic health should be explored in future studies.

关键词： impaired intake nitrate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制：半乳糖凝集素-3和白细胞介素-1RA／白细胞介素-1beta比例显著下降

引用

中华结核和呼吸杂志 2016年第11期39卷 898-898页

作者：高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan l James Christine Jenkins Matthew J Peters 张捷 jodie l simpson 吉林大学第二医院呼吸与危重症医学科长春130051 纽卡斯尔大学呼吸与睡眠研究中心悉尼Woolcock医学研究所昆士兰大学医科学校Prince Charles医院胸科布里斯本市Princess Alexandra医院呼吸科阿德莱德市Adelaide Hanson研究所肺研究室 Westem Australia大学医疗与药理学校悉尼George全球健康研究所临床呼吸实验室 Macquarie大学医疗学校Concord General医院胸科

支气管哮喘（哮喘）是具有异质性的气道炎症性疾病，其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中，过敏原诱导的TH2淋巴细胞激活以及Il-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50％的哮喘患者气道... 详细信息

支气管哮喘（哮喘）是具有异质性的气道炎症性疾病，其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中，过敏原诱导的TH2淋巴细胞激活以及Il-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50％的哮喘患者气道的嗜酸粒细胞水平并不增高，并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高，称为中性粒细胞型哮喘。

关键词：白细胞介素-1RA 支气管哮喘中性粒细胞半乳糖凝集素-3 粒细胞型发病机制抗炎介质气道高反应

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of the‘Seattle’and‘International’Criteria Electrocardiogram Interpretation in Division II Female Collegiate Athletes:A Preliminary Study

引用

Journal of Science in Sport and Exercise 2023年第3期5卷 274-279页

作者： ludmila Cosio-lima N.Kumar Brooke l.Adlof J.simpson A.Crawley Y.lee University of West Florida 11000 University Parkway#72/220PensacolaFL 32514USA

Purpose A 12-lead electrocardiogram(ECG)is a screening tool to detect abnormalities that may predispose athletes to sud-den cardiac *** standardized criteria have been introduced to better interpret ECG data,however this research has predominantly focused on male *** is important to include female athletes in research to better define ECG character-istics in this *** purpose of this study was to compare the Seattle and International Criteria ECG abnormalities in Division II female collegiate athletes of various *** Fifty-six females(age 20.2±1.4 years;height 1.70±0.7 m;weight 69.5±8.9 kg)completed a resting 12-lead ECG *** data was classified as‘normal’and‘abnormal’according to the parameters of each criterion and abnormal conditions were ***-square analysis was used to assess statistical comparisons between *** There was a significant difference in abnormal classifications as the total number of ECGs identified as abnormal using the Seattle Criteria decreased from 12(21.4%)to 2(3.6%)when using the International Criteria(Pletes had a higher number of abnormal ECG’s compared to White and latina athletes using the Seattle Criteria(P=0.03).Conclusions The International Criteria significantly reduces the total number of abnormal ECG readings in female collegiate athletes compared to the Seattle Criteria and did not overly identify African American athletes with *** research is necessary to expand on this study and clearly define criteria for female athletes of various ethnicities.

关键词： 12-lead ECG Female athletes Sudden cardiac death ECG abnormalities

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Trade-off between microbial carbon use efficiency and specific nutrient-acquiring extracellular enzyme activities under reduced oxygen

引用

Soil Ecology letters 2023年第2期5卷 43-53页

作者： Ji Chen Irene Cordero Daryl l.Moorhead Jennifer K.Rowntree lorae T.simpson Richard D.Bardgett Hayley Craig Department of Agroecology Aarhus University8830 TjeleDenmark Aarhus University Centre for Circular Bioeconomy Aarhus University8830 TjeleDenmark iClIMATE Interdisciplinary Centre for Climate Change Aarhus University4000 RoskildeDenmark Department of Earth and Environmental Sciences The University of ManchesterOxford RoadManchesterM139PTUK Department of Environmental Sciences University of Toledo2801 W.Bancroft St.ToledoOH 43606-3390USA School of Biological and Marine Sciences University of PlymouthDrake CircusPlymouthPL48AAUK Florida Oceanographic Society 890 NE Ocean BlvdStuartFL 34996USA NatureMetrics Occam CourtSurrey Research ParkGuildfordGU27HJUK

Mangroves are one of the most ecologically sensitive ecosystems to global climate change,which have cascading impacts on soil carbon(C),nitrogen(N)and phosphorus(P)***,mangroves are experiencing increasing N and P loadings and reduced oxygen availability due to intensified climate change and human ***,both direct and interactive effects of these perturbations on microbially mediated soil C,N and P cycling are poorly ***,we simultaneously investigated the effects of N and P loadings and reduced oxygen on microbial biomass,microbial respiration,and extracellular enzyme activities(EEAs)in mangrove *** calculated the microbial metabolic quotient(qCO_(2)),which is regarded as a useful inverse metric of microbial C use efficiency(CUE).Our results show that reduced oxygen significantly increases both qCO_(2) and microbial specific EEAs(enzyme activity per unit of microbial biomass)for C-,N-and P-acquisition regardless of N or P ***,we found that qCO_(2) positively correlated with microbial specific EEAs under reduced oxygen,whereas no clear relationship was detected under ambient *** results suggest that reduced oxygen increases microbial specific EEAs at the expense of increasing microbial respiration per unit biomass,indicating higher energy cost per unit enzyme production.

关键词： reduced oxygen extracellular enzyme microbial respiration nutrient acquisition nutrient addition mangrove

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Differential Splicing of Skipped Exons Predicts Drug Response in Cancer Cell lines

引用

Genomics, Proteomics & Bioinformatics 2021年第6期19卷 901-912页

作者： Edward simpson Steven Chen Jill l.Reiter Yunlong liu Center for Computational Biology and Bioinformatics Indiana University School of MedicineIndianapolisIN 46202USA Department of BioHealth Informatics School of Informatics and ComputingIndiana University-Purdue University IndianapolisIndianapolisIN 46202USA Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202USA

Alternative splicing of pre-mRNA transcripts is an important regulatory mechanism that increases the diversity of gene products in *** studies have linked specific transcript isoforms to altered drug response in cancer;however,few algorithms have incorporated splicing information into drug response *** this study,we evaluated whether basal-level splicing information could be used to predict drug sensitivity by constructing doxorubicin-sensitivity classification models with splicing and expression *** detailed splicing differences between sensitive and resistant cell lines by implementing quasi-binomial generalized linear modeling(QBGlM)and found altered inclusion of 277 skipped *** additionally conducted RNA-binding protein(RBP)binding motif enrichment and differential ex-pression analysis to characterize cis-and trans-acting elements that potentially influence doxorubicin response-mediating splicing *** results showed that a classification model built with skipped exon data exhibited strong predictive *** discovered an association between differentially spliced events and epithelial-mesenchymal transition(EMT)and observed motif enrichment,as well as differential expression of RBFOX and ElAVl RBP family *** work demonstrates the potential of incorporating splicing data into drug response algorithms and the utility of a QBGlM approach for fast,scalable identification of relevant splicing differences between large groups of samples.

关键词： Alternative splicing Transcript isoform Splicing regulation Drug sensitivity Precision medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Selective deletion of the soluble Colony-Stimulating Factor 1 isoform in vivo prevents estrogen-deficiency bone loss in mice

引用

Bone Research 2017年第4期5卷 367-374页

作者： Gang-Qing Yao Nancy Troiano Christine A simpson Karl l Insogna Department of Internal Medicine Yale University School of MedicineNew HavenUSA Department of Orthopaedics Yale University School of MedicineNew HavenUSA

Neutralizing CSF1 in vivo completely prevents ovariectomy （OVX）-induced bone loss in mice. There are two isoforms of CSF1, soluble （sCSF1）, and membrane-bound （mCSF1）, but their individual biological functions are unclear. It had been previously reported that mCSF1 knockout （K/O） and wild type （Wt） female mice experience the same degree of bone loss following OVX. In Wt mice the expression of sCSF1 was elevated fourfold in skeletal tissue following OVX while expression of mCSF1 was unchanged. To examine the role of sCSF1 in OVX-induced bone loss, mice were engineered in which sCSF1 was not expressed but expression of mCSF1 was unaffected （sCSF1 K/O）. Isoform-specific reverse transcription PCR confirmed the absence of transcripts for sCSF1 in bone tissue isolated from these animals and no circulating CSF1 was detected by ElISA. Surprisingly, there were no significant differences in bone mineral density （BMD） between sCSF1 K/O mice and Wt controls as assessed by dual-energy X-ray absorptiometry and micro-CT. However, one month after OVX, femoral, spinal and total BMD had declined by 11.2%, 8.9%, and 8.7% respectively in OVX-Wt animals as compared to Sham-OVX. In contrast OVX sCSF1 K/O mice showed changes of ＋0.1%, - 2.4%, and ＋2.3% at the same 3 sites compared to Sham-OVX sCSF1 K/O mice. These data indicate important non-redundant functions for the two isoforms of CSF1 and suggest that sCSF1, but not mCSF1, plays a key role in estrogen-deficiency bone loss.

关键词： CSF Selective deletion of the soluble Colony-Stimulating Factor 1 isoform in vivo prevents estrogen-deficiency bone loss in mice

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis

引用

World Journal of Gastroenterology 2017年第22期23卷 3999-4006页

作者： Robert G Bennett Ronda l simpson Frederick G Hamel Research Service Nebraska-Western Iowa Health Care System Department of Internal Medicine University of Nebraska Medical Center

AIM To determine the effect of combined serelaxin and rosiglitazone treatment on established hepatic *** Hepatic fibrosis was induced in mice by carbon tetrachloride administration for 6 wk, or vehicle alone(nonfibrotic mice). For the final 2 wk, mice were treated with rosiglitazone, serelaxin, or both rosiglitazone and serelaxin. Serum liver enzymes and relaxin levels were determined by standard methods. The degree of liver collagen content was determined by histology and immunohistochemistry. Expression of type?Ⅰ?collagen was determined by quantitative PCR. Activation of hepatic stellate cells was assessed by alpha-smoothmuscle actin(SMA) levels. liver peroxisome proliferator activated receptor-gamma coactivator 1 alpha(PGC1α) was determined by Western *** Treatment of mice with CCl4 resulted in hepatic fibrosis as evidenced by increased liver enzyme levels(AlT and AST), and increased liver collagen and SMA. Monotherapy with either serelaxin or rosiglitazone for 2 wk was generally without effect. In contrast, the combination of serelaxin and rosiglitazone resulted in significantly improved AlT levels(P l liver collagen content as determined by Sirius red staining revealed that only combination treatment was effective in reducing total liver collagen(P lts were supported by immunohistochemistry for type?Ⅰ?collagen, in which only combination treatment reduced fibrillar collagen levels(P level of hepatic stellate cell activation was modestly, but significantly, reduced by serelaxin treatment alone, but combination treatment resulted in significantly lower SMA levels. Finally, while hepatic fibrosis reduced liver PGC1α levels, the combination of serelaxin and rosiglitazone resulted in restoration of PGC1α protein *** The combination of serelaxin and rosiglitazone treatment for 2 wk was effective in significantly reducing established hepatic fibrosis, providing a potential new treatmen

关键词：松弛激素 Peroxisome 激活 proliferator 的受体肝肝硬化肝疾病纤维变性

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Note on the Relationship Between Temperature and Water Vapor over Oceans, Including Sea Surface Temperature Effects

引用

Advances in Atmospheric Sciences 2006年第1期23卷 141-148页

作者： C.-l. SHIE W.-K. TAO J. simpson Goddard Earth Sciences and Technology Center University of MarylandBaltimore CountyBaltimoreMaryland 21250USA Laboratory for AtmospheresNASA Goddard Space Flight CenterGreenbeltMaryland 20771USA laboratory for Atmospheres NASA Goddard Space Flight CenterGreenbeltMaryland 20771USA

An ideal and simple formulation is successfully derived that well represents a quasi-linear relationship found between the domain-averaged water vapor, Q （ram）, and temperature, T （K）, fields for the three tropical oceans （i.e., the Pacific, Atlantic and Indian Oceans） based on eleven GEOS-3 [Goddard Earth Observing System （EOS） Version-3] global re-analysis monthly products. A Q - T distribution analysis is also performed for the tropical and extra-tropical regions based on in-situ sounding data and numerical simulations [GEOS-3 and the Goddard Cumulus Ensemble （GCE） model]. A similar positively correlated Q - T distribution is found over the entire oceanic and tropical regions; however, Q increases faster with T for the former region. It is suspected that the tropical oceans may possess a moister boundary layer than the Tropics. The oceanic regime falls within the lower bound of the tropical regime embedded in a global, curvilinear Q - T relationship. A positive correlation is also found between T and sea surface temperature （SST）; however, for one degree of increase in T, SST is found to increase 1.1 degrees for a warmer ocean, which is slightly less than an increase of 1.25 degrees for a colder ocean. This seemingly indicates that more （less） heat is needed for an open ocean to maintain an air mass above it with a same degree of temperature rise during a colder （warmer） season [or in a colder （warmer） region]. Q and SST are also found to be positively correlated. Relative humidity （RH） exhibits similar behaviors for oceanic and tropical regions. RH increases with increasing SST and T over oceans, while it increases with increasing T in the Tropics. RH, however, decreases with increasing temperature in the extratropics. It is suspected that the tropical and oceanic regions may possess a moister local boundary layer than the extratropics so that a faster moisture increase than a saturated moisture increase is favored for the former regions. T, Q, saturated water v

关键词： moisture temperature relationship quasi-equilibrium states Tropics oceans

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：