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Emotions,Perceptions and Health Behaviors of Adult Congenital Heart Disease Patients during COVID-19 in New York City

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Congenital Heart Disease 2022年第5期17卷 519-531页

作者： jodi l.Feinberg Peter Sheng Stephanie Pena Adam J.Small Susanna Wendelboe Katlyn Nemani Vikram Agrawal Dan G.Halpern leon H.Charney Division of Cardiology NYU Grossman School of MedicineNew YorkUSA Department of Medicine NYU Grossman School of MedicineNew YorkUSA Department of Psychiatry NYU Grossman School of MedicineNew YorkUSA Department of Cardiology Mount Sinai MorningsideNew YorkUSA

Background:Adults with congenital heart disease(ACHD)have increased prevalence of mood and anxiety *** are limited data regarding the influence of the COVID-19 pandemic on the mental health and health behaviors of these ***:The purpose is to evaluate the perceptions,emotions,and health behaviors of ACHD patients during the COVID-19 ***:In this cross-sectional study of ACHD patients,we administered surveys evaluating self-reported emotions,perceptions and health *** regressions were performed to determine the adjusted odds of displaying each perception,emotion and health behavior based on predictor ***:Ninety-seven patients(mean age 38.3 years,46.4%female,85.6%moderate or complex lesion)completed the *** majority of patients reported feeling moderately or very sad(63.1%),and 48.4%of patients identified themselves as feeling moderately or very *** majority of patients perceived their risk of COVID-19 as moderate or *** were more likely to report feeling sad and anxious(95%CI 1.06–10.96,p-value 0.039,and 95%CI 1.44–15.30,p-value=0.012,respectively),and were associated with higher odds of having a perceived increased risk of COVID-19(95%CI 1.33–10.59,p-value 0.012).There was no association between ACHD anatomic or physiologic classification and perceptions,emotions and health ***:Females were more likely to report feeling sad,anxious and an increased risk of COVID-19 in comparison to *** findings indicate the need for mental health support and promotion of health behaviors during the pandemic amongst all ACHD patients,regardless of underlying condition.

关键词： Adult congenital heart disease COVID-19 health behaviors anxiety depression

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Iodoacetic acid exposure alters the transcriptome in mouse ovarian antral follicles

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Journal of Environmental Sciences 2022年第7期34卷 46-57页

作者： Andressa Gonsioroski Mary laws Vasiliki E.Mourikes Alison Neff Jenny Drnevich Michael J.Plewa jodi A.Flaws Department of Comparative Biosciences University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Roy J.Carver Biotechnology Center University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Department of Crop Sciences and the Safe Global Water Institute University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA

Iodoacetic acid(IAA) is an unregulated water disinfection byproduct that is an ovarian toxicant. However, the mechanisms of action underlying IAA toxicity in ovarian follicles remain unclear. Thus, we determined whether IAA alters gene expression in ovarian follicles in mice. Adult female mice were dosed with water or IAA(10 or 500 mg/l) in the water for 35-40 days. Antral follicles were collected for RNA-sequencing analysis and sera were collected to measure estradiol. RNA-sequencing analysis identified 1063 differentially expressed genes(DEGs) in the 10 and 500 mg/l IAA groups(false discovery rate FDR ly, compared to controls. Gene Ontology Enrichment analysis showed that DEGs were involved with RNA processing and regulation of angiogenesis(10 mg/l) and the cell cycle and cell division(500 mg/l). Pathway Enrichment analysis showed that DEGs were involved in the phosphatidylinositol 3-kinase and protein kinase B(PI3K-Akt), gonadotropin-releasing hormone(Gn RH), estrogen, and insulin signaling pathways(10 mg/l). Pathway Enrichment analysis showed that DEGs were involved in the oocyte meiosis, Gn RH, and oxytocin signaling pathways(500 mg/l). RNA-sequencing analysis identified 809 DEGs when comparing the 500 and 10 mg/l IAA groups(FDR lated to ribosome, translation, m RNA processing, oxidative phosphorylation, chromosome, cell cycle, cell division, protein folding, and the oxytocin signaling pathway. Moreover, IAA exposure significantly decreased estradiol levels(500 mg/l) compared to control. This study identified key candidate genes and pathways involved in IAA toxicity and can help to further understand the molecular mechanisms of IAA toxicity in ovarian follicles.

关键词： Disinfection byproducts Iodoacetic acid Ovary Ovarian follicles Steroidogenesis Endocrine disruptors

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B7-H7 (HHlA2) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling

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Cellular & Molecular Immunology 2021年第6期18卷 1503-1511页

作者： Sadiye Amcaoglu Rieder Jingya Wang Natalie White Ariful Qadri Catherine Menard Geoffrey Stephens jodi lKarnell Christopher ERudd Roland Kolbeck Present address:Viela Bio GaithersburgMDUSA Universite de Montreal MontrealQCCanada MedImmune/AstraZeneca GaithersburgMDUSA Biopharmaceuticals Early RIAAstraZenecaGaithersburgMDUSA Biopharmaceuticals Early RIAAstraZenecaGaithersburgMDUSA View author publications

Modulation of T-cell responses has played a key role in treating cancers and autoimmune ***,understanding how different receptors on T cells impact functional outcomes is *** influence of B7-H7(HHlA2)and CD28H(TMIGD2)on T-cell activation remains *** we examined global transcriptomic changes in human T cells induced by *** through TCR with OKT3 and B7-H7 resulted in modest fold changes in the expression of select genes;however,these fold changes were significantly lower than those induced by OKT3 and B7-1 *** transcriptional changes induced by OKT3 and B7-H7 were insufficient to provide functional stimulation as measured by evaluating T-cell proliferation and cytokine ***,B7-H7 was coinhibitory when simultaneously combined with TCR and CD28 *** inhibitory activity was comparable to that observed with ***,in physiological assays using T cells and APCs,blockade of B7-H7 enhanced T-cell activation and proliferation,demonstrating that this ligand acts as a break *** work defines that the transcriptomic changes induced by B7-H7 are insufficient to support full costimulation with TCR signaling and,instead,B7-H7 inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling.

关键词： T cell inhibition Checkpoint pathway T cell transcriptomics

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Evaluating Protective Terpenoid Aldehyde Compounds in Cotton (Gossypium hirsutum l.) Roots

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American Journal of Plant Sciences 2016年第7期7卷 1086-1097页

作者： jodi A. Scheffler Crop Genetics Research Unit Jamie Whitten Delta States Research Center United States Department of Agriculture Stoneville MS USA

Cotton (Gossypium hirsutum l.) has epidermal glands containing terpenoid aldehyde (TA) compounds that protect the plant from pests and diseases. One TA, gossypol, has two forms (+) and (-) that are present in varying amounts. This study evaluated the variation in roots for TA compounds and how environment affected the levels of these compounds. Similar to seed, gossypol was the predominant TA in roots. No heliocides were detected with only trace amounts of other TAs, such as hemigossypolone or hemigossypol, detected in a few lines. Among the glanded lines, there were significant differences in gossypol content. Percent plus gossypol was consistently 4% - 10% higher in roots than seed. One line, “Mac7”, had 12 - 14 ug/mg gossypol in roots and 18 ug/mg in seed as well as >90% (+) gossypol in both roots and seed. Unlike other tissues in glandless cotton, the roots of glandless lines consistently produced detectable amounts of gossypol with 77% to 82% in the (+) form. Multi-year field tests showed that although gossypol levels in the roots were more affected by insect pressure or other environmental conditions than seed, there was selectable variation in upland cotton for root gossypol content. Unlike other parts of a glandless plant, the roots retained a functioning biochemical pathway for gossypol production.

关键词： Cotton Gossypol Host Plant Resistance Roots Cotton Seed Terpenoid Aldehyde

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An overview of the latest developments in facial imaging

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Forensic Sciences Research 2019年第1期4卷 10-28页

作者： Carl N.Stephan jodi M.Caple Pierre Guyomarc'h Peter Claes laboratory for human Craniofacial and Skeletal Identification(HuCS-ID lab) School of Biomedical SciencesThe University of QueenslandSt LuciaAustralia Unite Mixte de Recherche(UMR)5199 De la Préhistoireàl'Actuel:Culture Environnement et Anthropologie(PACEA)Ministère de la Culture et de la Communication(MCC)Centre National de la Recherche Scientifique(CNRS)Universitéde BordeauxPessacFrance Department of Electrical Engineering Department of Electrical Engineering(ESAT)/Processing of Speech and Images(PSI)KU LeuvenLeuvenBelgium Medical Imaging Research Center(MIRC) Universitair ZiekenhuisLeuvenBelgium

Facial imaging is a term used to describe methods that use facial images to assist or facili-tate human identification. This pertains to two craniofacial identification procedures that use skulls and faces—facial approximation and photographic superimposition—as well as face-only methods for age progression/regression, the construction of facial graphics from eye-witness memory (including composites and artistic sketches), facial depiction, face mapping and newly emerging methods of molecular photofitting. Given the breadth of these facial imaging techniques, it is not surprising that a broad array of subject-matter experts partici-pate in and/or contribute to the formulation and implementation of these methods (includ-ing forensic odontologists, forensic artists, police officers, electrical engineers, anatomists, geneticists, medical image specialists, psychologists, computer graphic programmers and software developers). As they are concerned with the physical characteristics of humans, each of these facial imaging areas also falls in the domain of physical anthropology, although not all of them have been traditionally regarded as such. This too offers useful opportunities to adapt established methods in one domain to others more traditionally held to be disciplines within physical anthropology (e.g. facial approximation, craniofacial super-imposition and face photo-comparison). It is important to note that most facial imaging methods are not currently used for identification but serve to assist authorities in narrowing or directing investigations such that other, more potent, methods of identification can be used (e.g. DNA). Few, if any, facial imaging approaches can be considered honed end-stage scientific methods, with major opportunities for physical anthropologists to make meaningful contributions. Some facial imaging methods have considerably stronger scientific underpin-nings than others (e.g. facial approximation versus face mapping), some currently lie ent

关键词： Forensic anthropology craniofacial identification facial approximation photographic superimpos-ition facial depiction age progression facial composites molecular photofitting

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高产杀粉蝶菌素的链霉菌鉴定及其拮抗水稻白叶枯菌活性研究

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微生物学报 2023年第4期63卷 1447-1459页

作者：何亚文 Azad Sepideh Mazhari 崔莹姚润贤 law Woan-Fei jodi lee learn-Han 郝祥蕊张红艳上海交通大学生命科学技术学院、微生物代谢国家重点实验室、代谢与发育科学国际合作联合实验室、上海交通大学-上海农乐生物农药与生物肥料联合研发中心上海200240 Novel Bacteria and Drug Discovery Research Group(NBDD) Microbiome and Bioresource Research Strength(MBRS)Jeffrey Cheah School of Medicine and Health SciencesMonash University MalaysiaJohor Bahru 47500Malaysia 上海农乐生物制品股份有限公司上海201419

【目的】为保证农业生产可持续性发展,研发和使用环境友好的生物农药受到全社会的高度重视。微生物代谢产物农药是我国目前应用最广的生物农药,也是未来发展绿色农药的一个重要方向。【方法】利用包含水稻白叶枯菌(Xanthomonas oryzae *... 详细信息

【目的】为保证农业生产可持续性发展,研发和使用环境友好的生物农药受到全社会的高度重视。微生物代谢产物农药是我国目前应用最广的生物农药,也是未来发展绿色农药的一个重要方向。【方法】利用包含水稻白叶枯菌(Xanthomonas oryzae ***,Xoo)PXO99A的NA培养基琼脂平板,从水稻根际土壤中筛选能抑制Xoo生长的链霉菌。通过高效液相色谱和质谱分析活性代谢产物的化学结构;采用剪叶法接种Xoo到水稻叶片后,再喷施杀粉蝶菌素溶液(0.1 g/l),2周后测定叶枯症状;采用响应面分析法优化高产杀粉蝶菌素的发酵培养基;采用PacBio SMRT测序平台+Illumina HiSeq X Ten平台开展全基因组测序。平均核苷酸一致性(average nucleotide identity,ANI)用于比较HSW2009与其他链霉菌在全基因组水平的亲缘关系。【结果】分离到一株对Xoo生长有强抑制活性的链霉菌HSW2009,其活性代谢产物为杀粉蝶菌素A1(piericidin A1,简称PIE);喷施PIE可以减轻Xoo在水稻叶片内的侵染;优化HSW2009高产PIE的发酵条件,得到MFM培养基;HSW2009在MFM培养中生长快、PIE发酵效价最高可以达到0.72 g/l;菌落表型分析、PIE生物合成基因簇分析、全基因组测序和ANI分析表明HSW2009与目前有效描述的PIE产生菌不同。【结论】HSW2009是一株高产杀粉蝶菌素A1的链霉菌属候选新种,命名为绍武链霉菌,可作为杀粉蝶菌素产业化研究的出发菌株。

关键词：链霉菌代谢产物杀粉蝶菌素水稻白叶枯菌生物防治

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Evaluating host plant resistance in cotton (Gossypium hirsutuml.) with varying gland densities to tobacco budworm (Heliothis virescensF.) and bollworm (Helicoverpa zeaBoddie) in the field and laboratory

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Agricultural Sciences 2012年第1期3卷 14-23页

作者： jodi A. Scheffler Gabriela B. Romano Carlos A. Blanco Crop Genetics Research Unit United States Department of Agriculture—Agricultural Research Service (USDA-ARS) Stoneville USA Southern Insect Management Research Unit USDA-ARS Stoneville USA

Cotton (Gossypium hirsutum l.) produces a number of toxic terpenoid aldehyde (TA) compounds contained in epidermal glands that help protect the plant from pests and diseases. In the seed, one of these toxic compounds, gossypol, limits the use of the seed to ruminants such as dairy cows. There are breeding techniques and germplasm available to decrease gossypol in the seed, but the breeding process also needs to include methods to evaluate the plant’s ability to resist insect pests. Three approaches were used to assess resistance of cotton to herbivory from bollworm (Helicoverpa zea Boddie) and tobacco budworm (Heliothis virescens F.) including field counts, controlled field antibiosis assays and laboratory feeding tests of young field grown leaves. Results indicated that both field and laboratory evaluation could provide an assessment of the cotton host’s resistance. Measurements of terpenoid aldehydes (TAs) in the seed and the leaves, confirmed that the levels and types of TAs in the seed were not always good estimators of leaf TAs and that other TAs such as hemigossypolone and heliocides contribute to host plant resistance.

关键词： Cotton Gossypol Helicoverpa Heliothis Terpenoid Aldehydes Host Plant Resistance

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Defining the‘HoneySweet’insertion event utilizing NextGen sequencing and a de novo genome assembly of plum(Prunus domestica)

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Horticulture Research 2021年第1期8卷 25-37页

作者： Ann M.Callahan Tetyana N.Zhebentyayeva jodi l.human. Christopher A.Saski Kelsey D.Galimba laura l.Georgi Ralph Scorza Dorrie Main Christopher D.Dardick USDA-ARS Appalachian Fruit Research StationKearneysvilleWV 25430USA The Schatz Center for Tree Molecular Genetics Department of Ecosystem Science and ManagementThe Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Horticulture Washington State UniversityPullmanWA 99164USA Plant and Environmental Sciences Department Clemson UniversityClemsonSC 29634USA Department of Genetics and Biochemistry Clemson UniversityClemsonSC 29634USA

HoneySweet’plum(Prunus domestica)is resistant to Plum pox potyvirus,through an RNAi-triggered *** the precise nature of the transgene insertion event has been complicated due to the hexaploid genome of *** blots previously indicated an unintended hairpin arrangement of the Plum pox potyvirus coat protein gene as well as a multicopy insertion *** confirm the transgene arrangement of the insertion event,‘HoneySweet’DNA was subjected to whole genome sequencing using Illumina short-read *** indicated two different insertion events,one containing seven partial copies flanked by putative plum DNA sequence and a second with the predicted inverted repeat of the coat protein gene driven by a double 35S promoter on each side,flanked by plum *** determine the locations of the two transgene insertions,a phased plum genome assembly was developed from the commercial plum‘Improved French’.A subset of the scaffolds(2447)that were>10 kb in length and representing,>95%of the genome were annotated and used for alignment against the‘HoneySweet’transgene *** of eight matching scaffolds spanned both insertion sites ranging from 157,704 to 654,883 bp apart,however we were unable to identify which scaffold(s)represented the actual location of the insertion sites due to potential sequence differences between the two plum ***,there was no evidence of any gene(s)being interrupted as a result of the ***,RNA-seq data verified that the insertions created no new transcriptional units and no dramatic expression changes of neighboring genes.

关键词： plum insertion Sweet

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Blueberry and cranberry pangenomes as a resource for future genetic studies and breeding efforts

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Horticulture Research 2023年第11期10卷 96-105页

作者： Alan E.Yocca Adrian Platts Elizabeth Alger Scott Teresi Molla F.Mengist Juliana Benevenuto luis Felipe V.Ferrão MacKenzie Jacobs Michal Babinski Maria Magallanes-lundback Philipp Bayer Agnieszka Golicz jodi l.human. Dorrie Main Richard V.Espley David Chagné Nick W.Albert Sara Montanari Nicholi Vorsa James Polashock luis Díaz-Garcia Juan Zalapa Nahla V.Bassil Patricio R.Munoz Massimo Iorizzo Patrick P.Edger Department of Horticulture Michigan State UniversityEast LansingMI48824United States Department of Plant Biology Michigan State UniversityEast LansingMI48824United States Genetics and Genome Sciences Michigan State UniversityEast LansingMI48824United States Plants for human Health Institute North Carolina State UniversityKannapolisNC United States Horticultural Sciences Department University of FloridaGainesvilleFL 32611United States Department of Biochemistry and Molecular Biology Michigan State UniversityEast LansingMI48824United States University of Western Australia Perth 6009 Australia Justus liebig University Giessen35390 Germany Department of Horticulture Washington State UniversityPullmanWA99163United States The New Zealand Institute for Plant and Food Research limited(PFR) AucklandNew Zealand The New Zealand Institute for Plant and Food Research limited(PFR) PalmerstonNew Zealand The New Zealand Institute for Plant and Food Research limited(PFR) MotuekaNew Zealand SEBS Plant BiologyRutgers UniversityNew Brunswick NJ 01019 United States Department of Viticulture and Enology University of CaliforniaDavisDavisCA 95616United States National Clonal Germplasm Repository USDA-ARSCorvallisOR 97333United States Department of Horticulture North Carolina State UniversityKannapolisNC United States MSU AgBioResearch Michigan State UniversityEast LansingMI48824United States

Domestication of cranberry and blueberry began in the United States in the early 1800s and 1900s,respectively,and in part owing to their f lavors and health-promoting benefits are now cultivated and consumed *** industry continues to face a wide variety of production challenges(*** pressures),as well as a demand for higher-yielding cultivars with improved fruit quality ***,molecular tools to help guide breeding efforts for these species have been relatively limited compared with those for other high-value ***,we describe the construction and analysis of the first pangenome for both blueberry and *** analysis of these pangenomes revealed both crops exhibit great genetic diversity,including the presence-absence variation of 48.4%genes in highbush blueberry and 47.0%genes in *** genes,those not shared by all cultivars,are significantly enriched with molecular functions associated with disease resistance and the biosynthesis of specialized metabolites,including compounds previously associated with improving fruit quality *** discovery of thousands of genes,not present in the previous reference genomes for blueberry and cranberry,will serve as the basis of future research and as potential targets for future breeding *** pangenome,as a multiple-sequence alignment,as well as individual annotated genomes,are publicly available for analysis on the Genome Database for Vaccinium-a curated and integrated web-based relational ***,the core-gene predictions from the pangenomes will serve useful to develop a community genotyping platform to guide future molecular breeding efforts across the family.

关键词： breeding cultivar crops

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