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GC盒不是人胰岛素基因启动子中关键顺式作用元件

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南方医科大学学报 2007年第1期27卷 78-80页

作者：牛新捷王作仁 jochen Seufert 西安交通大学第一医院肝胆外科德国弗莱堡大学医学院内分泌和糖尿病科弗莱堡79095

目的鉴定人胰岛素基因启动子中的GC盒(-348￣-338)是否是启动子中的关键顺式作用元件。方法用PCR克隆人胰岛素基因启动子,构建由人胰岛素基因启动子驱动的分泌型碱性磷酸酶(SEAP)报告质粒,并对报告质粒中人胰岛素基因启动子中的GC盒进... 详细信息

目的鉴定人胰岛素基因启动子中的GC盒(-348￣-338)是否是启动子中的关键顺式作用元件。方法用PCR克隆人胰岛素基因启动子,构建由人胰岛素基因启动子驱动的分泌型碱性磷酸酶(SEAP)报告质粒,并对报告质粒中人胰岛素基因启动子中的GC盒进行删除和突变。将报告质粒转染到!细胞系"TC3中,测定细胞培养液上清中SEAP的活性强度,进而判定GC盒与人胰岛素基因启动子转录活性的关系。结果删除和突变人胰岛素启动子中的GC盒不能显著改变胰岛素基因启动子在#细胞中的转录活性。结论人胰岛素基因启动子中GC盒不是一个关键顺式作用元件。

关键词：胰岛素基因 GC盒启动子分泌型碱性磷酸酶顺式作用元件

Monitoring the levels of brominated and organophosphate flame retardants in passenger cars:Utilisation of car air filters as active samplers

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Journal of Environmental Sciences 2020年第5期32卷 142-150页

作者： Long KTran Chang He Dam Hoang Phuc Leisa-Maree LToms Xianyu Wang Meng Xiu jochen FMueller Adrian Covaci Lidia Morawska Phong KThai QAEHS Queensland Alliance for Environmental Health ScienceThe University of QueenslandBrisbaneAustralia International Laboratory for Air Quality and Health Queensland University of TechnologyBrisbaneAustralia Hanoi University of Science and Technology HanoiViet Nam School of Public Health and Social Work Institute of Health and Biomedical InnovationFaculty of HealthQueensland University of TechnologyKelvin GroveQLDAustralia Toxicological Center Department of Pharmaceutical SciencesUniversity of AntwerpUniversiteitsplein 1AntwerpBelgium

Filters in residential and office air conditioning(A/C)systems have been used as sampling devices for monitoring different ***,cabin air filters(CAFs)in the A/C system of passenger cars have not been utilised for this *** this study,we collected22 used CAFs from passenger cars in Hanoi,Vietnam to analyse for 8 polybrominated diphenyl ethers(PBDEs)and 10 organophosphate esters(OPEs).All the analytes were detected in more than 50%of samples with the exception of BDE153 and *** average concentrations of∑10OPEs and∑8 BDEs in the captured dust were 2600 and 40 ng/g,respectively with Tris(1-chloro-2-propyl)phosphate(TCIPP)and BDE209 as the dominant congener in OPE and BDE groups,*** are a potential tool to qualitatively assess the levels of semi-volatile chemicals in suspended dust in cars as a screening step for exposure assessment of those chemicals.

关键词： Flame retardants Vehicle cabin Air quality Human exposure PBDEs OPEs

Genome-wide prediction for hybrids between parents with distinguished difference on exotic introgressions in Brassica napus

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The Crop Journal 2021年第5期9卷 1169-1178页

作者： Dandan Hu Yusheng Zhao Jinxiong Shen Xiangxiang He Yikai Zhang Yong Jiang Rod Snowdon Jinling Meng jochen C.Reif Jun Zou National Key Laboratory of Crop Genetic Improvement College of Plant Science&TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina Department of Breeding Research Leibniz Institute of Plant Genetics and Crop Plant Research(IPK)Stadt Seeland 06466Germany Department of Plant Breeding IFZ Research Centre for BiosystemsLand Use and NutritionJustus Liebig UniversityGiessen 35392Germany

Extensive exotic introgression could significantly enlarge the genetic distance of hybrid parental populations to promote strong *** goal of this study was to investigate whether genome-wide prediction can support pre-breeding in populations with exotic *** evaluated seed yield,seed yield related traits and seed quality traits of 363 hybrids of Brassica napus (AACC) derived from two parental populations divergent on massive exotic introgression of related species in three *** hybrids presented strong heterosis on seed yield,which was much higher than other investigated *** genomic best linear unbiased prediction models considering the exotic introgression and different marker effects (additive,dominance,and epistatic effects) were constructed to test the prediction ability for different traits of the *** analysis showed that the trait complexity,exotic introgression,genetic relationship between the training set and testing set,training set size,and environments affected the prediction *** models with best prediction ability for different traits ***,relatively high prediction ability (e.g.,0.728 for seed yield) was also observed when the simplest models were used,excluding the effects of the special exotic introgression and epistasis effect by5-fold cross validation,which would simplify the prediction for the trait with complex architecture for hybrids with exotic *** results provide novel insights and strategies for genome-wide prediction of hybrids between genetically distinct parent groups with exotic introgressions.

关键词： Hybrid Genome-wide prediction Exotic introgression Brassica napus Heterosis

Recirculating IL-1R2^(+) Tregs fine-tune intrathymic Treg development under inflammatory conditions

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Cellular & Molecular Immunology 2021年第1期18卷 182-193页

作者： Eirini Nikolouli Yassin Elfaki Susanne Herppich Carsten Schelmbauer Michael Delacher Christine Falk Ilgiz A.Mufazalov Ari Waisman Markus Feuerer jochen Huehn Department of Experimental Immunology Helmholtz Centre for Infection ResearchBraunschweigGermany Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-University MainzMainzGermany Regensburg Center for Interventional Immunology(RCI) Chair for ImmunologyUniversity Regensburg and University Hospital RegensburgRegensburgGermany Institute of Transplant Immunology Integrated Research and Treatment Center TransplantationIFB-TxHannover Medical SchoolHannoverGermany Hannover Medical School HannoverGermany

The vast majority of Foxp3^(+)regulatory T cells(Tregs)are generated in the thymus,and several factors,such as cytokines and unique thymic antigen-presenting cells,are known to contribute to the development of these thymus-derived Tregs(tTregs).Here,we report the existence of a specific subset of Foxp3^(+)Tregs within the thymus that is characterized by the expression of IL-1R2,which is a decoy receptor for the inflammatory cytokine *** flow cytometric analysis of the thymocytes from Foxp3^(hCD2)xRAG1^(GFP) reporter mice revealed that the IL-1R2^(+)Tregs are mainly RAG1^(GFP-)and CCR6^(+)CCR7^(-),demonstrating that these Tregs are recirculating cells entering the thymus from the periphery and that they have an activated *** the spleen,the majority of IL-1R2^(+)Tregs express neuropilin-1(Nrp-1)and Helios,suggesting a thymic origin for these ***,among all tissues studied,the highest frequency of IL-1R2^(+)Tregs was observed in the thymus,indicating preferential recruitment of this Treg subset by the *** fetal thymic organ cultures(FTOCs),we demonstrated that increased concentrations of exogenous IL-1β blocked intrathymic Treg development resulting in a decreased frequency of CD25^(+)Foxp3^(+)tTregs and an accumulation of CD25^(+)Foxp3^(-)Treg ***,the addition of IL-1R2^(+)Tregs,but not IL-1R2^(+)Tregs,to reaggregated thymic organ cultures(RTOCs)abrogated the IL-1β-mediated blockade,demonstrating that these recirculating IL-1R2^(+)Tregs can quench IL-1 signaling in the thymus and thereby maintain thymic Treg development even under inflammatory conditions.

关键词： Thymus Treg development Inflammation IL-1 system

Redox flow batteries-Concepts and chemistries for cost-effective energy storage

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Frontiers in Energy 2018年第2期12卷 198-224页

作者： Matthaa Verena HOLLAND-CUNZ Faye CORDING jochen FRIEDL Ulrich STIMMING Chemistry-School of Natural and Environmental Sciences Newcastle University Newcastle upon Tyne NE1 7RU United Kingdom

Electrochemical energy storage is one of the few options to store the energy from intermittent renewable energy sources like wind and solar. Redox flow batteries （RFBs） are such an energy storage system, which has favorable features over other battery technologies, e.g. solid state batteries, due to their inherent safety and the independent scaling of energy and power content. However, because of their low energy-density, low powerdensity, and the cost of components such as redox species and membranes, commercialised RFB systems like the all- vanadium chemistry cannot make full use of the inherent advantages over other systems. In principle, there are three pathways to improve RFBs and to make them viable for large scale application： First, to employ electrolytes with higher energy density. This goal can be achieved by increasing the concentration of redox species, employing redox species that store more than one electron or by increasing the cell voltage. Second, to enhance the power output of the battery cells by using high kinetic redox species, increasing the cell voltage, implementing novel cell designs or membranes with lower resistance. The first two means reduce the electrode surface area needed to supply a certain power output, thereby bringing down costs for expensive components such as membranes. Third, to reduce the costs of single or multiple components such as redox species or membranes. To achieve these objectives it is necessary to develop new battery chemistries and cell configurations. In this review, a comparison of promising cell chemistries is focused on, be they all-liquid, slurries or hybrids combining liquid, gas and solid phases. The aim is to elucidate which redox-system is most favorable in terms of energy-density, power-density and capital cost. Besides, the choice of solvent and the selection of an inorganic or organic redox couples with the entailing consequences are discussed.

关键词： electrochemical energy storage redox flow battery vanadium

Development of guidelines for the education of doctors and nurses for the treatment of the DFS under special consideration of HBO

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Development of guidelines for the education of doctors and n...

Emission spectroscopy of NaYF_(4):Eu nanorods optically trapped by Fresnel lens fibers

中华医学会第十六次全国高压氧学术会议

作者： jochen Freier Consultant for Diving- and Hyperbaric Medicine （EDTC） Anaesthesiology and Intensive Care Vice President of the German Society for Diving and Hyperbaric Medicine （GTUEM）

＜正＞A diabetic foot syndrome appears in the diabetic population in of Germany in 6 per cent.70 per cent of all ampu- tations are carried out with *** paying the insurance these are more than 29000 major and minor amputa- tions with diabetics per *** it is necessary to standardize the precautions and therapy of diabetic in Ger- *** guaranty the success of this process guidelines are created and used. The charges for the wound management are part of the complete editions of the health insurance to which 1992 120 billions of euros amounted and reached 48% of the complete editions for health in Germany.

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Photonics Research 2022年第2期10卷 332-339页

作者： Aashutosh Kumar Asa Asadollahbaik Jeongmo Kim Khalid Lahlil Simon Thiele Alois M.Herkommer Síle Nic Chormaic Jongwook Kim Thierry Gacoin Harald Giessen jochen Flck Universite Grenoble Alpes CNRSInstitut Neel38000 GrenobleFrance 4th Physics Institute and Research Center SCoPE University of Stuttgart70569 StuttgartGermany Universite Paris Saclay CNRSLaboratoire de Physique de la Matiere CondenseeEcole Polytechnique91128 PalaiseauFrance Institute of Applied Optics and Research Center SCoPE University of Stuttgart70569 StuttgartGermany Okinawa Institute of Science and Technology Graduate University Okinawa 904-0495Japan

NaYF_(4):Eu nanorods with high aspect ratios are elaborated and optically trapped using dual fiber optical tweezers in a counterpropagating geometry. High trapping efficiency is observed using converging beams, emitted from diffractive Fresnel lenses directly 3D printed onto cleaved fiber facets. Stable nanorod trapping and alignment are reported for a fiber-to-fiber distance of 200 μm and light powers down to 10 m W. Trapping of nanorod clusters containing one to three nanorods and the coupling of nanorod motion in both axial and transverse directions are considered and discussed. The europium emission is studied by polarization-resolved spectroscopy with particular emphasis on the magnetic and electric dipole transitions. The respective σ and π orientations of the different emission lines are determined. The angles with respect to the nanorod axes of the corresponding magnetic and electric dipoles are calculated. Mono-exponential emission decay with decay time of 4–5 ms is reported. It is shown that the nanorod orientation can be determined by purely spectroscopic means.

关键词： nanorods Fresnel trapping

Correction:The interplay between dendritic cells and CD8 T lymphocytes is a crucial component of SARS-CoV-2 immunity

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Cellular & Molecular Immunology 2022年第12期19卷 1441-1441页

作者： Jonas Buttenschon jochen Mattner Mikrobiologisches Institut - Klinische Mikrobiologie Immunologie und Hygiene Universitätsklinikum Erlangen and Friedrich-Alexander Universität (FAU) Erlangen-Nürnberg Erlangen Germany Medical Immunology Campus Erlangen FAU Erlangen-Nürnberg Erlangen Germany

Correction to:Cellular&Molecular Immunology https://***/10.1038/s41423-020-00624-1,published online 08 January 2021 The licence information was missing from this article and should *** original article has been correc... 详细信息

关键词： immunity lymphocytes Immunology