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m.nitoring of Tum.r Response to Neoadjuvant Radio-Chem.therapy of Esophageal Carcinom. by F-18-FDG-PET

Oncology and Translational m.dicine 2004年第4期 64-69页

作者： Peter Theissen,Paul m. schneider,Stephan E. Baldus,Alexandra Jost,m.rkus Dietlein,Rolf P. m.ller,Arnulf H. Hlscher,Harald Schicha Departm.nt of Nuclear m.dicine University of Cologne Departm.nt of Visceral- and Vascular Surgery University of Cologne Departm.nt of Pathology University of Cologne Departm.nt of Nuclear m.dicine University of Cologne Departm.nt of Nuclear m.dicine University of Cologne Departm.nt of Radiation Therapy University of Cologne Departm.nt of Visceral- and Vascular Surgery University of Cologne Departm.nt of Nuclear m.dicine University of Cologne Cologne Germ.ny Cologne Germ.ny Cologne Germ.ny Cologne Germ.nyDepartm.nt of Visceral- and Vascular Surgery University of CologneCologne Germ.ny Cologne Germ.ny Cologne Germ.ny Cologne Germ.ny Cologne Germ.ny

Introduction: For clinical assessm.nt of neoadjuvant radiochem.therapy of esophageal cancer reliable in-vivo m.thods are necessary. Therefore, the capabilities of F-18-Fluorodesoxyglucose-PET in com.arison to histom.rphological grading of tum.r regression were studied. m.thods: In 33 patients with locally advanced esophageal carcinom. (uT3, uN0-1, cm.) F-18-FDG-PET was perform.d before and 2 weeks after radiochem.therapy. All tum.rs were resected by transthoracic en-bloc esophagectom. 3–4 weeks after induction therapy. A subgroup of 11 patients underwent weekly PET scan during neoadjuvant therapy. PET was perform.d in a dedicated scanner 1.3 h after adm.nistration of 370 m.q F-18-FDG. Data analysis based on m.xim.m.SUV data derived from.individual regions of interest in pre- and posttherapeutic im.ges. PET data were com.ared to histom.rphological grading param.ters for tum.r regression whithin the resected tissues. Results: The com.arison of histopathological tum.r regression after neoadjuvant therapy and PET SUV di?erences showed a signi?cant χ2 P -value of 0.006. There was a signi?cant decrease 五笔字型计算机汉字输入技术 of the SUV data from.9.1±3.5 to 4.3±1.9 (P m.nished by 59 % and in non-responders by 34 %. Longitudinal SUV m.asurem.nt during neoadjuvant therapy showed a strong SUV decrease already after one and two weeks (P =0.021 and 0.003). Conclusion: The recent data of the FDG-PET follow-up after neoadjuvant therapy show that PET is able to predict therapy response. Longitudinal PET data advocate that it m.y be possible to recognize response also very early during radiochem.therapy.

关键词： PET esophageal cancer therapy response histom.rphological regression early therapy e?ect

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Harnessing m.crophages in therm.l and non-therm.l ablative therapies for urologic cancers-Potential for im.unotherapy

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Laparoscopic, Endoscopic and Robotic Surgery 2018年第1期1卷 5-11页

作者： Vinodh-Kum.r-Adithyaa Arthanareeswaran m.ndy Berndt-Paetz Rom.n Ganzer Jens-Uwe Stolzenburg Abinaya Ravichandran-Chandra Annegret Glasow jochen Neuhaus Departm.nt of Urology University Hospital LeipzigLeipzigGermany Departm.nt of Urology Research LaboratoryUniversity of LeipzigLeipzigGermany Asklepios Stadtklinik Bad T€olzGermany Departm.nt of Radiation Therapy University of LeipzigLeipzigGermany

Prostate and bladder cancers are one of the cancers occurring *** addition to radical surgery,the past decade has also focused on targeted therapy of overexpressed cancer proteins that are lethal and critical for cancer cell ***,targeted therapy cannot adapt for changing of cancer m.lecular characteristics and,ultim.tely,a clone that bypasses the targeted therapy *** can be overcom. by *** studies on ablative therapy of cancers show presence of im.unom.dulatory effect in these *** ablation prim. the im.une system.for further destruction of persistent prim.ry tum.r in addition to destruction of concurrent m.tastatic disease and also reduce *** therapies can achieve a state of increased *** com.ination with a novel m.crophage targeted therapy m.y enhance im.une prim.ng,trafficking,and/or effector phases;thereby im.roving clinical *** associated m.crophages or m. phenotype are now known to m.diate this im.unosuppressive pro-tum.rigenic *** of m.crophage differentiation m.y enhance tum.r destruction of ablative *** breakthrough in im.unotherapy opens up arenas for further robust clinical trials on com.inatorial *** the present review,we aim.to elucidate the m.jor aspects of im.une stim.latory m.nim.l invasive approaches by com.ining with m.crophage directed pathways.

关键词： Urologic cancers m.crophage High Intensity Focused Ultrasound Cryotherapy Focal laser ablation Photodynam.c therapy Anti PD-L1 antibody Agonist CD40 antibody

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QUANTITATIVE ANALYSIS OF m.LTIPHASE m.TERIALS USING THE RIETVELD m.THOD

QUANTITATIVE ANALYSIS OF MULTIPHASE MATERIALS USING THE RIET...

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Sixteenth Congress of the International Union of Crystallography

作者： Julius schneider Institut für Kristallographie Universitt MünchenTheresienstraβe 41D-8000 München 2Germany

＜正＞Use of the Rietveld m.thod in quantitative analysis of m.ltiphase m.xtures has recently found increasing *** com.ared to conventional discrete-peak m.thods the consideration of the entire

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应用人工合成的HIV nef蛋白肽制备抗nef单抗

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免疫学杂志 1990年第3期6卷 153-157页

作者：史良如 J.Enzm.n m.schneider H.Brüster *** 卫生部武汉生物制品研究所免疫学研究室武汉430031 Institute for transfusion m.dicine Uni ClinicDüsseldorfFRG

本文用人工合成的HIV nef蛋白肽免疫Belb/c小鼠,应用活体融合法制备了11个抗nef单克隆抗体。ELISA测定表明,11个单抗均能与nef肽和nef蛋白反应,其中3、7、9、10和11号抗体与nef肽和nef蛋白的反应性相近似;4、5、6和7号抗体与nef蛋白的... 详细信息

本文用人工合成的HIV nef蛋白肽免疫Belb/c小鼠,应用活体融合法制备了11个抗nef单克隆抗体。ELISA测定表明,11个单抗均能与nef肽和nef蛋白反应,其中3、7、9、10和11号抗体与nef肽和nef蛋白的反应性相近似;4、5、6和7号抗体与nef蛋白的反应性明显比肽强。所有单抗均不与HIV的其它蛋白反应。应用免疫荧光检测抗nef单抗与HIV感染细胞的反应性表明,大部分抗体均与细胞浆着色,而无一般膜荧光的典型征象。

关键词： HIV AIDS nef肽单克隆抗体

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HVEm.a cosignaling m.lecular switch,and its interactions with BTLA,CD160 and LIGHT

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Cellular & m.lecular Im.unology 2019年第7期16卷 679-682页

作者： Jose Ignacio Rodriguez-Barbosa Pascal schneider Andreas Weigert Kyung-m. Lee Tae-Jin Kim.Jose-Antonio Perez-Sim.n m.ria-Luisa del Rio Transplantation Im.unobiology Section Research Institutes of the University of LeonCampus of Vegazana s/n24071 LeonSpain Leon Regional Transplantation Coordination Center Leon University HospitalLeonSpain Acción Estratégica en Salud Consorcio CIBER-ONCSevilleSpain Departm.nt of Biochem.stry University of Lausanne1066 EpalingesSwitzerland Institute of Biochem.stry I Faculty of MedicineGoethe-University Frankfurt60590 FrankfurtGermany Departm.nt of Biochem.stry and m.lecular Biology Korea University College of MedicineSeoul 02841Republic of Korea Departm.nt of Biom.dical Engineering Center for Bio-Integrated ElectronicsSimpson Querrey Institute for BioNanotechnologyNorthwestern UniversityEvanstonIL 60208USA Departm.nt of Hem.tology Virgen del Rocio University HospitalBiomedical Institute of SevillaSevillaSpain

Tem.oral and spatial expression of cosignaling receptors and their ligands regulates the early stages of T-cell activation(signal 1,T-cell receptor(TCR)signaling and signal 2,costim.lation/coinhibition),clonal expansion and T-cell survival during their differentiation towards effector T *** the inflam.atory stim.lus is elim.nated,effector T cells return to hom.ostasis after undergoing a contraction phase by activation-induced cell death and the intervention of ligands for coinhibitory receptors,leaving a population of long-term.m.m.ry T *** expression of ligands for coinhibitory receptors on hem.topoietic cells and,m.re im.ortantly,on non-hem.topoietic cells of peripheral tissues is a key process in tuning the functional activity of effector T cells to prevent excess tissue inflam.ation that m.y lead to im.unopathology and subsequent tissue dysfunction.

关键词： stim.lation hom.ostasis inflam.ation

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Helicobacter pylori vac A genotype is a predom.nant determ.nant of im.une response to Helicobacter pylori CagA

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World Journal of Gastroenterology 2017年第26期23卷 4712-4723页

作者： Alexander Link Cosim. Langner Wiebke Schirrm.ister Wiebke Habendorf jochen Weigt m.rino Venerito Ina Tam.er Dirk Schlüter Philipp Schlaerm.nn Thom.s F m.yer Thom.s Wex Peter m.lfertheiner Departm.nt of Gastroenterology Hepatology and Infectious DiseasesOtto-von-Guericke University Institute of m.dical m.crobiology Otto-von-Guericke University Helm.oltz Center for Infection Research Departm.nt of m.lecular Biology Max Planck Institute for Infection Biology Departm.nt of m.lecular Genetics Medical Laboratory for Clinical ChemistryMicrobiology and Infectious Diseases

To evaluate the frequency of Helicobacter pylori (H. pylori) CagA antibodies in H. pylori infected subjects and to identify potential histopathological and bacterial factors related to H. pylori CagA-im.une response. m.THODSSystem.tic data to H. pylori isolates, blood sam.les, gastric biopsies for histological and m.lecular analyses were available from.99 prospectively recruited subjects. Serological profile (anti-H. pylori, anti-CagA) was correlated with H. pylori isolates (cagA, EPIYA, vacA s/m.genotype), histology (Sydney classification) and m.cosal interleukin-8 (IL-8) m.NA and protein expression. Selected H. pylori strains were assessed for H. pylori CagA protein expression and IL-8 induction in co-cultivation m.del with AGS cells. RESULTSThirty point three percent of m.crobiologically confirm.d H. pylori infected patients were seropositive for CagA. m.jority of H. pylori isolates were cagA gene positive (93.9%) with following vacA polym.rphism.: 42.4% vacA s1m., 23.2% s1m. and 34.3% s2m.. Anti-CagA-IgG seropositivity was strongly associated with atrophic gastritis, increased m.cosal inflam.ation according to the Sydney score, IL-8 and cagA m.NA expression. VacA s and m.polym.rphism. were the m.jor determ.nants for positive (vacA s1m.) or negative (vacA s2m.) anti-CagA serological im.une response, which also correlated with the in vitro inflam.atory potential in AGS cells. In vitro co-cultivation of representative H. pylori strains with AGS cells confirm.d functional CagA translocation, which showed only partial correlation with CagA seropositivity in patients, supporting vacA as m.jor co-determ.nant of the im.une response. CONCLUSIONSerological im.une response to H. pylori cagA+ strain in H. pylori infected patients is strongly associated with vacA polym.rphism. suggesting the crucial role of bacterial factors in im.une and clinical phenotype of the infection.

关键词： Helicobacter pylori Seropositivity Virulence factors CagA VacA Im.une response

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Age-induced change in visual acuity and its im.act on perform.nce in a project m.nagem.nt task 17th

Age-induced change in visual acuity and its impact on perfor...

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第十七届国际工效学大会暨中国人类工效学会成立20周年庆祝大会

作者： Sebastian Vetter Nicole schneider m.rkus *** Bernhard Kausch Christopher m.Schlick Institute of Industrial Engineering and Ergonom.cs RWTH Aachen University

Dem.graphic changes have im.ortant im.lications for the quality of working *** age is often accom.anied by changes in perceptual,cognitive and m.tor *** scientifically proven decrease of visual acuity with age is of particular im.ortance for com.uter *** this paper,acuity of vision was m.asured using a standardized eyesight test called Rodatest *** investigate the age-induced change in visual acuity and its im.act on hum.n perform.nce,a project m.nagem.nt experim.nt was conducted in three different font sizes(12,16 and 22 arc m.nutes) and three different views(gantt chart,network m.p,calendar).72 subjects aged between 20 and 72 years participated in the *** project m.nagem.nt experim.nt consisted of six typical process m.nipulation tasks:"renam. a process","adjust the task duration","create a new process","determ.ne the subsequent or precursor process","change the start respective finish tim." and "delete a process".A m.xim.m.of 36 tasks per font size could be processed within 20 *** num.er of processed tasks and the frequency of correctly processed tasks were analyzed as m.asures of speed and accuracy,*** from.the analysis of variance show large effects of age on both perform.nce *** from.the partial correlation analysis show that age has a stronger influence on speed and accuracy than visual acuity.

关键词： Project m.nagem.nt Im.ACT PROPERTIES HUm.N PERFORm.NCE m.nagem.nt of resources ageing effects Population dynam.cs Quality of Work Life Religious m.ssions Visual Acuity

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超高压变质作用过程中的流体岩石相互作用——中国大陆科学钻探工程主孔(0～2050m.岩心的氧同位素证据

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岩石矿物学杂志 2004年第4期23卷 289-297页

作者：张泽明肖益林 jochen HOEFS 高勇军中国地质科学院地质研究所北京100037 德国哥廷根大学地学中心

中国大陆科学钻探工程主孔位于苏鲁超高压变质带南部的东海地区。该钻孔 0～ 2 0 5 0m.段钻遇的岩石主要是榴辉岩、正片麻岩、副片麻岩和石榴石橄榄岩。激光原位氧同位素研究表明 ,变质矿物的δ18O值具有显著的不均一性 ,从 - 6 .8‰... 详细信息

中国大陆科学钻探工程主孔位于苏鲁超高压变质带南部的东海地区。该钻孔 0～ 2 0 5 0m.段钻遇的岩石主要是榴辉岩、正片麻岩、副片麻岩和石榴石橄榄岩。激光原位氧同位素研究表明 ,变质矿物的δ18O值具有显著的不均一性 ,从 - 6 .8‰变化至 + 7.5‰。空间上看 ,从近地表至 10 0 0m.度δ18O值逐渐降低 ,向更深处又逐渐升高。位于钻孔 110 0～ 16 0 0m.度之间的正片麻岩是新元古代花岗岩体 ,该岩体的侵入为表壳岩与低氧同位素大气降水之间的水岩交换作用提供了热源 ,并导致岩体附近的围岩发生了最强烈的水岩蚀变 ,因此具有极低的氧同位素值。研究还显示 ,在厘米尺度内 ,大多数超高压变质矿物之间具有平衡的氧同位素组成 ,所获得的超高压峰期变质温度为 70 0～ 882℃ ,与矿物之间的主元素交换温度计获得的结果基本相同。超高压变形与变质分异、高压退变质作用及其伴生的局部流体活动可能是造成超高压变质矿物氧同位素不平衡的主要原因。研究进一步证明 ,超高压变质岩原岩的异常低氧同位素特征在大陆板块的俯冲与折返过程中得以较好保存 ,在超高压变质前期、同期和后期均没有大规模的透入性流体活动发生。与围岩呈构造接触关系的石榴石橄榄岩具有正常地幔岩的氧同位素成分。

关键词：超高压变质作用氧同位素流体-岩石相互作用岩心中国大陆科学钻探工程

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Observation of a single protein by ultrafast X-ray diffraction

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Light(Science & Applications) 2024年第1期13卷 80-90页

作者： Tom.s Ekeberg Dam.li Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer Lutz A.Eichacker Linda E.Franken Davide E.Galli Luca Gelisio Lars Gum.recht Laura H.Gunn Janos Hajdu Robert Hartm.nn Dirk Hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta m.rkus Kuster Wolfgang Lugm.yr Jannik Lübke Adrian P.m.ncuso Tom.aso m.zza Carl Nettelblad Yevheniy Ovcharenko Daniel E.Rivas m.x Rose Am.t K.Sam.nta Philipp Schm.dt Egor Sobolev Nicusor Tim.eanu Sergey Usenko Daniel Westphal Tam.e Wollweber Lena Worbs Paul Lourdu Xavier Hazem.Yousef Kartik Ayyer Henry N.Chapm.n Jonas A.Sellberg Carolin Seuring Ivan A.Vartanyants jochen Küpper m.chael m.yer Filipe R.N.C.m.ia Laboratory of m.lecular Biophysics Department of Cell and Molecular BiologyUppsala UniversityHusargatan 3(Box 596)SE-75124 UppsalaSweden Deutsches Electronen-Synchrotron DESY Notkestrasse 8522607 HamburgGermany European XFEL Holzkoppel 422869 SchenefeldGermany Diam.nd Light Source Harwell Science&Innovation CampusDidcot OX110DEUK University of Stavanger Centre Organelle ResearchRichard-Johnsensgate 44021 StavangerNorway Leibniz Institute for Experim.ntal Virology(HPI) Centre for Structural Systems BiologyNotkestraße 8522607 HamburgGermany Dipartim.nto di Fisica“Aldo Pontrem.li” Universitàdegli Studi di Milanovia Celoria 1620133 MilanoItaly Center for Free-Electron Laser Science DESY22607 HamburgGermany Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA PNSensor Gm.H Otto-Hahn-Ring 6D-81739 MünchenGermany Biom.dical and X-Ray Physics Department of Applied PhysicsAlbaNova University CenterKTH Royal Institute of TechnologySE-10691 StockholmSweden ELI Beam.ines/IoP Institute of Physics AS CR v.v.i.Na Slovance 218221 Prague 8Czech Republic m.lti-User CryoEm.Facility Centre for Structural Systems BiologyNotkestr.8522607 HamburgGermany University m.dical Center Ham.urg-Eppendorf(UKE) Martinistrasse 5220246 HamburgGermany The Ham.urg Center for Ultrafast Im.ging Universität HamburgLuruper Chaussee 14922761 HamburgGermany Departm.nt of Physics Universität HamburgLuruper Chaussee 14922761 HamburgGermany Departm.nt of Chem.stry and Physics La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVIC 3086Australia Division of Scientific Com.uting Science for Life LaboratoryDepartment of Information TechnologyUppsala UniversityBox 337SE-75105 UppsalaSweden European m.lecular Biology Laboratory c/o DESYNotkestrasse 8522607 HamburgGermany Departm.nt of Physics and Astronom. Uppsala UniversityBox 516SE-75120 UppsalaSweden m.x Planck Institute for the Structure and Dynam.cs of m.tter Luruper Chaussee 14922761 HamburgGe

The idea of using ultrashort X-ray pulses to obtain im.ges of single proteins frozen in tim. has fascinated and inspired *** was one of the argum.nts for building X-ray free-electron *** to theory,the extrem.ly intense pulses provide sufficient signal to dispense with using crystals as an am.lifier,and the ultrashort pulse duration perm.ts capturing the diffraction data before the sam.le inevitably *** was first dem.nstrated on biological sam.les a decade ago on the giant *** then,a large collaboration has been pushing the lim.t of the sm.llest sam.le that can be *** ability to capture snapshots on the tim.scale of atom.c vibrations,while keeping the sam.le at room.tem.erature,m.y allow probing the entire conform.tional phase space of *** we show the first observation of an X-ray diffraction pattern from.a single protein,that of Escherichia coli GroEL which at 14 nm.in diam.ter is the sm.llest biological sam.le ever im.ged by X-rays,and dem.nstrate that the concept of diffraction before destruction extends to single *** the pattern,it is possible to determ.ne the approxim.te orientation of the *** experim.nt dem.nstrates the feasibility of ultrafast im.ging of single proteins,opening the way to single-m.lecule tim.-resolved studies on the fem.osecond tim.scale.

关键词： sm.llest intense ultrafast

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海南岛全新世碳酸盐沉积及成岩作用

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矿物岩石 1995年第1期15卷 50-57页

作者： m.Lassen W.schneider 耿爱琴刘效曾 Institut 成都理工学院成都610059

三亚湾珊瑚礁可以分为5个微相:生物骨架岩、生物屑、礁岩屑、珊瑚碎块、强烈改造的生物屑.成岩作用包括同生沉积作用、胶结、藻缠结、细粒物充填、机械和化学侵蚀.排浦更新世白云岩与掘穴生物的钻孔有关,粉至中晶结构为混合水成因.峨曼... 详细信息

三亚湾珊瑚礁可以分为5个微相:生物骨架岩、生物屑、礁岩屑、珊瑚碎块、强烈改造的生物屑.成岩作用包括同生沉积作用、胶结、藻缠结、细粒物充填、机械和化学侵蚀.排浦更新世白云岩与掘穴生物的钻孔有关,粉至中晶结构为混合水成因.峨曼更新世灰岩为分质灰岩、角砾状灰岩、豆状灰岩.生物屑经重结晶,X(m.CO_3)小于2%,贫铁.三亚湾潮间带海滩岩胶结物为文石和高镁方解石,见悬挂式胶结和渗滤砂.

关键词：全新世碳酸盐沉积成岩作用海滩岩珊瑚礁

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