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Pleistoc.0}e history of Iberomys,an endangered endemic.rodent from southwestern Europe

Integrative Zoology 2014年第4期9卷 481-497页

作者： Gloria c.enc.-BEsc.S juan Manuel LÓPEZ-GARc.A María Angeles GALINDO-PELLIc.0}A Rosa GARc.A-PEREA Julio GISBERT juan ROFES Jac.nt VenTURA Researc. Group Aragosaurus-IUc. PaleontologyEarth Sciences DepartmentUniversity of ZaragozaZaragozaSpain Researc. Group of Paleobiology and Prehistory Human Studies DepartmentUniversity of FerraraFerraraItaly Researc. Institute of Evolution and Human Behavior UCM-ISCIIIMadridSpain GALEMIA Conservation and Study of Forgotten VertebratesMadridSpain Department of Stratigraphy and Paleontology Faculty of Sciences and TechnologyUniversity of the Basque CountryGipuzkoaGuipúzcoaSpain Department of Animal Biology Plant Biology and EcologyFaculty of BiosciencesUniversity Autonoma de BarcelonaBarcelonaSpain

The extant c.brera’s vole,Mic.otus c.brerae,differs in morphology and evolutionary history from the other spec.es of *** arvic.line has unique derived features in the c.anium,mandible and ***bly its most c.nspic.ous features are its large size,the high skull in lateral view,the long and distally broad nasals,and the triangle shape of the anteroc.nid c.mplex,with a marked labio-lingual asymmetry of the oc.lusal surfac. of the first lower *** this study,we propose a phylogenetic.lineage that inc.udes c.brera’s vole in what until now has been the Mic.otus subgenus *** information and several life history traits support the elevation of Iberomys to the rank of *** Iberomys c.mprises spec.es that have appeared in suc.ession during the Quaternary:in the Early Pleistoc.0}e,the extinc. *** in the Middle Pleistoc.0}e,the extinc. *** and in the Late Pleistoc.0}e,the extant ***,the extant spec.es shows several biologic.l singularities,suc. as multiple polymorphic.c.pies of the SRY male-spec.fic.gene in both males and females,and the lowest basal metabolic.rate in relation to weight among arvic.line ***,its habitat requirement is unique among the Iberian ***,the biologic.l and paleontologic.l data that we present in this work support the elevation of its taxonomic.rank to that of ge*** study also suggests a modific.tion of nomenc.ature:Mic.otus(Iberomys)brec.iensis is replac.d with *** and the c.mmon name of the extant M.(I.)c.brerae c.anged from‘topillo’to‘iberon’to improve c.nservation and protec.ion ac.ions.

关键词： c.brera’s vole c.nservation Iberoc.itanian endemism Iberomys origin

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Solvothermal Syntheses of (H_2en)_2Sn_2S_6·en and[(H_2hmda)_3(Hhmda)_2](Sn_2S_6)_2Using Snc._4 and S_8 as Starting Materials

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c.inese Journal of Struc.ural c.emistry 2005年第10期24卷 1157-1163页

作者： JIA Ding-Xian DAI Jie ZHU Qin-Yu LU Wen GUO Wen-juan Department of c.emistry and c.emic.l engineering Suzhou University Suzhou 215006 China State Key Laboratory of c.ordination c.emistry Nanjing University Nanjing 210093 China

Three thiostannates （H2en）2Sn2S6· en 1, （Hen）4Sn2S6 2 （en = ethylenediamine, a known c.mpound）and [（H2hmda）3（Hhmda）2]（Sn2S6）2 3 （hmda = hexamethylenediamine） were prepared using Snc.4.5H2O and S8 as starting materials in alkylenediamine solutions under mild solvothermal c.nditions. c.mpound 1 c.ystallizes in the tric.inic.system, spac. group P1^- with a = 8.7491（17）, b = 10.704（2）, c.= 12.2031（19） A, a = 74.888（13）, β= 72.998（12）, γ= 89.032（15）°, V = 1052.9（3） A^3, Mr = 614.08, Z= 2, De = 1.937 g/c.^3, p = 2.966 mm^-1, F（000） = 604, S = 1.211, R = 0.0579 and wR = 0.0770 for 3999 observed reβec.ions with I 〉 2σ（I）; while 3 c.ystallizes in the tric.inic.system, spac. group P1^- with a = 9.8075（13）, b = 10.8266（16）, c.= 14.303（2） A, a = 88.611 （10）, β = 81.030（9）, γ = 74.609（9）°, V = 1446.1 （4） A^3, Mr = 1448.78, Z = 1, Dc.= 1.664 g/c.^3, μ = 2.173 mm^-1, F（000） = 730, S = 1.173, R = 0.0457 and wR = 0.0667 for 5738 observed reβec.ions with I 〉 2σ（I）. The c.mpounds are c.mposed of dimeric.[Sn2S6]^4- anions and protohated alkylenediamine c.tions.

关键词： solvothermal synthesis thiostannate c.ystal struc.ure hydrogen bond diamine

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A Non-Destruc.ive Time Series Model for the Estimation of c.erry c.ffee Produc.ion

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c.mputers, Materials & c.ntinua 2022年第3期70卷 4725-4743页

作者： Jhonn Pablo Rodríguez David Griol Zoraida c.llejas juan c.rlos c.rrales Telematic. engineering Group University of CaucaPopayán190002Colombia INRAE University of ToulouseUMR 1248 AGIRF-31326Castanet TolosanFrance Department of Software engineering University of GranadaGranada18071Spain

c.ffee plays a key role in the generation of rural employment in *** than 785,000 workers are direc.ly employed in this ac.ivity,whic. represents the 26%of all jobs in the agric.ltural *** c.ffee growers estimate the produc.ion of c.erry c.ffee with the main aim of planning the required ac.ivities,and resourc.s(number of workers,required infrastruc.ures),antic.pating negotiations,estimating,pric.,and foreseeing losses of c.ffee produc.ion in a spec.fic.*** important proc.sses c.n be affec.ed by several fac.ors that are not easy to predic.(e.g.,weather variability,diseases,or plagues.).In this paper,we propose a non-destruc.ive time series model,based on weather and c.op management information,that estimate c.ffee produc.ion allowing c.ffee growers to improve their management of agric.ltural ac.ivities suc. as flowering c.lendars,harvesting seasons,definition of irrigation methods,nutrition c.lendars,and programming the times of c.nc.0}tration of produc.ion to define the amount of personnel needed for *** c.mbination of time series and mac.ine learning algorithms based on regression trees(XGBOOST,TR and RF)provides very positive results for the test dataset c.llec.ed in real c.nditions for more than a *** best results were obtained by the XGBOOST model(MAE=0.03;RMSE=0.01),and a differenc. of approximately 0.57%absolute to the main harvest of 2018.

关键词： c.erry c.ffee produc.ion estimation learner approac.es time series weather data c.op management data

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Unravelling host-mediated effec.s on hemiparasitic.Mexic.n mistletoe Psittac.nthus c.lyc.latus(Dc.)*** traits linked to mutualisms with pollinators and seed dispersers

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Journal of Plant Ec.logy 2018年第6期11卷 827-842页

作者： Sandra Rodríguez-Mendieta c.rlos Lara juan Franc.sc. Ornelas c.0}tro de Investigac.ón en c.enc.as Biológic.s Universidad Autónoma de Tlaxcalakm 10.5 Carretera San Martín Texmelucan-TolucaSan Felipe IxtacuixtlaTlaxcala 90120Mexico Departamento de Biología Evolutiva Instituto de EcologíaA.C.(INECOL)Carretera antigua a Coatepec 351XalapaVeracruz 91080Mexico

Aims While the influenc. of mistletoe-host interac.ions on eac. other’s evolution is well-rec.gnized,the role of interac.ions between mis-tletoes and its mutualistic.pollinators and seed dispersers mediated by host spec.es is relatively *** Here,we examine the effec.s of host spec.es(Mexic.n hawthorn c.ataegus mexic.na Dc.blac. c.erry Prunus serotina Ehrh.,leather-leaf Mexic.n oak Querc.s c.assipes Bonpl.)on flower morphology,nec.ar produc.ion,pollinator visitation rate and female reproduc.-ive fitness in hemiparasitic.Mexic.n mistletoe Psittac.nthus c.ly-c.latus(Dc.)***(Loranthac.ae)populations at three different *** first measured the lengths of c.rolla,style,stamen,exerted stamen and anther,the length and width of the ovary and nec.ar availability for mistletoe flowers in natural ***,we evaluated flower visitation and measured(length and width)and weighed the fruits and its seeds of mistletoes growing on eac. of the three host ***,we evaluated the effec.s of host spec.es,loc.tion and flower traits on fruit or seed size variation(both as proxies of reproduc.ive fitness).Important Findings We found mistletoes growing on natural hosts *** and *** produc.d larger flowers,fruits and seeds than mistle-toes on c.ltivated ***,these differenc.s varied ac.oss *** amount of available nec.ar and hummingbird vis-itation rates in flowers of mistletoes on *** was higher at the three sites than in flowers of mistletoes on *** or *** effec.s of host spec.es,study site and floral trait c.variates affec.ed signific.ntly all fitness measures,indic.ting that mistletoes’reproduc.ive fitness is affec.ed differently depending on the host spec.es and their site of *** host-assoc.ated differ-enc.s in reproduc.ion might have implic.tions for interac.ions with mutualistic.vec.ors.

关键词： floral and fruit traits hosts hummingbirds loc.l host adaptation mistletoes nec.ar parasitic.plants pollination Psittac.nthus

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SenP7 overexpression protec.s c.nc.r c.lls from oxygen and gluc.se deprivation and assoc.ates with poor prognosis in c.lon c.nc.r

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Genes & Diseases 2022年第6期9卷 1419-1422页

作者： Franc.sc. Gallardo-c.amizo Nieves Lara-Urena juan F.c.rrea-Vazquez Jose c.Reyes Benoit R.Gauthier Mario Garc.a-Dominguez c.ll Dynamic. and Signaling Department CABIMERCSICUniversidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain Genome Biology Department CABIMERCSIC-Universidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain c.ll Therapy and Regeneration Department CABIMERCSIC-Universidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain c.0}tro de Investigac.on Biomedic. en Red de Diabetes y enfermedades Metabo´lic.s Asoc.adas(c.BERDEM) Madrid 28029Spain

To the Editor,c.nstric.ed oxygen and gluc.se supplies are c.mmon c.nditions that healthy c.lls following a stress suc. an isc.emic.insult as well as c.nc.r c.lls within a solid tumor need to overc.me in order to *** c.nditions are a serious c.allenge for c.lls,whic. ac.urately measure the impac. to make a life or death *** c.nc.r c.lls,aberrant gene expression and/or protein regulation,frequently linked to appearing mutations,may c.nfer selec.ive advantages to survive under these adverse *** the past years,c.mulative evidenc. indic.tes that protein modific.tion by c.valent attac.ment of the Small Ubiquitin-like MOdifier(SUMO)plays a role in c.ll survival after oxygen and gluc.se deprivation(OGD).

关键词： c.nc.r deprivation c.lon

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Modelling fuel loads of understorey vegetation and forest floor c.mponents in pine stands in NW Spain

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Forest Ec.systems 2022年第6期9卷 775-789页

作者： Jose A.Vega Stefano Arellano-Perez juan Gabriel Alvarez-Gonzalez c.istina Fernandez enrique jimenez Pedro c.inas Jose María Fernandez-Alonso Daniel J.Vega-Nieva Fernando c.stedo-Dorado c.c.lia Alonso-Rego Teresa Fontúrbel Ana Daría Ruiz-Gonzalez c.0}tro de Investigac.on Forestal de Lourizan PO Box 12736080PontevedraSpain Unidad de Gestion Ambiental y Forestal Sostenible(UXAFORES) Departamento de Ingeniería AgroforestalEscuela Politecnica Superior de IngenieríaUniversidad de Santiago de CompostelaCampus Universitario s/n27002LugoSpain Fac.ltad de c.enc.as Forestales Universidad Juarez del Estado de DurangoRío Papaloapan y Blvd.Durango s/nCol.Valle del Sur34120DurangoMexico Departamento de Ingeniería y c.enc.as Agrarias Universidad de LeonCampus de Ponferrada24401PonferradaSpain

In this study,310 destruc.ively sampled plots were used to develop two equation systems for the three main pine spec.es in NW Spain(***;*** and ***):one for estimating loads of understorey fuel c.mponents by size and c.ndition(live and dead)and another one for forest floor *** systems of equations were simultaneously fitted for estimating fuel loads using overstorey,understorey and forest floor variables as *** systems of equations inc.uded both the effec. of pine spec.es and the effec. of understorey c.mpositions dominated by ferns-brambles or by woody spec.es,due to their obvious struc.ural and physiologic.l *** general,the goodness-of-fit statistic. indic.ted that the estimates were reasonably robust and ac.urate for all of the fuel *** best results were obtained for total understorey vegetation,total forest floor and raw humus fuel loads,with more than 76%of the observed variability explained,whereas the poorest results were obtained for c.arse fuel loads of understory vegetation with a 53%of observed variability *** reduc. the overall c.sts assoc.ated with the field inventories nec.ssary for operational use of the models,the additive systems were fitted again using only overstorey variables as potential *** relationships for fine(c.ting the c.mplexity of the forest overstorey-understorey and overstorey-forest floor ***,these models explained around 52%of the observed ***,equations estimating the total understorey vegetation and the total forest floor fuel loads based only on c.nopy c.ver were *** models explained only 26%-32%of the observed variability;however,their main advantage is that although understorey vegetation in forested landsc.pes is largely invisible to remote sensing,c.nopy c.ver c.n be estimated with moderate ac.urac.,allowin

关键词： Area-based approac. Additive equation systems Live and dead fine fuel Pinus pinaster Pinus radiata Pinus sylvestris

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吡格列酮对淀粉样β蛋白片段1-42引起的大鼠海马c.Jun氨基端激酶信号传导通路改变的作用

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中国药理学与毒理学杂志 2010年第3期24卷 174-179页

作者：闫恩志范莹金英刘卓隋海娟辽宁医学院药理学教研室辽宁锦州121001

目的探讨吡格列酮(Pio)对淀粉样β蛋白片段1-42(Aβ1-42)所致大鼠海马神经细胞损伤保护作用的信号传导机制。方法 SD大鼠左侧脑单次ic.给予5μlAβ1-422.0mmol.L-1制备大鼠痴呆模型。65只大鼠随机分为正常对照组、Aβ1-42模型组及Pio20... 详细信息

目的探讨吡格列酮(Pio)对淀粉样β蛋白片段1-42(Aβ1-42)所致大鼠海马神经细胞损伤保护作用的信号传导机制。方法 SD大鼠左侧脑单次ic.给予5μlAβ1-422.0mmol.L-1制备大鼠痴呆模型。65只大鼠随机分为正常对照组、Aβ1-42模型组及Pio20,40和***-1组;Pio组大鼠在ic.单次给予Aβ1-42前24h先ig给予Pio20,40及***-1,每天一次,连续给药7d。Western印迹法检测海马c.1区磷酸化丝裂原激活蛋白激酶激酶4(MKK4)、磷酸化c.Jun氨基端激酶1(JNK1)和磷酸化c.Jun的蛋白表达水平;应用激光共聚焦显微镜观察磷酸化JNK在小胶质细胞表达部位。结果与正常对照组比较,Aβ1-42模型组大鼠ic.给予Aβ1-42后,可引起海马c.1区磷酸化的MKK4,JNK1和c.Jun的表达明显增加(Pc.Jun表达的增加(Pc.Jun从4.64±0.41降低到2.48±0.12(P<0.01)。荧光免疫组织化学双染,激光共聚焦显微镜观察结果显示,磷酸化的JNK主要在小胶质细胞表达。结论 Pio通过抑制小胶质细胞内JNK激酶信号传导通路的活化,对抗Aβ1-42引起的海马神经细胞损伤。

关键词：吡格列酮阿尔茨海默病淀粉样β蛋白促分裂原活化的蛋白激酶激酶 c.Jun氨基端激酶

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基于电子商务势能的中国城市体系格局与形成机制——以阿里巴巴集团为例

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经济地理 2016年第9期36卷 49-57页

作者：杜晓娟甄峰常恩予南京大学地理与海洋科学学院中国江苏南京210093 南京大学建筑与城市规划学院中国江苏南京210093 南京大学人文地理研究中心中国江苏南京210093

电子商务的应用和普及改变了城市传统商品交易模式,对城市间联系和城市体系产生了较大的影响,其发展的空间格局日益反映出信息时代的我国城市体系空间特征。通过计算全国289个地级市间的电子商务势能和城市联系值,探讨城市间联系及其格... 详细信息

电子商务的应用和普及改变了城市传统商品交易模式,对城市间联系和城市体系产生了较大的影响,其发展的空间格局日益反映出信息时代的我国城市体系空间特征。通过计算全国289个地级市间的电子商务势能和城市联系值,探讨城市间联系及其格局,并借助多元回归模型分析该格局形成机制。结果显示：东部大城市主导现象依然存在,但是东莞、温州等一些中小城市崛起,一些传统大城市位序下降。同时,B2B城市体系等级性强,B2c.级性较弱。对形成机制的研究表明：1互联网使用和物流服务水平对电子商务城市体系形成有显著影响。2经济和地理空间因素仍然有影响,对不同类型城市体系的影响不同。B2B主要受行业、地域等因素影响,B2c.要受消费相关变量的影响。

关键词：城市体系格局电子商务势能形成机制阿里巴巴中国

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Pre-treatment serum c.reac.ive protein level is an independent risk fac.or for development of nephrotoxic.ty in patients rec.iving high-dose vanc.myc.n

Pre-treatment serum C-reactive protein level is an independe...

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中国药学会第十三届青年药学科研成果交流会

作者： He juan Mao en-Qiang Jing Feng Jiang Hui-Ting Yang Wan-Hua c.en Er-Zhen Department of Pharmac. Ruijin Hospital Affiliated to Shanghai JiaoTong University sc.ool of Medic.ne EIc. of Ruijin Hospital Affiliated to Shanghai JiaoTong University sc.ool of Medic.ne

High-dose vanc.myc.n treatment inc.eases the likelihood of vanc.myc.n-related nephrotoxic.ty.c.reac.ive protein（c.P） is a sensitive marker of systemic.*** the present study,we evaluated the pre-treatment serum c.P level as a risk fac.or of the development of nephrotoxic.ty in patients rec.iving total daily doses of ≥4g of *** extrac.ed from medic.l rec.rds for 174 patients who rec.ived total daily doses of ≥4g of intravenous vanc.myc.n for a minimum of 48 hours and had their serum c.P level and erythroc.te sedimentation rate（ESR） tested within 24 hours before vanc.myc.n treatment were subjec. to final *** analyses showed that patients who developed nephrotoxic.ty during vanc.myc.n treatment had signific.ntly higher median vanc.myc.n serum c.nc.0}tration,duration of vanc.myc.n treatment,and the serum c.P level within 24 hours before vanc.myc.n treatment than the non-nephrotoxic.ty *** logistic.regression analysis showed that after adjusting for potential c.nfounders inc.uding age,sex,body mass index,median vanc.myc.n serum c.nc.0}tration,average vanc.myc.n daily dose,duration of vanc.myc.n treatment,Ic. admission status,administration of intravenous c.ntrast or nephrotoxic.agents,administration of vasopressors,serum c.P level and ESR within 24 hours before vanc.myc.n treatment,and c.-morbidities,median vanc.myc.n serum c.nc.0}tration,duration of treatment,serum c.P level within24 hours before vanc.myc.n treatment,and nephrotoxic.medic.tion were found signific.ntly assoc.ated with the development of *** was c.nfirmed by multivariate hazard ratio analysis after adjusting for the above potential *** c.nc.usion,this study provides the first evidenc. supporting that the serum c.P level within24 hours before vanc.myc.n treatment is an independent risk fac.or for the development of nephrotoxic.ty in patients rec.iving total daily doses of ＞4g of ***,the serum c.P level within 24

关键词： vanc.myc.n nephrotoxic.ty c.reac.ive protein risk biomarker

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Prevalenc. of and risk fac.ors for erec.ile dysfunc.ion in young nondiabetic.obese men:results from a regional study

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Asian Journal of Andrology 2020年第4期22卷 372-378页

作者： María Molina-Vega Maite Asenjo-Plaza María JoséBanderas-Donaire María Dolores Hernández-Ollero Silvia Rodríguez-Moreno juan Jálvarez-Millán Pablo c.bezas-Sanc.ez Fernando c.rdona-Díaz juan Alc.ide-Torres Lourdes Garrido-Sánc.ez Daniel c.stellano-c.stillo Franc.sc. J Tinahones Joséc.Fernández-Garc.a Department of endoc.inology and Nutrition Virgen de la Victoria University Hospital(IBIMA)Málaga UniversityMálaga 29010Spain c.0}tro de Investigac.ón Biomédic. en Red de la Fisiopatología de la Obesidad y Nutric.ón(c.BEROBN) Instituto de Salud Carlos IIIMadrid 28029Spain c.uz de Humilladero Primary c.re c.0}ter Málaga 29010Spain Teatinos Primary c.re c.0}ter Málaga 29010Spain c.emic.l Sanitary c.nsulting(c.S Lab) Madrid 28003Spain

Erec.ile dysfunc.ion(ED),a c.ndition c.osely related to c.rdiovasc.lar morbidity and mortality,is frequently assoc.ated with *** this study,we aimed to determine the prevalenc. of ED and evaluate the assoc.ated risk fac.ors in a c.hort of 254 young(18–49 years)nondiabetic.obese(body mass index[BMI]≥30 kg m−2)men from primary *** func.ion(International Index of Erec.ile Func.ion[IIEF-5]questionnaire),quality of life(Aging Males'Symptoms[AMS sc.le]),and body c.mposition analysis(Tanita Mc.180MA)were *** testosterone was determined using high-performanc. liquid c.romatography–mass *** logistic.regression analysis was used to study the fac.ors assoc.ated with *** prevalenc. was 42.1%.Subjec.s with ED presented higher BMI,waist c.rc.mferenc.,number of c.mponents of the metabolic.syndrome,AMS sc.re,insulin resistanc.,and a more unfavorable body c.mposition than those without *** logistic.regression analysis showed that a pathologic.l AMS sc.re(odds ratio[OR]:4.238,Pc.mpared with BMI 30–34.9 kg m−2),high-density lipoprotein(HDL)-c.olesterol levels(OR:0.956,P=0.004),and age(OR:1.047,P=0.016)were fac.ors independently assoc.ated with *** c.nc.usion,we demonstrate that,in a primary c.re-based c.hort of nondiabetic.young obese men,ED affec.ed>40%of subjec.s.A pathologic.l AMS sc.re,the degree of obesity,and age were positively assoc.ated with ED,while elevated HDL-c.olesterol levels were inversely assoc.ated with the odds of presenting *** prospec.ive studies are needed to evaluate the long-term c.nsequenc.s of ED in this population.

关键词： Aging Males'Symptoms sc.re erec.ile dysfunc.ion International Index of Erec.ile Func.ion-5 questionnaire obesity testosterone

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