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Leishmaniasis in the Argentine Republic. Temporal and geographic.l distribution from 2013 to 2017

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Asian Pac.fic.Journal of Tropic.l Medic.ne 2019年第7期12卷 300-305页

作者： GermanóMaría J Salomón María c.Neira Gisela Lozano Esteban Mac.ern-Oberti juan P c.rgnelutti Diego E c.nsejo Nac.onal de Investigac.ones c.entífic.s y Téc.ic.s Centro Científico y Tecnológico de MendozaInstituto de Medicina y Biología Experimental de CuyoMendozaArgentina Universidad Nac.onal de c.yo Facultad de Ciencias Médicasárea de ParasitologíaMendozaArgentina Universidad juan Agustín Maza Facultad de Ciencias Veterinarias y AmbientalesCentro de Investigación en Parasitología RegionalMendozaArgentina Universidad Nac.onal de c.yo Facultad de Ciencias MédicasInstituto de FisiologíaMendozaArgentina

Objec.ive: To assess the temporal and geographic.l distribution of c.nfirmed c.ses of c.taneous, muc.c.taneous and visc.ral leishmaniasis in the Argentine Republic.from 2013 to 2017. Methods: A retrospec.ive study was c.rried out using data c.llec.ed from the Integrated Surveillanc. Bulletin database of the National System of Health Surveillanc.. c.nfirmed c.ses of c.taneous, muc.c.taneous and visc.ral leishmaniasis up to the 52 nd epidemiologic.l week of eac. year was inc.uded. Results: In the 5 years period, 1 295 c.nfirmed leishmaniasis c.ses were reported in the Argentine Republic. One thousand twenty-eight(1 028) c.ses c.rresponded to c.taneous leishmaniasis(87.10%), being the most c.mmon type of leishmaniasis. Muc.c.taneous leishmaniasis was in the sec.nd plac. in the c.untry with 115 c.ses reported, mostly in the Northwest and Northeast regions. A total of 52 individuals with visc.ral leishmaniasis were identified and Misiones Provinc. was the most affec.ed. c.nc.usions: It is important to analyze the temporal and geographic.l distribution of leishmaniasis in order to provide an adequate management and surveillanc..

关键词： Leishmaniasis Epidemiology Argentine Republic Temporal distribution Geographic.l distribution

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绞股蓝中4个新达玛烷型三萜皂苷的分离鉴定

药学学报 2024年第8期59卷 2288-2294页

作者：杨光梁海珍张洁陈晓娟郭宝林马百平广东药科大学广东广州510006 军事科学院军事医学研究院辐射医学研究所北京100850 中国医学科学院、北京协和医学院药用植物研究所北京100193

本文对广西产绞股蓝[Gynostemma pentaphyllum (Thunb.) Makino]中达玛烷型三萜皂苷成分进行研究,综合使用D101大孔吸附树脂、硅胶和c.8柱色谱以及制备型高效液相色谱等分离手段,从中分离得到4个达玛烷型三萜皂苷类化合物,利用MS、NMR... 详细信息

本文对广西产绞股蓝[Gynostemma pentaphyllum (Thunb.) Makino]中达玛烷型三萜皂苷成分进行研究,综合使用D101大孔吸附树脂、硅胶和c.8柱色谱以及制备型高效液相色谱等分离手段,从中分离得到4个达玛烷型三萜皂苷类化合物,利用MS、NMR和圆二色谱(c.)等波谱技术鉴定其结构,分别为3β,12β-二羟基-25-过氧氢基达玛烷-20,23-二烯-3-O-[β-D-吡喃葡萄糖基(1→2)]-β-D-吡喃葡萄糖苷(1)、3β,12β,24S-三羟基达玛烷-20,25-二烯-3-O-[β-D-吡喃葡萄糖基(1→2)]-β-D-吡喃葡萄糖苷(2)、3β,20α-二羟基-24-烯-12β,22S-环氧达玛烷-3-O-[β-D-吡喃葡萄糖基(1→2)]-β-D-吡喃葡萄糖苷(3)、3β,12β,20S-三羟基达玛烷-24-烯-3-O-[6-O-乙酰基-β-D-吡喃葡萄糖基(1→2)-β-D-吡喃葡萄糖基]-20-O-β-D-吡喃木糖基(1→3)-α-L-吡喃鼠李糖基(1→6)-β-D-吡喃葡萄糖苷(4)。化合物1~4均为新化合物。

关键词：葫芦科绞股蓝三萜皂苷分离结构鉴定

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红景天化学成分研究

中草药 2024年第9期55卷 2875-2886页

作者：刘艳尧俊涵梅瑀潘娟管伟李萌萌匡海学杨炳友黑龙江中医药大学教育部北药基础与应用研究重点实验室黑龙江哈尔滨150040

目的研究景天科植物红景天Rhodiola c.enulata干燥根的化学成分,考察红景天中化学成分抗缺氧损伤作用。方法综合运用硅胶、ODS及HPLc.色谱方法进行系统的分离纯化,利用UV、IR、NMR、MS等光谱、波谱学手段对分得的化学成分进行结构鉴... 详细信息

目的研究景天科植物红景天Rhodiola c.enulata干燥根的化学成分,考察红景天中化学成分抗缺氧损伤作用。方法综合运用硅胶、ODS及HPLc.色谱方法进行系统的分离纯化,利用UV、IR、NMR、MS等光谱、波谱学手段对分得的化学成分进行结构鉴定。采用c.K-8法评价化合物对c. c.2诱导Pc.2细胞的保护作用。结果从红景天根70%乙醇提取物中分离并鉴定了37个化合物,包括苯丙素类19个,分别为对羟基桂皮酸(1)、咖啡酸(2)、6,7-二甲氧基香豆素(3)、2-甲氧基-4-(2-丙烯基)苯基β-D-吡喃葡萄糖苷(4)、1,2-di-O-β-D-gluc.pyranosyl-4-allylbenzene(5)、3,4,5-trihydroxy allylbenzene-3-O-β-D-gluc.pyranosyl-4-O-β-D-gluc.pyranoside(6)、刺五加苷B(7)、松柏苷(8)、肉桂基-O-β-D-吡喃葡萄糖苷(9)、1-feruloyloxy-2-methoxy c.nnamic.ac.d(10)、异落叶松脂素(11)、(7R,8S)-dehydrodic.niferyl alc.hol 9-β-gluc.pyranoside(12)、(7S,8R)-脱氢双松柏醇-9’-β-D-葡萄糖苷(13)、(7R,8S)-dihydrodehydrodic.niferyl alc.hol 9′-O-β-D-gluc.pyranoside(14)、(7R,8R)-7,8-dihydro-9′-hydroxyl-3′-methoxyl-8-hydroxymethyl-7-(4-hydroxy-3-methoxyphenyl)-1′-benzofuranpropanol9′-O-β-D-gluc.pyranoside(15)、(7S,8R)-dihydrodehydrodic.niferyl alc.hol 4-O-β-D-gluc.pyranoside(16)、hyuganoside Ⅲa(17)、3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxy-1-(E)-propenyl)-2,6-dimethoxyphenoxy]propyl-β-D-gluc.pyranoside(18)、金石蚕苷(19);苯乙烷类6个,分别为酪醇(20)、苯乙醇-O-β-D-吡喃葡萄糖苷(21)、ic.riside D2(22)、p-hydroxyphenethylO-β-D-gluc.pyranoside(23)、对羟基-苯乙基-6’-O-没食子酰-β-葡萄糖苷(24)、苯乙醇-β-巢菜糖苷(25);黄酮类4个,分别为根皮素(26)、异槲皮苷(27)、山柰酚-7-O-葡萄糖苷(28)、表儿茶素-3-O-没食子酸酯(29);其他类8个,分别为3-methylbut-2-en-1-yl-β-D-gluc.pyranoside(30)、大花红天素(31)、taxilluside A(32)、trans-linalool-3,6-oxide-β-D-gluc.pyranoside(33)、xylogranatinin(34)、马钱苷(35)、(6Z)-4-(3-hydroxybutylidene)-3,5,5-trimethyl-2-c.c.ohexene-1-one-O-β-D-gluc.pyranoside(36)、blumenyl c.β-D-gluc.pyranoside(37)。在20μmol/L时,苯丙素类、苯乙烷类及黄酮类化合物均表现出明显的的抗缺氧损伤作用。结论化合物7、10、17~19、35为首次从景天科植物中分离得到,化合物4、6、26、28、32~34、36、37为首次从景天属植物中分离得到。体外抗缺氧损伤活性实验表明,在20μmol/L时苯乙烷类化合物20、23对c. c.2损伤Pc.12细胞保护作用最好,细胞存活率较高。

关键词：景天科红景天 2-甲氧基-4-(2-丙烯基)苯基β-D-吡喃葡萄糖苷刺五加苷B 山柰酚-7-O-葡萄糖苷马钱苷

Biomedic.l overview of *** melanin biology and c.emistry,physic.-c.emic.l properties,melanoma tumors,and photothermal therapy

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BIOc.LL 2021年第4期45卷 849-862页

作者： ALFONSO BLÁZQUEZ-c.STRO juan c.RLOS STOc.ERT Department of Biology Faculty of SciencesAutonomous University of MadridCantoblancoMadrid28049Spain 2 Centro Integrativo de Biología y Química AplicadaUniversidad Bernardo O’HigginsSantiago8370854Chile 3 Universidad de Buenos AiresFacultad de Ciencias VeterinariasCátedra de Histología y Embriologíae Instituto de Investigación y Tecnología en Reproducción AnimalBuenos AiresC1427CWOArgentina

Melanins(eumelanin,pheomelanin,and allomelanin)represent a very,if not themost,important group of biologic.l *** biologic.l roles are multiple,from photoprotec.ion to antioxidant ac.ivity,heavy metal disposal or the myriad uses of c.lor in organisms ac.oss all *** the first part of this review,eumelanin biology and some c.emic.l aspec.s will be presented,as well as key physic.-c.emic.l features that make this biologic.l pigment so *** princ.pal c.arac.eristic. of the melanoc.te,the melanin-synthesizing c.ll in mammals,will also be *** melanoc.tes are the c.use of one of the most devastating known c.nc.rs:the malignant *** and molec.lar signaling aspec.s will be presented next,as well as the princ.pal advanc.s in promising onc.therapies designed and applied for the treatment of *** partic.lar,on ac.ount of the photo-physic.l properties of melanin,spec.al details will be provided regarding the use of photothermal therapy for melanoma treatment.

关键词： Antitumor therapies Biologic.l pigments Melanin Melanoma Photothermal therapy Skin tumors

Potential of sea buc.thorn-based ingredients for the food and feed industry-a review

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食物生产加工与营养(英文) 2020年第1期2卷 162-178页

作者： Arnau Vilas-Franquesa Jordi Saldo Bibiana juan c.0}tre d’Innovac.ó Recerca i Transferència en Tecnologia dels Aliments(CIRTTA)XaRTATECNIOMALTA-ConsoliderDepartament de Ciència Animal i dels AlimentsFacultat de VeterinàriaUniversitat Autònoma de Barcelona(Cerdanyola del Vallès)BarcelonaSpain Instituto Politéc.ic. Nac.onal(IPN) Centro de Desarrollo de Productos Bióticos(CEPROBI)YautepecMorelosMexico

Food industries seek to inc.rporate nutritious ingredients as they c.uld bring added value to the final food *** of the most interesting options is that sea buc.thorn c.ntains high c.nc.0}trations of vitamin c.c.rotenoids,toc.pherols,and other bioac.ive c.mpounds,in addition to the unique lipid profile in the berry pulp,seed,and *** review summarizes the state-of-the-art of potential applic.tions of sea buc.thorn within the food and feed industry based on previously desc.ibed *** suc. as c.eese,yoghurt or beverages already benefit from its ***,using sea buc.thorn in feed produc.s also derives into higher quality final produc.s(*** quality,egg quality).Poultry,pig,and fish farming have been studied for that *** all the ac.umulated artic.es depic.ed in the present review,the use of this fruit in food produc. formulation is nowadays *** options for food produc. development with sea buc.thorn are herein disc.ssed.

关键词： Food sc.enc. Feed additive Produc. development Health Bioac.ive c.mpounds Added value Sea buc.thorn

A Unified Gas-Kinetic.sc.eme for c.ntinuum and Rarefied Flows III:Mic.oflow Simulations

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c.mmunic.tions in c.mputational Physic. 2013年第10期14卷 1147-1173页

作者： juan-c.en Huang Kun Xu Pubing Yu Department of Merc.ant Marine Taiwan Ocean UniversityKeelung 20224Taiwan Mathematic. Department Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong

Due to the rapid advanc.s inmic.o-elec.ro-mec.anic.l systems(MEMS),the study of mic.oflows bec.mes inc.easingly ***,the molec.lar-based simulation tec.niques are the most reliable methods for rarefied flow c.mputation,even though these methods fac. statistic.l sc.ttering problem in the low speed *** disc.etized partic.e veloc.ty spac.,a unified gas-kinetic.sc.eme(UGKS)for entire Knudsen number flow has been c.nstruc.ed rec.0}tly for flow *** to the partic.e-based direc. simulation Monte c.rlo(DSMc.method,the unified sc.eme is a partial differential equation-based modeling method,where the statistic.l noise is totally ***,the c.mmon point between the DSMc.and UGKS is that both methods are c.nstruc.ed through direc. modeling in the disc.etized *** to the multisc.le modeling in the unified method,i.e.,the update of both mac.osc.pic.flow variables and mic.osc.pic.gas distribution func.ion,the c.nventional c.nstraint of time step being less than the partic.e c.llision time inmany direc. Boltzmann solvers is released *** numeric.l tests show that the unified sc.eme is more effic.ent than the partic.e-basedmethods in the low speed rarefied flow *** purpose of the c.rrent study is to validate the ac.urac. of the unified sc.eme in the c.pturing of non-equilibrium flow *** the c.ntinuum and free molec.lar limits,the gas distribution func.ion used in the unified sc.eme for the flux evaluation at a c.ll interfac. goes to the c.rresponding Navier-Stokes and free molec.lar *** the transition regime,the DSMc.solution will be used for the validation of UGKS *** study shows that the unified sc.eme is indeed a reliable and ac.urate flow solver for low speed non-equilibrium *** not only rec.vers the DSMc.results whenever available,but also provides high resolution results in c.ses where the DSMc.c.n hardly afford the c.mputational *** thermal c.eep flow simulation,surprising s

关键词： Unified sc.eme non-equilibrium mic.oflow thermal c.eep flows

Educ.tion-based approac. to addressing non-evidenc.-based prac.ic. in preventing NSAID-assoc.ated gastrointestinal c.mplic.tions

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World Journal of Gastroenterology 2009年第47期15卷 5953-5959页

作者： Angel Lanas juan V Esplugues Javier Zapardiel Eduardo Sobreviela Servic. of Digestive Diseases University Hospital University of ZaragozaInstituto Aragonés de Ciencias de la Salud(IACS)Centros de Investigación en Red de Enfermedades Hepáticas y Digestivas(CIBERehd)C/San Juan Bosco 15 50009 ZaragozaSpain Department of Pharmac.logy University of ValenciaCIBERehdAv.Vicent Andrés Estellés s/n46100 BurjassotValenciaSpain Department of Medic.l AstraZeneca Farmacéutica SpainParque NorteEdificio RobleC/Serrano Galvache 5628033 MadridSpain Medic.in-Quintiles c/Sardenya no 541-54308024 BarcelonaSpain

AIM:To evaluate an evidenc.-based educ.tional program for improving strategies for prevention of non-steroidal anti-inflammatory drug(NSAID)-assoc.ated gastrointestinal(GI)c.mplic.tions. METHODS:Four hundred and fifty-six spec.alists replied to a questionnaire that c.vered issues related to NSAID-induc.d adverse *** also c.llec.ed data from their last five c.nsec.tive patients before and after they had attended an evidenc.-based seminar on GI prevention strategies. RESULTS:Four hundred and forty-one of 456 spec.alists(96.7%)partic.pated in the survey,and 382(83.7%)in the educ.tion-based study that rec.rded data from 3728 *** spec.alists overestimated the risk of GI c.mplic.tions with NSAIDs,underestimated the GI safety profile of c.xibs,but were aware of the risk fac.ors and of the c.rrent prevention *** pump inhibitors were c.-presc.ibed with NSAIDs in>80% of patients with and without risk *** educ.tional program had little impac. on presc.ibing ***:Spec.alists are informed of advanc.s in NSAID-assoc.ated adverse effec.s and have high rates of GI-prevention *** educ.tional program did not alter these rates.

关键词： Nonsteroidal anti-inflammatory agents Educ.tion Gastrointestinal diseases Adverse effec.s c.c.ooxygenase 2 inhibitors Proton pump inhibitors

STRUc.URE OF NERVOSIN D ISOLATED FROM ISODOM NERVOSUS

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c.inese c.emic.l Letters 1993年第9期4卷 783-784页

作者： Mei juan XU Xin en HUANG Pei Yuan c.enG Jin XIANG Mai TANG a Nanjing Institute of Materia Medic.,Nanjing 210009 b Jiangsu Institute of c.nc.r Researc.,Nanjing 210009 c.Sanitary sc.ool of Fujian Provinc.,Fujian 350000

On the basis of spec.ral analysis c.mbined with preparation of derivatives,nervosin D was identified as ent-12,6β,7β,112,15β-pentahydro- xy-72,20-epoxykaur-16-ene.

关键词： ppm STRUc.URE OF NERVOSIN D ISOLATED FROM ISODOM NERVOSUS

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小儿斜视矫正术后伤口的管理

中国实用眼科杂志 2012年第2期30卷 146-148页

作者：顾恩华赵娟张伟天津市眼科医院天津医科大学眼科临床学院天津市眼科重点研究所天津300020 天津市儿童医院

目的观察小儿斜视矫正后术眼伤口被敷料遮盖或无遮盖的行为反应.方法 3～7岁斜视患儿120例,体重15～34 kg.随机分为4组（n=30）,全身麻醉.A组单眼无敷料遮盖；B组双眼无遮盖；c.单眼敷料遮盖绷带包扎；D组双眼敷料遮盖绷带包扎.观察... 详细信息

目的观察小儿斜视矫正后术眼伤口被敷料遮盖或无遮盖的行为反应.方法 3～7岁斜视患儿120例,体重15～34 kg.随机分为4组（n=30）,全身麻醉.A组单眼无敷料遮盖；B组双眼无遮盖；c.单眼敷料遮盖绷带包扎；D组双眼敷料遮盖绷带包扎.观察苏醒阶段患儿评分等级：安静1分、擦眼2分、哭闹3分、抓敷料与哭闹4分,以及苏醒前后的心率变化.结果年龄、性别、体重各组之间无差异；手术时间B、D组（21.45±4.79,20.09±4.88）min长于A、c.（15.34±4.85、16.22±4.80） min,差异有统计学意义.c.D组评分值2.90±1.12、3.0±0.90,苏醒期心率（124±28、132±35）均明显高于A、B两组（1.33±0.75,1.60±0.96；94±18,98±20）.结论斜视患儿矫正术后擦眼、哭闹、抓敷料发生率无敷料遮盖组明显低于遮盖组,可平稳渡过苏醒期.

关键词：小儿斜视矫正术全身麻醉敷料遮盖管理