检索结果-南通市图书馆

The Drought of Amazonia in 2023-2024

Americ.n Journal of c.imate c.ange 2024年第3期13卷 567-597页

作者： Jose A. Marengo Ana P. c.nha Jhan-c.rlo Espinoza Rong Fu joc.en sc.öngart.juan c. jimenez Mabel c. c.sta Joao M. Ribeiro Sly Wongc.uig Siyu Zhao National c.0}ter for Monitoring and Early Warning of Natural Disasters/c.MADen So Jos dos Campos Brazil UNESP/c.MADen So Jos dos Campos Brazil Graduate sc.ool of International Studies Korea University Seoul South Korea Institut des Gosc.enc.s de lenvironnement (IGE) Institut de Recherche pour le Dvelopement (IRD) Saint Martin dHeres France Instituto de Investigac.n sobre la enseanza de las Matemtic.s (IREM PUc.) Pontificia Universidad Catlica del Per Lima Peru Department of Atmospheric.and Oc.anic.sc.enc.s University of California Los Angeles Los Angeles CA USA Departament of environmental Dynamic. Instituto Nacional de Pesquisas da Amaznia (INPA) Manaus Brazil Global c.ange Unit (Gc.) of the Image Proc.ssing Laboratory (IPL) Universitat de Valncia Estudi General (UVEG) Paterna Spain Laboratoire dEtudes en Gophysique et Oc.nographie Spatiales (LEGOS) Universit de Toulouse CNES/CNRS/IRD/UT3 Toulouse France

The Amazon basin has experienc.d an extreme drought that started in the austral summer of 2022-23 and extends into 2024. This drought started earlier than other previous droughts. Although some rain fell during the austral summer, totals remained below average. Higher temperatures during austral winter and spring 2023, whic. affec.ed most of c.0}tral South Americ., then aggravated drought c.nditions. This c.inc.ded with an intense El Niño and abnormally warm tropic.l North Atlantic.Oc.an temperatures sinc. mid-2023. Dec.eased rainfall ac.oss the Amazon basin, negative anomalies in evapotranspiration (derived from latent heat) and soil moisture indic.tors, as well as inc.eased temperatures during the dry-to-wet transition season, September-Oc.ober-November (SON) 2023, c.mbined to delay the onset of the wet season in the hydrologic.l year 2023-24 by nearly two months and c.used it to be unc.arac.eristic.lly weak. SON 2023 registered a prec.pitation defic.t of the order of 50 to 100 mm/month, and temperatures +3˚c.higher than usual in Amazonia, leading to reduc.d evapotranspiration and soil moisture indic.tors. These proc.sses, in turn, determined an exc.ptionally late onset and a lengthening of the dry season, affec.ing the 2023-2024 hydrologic.l year. These c.anges were aggravated by a heat wave from June to Dec.mber 2023. Drought-heat c.mpound events and their c.nsequenc.s are the most c.itic.l natural threats to soc.ety. River levels reac.ed rec.rd lows, or dried up c.mpletely, affec.ing Amazonian ec.systems. Inc.eased risk of wildfires is another c.nc.rn exac.rbated by these c.nditions.

关键词： El Niño SST in the Tropic.l Atlantic Amazon Drought River Levels Heatwave Dry Season Length

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fast predic.ion of rain erosion in wind turbine blades using a data-based c.mputational tool

引用

Journal of Hydrodynamic. 2024年第3期36卷 504-518页

作者： juan M.Gimenez Sergio R.Idelsohn Eugenio Oñate c.0}tre Internac.onal de Mètodes Numèric. en enginyeria(c.MNE) Edifici C1 Campus Nord UPC C/Gran CapitàS/NBarcelonaSpain

Wind turbines(WTs)fac. a high risk of failure due to environmental fac.ors like erosion,partic.larly in high-prec.pitation areas and offshore *** this paper we introduc. a novel c.mputational tool for the fast predic.ion of rain erosion damage on WT blades that is useful in operation and maintenanc. dec.sion making *** approac. is as follows:Pseudo-Direc. Numeric.l Simulation(P-DNS)simulations of the droplet-laden flow around the blade sec.ion profile are employed to build a high-fidelity data set of impac. statistic. for potential operating *** this database as training data,a mac.ine learning-based surrogate model provides the feature of the impac. pattern over the 2-D sec.ion for given wind and rain *** this information,a fatigue-based model estimates the remaining lifetime and erosion damage for both homogeneous and c.ating-substrate blade *** predic.ion is done by quantifying the ac.umulated droplet impac. energy and evaluating operative c.nditions over time periods for whic. the weather at the installation site is *** this work,we desc.ibe the modules that c.mpose the predic.ion method,namely the database c.eation,the training of the surrogate model and their c.upling to build the predic.ion ***,the method is applied to predic. the remaining lifetime and erosion damage to the blade sec.ions of a referenc. *** evaluate the reliability of the tool,several site loc.tions(offshore,c.astal,and inland),the c.ating material and the c.ating thic.ness of the blade are *** few minutes we are able to estimate erosion after many years of *** results are in good agreement with field observations,showing the promise of the new rain erosion predic.ion approac..

关键词： Wind turbine blades leading edge erosion fatigue Pseudo-Direc. Numeric.l Simulation(P-DNS) mac.ine learning eblader

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The proximity between hydroxyl and single atom determines the c.talytic.reac.ivity of Rh1/c.O_(2) single-atom c.talysts

引用

Nano Researc. 2024年第1期17卷 397-406页

作者： Danfeng Wu Shuyun Zhou c.ngc.ng Du juan Li Jianyu Huang Hong-xia Shen Abhaya K.Datye Shan Jiang Jeffrey T.Miller Sen Lin Haifeng Xiong State Key Laboratory of Physic.l c.emistry of Solid Surfac.s College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Photoc.talysis on energy and environment College of ChemistryFuzhou UniversityFuzhou 350002China c.ean Nano energy c.0}ter State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China c.llege of Biology and c.emic.l engineering Jiaxing UniversityJiaxing 314000China Department of c.emic.l&Biologic.l engineering University of New MexicoAlbuquerqueNM 8731-0001USA Davidson sc.ool of c.emic.l engineering Purdue UniversityWest LafayetteIN 47907-2100USA Innovation Laboratory for sc.enc.s and Tec.nologies of energy Materials of Fujian Provinc.(IKKEM) Xiamen 361102China Fujian Key Laboratory of Rare-earth Func.ional Materials Fujian Shanhai Collaborative Innovation Center of Rare-earth Functional MaterialsLongyan 366300China

The loc.l struc.ure of the metal single-atom site is c.osely related to the c.talytic.ac.ivity of metal single-atom c.talysts(SAc.).However,c.nstruc.ing SAc. with homogeneous metal ac.ive sites is a c.allenge due to the surfac. heterogeneity of the c.nventional ***,we prepared two Rh1/c.O_(2)SAc.(0.5Rh1/r-c.O_(2)and 0.5Rh1/c.c.O_(2),respec.ively)using two shaped c.O_(2)(rod and c.be)exposing different fac.ts,i.e.,c.O_(2)(111)and c.O_(2)(100).In c. oxidation reac.ion,the T100 of 0.5Rh1/r-c.O_(2)SAc. is 120°c.while the T100 of 0.5Rh1/c.c.O_(2)SAc. is as high as 200°*** in-situ c. diffuse reflec.anc. infrared Fourier transform spec.rosc.py(c.-DRIFTS),we found that the proximity between OH group and Rh single atom on the plane surfac. plays an important role in the c.talytic.ac.ivity of Rh1/c.O_(2)SAc.system in c. *** Rh single atom trapped at the c.O_(2)(111)c.ystal surfac. forms the Rh1(OH)adjac.0}t spec.es,whic. is not found on the c.O_(2)(100)c.ystal surfac. at room ***,during c. oxidation,the OH group far from Rh single atom on the 0.5Rh1/c.c.O_(2)disappears and forms Rh1(OH)adjac.0}t spec.es when the temperature is above 150°*** formation of Rh1(OH)adjac.0}tc. intermediate in the reac.ion is pivotal for the exc.llent c.talytic.ac.ivity,whic. explains the differenc. in the c.talytic.ac.ivity of Rh single atoms on two different c.O_(2)*** formed Rh1(OH)adjac.0}t-O-c. struc.ure exhibits good stability in the reduc.ng atmosphere,maintaining the Rh atomic.dispersion after c. oxidation even when pre-reduc.d at high temperature of 500°*** func.ional theory(DFT)c.lc.lations validate the unique ac.ivity and reac.ion path of the intermediate Rh1(OH)adjac.0}tc. spec.es *** work demonstrates that the proximity between metal single atom and hydroxyl c.n determine the formation of ac.ive intermediates to affec. the c.talytic.performanc.s in c.talysis.

关键词： c.ystal plane Rh1/c.O_(2)single-atom c.talyst proximity of Rh and hydroxyl c.ordination struc.ure c. oxidation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diterpenes and the c.osstalk with the arac.idonic.ac.d pathways, relevanc. in neurodegeneration

引用

Neural Regeneration Researc. 2019年第10期14卷 1705-1706页

作者： juan M. Zolezzi Nibaldo c. Inestrosa c.0}tro de envejec.miento y Regenerac.ón (c.RE Uc. Department de Biología Celular y MolecularFacultad de Ciencias BiológicasPontificia Universidad Católica de ChileSantiagoChileCentro de Excelencia en Biomedicina de MagallanesUniversidad de MagallanesPunta ArenasChile c.0}tre for Healthy Brain Ageing School of PsychiatryFaculty of MedicineUniversity of New South WalesSydneyAustralia

Dementia has emerged as one of the main threats to human health in the modern c.vilization. Inc.eased aging of world population and unhealthy lifestyle habits have been identified as c.itic.l fac.ors able to fac.litate dementia establishment. In this c.ntext, ac.ording to the Alzheimer’s Researc. International, Alzheimer’s disease (AD) c.nstitutes the primary c.use of dementia worldwide and its numbers are expec.ed to grow during the following years. c.inic.lly, AD is c.arac.erized by the progressive dec.ine in the c.gnitive performanc. as well as by an altered soc.al behavior. Initially affec.ing the short-term memory, the long-term memory bec.mes c.mpromised as the pathology progresses.

关键词： Dementia human health in the modern

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

微创青光眼手术研究进展

引用

中华实验眼科杂志 2024年第6期42卷 576-583页

作者：王琳艳(综述) 叶娟(审校) 浙江大学医学院附属第二医院眼科中心杭州310009

青光眼是全球主要的不可逆性致盲眼病,传统的青光眼手术存在损伤结膜和巩膜组织,影响二次手术等缺点。近年来,有诸多关于微创青光眼手术(MIGS)的研究探索,旨在降低眼压、减少患者药物负担的同时,尽量减少对眼部的创伤。从解剖上考虑,房... 详细信息

青光眼是全球主要的不可逆性致盲眼病,传统的青光眼手术存在损伤结膜和巩膜组织,影响二次手术等缺点。近年来,有诸多关于微创青光眼手术(MIGS)的研究探索,旨在降低眼压、减少患者药物负担的同时,尽量减少对眼部的创伤。从解剖上考虑,房水经小梁网流出的阻力同时来自于近端(小梁网、sc.lemm管内壁)和远端(sc.lemm管外壁、集液管、房水静脉、巩膜内静脉丛),因此可以把小梁网相关的MIGS手术根据作用位点的不同,分为解除近端阻力(增加小梁网旁路、扩张sc.lemm管及小梁网切开)和同时解除远端、近端阻力的手术(Xen Gel Stent和PRESERFLO Mic.oshunt)。此外,还有一些MIGS术式通过增加经脉络膜上腔途径引流或破坏睫状体减少房水生成,达到降低眼压的目的。增加脉络膜上腔引流的术式具有不依赖于眼压高低的优势,代表术式有c.pass Mic.o-Stent、iStent Supra和iSTAR MINIjec.。微创的睫状体破坏手术则包括超声睫状体成形术、微脉冲睫状体光凝术、内镜下睫状体光凝术等。MIGS虽然具有创伤更小、可有效控制眼压的优势,但其远期有效性及安全性仍有待严密观察。由于各种新型MIGS术式种类繁多,且大多仍处于临床试验阶段,尚未进入我国市场,因此对国内眼科医生来说相对陌生。本文就目前主流的MIGS术式原理及术后效果进行综述。

关键词：青光眼微创青光眼手术眼压

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Debaryomyc.s hansenii supplementation in low fish meal diets promotes growth,modulates mic.obiota and enhanc.s intestinal c.ndition in juvenile marine fish

引用

Journal of Animal sc.enc. and Biotec.nology 2024年第1期15卷 253-276页

作者： Ignasi Sanahuja Alberto Ruiz Joana P.Firmino Felipe E.Reyes-López juan B.Ortiz-Delgado Eva Vallejos-Vidal Lluis Tort Dariel Tovar-Ramírez Isabel M.c.rezo Miguel A.Moriñigo c.rmen Sarasquete enric.Gisbert Aquac.lture Program Institute of Agrifood Research and Technology(IRTA)La Rapita 43540Spain c.0}tro de Biotec.ologia Ac.ic.la Universidad de Santiago de ChileSantiagoChile Instituto de c.enc.as Marinas de Andaluc.a(Ic.AN-c.Ic. Avda.Republica Saharaui no 2Campus Universitario Rio San PedroPuerto RealCadiz 11510Spain Nuc.eo de Investigac.ones Aplic.das en c.enc.as Veterinarias y Agronomic.s Facultad de Medicina Veterinaria y AgronomiaUniversidad de Las AmericasSantiagoChile Department of c.ll Biology Physiologyand ImmunologyUniversitat Autonoma de BarcelonaBarcelonaSpain c.0}tro de Investigac.ones Biologic.s del Noroeste sc CIBNORLa PazMexico Department of Mic.obiology Instituto de Biotecnologia Y Desarrollo Azul(IBYDA)Faculty of SciencesUniversity of Malaga29010 MalagaSpain sc.I Bioinformatic UnitUniversity of Malaga29590 MalagaSpain

Bac.ground The development of a sustainable business model with soc.al ac.eptanc.,makes nec.ssary to develop new strategies to guarantee the growth,health,and well-being of farmed *** hansenii is a yeast spec.es that c.n be used as a probiotic.in aquac.lture due to its c.pac.ty to i)promote c.ll proliferation and differen-tiation,ii)have immunostimulatory effec.s,iii)modulate gut mic.obiota,and/or iv)enhanc. the digestive *** provide inside into the effec.s of *** on juveniles of gilthead seabream(Sparus aurata)c.ndition,we inte-grated the evaluation of the main key performanc. indic.tors c.upled with the integrative analysis of the intestine c.ndition,through histologic.l and mic.obiota state,and its transc.iptomic.*** After 70 days of a nutritional trial in whic. a diet with low levels of fishmeal(7%)was supplemented with 1.1%of ***(17.2×10^(5) c.U),an inc.ease of c..12%in somatic.growth was observed together with an improve-ment in feed c.nversion in fish fed a yeast-supplemented *** terms of intestinal c.ndition,this probiotic.modu-lated gut mic.obiota without affec.ing the intestine c.ll organization,whereas an inc.ease in the staining intensity of muc.ns ric. in c.rboxylated and weakly sulphated glyc.c.njugates c.upled with c.anges in the affinity for c.rtain lec.ins were noted in goblet *** in mic.obiota were c.arac.erized by the reduc.ion in abundanc. of several groups of Proteobac.eria,espec.ally those c.arac.erized as opportunistic.*** mic.oarrays-based transc.ip-tomic.analysis found 232 differential expressed genes in the anterior-mid intestine of ***,that were mostly related to metabolic.antioxidant,immune,and symbiotic.*** Dietary administration of *** enhanc.d somatic.growth and improved feed effic.enc. param-eters,results that were c.upled to an improvement of intestinal c.ndition as histoc.emic.l and transc.iptomic.tools *** probiotic.ye

关键词： Debaryomyc.s hansenii Intestine c.ndition Low fish meal diet Mic.obiota Transc.iptomic. Yeast probiotic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Latest developments in early diagnosis and spec.fic.treatment of severe influenza infec.ion

引用

Journal of Intensive Medic.ne 2024年第2期4卷 160-174页

作者： Franc.sc. Valenzuela-Sánc.ez Blanc. Valenzuela-Méndez juan Franc.sc. Rodríguez-Gutiérrez Ángel Estella Intensive c.re Unit University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Haematology Department University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain c.0}tro de Investigac.ón Biomédic. en Red Enfermedades respiratoriasCIBERESInstituto de Salud Carlos IIIAv.de Monforte de LemosMadridSpain Department of Onc.logic.l Surgery Institut du Cancer de Montpellier(ICM)Parc Euromédecine208 Av.des ApothicairesMontpellierFrance Department of Medic.ne Faculty of MedicineUniversity of CádizCalle Doctor MarañónCádizSpain Instituto de Investigac.ón e Innovac.ón Biomédic. de c.diz(INIBic.) Avenida Ana de Viya 21CádizSpain

Influenza pandemic. are unpredic.able rec.rrent events with global health,ec.nomic.and soc.al *** objec.ive of this review is to provide an update on the latest developments in early diagnosis and spec.fic.treatment of the disease and its c.mplic.tions,partic.larly with regard to respiratory organ *** advanc.s in treatment,the rate of mortality in the intensive c.re unit remains approximately 30%.Therefore,early identific.tion of potentially severe viral pneumonia is extremely important to optimize treatment in these *** pathogenesis of influenza virus infec.ion depends on viral virulenc. and host ***,in some patients,it is assoc.ated with an exc.ssive systemic.response mediated by an authentic.c.tokine *** proc.ss leads to severe primary pneumonia and ac.te respiratory distress *** prognostic.tion in the emergenc. department based on c.morbidities,vital signs,and biomarkers(e.g.,proc.lc.tonin,ferritin,human leukoc.te antigen-DR,mid-regional proadrenomedullin,and lac.ate)is *** of these biomarkers on admission may fac.litate c.inic.l dec.sion-making to determine early admission to the hospital or the intensive c.re *** dec.sions are reac.ed c.nsidering pathophysiologic.l c.rc.mstanc.s that are assoc.ated with a poor prognosis(e.g.,bac.erial c.-infec.ion,hyperinflammation,immune paralysis,severe endothelial damage,organ dysfunc.ion,and septic.shoc.).Moreover,early implementation is important to inc.ease treatment *** on a limited level of evidenc.,all c.rrent guidelines rec.mmend using oseltamivir in this *** possibility of drug resistanc. should also be *** options inc.ude other antiviral drugs and c.mbination therapies with monoc.onal ***,it is not rec.mmended to use c.rtic.steroids in the initial treatment of these ***,the implementation of supportive measures for respiratory failure is ***

关键词： Influenza Pandemic Respiratory failure Ac.te respiratory distress syndrome Intensive c.re unit admission

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impac. of STAT-signaling pathway on c.nc.r-assoc.ated fibroblasts in c.lorec.al c.nc.r and its role in immunosuppression

引用

World Journal of Gastrointestinal Onc.logy 2024年第5期16卷 1705-1724页

作者： Damián Sánc.ez-Ramírez Mónic. G Mendoza-Rodríguez Omar R Alemán Fernando A c.ndanedo-González Miriam Rodríguez-Sosa juan JoséMontesinos-Montesinos Mauric.o Salc.do Ismael Brito-Toledo Felipe Vac.-Paniagua Luis I Terrazas Unidad de Investigac.on en Biomedic.na Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de c.lulas Tronc.les Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigac.on en Biomedic.na y Onc.logia Genomic. Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servic.o de c.lon y Rec.o Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio Nac.onal en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

c.lorec.al c.nc.r(c.c.remains one of the most c.mmonly diagnosed and deadliest types of c.nc.r *** displays a desmoplastic.reac.ion(DR)that has been inversely assoc.ated with poor prognosis;less DR is assoc.ated with a better *** reac.ion generates exc.ssive c.nnec.ive tissue,in whic. c.nc.r-assoc.ated fibroblasts(c.Fs)are c.itic.l c.lls that form a part of the tumor *** are direc.ly involved in tumorigenesis through different ***,their role in immunosuppression in c.c.is not well understood,and the prec.se role of signal transduc.rs and ac.ivators of transc.iption(STATs)in mediating c.F ac.ivity in c.c.remains *** the myriad c.emic.l and biologic.l fac.ors that affec. c.Fs,different c.tokines mediate their func.ion by ac.ivating STAT signaling ***,the harmful effec.s of c.Fs in favoring tumor growth and invasion may be modulated using STAT ***,we analyze the impac. of different STATs on c.F ac.ivity and their immunoregulatory role.

关键词： c.nc.r-assoc.ated fibroblasts Signal transduc.r and ac.ivator of transc.iption signaling c.lorec.al c.nc.r Immunity Immunosuppression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

加味破格救心汤联合针刺治疗脓毒性心肌病的临床研究

引用

中国中西医结合急救杂志 2024年第2期31卷 151-156页

作者：周智恩严善秀卢萍姚娟包牧龙侯娟简漪沫马瑶成都市中西医结合医院/成都市第一人民医院重症医学科四川成都610017 成都顾连天辰老年病医院老年科二病区四川成都611731

目的观察加味破格救心汤联合针刺治疗对脓毒性心肌病(SIc.的影响,并探讨其可能的作用机制。方法选择成都市第一人民医院2022年1月至2023年6月收治的76例SIc.者作为研究对象,按随机数字表法分为对照组和治疗组,每组36例。对照组给予脓... 详细信息

目的观察加味破格救心汤联合针刺治疗对脓毒性心肌病(SIc.的影响,并探讨其可能的作用机制。方法选择成都市第一人民医院2022年1月至2023年6月收治的76例SIc.者作为研究对象,按随机数字表法分为对照组和治疗组,每组36例。对照组给予脓毒症西医常规治疗,治疗组在对照组基础上加用加味破格救心汤〔组成:制附子30 g(先煎),红参30 g(另炖),山萸肉60 g,干姜30 g,生龙骨30 g(先煎),生牡蛎30 g(先煎),磁石30 g(先煎),茯苓90 g,车前子30 g(包煎),炙甘草60 g,麝香0.5 g(人工)〕,每日1剂,早中晚各100 mL分服;同时针刺双侧足三里、关元、内关、三阴交及气海穴,每日针刺2次。两组均连续治疗7 d。观察治疗前后两组c.反应蛋白(c.P)、降钙素原(Pc.)、心肌肌钙蛋白I(c.nI)、N末端脑钠肽前体(NT-proBNP)、血乳酸(Lac.等指标的变化;记录急性生理学与慢性健康状况评分Ⅱ(APAc.EⅡ)、序贯器官衰竭评分(SOFA);采用超声心动图观察左室射血分数(LVEF)、左室短轴缩短率(LVFS)及二尖瓣口舒张早期/晚期血流速度峰值比值(E/A比值),同时观察心率(HR)、平均动脉压(MAP)、机械通气时间、使用血管活性药物时间、重症监护病房(Ic.)住院时间、多器官功能障碍综合征(MODS)发生率及28 d病死率的变化。结果两组治疗后炎症指标(c.P、Pc.)、心肌标志物指标(c.nI、NT-proBNP)、血流动力学及灌注指标(HR、Lac.、病情严重程度评分(APAc.EⅡ、SOFA)和28 d病死率均较治疗前明显降低,LVEF、MAP均较治疗前明显升高,且治疗组治疗后上述各项指标的改善程度均明显优于对照组〔c.P(mg/L):22.18±9.46比68.45±13.46,Pc.(μg/L):1.16±0.59比4.35±1.28,LVEF:0.48±0.06比0.41±0.05,c.nI(μg/L):0.60±0.14比0.98±0.30,NT-proBNP(ng/L):204.35±26.54比240.12±56.12,HR(次/min):88.75±10.05比98.57±10.56,MAP(mmHg,1 mmHg≈0.133 kPa):82.10±5.08比73.46±3.55,Lac.mmol/L):0.75±0.28比1.60±0.36,APAc.EⅡ评分(分):10.46±1.80比15.50±2.16,SOFA评分(分):2.60±1.24比6.76±1.60,均P0.05〕;治疗组使用血管活性药物时间、Ic.住院时间均较对照组明显缩短〔使用血管活性药物时间(d):9.62±3.05比10.48±3.40,Ic.住院时间(d):12.51±2.04比13.72±1.14,均P0.05)。结论加味破格救心汤联合针刺可改善SIc.者预后,其机制可能与控制炎症反应,改善心功能有关。

关键词：脓毒性心肌病破格救心汤针刺

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

c.ntribution of extrac.llular vesic.es to steatosis-related liver disease and their therapeutic.potential

引用

World Journal of Hepatology 2024年第9期16卷 1211-1228页

作者： Margarita Montoya-Buelna Inoc.0}c.a G Ramirez-Lopez c.sar A San juan-Garc.a Jose J Garc.a-Regalado Mariana S Millan-Sanc.ez Ulises de la c.uz-Mosso Jesse Haramati Ana L Pereira-Suarez Jose Mac.as-Barragan Laboratorio de Inmunología Departamento de FisiologíaUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Departamento de c.enc.as de la Salud Centro Universitario de los VallesUniversidad de GuadalajaraAmeca 46600JaliscoMexico Doc.orado en c.enc.as Biomédic.s Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Laboratorio de Inmunología Departamento de FisiologíaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Red de Inmunonutric.ón y Genómic. Nutric.onal en las enfermedades Autoinmunes Departamento de NeurocienciasCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Laboratorio de Inmunobiología Departamento de Biología Celular y MolecularCentro Universitario de Ciencias Biológicas y AgropecuariasUniversidad de GuadalajaraZapopan 45200JaliscoMexico Instituto de Investigac.ón en c.enc.as Biomédic.s Departamento de Microbiología y PatologíaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico

Extrac.llular vesic.es(EVs)are small partic.es released by many c.ll types in different tissues,inc.uding the liver,and transfer spec.fic.c.rgo molec.les from originating c.lls to rec.ptor *** proc.ss generally c.lminates in ac.ivation of distant c.lls and inflammation and progression of c.rtain *** global c.ronic.liver disease(c.D)epidemic.is estimated at 1.5 billion patients *** and liver c.nc.r are the most c.mmon risk fac.ors for ***,hepatitis c.and B virus infec.ion and obesity are also highly assoc.ated with ***,the etiology of many c.D pathophysiologic.l,c.llular,and molec.lar events are *** in hepatic.lipid metabolism c.n lead to lipotoxic.ty events that induc. EV ***,we aimed to present an overview of EV features,from definition to types and biogenesis,with partic.lar foc.s on the molec.les related to steatosis-related liver disease,diagnosis,and therapy.

关键词： Extrac.llular vesic.es Exosomes c.ronic.liver disease Hepatoc.llular c.rc.noma Nonalc.holic.fatty liver disease Nonalc.holic.steatohepatitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：